DE2748132A1 - Stabilisator fuer polysaccharid - Google Patents

Stabilisator fuer polysaccharid

Info

Publication number
DE2748132A1
DE2748132A1 DE19772748132 DE2748132A DE2748132A1 DE 2748132 A1 DE2748132 A1 DE 2748132A1 DE 19772748132 DE19772748132 DE 19772748132 DE 2748132 A DE2748132 A DE 2748132A DE 2748132 A1 DE2748132 A1 DE 2748132A1
Authority
DE
Germany
Prior art keywords
polysaccharide
lactose
meningococcal
sucrose
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19772748132
Other languages
German (de)
English (en)
Other versions
DE2748132C2 (enExample
Inventor
Gerhard Dipl Chem Guthoehrlein
Torsten Bertil Dr Helting
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Priority to DE19772748132 priority Critical patent/DE2748132A1/de
Priority to ES474412A priority patent/ES474412A1/es
Priority to FI783250A priority patent/FI61807B/fi
Priority to SE7811083A priority patent/SE447700B/sv
Priority to US05/954,461 priority patent/US4206200A/en
Priority to DK477278A priority patent/DK158006C/da
Priority to CA314,311A priority patent/CA1113861A/en
Priority to BE191411A priority patent/BE871612A/xx
Priority to GB7842190A priority patent/GB2009198B/en
Priority to JP13173878A priority patent/JPS5470422A/ja
Priority to FR7830616A priority patent/FR2406999A1/fr
Publication of DE2748132A1 publication Critical patent/DE2748132A1/de
Application granted granted Critical
Publication of DE2748132C2 publication Critical patent/DE2748132C2/de
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DE19772748132 1977-10-27 1977-10-27 Stabilisator fuer polysaccharid Granted DE2748132A1 (de)

Priority Applications (11)

Application Number Priority Date Filing Date Title
DE19772748132 DE2748132A1 (de) 1977-10-27 1977-10-27 Stabilisator fuer polysaccharid
ES474412A ES474412A1 (es) 1977-10-27 1978-10-21 Procedimiento para mejorar la estabilizacion de polisacarido meningococico.
SE7811083A SE447700B (sv) 1977-10-27 1978-10-25 Stabilisering av meningokockpolysackarid, vaccin innehallande polysackariden och stabilisator(er) samt anvendningen av sackaros, raffinos eller glutaminat och eventuellt laktos som stabilisator
US05/954,461 US4206200A (en) 1977-10-27 1978-10-25 Stabilizer for polysaccharides
FI783250A FI61807B (fi) 1977-10-27 1978-10-25 Foerfarande foer stabilisering av meningokockpolysackarid
CA314,311A CA1113861A (en) 1977-10-27 1978-10-26 Stabilizer for polysaccharides
DK477278A DK158006C (da) 1977-10-27 1978-10-26 Fremgangsmaade til stabilisering af toerret meningokokpolysaccharid
BE191411A BE871612A (fr) 1977-10-27 1978-10-27 Stabilisant pour polysaccharides
GB7842190A GB2009198B (en) 1977-10-27 1978-10-27 Stabilized polysaccharides
JP13173878A JPS5470422A (en) 1977-10-27 1978-10-27 Stabilizer for polysaccharide
FR7830616A FR2406999A1 (fr) 1977-10-27 1978-10-27 Stabilisant pour polysaccharides de meningocoques

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19772748132 DE2748132A1 (de) 1977-10-27 1977-10-27 Stabilisator fuer polysaccharid

Publications (2)

Publication Number Publication Date
DE2748132A1 true DE2748132A1 (de) 1979-05-03
DE2748132C2 DE2748132C2 (enExample) 1989-04-06

Family

ID=6022367

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19772748132 Granted DE2748132A1 (de) 1977-10-27 1977-10-27 Stabilisator fuer polysaccharid

Country Status (11)

