GB1455737A - Acetals - Google Patents

Acetals

Info

Publication number
GB1455737A
GB1455737A GB455976A GB455976A GB1455737A GB 1455737 A GB1455737 A GB 1455737A GB 455976 A GB455976 A GB 455976A GB 455976 A GB455976 A GB 455976A GB 1455737 A GB1455737 A GB 1455737A
Authority
GB
United Kingdom
Prior art keywords
alkyl
dimethoxy
july
acetals
ptolualdehyde
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB455976A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB1455737A publication Critical patent/GB1455737A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/515—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an acetalised, ketalised hemi-acetalised, or hemi-ketalised hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1455737 Acetals F HOFFMANN-LA ROCHE & CO AG 26 July 1974 [27 July 1973] 04559/76 Divided out of 1455736 Heading C2C Compounds of the general formula (R<SP>1,2</SP> = alkyl, alkenyl; R<SP>5</SP> = alkyl; A<SP>2</SP> = CF 3 , CN, alkoxycarbonyl, CR<SP>8</SP>R<SP>9</SP>R<SP>13</SP>; R<SP>8,9</SP> = H, alkyl; R<SP>13</SP> = OH, alkoxy, NR<SP>3</SP>R<SP>4</SP>; R<SP>3,4</SP> = H, alkyl, alkanoyl) are prepared by standard methods, e.g. reacting the corresponding substituted benzaldehyde with acrylonitrile or a #-alkoxypropionitrile and R<SP>5</SP>OH in an alkaline medium, The preparation of 2,6-dimethoxy-4-diethoxymethylbenzyl alcohol, α - hydroxy - 3,5 - dimethoxy - p - tolualdehyde and α,3,5 - trimethoxy - ptolualdehyde is described.
GB455976A 1973-07-27 1974-07-26 Acetals Expired GB1455737A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1099573A CH598231A5 (en) 1973-07-27 1973-07-27

Publications (1)

Publication Number Publication Date
GB1455737A true GB1455737A (en) 1976-11-17

Family

ID=4368954

Family Applications (5)

Application Number Title Priority Date Filing Date
GB455976A Expired GB1455737A (en) 1973-07-27 1974-07-26 Acetals
GB3316974A Expired GB1455736A (en) 1973-07-27 1974-07-26 Benzylpyrimidine derivatives
GB456176A Expired GB1455739A (en) 1973-07-27 1974-07-26 Acid amides
GB456076A Expired GB1455738A (en) 1973-07-27 1974-07-26 Unsaturated nitriles
GB456276A Expired GB1455740A (en) 1973-07-27 1974-07-26 Benzylpyrimidine derivatives

Family Applications After (4)

Application Number Title Priority Date Filing Date
GB3316974A Expired GB1455736A (en) 1973-07-27 1974-07-26 Benzylpyrimidine derivatives
GB456176A Expired GB1455739A (en) 1973-07-27 1974-07-26 Acid amides
GB456076A Expired GB1455738A (en) 1973-07-27 1974-07-26 Unsaturated nitriles
GB456276A Expired GB1455740A (en) 1973-07-27 1974-07-26 Benzylpyrimidine derivatives

Country Status (11)

Country Link
JP (1) JPS5041876A (en)
BE (1) BE818131A (en)
CA (1) CA1026759A (en)
CH (1) CH598231A5 (en)
DE (1) DE2435934A1 (en)
DK (1) DK135374B (en)
FR (1) FR2238496B1 (en)
GB (5) GB1455737A (en)
NL (1) NL7410100A (en)
SE (1) SE415975B (en)
ZA (1) ZA744512B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1084498A (en) 1977-05-05 1980-08-26 Alexander E. Wick Benzylpyrimidines and process for the preparation thereof
HU188588B (en) * 1982-08-13 1986-04-28 Egyt Gyogyszervegyeszeti Gyar Process for the production of 2,4-diamino-5-benzyl-pyrimidine-derivatives
KR100962732B1 (en) 2005-06-02 2010-06-09 에프. 호프만-라 로슈 아게 Piperidin-4-yl-amide derivatives and their use as sst receptor subtype 5 antagonists
US7855194B2 (en) 2006-03-27 2010-12-21 Hoffmann-La Roche Inc. Pyrimidine, quinazoline, pteridine and triazine derivatives

Also Published As

Publication number Publication date
SE415975B (en) 1980-11-17
DK135374B (en) 1977-04-18
CA1026759A (en) 1978-02-21
SE7409733L (en) 1975-01-28
AU7148874A (en) 1976-01-22
CH598231A5 (en) 1978-04-28
GB1455738A (en) 1976-11-17
JPS5041876A (en) 1975-04-16
DK374174A (en) 1975-04-01
GB1455739A (en) 1976-11-17
GB1455736A (en) 1976-11-17
DE2435934A1 (en) 1975-02-13
BE818131A (en) 1975-01-27
FR2238496B1 (en) 1977-09-09
NL7410100A (en) 1975-01-29
ZA744512B (en) 1975-09-24
DK135374C (en) 1977-10-03
FR2238496A1 (en) 1975-02-21
GB1455740A (en) 1976-11-17

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee