DE2446058A1 - Galenische zubereitung fuer die allopurinol-dauertherapie - Google Patents
Galenische zubereitung fuer die allopurinol-dauertherapieInfo
- Publication number
- DE2446058A1 DE2446058A1 DE19742446058 DE2446058A DE2446058A1 DE 2446058 A1 DE2446058 A1 DE 2446058A1 DE 19742446058 DE19742446058 DE 19742446058 DE 2446058 A DE2446058 A DE 2446058A DE 2446058 A1 DE2446058 A1 DE 2446058A1
- Authority
- DE
- Germany
- Prior art keywords
- allopurinol
- tablet
- microcrystalline cellulose
- tablets
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- OFCNXPDARWKPPY-UHFFFAOYSA-N allopurinol Chemical compound OC1=NC=NC2=C1C=NN2 OFCNXPDARWKPPY-UHFFFAOYSA-N 0.000 title claims description 32
- 229960003459 allopurinol Drugs 0.000 title claims description 31
- 238000002360 preparation method Methods 0.000 title claims description 8
- 238000011340 continuous therapy Methods 0.000 title 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 14
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 14
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 14
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 14
- 229920000881 Modified starch Polymers 0.000 claims description 8
- 235000019426 modified starch Nutrition 0.000 claims description 8
- 238000012153 long-term therapy Methods 0.000 claims description 6
- 239000008107 starch Substances 0.000 claims description 3
- 229920002472 Starch Polymers 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims 1
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 18
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 13
- 239000004480 active ingredient Substances 0.000 description 11
- 235000019359 magnesium stearate Nutrition 0.000 description 9
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 5
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 5
- 230000007774 longterm Effects 0.000 description 5
- 239000000377 silicon dioxide Substances 0.000 description 5
- 229940116269 uric acid Drugs 0.000 description 5
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 4
- 229910002012 Aerosil® Inorganic materials 0.000 description 3
- 229920002261 Corn starch Polymers 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008120 corn starch Substances 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 239000003979 granulating agent Substances 0.000 description 3
- 239000000314 lubricant Substances 0.000 description 3
- 239000000825 pharmaceutical preparation Substances 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 2
- 201000005569 Gout Diseases 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 description 2
- 239000001814 pectin Substances 0.000 description 2
- 235000010987 pectin Nutrition 0.000 description 2
- 229920001277 pectin Polymers 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229920000945 Amylopectin Polymers 0.000 description 1
- UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 description 1
- 108010093894 Xanthine oxidase Proteins 0.000 description 1
- 102100033220 Xanthine oxidase Human genes 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- -1 for example Substances 0.000 description 1
- 238000000099 in vitro assay Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229950002752 oxipurinol Drugs 0.000 description 1
- HXNFUBHNUDHIGC-UHFFFAOYSA-N oxypurinol Chemical compound O=C1NC(=O)N=C2NNC=C21 HXNFUBHNUDHIGC-UHFFFAOYSA-N 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229940057838 polyethylene glycol 4000 Drugs 0.000 description 1
- 229940093429 polyethylene glycol 6000 Drugs 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19742446058 DE2446058A1 (de) | 1974-09-26 | 1974-09-26 | Galenische zubereitung fuer die allopurinol-dauertherapie |
ES441204A ES441204A1 (es) | 1974-09-26 | 1975-09-23 | Procedimiento para la produccion de formas de preparados ga-lenicos en forma de tabletas. |
GB3910075A GB1464200A (en) | 1974-09-26 | 1975-09-24 | Pharmaceutical composition |
SE7510752A SE7510752L (sv) | 1974-09-26 | 1975-09-25 | Galenisk beredning for allopyrinol-langtidsterapi |
