DE2604718C2 - Therapeutische Vorrichtung zur Verabreichung von Skopolaminbase und Verfahren zu deren Herstellung - Google Patents
Therapeutische Vorrichtung zur Verabreichung von Skopolaminbase und Verfahren zu deren HerstellungInfo
- Publication number
- DE2604718C2 DE2604718C2 DE2604718A DE2604718A DE2604718C2 DE 2604718 C2 DE2604718 C2 DE 2604718C2 DE 2604718 A DE2604718 A DE 2604718A DE 2604718 A DE2604718 A DE 2604718A DE 2604718 C2 DE2604718 C2 DE 2604718C2
- Authority
- DE
- Germany
- Prior art keywords
- layer
- scopolamine
- polyisobutene
- skin
- pad
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 title claims description 69
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 title claims description 67
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 title claims description 67
- 229960002646 scopolamine Drugs 0.000 title claims description 67
- 229930000680 A04AD01 - Scopolamine Natural products 0.000 title claims description 66
- 230000001225 therapeutic effect Effects 0.000 title claims description 9
- 238000000034 method Methods 0.000 title claims description 3
- 239000010410 layer Substances 0.000 claims description 57
- 229920002367 Polyisobutene Polymers 0.000 claims description 21
- 239000002480 mineral oil Substances 0.000 claims description 20
- 235000010446 mineral oil Nutrition 0.000 claims description 20
- 239000012528 membrane Substances 0.000 claims description 17
- 239000000203 mixture Substances 0.000 claims description 14
- 239000003795 chemical substances by application Substances 0.000 claims description 12
- -1 polypropylene Polymers 0.000 claims description 10
- 239000012982 microporous membrane Substances 0.000 claims description 7
- 239000004480 active ingredient Substances 0.000 claims description 6
- 238000005259 measurement Methods 0.000 claims description 6
- 239000011241 protective layer Substances 0.000 claims description 6
- 239000004743 Polypropylene Substances 0.000 claims description 5
- 239000005020 polyethylene terephthalate Substances 0.000 claims description 5
- 229920000139 polyethylene terephthalate Polymers 0.000 claims description 5
- 229920001155 polypropylene Polymers 0.000 claims description 5
- 239000012790 adhesive layer Substances 0.000 claims description 4
- 239000011148 porous material Substances 0.000 claims description 4
- 239000004821 Contact adhesive Substances 0.000 claims description 3
- 229910052782 aluminium Inorganic materials 0.000 claims description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims 3
- 238000000576 coating method Methods 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 2
- 210000003491 skin Anatomy 0.000 description 27
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 8
- 229940079593 drug Drugs 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 230000001166 anti-perspirative effect Effects 0.000 description 5
- 239000003213 antiperspirant Substances 0.000 description 5
- 150000002148 esters Chemical class 0.000 description 5
- VQTUBCCKSQIDNK-UHFFFAOYSA-N Isobutene Chemical compound CC(C)=C VQTUBCCKSQIDNK-UHFFFAOYSA-N 0.000 description 4
- 206010028813 Nausea Diseases 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 210000001595 mastoid Anatomy 0.000 description 4
- 201000003152 motion sickness Diseases 0.000 description 4
- 230000008693 nausea Effects 0.000 description 4
- 229920006395 saturated elastomer Polymers 0.000 description 4
- 206010047700 Vomiting Diseases 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 229920001296 polysiloxane Polymers 0.000 description 3
- 230000009885 systemic effect Effects 0.000 description 3
- 241001263092 Alchornea latifolia Species 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 230000004907 flux Effects 0.000 description 2
- 239000011888 foil Substances 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 238000007918 intramuscular administration Methods 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 239000000902 placebo Substances 0.000 description 2
- 229920000915 polyvinyl chloride Polymers 0.000 description 2
- 239000004800 polyvinyl chloride Substances 0.000 description 2
- 230000036325 urinary excretion Effects 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- NJPQAIBZIHNJDO-UHFFFAOYSA-N 1-dodecylpyrrolidin-2-one Chemical compound CCCCCCCCCCCCN1CCCC1=O NJPQAIBZIHNJDO-UHFFFAOYSA-N 0.000 description 1
- 208000027601 Inner ear disease Diseases 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 1
- FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 229940035674 anesthetics Drugs 0.000 description 1
