DE2435934A1 - Neue benzylpyrimidine - Google Patents

Neue benzylpyrimidine

Info

Publication number
DE2435934A1
DE2435934A1 DE2435934A DE2435934A DE2435934A1 DE 2435934 A1 DE2435934 A1 DE 2435934A1 DE 2435934 A DE2435934 A DE 2435934A DE 2435934 A DE2435934 A DE 2435934A DE 2435934 A1 DE2435934 A1 DE 2435934A1
Authority
DE
Germany
Prior art keywords
compound
formula
group
alkyl
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE2435934A
Other languages
German (de)
English (en)
Inventor
Ivan Dr Kompis
Gerald Dr Rey-Bellet
Guido Dr Zanetti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE2435934A1 publication Critical patent/DE2435934A1/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/515—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an acetalised, ketalised hemi-acetalised, or hemi-ketalised hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE2435934A 1973-07-27 1974-07-25 Neue benzylpyrimidine Ceased DE2435934A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1099573A CH598231A5 (da) 1973-07-27 1973-07-27

Publications (1)

Publication Number Publication Date
DE2435934A1 true DE2435934A1 (de) 1975-02-13

Family

ID=4368954

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2435934A Ceased DE2435934A1 (de) 1973-07-27 1974-07-25 Neue benzylpyrimidine

Country Status (11)

Country Link
JP (1) JPS5041876A (da)
BE (1) BE818131A (da)
CA (1) CA1026759A (da)
CH (1) CH598231A5 (da)
DE (1) DE2435934A1 (da)
DK (1) DK135374B (da)
FR (1) FR2238496B1 (da)
GB (5) GB1455738A (da)
NL (1) NL7410100A (da)
SE (1) SE415975B (da)
ZA (1) ZA744512B (da)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7772253B2 (en) 2005-06-02 2010-08-10 Hoffman-La Roche Inc. Amide derivatives as somatostatin receptor 5 antagonists
US7855194B2 (en) 2006-03-27 2010-12-21 Hoffmann-La Roche Inc. Pyrimidine, quinazoline, pteridine and triazine derivatives

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1084498A (en) 1977-05-05 1980-08-26 Alexander E. Wick Benzylpyrimidines and process for the preparation thereof
HU188588B (en) * 1982-08-13 1986-04-28 Egyt Gyogyszervegyeszeti Gyar Process for the production of 2,4-diamino-5-benzyl-pyrimidine-derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7772253B2 (en) 2005-06-02 2010-08-10 Hoffman-La Roche Inc. Amide derivatives as somatostatin receptor 5 antagonists
US7855194B2 (en) 2006-03-27 2010-12-21 Hoffmann-La Roche Inc. Pyrimidine, quinazoline, pteridine and triazine derivatives

Also Published As

Publication number Publication date
GB1455737A (en) 1976-11-17
GB1455738A (en) 1976-11-17
DK374174A (da) 1975-04-01
GB1455740A (en) 1976-11-17
GB1455736A (en) 1976-11-17
GB1455739A (en) 1976-11-17
SE7409733L (da) 1975-01-28
CH598231A5 (da) 1978-04-28
ZA744512B (en) 1975-09-24
JPS5041876A (da) 1975-04-16
BE818131A (fr) 1975-01-27
FR2238496B1 (da) 1977-09-09
DK135374C (da) 1977-10-03
CA1026759A (en) 1978-02-21
SE415975B (sv) 1980-11-17
AU7148874A (en) 1976-01-22
DK135374B (da) 1977-04-18
NL7410100A (nl) 1975-01-29
FR2238496A1 (da) 1975-02-21

Similar Documents

Publication Publication Date Title
DE69021444T2 (de) Pteridin-4 (3H)-onen, Verfahren zu ihrer Herstellung und sie enthaltende Medikamente.
NO115800B (da)
EP0019811A1 (de) Pyrimidin-Verbindungen, Verfahren zu ihrer Herstellung, pharmazeutische Präparate enthaltend diese Verbindungen, sowie ihre therapeutische Verwendung
FI77454C (fi) Foerfarande foer framstaellning av som laekemedel anvaendbara 4-anilino-pyrimidinderivat.
EP0011142B1 (de) Pyrido (2,1-b) chinazolinon-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate
Magnus et al. The pyridylethylation of active hydrogen compounds. V. The reaction of ammonia, certain amines, amides and nitriles with 2-and 4-vinylpyridine and 2-methyl-5-vinylpyridine1
EP0165422B1 (de) Neue substituierte Bis(4-aminophenyl)sulfone, ihre Herstellung und ihre Verwendung als Arzneimittel
DE60004671T2 (de) Neue piperazinylalkylthiopyrimidine derivate, diese enthaltende pharmazeutische zusammenstellungen und verfahren zu deren herstellung
DE60012288T2 (de) Antivirale pyrimidindion-derivate und verfahren zu ihrer herstellung
CN110981816B (zh) 一种4-氨基-2.6-二甲氧基嘧啶的合成方法
US3931181A (en) 2,4-Diamino-5-benzylpyrimidines
DE2435934A1 (de) Neue benzylpyrimidine
EP0000334B1 (de) 2,4--Diamino-5-benzylpyrimidine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE2452889A1 (de) Neue benzylpyrimidine
EP0171645A1 (de) Neue 2H-1-Benzopyran-2-on-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel, die diese Verbindungen enthalten
DE2418498A1 (de) Verschmolzene pyrimidine und deren herstellung
EP1003728B1 (de) 2-(3-(4-(2-t-Butyl-6-trifluormethylpyrimidin-4-yl)piperazin-1-yl)propylmercapto)pyrimidin-4-ol-fumarat
US4024145A (en) Benzylpyrimidine derivatives
EP0994861A1 (de) NEUE $g(b)-AMINO UND $g(b)-AZIDOCARBONSÄUREDERIVATE, IHRE HERSTELLUNG UND VERWENDUNG ALS ENDOTHELINREZEPTORANTAGONISTEN
CH625217A5 (da)
McCasland et al. Analogs of Pyridoxine. II. Synthesis of a Pyrimidine Analog
DE2847825A1 (de) 2,4-diamino-5-benzylpyrimidine und verfahren zu deren herstellung
DE3245950A1 (de) Verfahren zur herstellung substituierter pyridine
US3954760A (en) Process for producing N1 -(α-butyrolactone- and N1 (α-
DE2937023A1 (de) Neue substituierte 5-(2-imidazolin-2-yl)-aminopyrimidine und verfahren zu deren herstellung

Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8131 Rejection