Country Link
US (1) US4206200A (enExample)
JP (1) JPS5470422A (enExample)
BE (1) BE871612A (enExample)
CA (1) CA1113861A (enExample)
DE (1) DE2748132A1 (enExample)
DK (1) DK158006C (enExample)
ES (1) ES474412A1 (enExample)
FI (1) FI61807B (enExample)
FR (1) FR2406999A1 (enExample)
GB (1) GB2009198B (enExample)
SE (1) SE447700B (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE889979A (fr) * 1981-08-14 1982-02-15 Smith Kline Rit Procede de preparation de polysaccharides bacteriens capsulaires antigeniques purifies, produits obtenus et leur utilisation
US4451446A (en) * 1982-03-04 1984-05-29 Smithkline-Rit Process for the preparation of polysaccharide-protein complexes from bacterial capsules, obtained products and immunogenic compositions containing them
WO1987000196A1 (en) * 1985-07-09 1987-01-15 Quadrant Bioresources Limited Protection of proteins and the like
GB2187191B (en) * 1984-01-30 1989-11-01 Quadrant Bioresources Ltd Protection of proteins and the like
US4931385A (en) * 1985-06-24 1990-06-05 Hygeia Sciences, Incorporated Enzyme immunoassays and immunologic reagents
US4868108A (en) * 1985-12-12 1989-09-19 Hygeia Sciences, Incorporated Multiple-antibody detection of antigen
US4762857A (en) * 1986-05-30 1988-08-09 E. I. Du Pont De Nemours And Company Trehalose as stabilizer and tableting excipient
US4678812A (en) * 1986-05-30 1987-07-07 E. I. Du Pont De Nemours And Company Trehalose as stabilizer and tableting excipient
US5102788A (en) * 1988-11-21 1992-04-07 Hygeia Sciences, Inc. Immunoassay including lyophilized reactant mixture
JPH03208485A (ja) * 1990-01-11 1991-09-11 Matsushita Electric Ind Co Ltd 文字放送受信装置
US5200399A (en) * 1990-09-14 1993-04-06 Boyce Thompson Institute For Plant Research, Inc. Method of protecting biological materials from destructive reactions in the dry state
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
US6509006B1 (en) 1992-07-08 2003-01-21 Inhale Therapeutic Systems, Inc. Devices compositions and methods for the pulmonary delivery of aerosolized medicaments
US6024090A (en) * 1993-01-29 2000-02-15 Aradigm Corporation Method of treating a diabetic patient by aerosolized administration of insulin lispro
US7448375B2 (en) * 1993-01-29 2008-11-11 Aradigm Corporation Method of treating diabetes mellitus in a patient
EP0748213B1 (en) * 1994-03-07 2004-04-14 Nektar Therapeutics Methods and compositions for pulmonary delivery of insulin
CN1188171C (zh) 1994-06-02 2005-02-09 廓德伦特控股剑桥有限公司 防止各种特质在再水化或熔化时聚集的方法以及由此获得的组合物
GB9508691D0 (en) 1995-04-28 1995-06-14 Pafra Ltd Stable compositions
US5876992A (en) * 1996-07-03 1999-03-02 Molecular Biology Resources, Inc. Method and formulation for stabilization of enzymes
US6306404B1 (en) 1998-07-14 2001-10-23 American Cyanamid Company Adjuvant and vaccine compositions containing monophosphoryl lipid A
FR2791895B1 (fr) * 1999-03-23 2001-06-15 Pasteur Merieux Serums Vacc Utilisation de trehalose pour stabiliser un vaccin liquide
US6635261B2 (en) 1999-07-13 2003-10-21 Wyeth Holdings Corporation Adjuvant and vaccine compositions containing monophosphoryl lipid A
GB0115176D0 (en) * 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
KR100887429B1 (ko) 2001-10-22 2009-03-09 돔페 파르마 에스.피.에이. 초임계 유체 공정: 단백질 미세입자의 제조 및 그의 안정화
WO2003080678A1 (en) * 2002-03-26 2003-10-02 Chiron Srl Modified saccharides having improved stability in water
US20030124139A1 (en) * 2002-11-20 2003-07-03 Irina Esikova Compositions and methods for stabilizing biological molecules upon lyophilization
CN102512429A (zh) 2005-03-14 2012-06-27 惠氏公司 替加环素组合物及制备方法
US9486515B2 (en) * 2005-06-27 2016-11-08 Glaxosmithkline Biologicals S.A. Immunogenic composition
GB0612854D0 (en) * 2006-06-28 2006-08-09 Novartis Ag Saccharide analysis
EP2440658B1 (en) 2009-06-12 2014-10-08 Micronics, Inc. Rehydratable matrices for dry storage of taq polymerase in a microfluidic device
CN102803507B (zh) 2009-06-12 2016-05-25 精密公司 用于微流体装置中在板反应剂的脱水储存的组合物及方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2908614A (en) * 1954-08-10 1959-10-13 Glaxo Lab Ltd Use of dextran in freeze-drying process
GB995362A (en) * 1962-05-11 1965-06-16 Smith Kline French Lab Improvements in or relating to freeze-drying biological material
US3567585A (en) * 1963-07-12 1971-03-02 Ciba Geigy Corp Process for obtaining bcg-cultures