- 230000001062 anti-nausea Effects 0.000 description 1
- 230000003457 anti-vomiting effect Effects 0.000 description 1
- 210000001099 axilla Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- ILRSCQWREDREME-UHFFFAOYSA-N dodecanamide Chemical compound CCCCCCCCCCCC(N)=O ILRSCQWREDREME-UHFFFAOYSA-N 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 239000003193 general anesthetic agent Substances 0.000 description 1
- 230000024924 glomerular filtration Effects 0.000 description 1
- 229920001903 high density polyethylene Polymers 0.000 description 1
- 239000004700 high-density polyethylene Substances 0.000 description 1
- 229920001684 low density polyethylene Polymers 0.000 description 1
- 239000004702 low-density polyethylene Substances 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 230000001734 parasympathetic effect Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 229920002239 polyacrylonitrile Polymers 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920006254 polymer film Polymers 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000036647 reaction Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 208000027491 vestibular disease Diseases 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B7/00—Layered products characterised by the relation between layers; Layered products characterised by the relative orientation of features between layers, or by the relative values of a measurable parameter between layers, i.e. products comprising layers having different physical, chemical or physicochemical properties; Layered products characterised by the interconnection of layers
- B32B7/04—Interconnection of layers
- B32B7/12—Interconnection of layers using interposed adhesives or interposed materials with bonding properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B27/08—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/36—Layered products comprising a layer of synthetic resin comprising polyesters
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/70—Other properties
- B32B2307/726—Permeability to liquids, absorption
- B32B2307/7265—Non-permeable
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2323/00—Polyalkenes
- B32B2323/10—Polypropylene
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2367/00—Polyesters, e.g. PET, i.e. polyethylene terephthalate
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2556/00—Patches, e.g. medical patches, repair patches
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54750475A | 1975-02-06 | 1975-02-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2604718A1 DE2604718A1 (de) | 1976-08-19 |
| DE2604718C2 true DE2604718C2 (de) | 1987-03-05 |
Family
ID=24184910
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2604718A Expired DE2604718C2 (de) | 1975-02-06 | 1976-02-06 | Therapeutische Vorrichtung zur Verabreichung von Skopolaminbase und Verfahren zu deren Herstellung |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS6049601B2 (nl) |
| AR (1) | AR207805A1 (nl) |
| AT (1) | AT344326B (nl) |
| AU (1) | AU497383B2 (nl) |
| BE (1) | BE838295A (nl) |
| CA (1) | CA1059909A (nl) |
| CH (1) | CH624848A5 (nl) |
| DE (1) | DE2604718C2 (nl) |
| DK (1) | DK145284C (nl) |
| ES (1) | ES444552A1 (nl) |
| FR (1) | FR2299853A1 (nl) |
| GB (1) | GB1511121A (nl) |
| IL (1) | IL48840A (nl) |
| IT (1) | IT1057132B (nl) |
| NL (1) | NL187379C (nl) |
| SE (1) | SE424957B (nl) |
| ZA (1) | ZA76234B (nl) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3823395A1 (de) * | 1988-07-09 | 1990-03-15 | Holzapfel Boeving Partner Werb | Mit einem wirkstoff getraenktes tuch |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5621589Y2 (nl) * | 1977-05-30 | 1981-05-21 | ||
| US4201211A (en) * | 1977-07-12 | 1980-05-06 | Alza Corporation | Therapeutic system for administering clonidine transdermally |
| JPS5843368B2 (ja) * | 1980-10-30 | 1983-09-27 | 日東電工株式会社 | 消炎鎮痛貼付剤 |
| JPS5942314A (ja) * | 1982-08-31 | 1984-03-08 | Nitto Electric Ind Co Ltd | 外用部材 |
| JPS5984816A (ja) * | 1982-11-08 | 1984-05-16 | Sekisui Chem Co Ltd | 薬剤徐放性製剤 |
| IE54286B1 (en) * | 1983-01-18 | 1989-08-16 | Elan Corp Plc | Drug delivery device |
| JPS6016916A (ja) * | 1983-07-08 | 1985-01-28 | Nitto Electric Ind Co Ltd | 生物活性物質含有基剤及び該基剤の製法 |
| DE3347277A1 (de) * | 1983-12-28 | 1985-07-11 | Bayer Ag, 5090 Leverkusen | Wirkstoffabgabesysteme |
| DE3423328A1 (de) * | 1984-06-23 | 1986-01-02 | Beiersdorf Ag, 2000 Hamburg | Selbstklebendes pflaster |
| DE3423293C2 (de) * | 1984-06-23 | 1995-08-24 | Lohmann Therapie Syst Lts | Selbstklebendes Pflaster |