FR7529371A FR2285856A1 (fr) | 1974-09-26 | 1975-09-25 | Preparation galenique pour la therapeutique de longue duree a l'allopurinol |
BE160355A BE833797A (fr) | 1974-09-26 | 1975-09-25 | Preparation galenique pour traitements de longue duree a l'allopurinol |
ZA00756096A ZA756096B (en) | 1974-09-26 | 1975-09-25 | Galenic preparation for permanent treatment with allopurinol |
AT735075A AT342774B (de) | 1974-09-26 | 1975-09-25 | Verfahren zur herstellung einer galenischen zubereitung in tablettenform fur die allopurinol-dauertherapie |
JP50116280A JPS5161622A (en:Method) | 1974-09-26 | 1975-09-26 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19742446058 DE2446058A1 (de) | 1974-09-26 | 1974-09-26 | Galenische zubereitung fuer die allopurinol-dauertherapie |
Publications (1)
Publication Number | Publication Date |
---|---|
DE2446058A1 true DE2446058A1 (de) | 1976-04-08 |
Family
ID=5926832
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19742446058 Withdrawn DE2446058A1 (de) | 1974-09-26 | 1974-09-26 | Galenische zubereitung fuer die allopurinol-dauertherapie |
Country Status (9)
Country | Link |
---|---|
JP (1) | JPS5161622A (en:Method) |
AT (1) | AT342774B (en:Method) |
BE (1) | BE833797A (en:Method) |
DE (1) | DE2446058A1 (en:Method) |
ES (1) | ES441204A1 (en:Method) |
FR (1) | FR2285856A1 (en:Method) |
GB (1) | GB1464200A (en:Method) |
SE (1) | SE7510752L (en:Method) |
ZA (1) | ZA756096B (en:Method) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU191246B (en) * | 1984-02-21 | 1987-01-28 | Alkaloida Vegyeszeti Gyara,Hu | Process for producing oral pharmaceutical compositions of retaed activity |
JP2804048B2 (ja) * | 1987-09-11 | 1998-09-24 | イー・アール・スクイブ・アンド・サンズ・インコーポレイテッド | 高薬物含量医薬組成物およびその製造法 |
FR2661611B1 (fr) * | 1990-05-04 | 1994-11-18 | Theramex | Nouvelles compositions pharmaceutiques a base de polycarbophil et leur procede d'obtention. |
US6936277B2 (en) | 1995-01-09 | 2005-08-30 | J. Rettenmaier & Soehne Gmbh & Co. Kg | Pharmaceutical excipient having improved compressibility |
US5948438A (en) * | 1995-01-09 | 1999-09-07 | Edward Mendell Co., Inc. | Pharmaceutical formulations having improved disintegration and/or absorptivity |
US6471994B1 (en) | 1995-01-09 | 2002-10-29 | Edward Mendell Co., Inc. | Pharmaceutical excipient having improved compressibility |
US5585115A (en) * | 1995-01-09 | 1996-12-17 | Edward H. Mendell Co., Inc. | Pharmaceutical excipient having improved compressability |
US6395303B1 (en) | 1996-06-10 | 2002-05-28 | Edward Mendell Co., Inc. | Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose |
US6391337B2 (en) | 1995-11-15 | 2002-05-21 | Edward Mendell Co., Inc. | Directly compressible high load acetaminophen formulations |
US6852336B2 (en) | 1995-11-15 | 2005-02-08 | J. Rettenmaier & Soehne Gmbh + Co. Kg | Directly compressible high load acetaminophen formulations |
US5733578A (en) | 1995-11-15 | 1998-03-31 | Edward Mendell Co., Inc. | Directly compressible high load acetaminophen formulations |
CN113081989B (zh) * | 2021-03-29 | 2022-10-21 | 海南普利制药股份有限公司 | 别嘌醇缓释片剂 |
-
1974
- 1974-09-26 DE DE19742446058 patent/DE2446058A1/de not_active Withdrawn
-
1975
- 1975-09-23 ES ES441204A patent/ES441204A1/es not_active Expired
- 1975-09-24 GB GB3910075A patent/GB1464200A/en not_active Expired
- 1975-09-25 AT AT735075A patent/AT342774B/de active
- 1975-09-25 ZA ZA00756096A patent/ZA756096B/xx unknown
- 1975-09-25 SE SE7510752A patent/SE7510752L/xx unknown
- 1975-09-25 FR FR7529371A patent/FR2285856A1/fr active Granted
- 1975-09-25 BE BE160355A patent/BE833797A/xx unknown
- 1975-09-26 JP JP50116280A patent/JPS5161622A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
FR2285856B1 (en:Method) | 1980-04-25 |
ES441204A1 (es) | 1977-03-16 |
SE7510752L (sv) | 1976-03-29 |
AT342774B (de) | 1978-04-25 |
JPS5161622A (en:Method) | 1976-05-28 |
BE833797A (fr) | 1976-03-25 |
FR2285856A1 (fr) | 1976-04-23 |
ATA735075A (de) | 1977-08-15 |
GB1464200A (en) | 1977-02-09 |
ZA756096B (en) | 1976-10-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8141 | Disposal/no request for examination |