DE2644911C3 - Derivate von Kanamycin A oder B, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel - Google Patents

Derivate von Kanamycin A oder B, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel

Info

Publication number
DE2644911C3
DE2644911C3 DE2644911A DE2644911A DE2644911C3 DE 2644911 C3 DE2644911 C3 DE 2644911C3 DE 2644911 A DE2644911 A DE 2644911A DE 2644911 A DE2644911 A DE 2644911A DE 2644911 C3 DE2644911 C3 DE 2644911C3
Authority
DE
Germany
Prior art keywords
kanamycin
same
compounds
derivatives
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2644911A
Other languages
German (de)
English (en)
Other versions
DE2644911B2 (de
DE2644911A1 (de
Inventor
James William Dr. Sandwich Kent Moore (Grossbritannien)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp SRL
Original Assignee
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB4641274A external-priority patent/GB1464401A/en
Priority claimed from GB1542576A external-priority patent/GB1512475A/en
Application filed by Pfizer Corp SRL filed Critical Pfizer Corp SRL
Publication of DE2644911A1 publication Critical patent/DE2644911A1/de
Publication of DE2644911B2 publication Critical patent/DE2644911B2/de
Application granted granted Critical
Publication of DE2644911C3 publication Critical patent/DE2644911C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
    • C07H15/23—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with only two saccharide radicals in the molecule, e.g. ambutyrosin, butyrosin, xylostatin, ribostamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE2644911A 1974-10-26 1976-10-05 Derivate von Kanamycin A oder B, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel Expired DE2644911C3 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB4641274A GB1464401A (en) 1974-10-26 1974-10-26 Aminoglycosides
ZA00756326A ZA756326B (en) 1974-10-26 1975-10-06 2-hydroxy-aminoalkyl-derivatives of aminoglycoside antibiotics
NZ179050A NZ179050A (en) 1974-10-26 1975-10-24 Antibacterial 2-deoxystreptamine amino-glycosides (2-hydroxy-w-aminoalkyl derivatiues): and pharmaceutical compositions
GB1542576A GB1512475A (en) 1974-10-26 1976-04-15 Aminoglycosides

Publications (3)

Publication Number Publication Date
DE2644911A1 DE2644911A1 (de) 1977-04-28
DE2644911B2 DE2644911B2 (de) 1978-12-21
DE2644911C3 true DE2644911C3 (de) 1979-08-23

Family

ID=27448310

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2644911A Expired DE2644911C3 (de) 1974-10-26 1976-10-05 Derivate von Kanamycin A oder B, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel

Country Status (4)

Country Link
BE (1) BE846962R (https=)
CH (1) CH608812A5 (https=)
DE (1) DE2644911C3 (https=)
LU (1) LU75939A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5488241A (en) * 1977-12-21 1979-07-13 Kyowa Hakko Kogyo Co Ltd Novel fortimicin a derivative

Also Published As

Publication number Publication date
BE846962R (fr) 1977-04-05
CH608812A5 (https=) 1979-01-31
LU75939A1 (https=) 1978-05-16
DE2644911B2 (de) 1978-12-21
DE2644911A1 (de) 1977-04-28

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Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)
8340 Patent of addition ceased/non-payment of fee of main patent