| US4588580B2 (en) * | 1984-07-23 | 1999-02-16 | Alaz Corp | Transdermal administration of fentanyl and device therefor |
| IL72684A (en) * | 1984-08-14 | 1989-02-28 | Israel State | Pharmaceutical compositions for controlled transdermal delivery of cholinergic or anticholinergic basic drugs |
| US4532244A (en) * | 1984-09-06 | 1985-07-30 | Innes Margaret N | Method of treating migraine headaches |
| EP0249475A3 (en) * | 1986-06-13 | 1989-10-11 | Alza Corporation | Delayed percutaneous delivery |
| FR2599976A1 (fr) * | 1986-06-16 | 1987-12-18 | Michel Pistor | Dispositif therapeutique, portable, totalement autonome, transdermique, pourvu d'au moins un organe formant aiguille ou pointe franchissant la barriere cutanee |
| GB8700150D0 (en) * | 1987-01-06 | 1987-02-11 | Martin I F | Wound dressings |
| CH674618A5 (nl) | 1987-04-02 | 1990-06-29 | Ciba Geigy Ag | |
| GB2212063A (en) * | 1987-11-12 | 1989-07-19 | Original Norfolk Trading Co Lt | Application of chemicals such as systemic herbicides and insecticides |
| FR2623718B1 (fr) * | 1987-11-27 | 1994-04-15 | Fabre Medicament Pierre | Dispositif therapeutique transdermique et son procede de preparation |
| DE4342174C1 (de) * | 1993-12-10 | 1995-05-11 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System sowie ein Verfahren zur Herstellung eines transdermalen therapeutischen Systems zur kombinierten transdermalen Anwendung von Physostigmin und Scopolamin für die Prophylaxe und zur Vorbehandlung einer Vergiftung durch hochtoxische phosphororganische Nervengifte, insbesondere Soman und seine Verwendung |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3767786A (en) * | 1961-04-20 | 1973-10-23 | Procter & Gamble | Inhibiting perspiration with scopolamine esters |
| NL6902314A (nl) * | 1969-02-13 | 1970-08-17 | ||
| US3797494A (en) * | 1969-04-01 | 1974-03-19 | Alza Corp | Bandage for the administration of drug by controlled metering through microporous materials |
| DE2012775C3 (de) * | 1970-03-18 | 1973-10-04 | V.P. Variopharm Gmbh Herstellung Und Vertrieb Pharmazeutischer, Kosmetischer Und Chemischer Erzeugnisse, 6656 Einoed | Salbenfohe und Verfahren zu ihrer Herstellung |
-
1976
- 1976-01-01 AR AR261972A patent/AR207805A1/es active
- 1976-01-02 GB GB101/76A patent/GB1511121A/en not_active Expired
- 1976-01-14 IL IL48840A patent/IL48840A/xx unknown
- 1976-01-15 ZA ZA234A patent/ZA76234B/xx unknown
- 1976-01-22 ES ES444552A patent/ES444552A1/es not_active Expired
- 1976-01-30 AU AU10678/76A patent/AU497383B2/en not_active Expired
- 1976-01-30 AT AT65676A patent/AT344326B/de not_active IP Right Cessation
- 1976-02-04 SE SE7601204A patent/SE424957B/xx not_active IP Right Cessation
- 1976-02-05 DK DK47676A patent/DK145284C/da active
- 1976-02-05 JP JP51011838A patent/JPS6049601B2/ja not_active Expired
- 1976-02-05 CA CA245,106A patent/CA1059909A/en not_active Expired
- 1976-02-05 BE BE164114A patent/BE838295A/xx not_active IP Right Cessation
- 1976-02-05 FR FR7603167A patent/FR2299853A1/fr active Granted
- 1976-02-05 IT IT67264/76A patent/IT1057132B/it active Protection Beyond IP Right Term
- 1976-02-05 CH CH142376A patent/CH624848A5/de active Protection Beyond IP Right Term
- 1976-02-06 NL NLAANVRAGE7601248,A patent/NL187379C/nl not_active IP Right Cessation
- 1976-02-06 DE DE2604718A patent/DE2604718C2/de not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3823395A1 (de) * | 1988-07-09 | 1990-03-15 | Holzapfel Boeving Partner Werb | Mit einem wirkstoff getraenktes tuch |
Also Published As
| Publication number | Publication date |
|---|---|
| NL187379C (nl) | 1991-09-16 |
| IL48840A (en) | 1978-01-31 |
| JPS6049601B2 (ja) | 1985-11-02 |
| IL48840A0 (en) | 1976-03-31 |
| SE424957B (sv) | 1982-08-23 |
| DE2604718A1 (de) | 1976-08-19 |
| GB1511121A (en) | 1978-05-17 |
| BE838295A (fr) | 1976-05-28 |
| FR2299853A1 (fr) | 1976-09-03 |
| ATA65676A (de) | 1977-11-15 |
| DK145284C (da) | 1983-03-21 |
| DK145284B (da) | 1982-10-25 |
| CA1059909A (en) | 1979-08-07 |
| AU497383B2 (en) | 1978-12-14 |
| CH624848A5 (en) | 1981-08-31 |
| FR2299853B1 (nl) | 1978-08-18 |
| DK47676A (da) | 1976-08-07 |
| NL7601248A (nl) | 1976-08-10 |
| ZA76234B (en) | 1977-01-26 |
| NL187379B (nl) | 1991-04-16 |
| JPS51104021A (nl) | 1976-09-14 |
| ES444552A1 (es) | 1977-08-16 |
| IT1057132B (it) | 1982-03-10 |
| AU1067876A (en) | 1977-08-04 |
| SE7601204L (sv) | 1976-08-09 |
| AR207805A1 (es) | 1976-10-29 |
| AT344326B (de) | 1978-07-10 |
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