DE2757157C3 - Verfahren zur Herstellung von 16 a -alkylierten Steroiden - Google Patents

Verfahren zur Herstellung von 16 a -alkylierten Steroiden

Info

Publication number
DE2757157C3
DE2757157C3 DE19772757157 DE2757157A DE2757157C3 DE 2757157 C3 DE2757157 C3 DE 2757157C3 DE 19772757157 DE19772757157 DE 19772757157 DE 2757157 A DE2757157 A DE 2757157A DE 2757157 C3 DE2757157 C3 DE 2757157C3
Authority
DE
Germany
Prior art keywords
alkyl
dimethylhydrazone
methyl
keto
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE19772757157
Other languages
German (de)
English (en)
Other versions
DE2757157B2 (de
DE2757157A1 (de
Inventor
Ulrich Dr. Eder
Gregor Dr. Haffer
Guenter Dr. Neef
Robert Dr. Nickolson
Gerhard Dr. Sauer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to DE19772757157 priority Critical patent/DE2757157C3/de
Priority to JP15429478A priority patent/JPS5488252A/ja
Publication of DE2757157A1 publication Critical patent/DE2757157A1/de
Publication of DE2757157B2 publication Critical patent/DE2757157B2/de
Application granted granted Critical
Publication of DE2757157C3 publication Critical patent/DE2757157C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
DE19772757157 1977-12-19 1977-12-19 Verfahren zur Herstellung von 16 a -alkylierten Steroiden Expired DE2757157C3 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE19772757157 DE2757157C3 (de) 1977-12-19 1977-12-19 Verfahren zur Herstellung von 16 a -alkylierten Steroiden
JP15429478A JPS5488252A (en) 1977-12-19 1978-12-15 Manufacture of 16 alphaaalkylated steroid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19772757157 DE2757157C3 (de) 1977-12-19 1977-12-19 Verfahren zur Herstellung von 16 a -alkylierten Steroiden

Publications (3)

Publication Number Publication Date
DE2757157A1 DE2757157A1 (de) 1979-06-21
DE2757157B2 DE2757157B2 (de) 1980-02-21
DE2757157C3 true DE2757157C3 (de) 1980-10-09

Family

ID=6026799

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19772757157 Expired DE2757157C3 (de) 1977-12-19 1977-12-19 Verfahren zur Herstellung von 16 a -alkylierten Steroiden

Country Status (2)

Country Link
JP (1) JPS5488252A (zh)
DE (1) DE2757157C3 (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7867975B2 (en) 1995-10-23 2011-01-11 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
US8399440B2 (en) 2006-03-20 2013-03-19 Entremed, Inc. Disease modifying anti-arthritic activity of 2-methoxyestradiol

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR80020B (en) * 1983-08-02 1984-12-11 Research Corp Steroids useful as anti-cancer,anti-obesity,anti-hyperglycemic, anti-autoimmune and anti-hypercholesterolemic agents
US5504074A (en) 1993-08-06 1996-04-02 Children's Medical Center Corporation Estrogenic compounds as anti-angiogenic agents
US6908910B2 (en) 1993-08-06 2005-06-21 The Children's Medical Center Corporation Estrogenic compounds as anti-mitotic agents
US7087592B1 (en) 1999-08-23 2006-08-08 Entre Med, Inc. Compositions comprising purified 2-methoxyestradiol and methods of producing same
SK882003A3 (en) 2000-07-28 2003-07-01 Akzo Nobel Nv 16alpha-substituted steroid compounds, pharmaceutical composition comprising same and their use
US7135581B2 (en) 2000-08-18 2006-11-14 Entremed, Inc. Antiangiogenic agents
AU2005244167A1 (en) 2004-05-04 2005-11-24 Beth Israel Deaconess Medical Center Methods and compositions for treatment of preeclampsia
UA89964C2 (ru) 2004-09-08 2010-03-25 Н.В. Органон 15β-ЗАМЕЩЕННЫЕ СТЕРОИДЫ, КОТОРЫЕ ИМЕЮТ СЕЛЕКТИВНУЮ ЭСТРОГЕННУЮ АКТИВНОСТЬ

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7867975B2 (en) 1995-10-23 2011-01-11 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
US8399440B2 (en) 2006-03-20 2013-03-19 Entremed, Inc. Disease modifying anti-arthritic activity of 2-methoxyestradiol

Also Published As

Publication number Publication date
DE2757157B2 (de) 1980-02-21
JPS5488252A (en) 1979-07-13
JPS6225158B2 (zh) 1987-06-01
DE2757157A1 (de) 1979-06-21

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Legal Events

Date Code Title Description
OAP Request for examination filed
OD Request for examination
C3 Grant after two publication steps (3rd publication)
8327 Change in the person/name/address of the patent owner

Owner name: SCHERING AG, 13353 BERLIN, DE

8339 Ceased/non-payment of the annual fee