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3135663A (en) * 1960-06-28 1964-06-02 Glaxo Group Ltd Vaccines
DE1183629B (de) * 1962-12-21 1964-12-17 Behringwerke Ag Verfahren zur Stabilisierung biologisch aktiven Materials
DE1617350C3 (de) * 1967-06-22 1979-09-06 Behringwerke Ag, 3550 Marburg Verfahren zur Inaktivierung von biologischem Material
US3532790A (en) * 1968-02-23 1970-10-06 Canadian Patents Dev Somatic antigen vaccines from lysed inactivated bacteria and process for producing them
FR7461M (enExample) * 1968-06-19 1970-01-05
GB1218277A (en) * 1968-08-20 1971-01-06 Miles Lab Dry water-dispersible aluminium hydroxide gels
US3577527A (en) * 1969-01-27 1971-05-04 Us Navy Neisseria meningitidis antigen
US3599150A (en) * 1969-08-01 1971-08-10 Miles Lab Stabilized aluminum hydroxide suspensions
US3636192A (en) * 1970-01-13 1972-01-18 Us Army Meningococcal polysaccharide vaccines
US3859434A (en) * 1973-01-08 1975-01-07 Canadian Patents Dev Meningococcal antigens

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2908614A (en) * 1954-08-10 1959-10-13 Glaxo Lab Ltd Use of dextran in freeze-drying process
GB995362A (en) * 1962-05-11 1965-06-16 Smith Kline French Lab Improvements in or relating to freeze-drying biological material
US3567585A (en) * 1963-07-12 1971-03-02 Ciba Geigy Corp Process for obtaining bcg-cultures

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Freeze Drying and Advanced Food Technology, Academic Press, 1975, S.95, 96, 463 u. 467-469 *

Also Published As

Publication number Publication date
JPS6310686B2 (enExample) 1988-03-08
ES474412A1 (es) 1979-04-16
DK158006C (da) 1990-08-06
FI61807B (fi) 1982-06-30
DK477278A (da) 1979-04-28
GB2009198A (en) 1979-06-13
US4206200A (en) 1980-06-03
JPS5470422A (en) 1979-06-06
FR2406999B1 (enExample) 1982-11-12
CA1113861A (en) 1981-12-08
DE2748132C2 (enExample) 1989-04-06
DK158006B (da) 1990-03-12
FR2406999A1 (fr) 1979-05-25
SE7811083L (sv) 1979-04-28
SE447700B (sv) 1986-12-08
GB2009198B (en) 1982-10-27
BE871612A (fr) 1979-04-27
FI783250A7 (fi) 1979-04-28

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Legal Events

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8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition