DE2304780A1 - Plasminostreptin und verfahren zu seiner herstellung - Google Patents
Plasminostreptin und verfahren zu seiner herstellungInfo
- Publication number
- DE2304780A1 DE2304780A1 DE2304780A DE2304780A DE2304780A1 DE 2304780 A1 DE2304780 A1 DE 2304780A1 DE 2304780 A DE2304780 A DE 2304780A DE 2304780 A DE2304780 A DE 2304780A DE 2304780 A1 DE2304780 A1 DE 2304780A1
- Authority
- DE
- Germany
- Prior art keywords
- plasminostreptin
- molar
- parts
- solution
- volume
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 1
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- 241000544912 Melanoides Species 0.000 description 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 1
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- 229940122791 Plasmin inhibitor Drugs 0.000 description 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical class CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 1
- 108010009736 Protein Hydrolysates Proteins 0.000 description 1
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- 239000007983 Tris buffer Substances 0.000 description 1
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- 238000002835 absorbance Methods 0.000 description 1
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- 239000003463 adsorbent Substances 0.000 description 1
- 238000005377 adsorption chromatography Methods 0.000 description 1
- PNNNRSAQSRJVSB-BXKVDMCESA-N aldehydo-L-rhamnose Chemical compound C[C@H](O)[C@H](O)[C@@H](O)[C@@H](O)C=O PNNNRSAQSRJVSB-BXKVDMCESA-N 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
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- 239000007864 aqueous solution Substances 0.000 description 1
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- 239000011324 bead Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
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- 238000002474 experimental method Methods 0.000 description 1
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- 229940001501 fibrinolysin Drugs 0.000 description 1
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- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
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- 238000002955 isolation Methods 0.000 description 1
- 238000009630 liquid culture Methods 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- NQMRYBIKMRVZLB-UHFFFAOYSA-N methylamine hydrochloride Chemical compound [Cl-].[NH3+]C NQMRYBIKMRVZLB-UHFFFAOYSA-N 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 235000013379 molasses Nutrition 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
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- 150000002823 nitrates Chemical class 0.000 description 1
- 229910017464 nitrogen compound Inorganic materials 0.000 description 1
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- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
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- 210000000496 pancreas Anatomy 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 239000003531 protein hydrolysate Substances 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 229960005202 streptokinase Drugs 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/8142—Aspartate protease (E.C. 3.4.23) inhibitors, e.g. HIV protease inhibitors
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- AIDS & HIV (AREA)
- Mycology (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1413272A JPS5434837B2 (US20070031759A1-20070208-C00026.png) | 1972-02-08 | 1972-02-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE2304780A1 true DE2304780A1 (de) | 1973-08-09 |
Family
ID=11852593
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE2304780A Pending DE2304780A1 (de) | 1972-02-08 | 1973-02-01 | Plasminostreptin und verfahren zu seiner herstellung |
Country Status (12)
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1984002917A1 (en) * | 1983-01-28 | 1984-08-02 | Inst Medical W & E Hall | EXPRESSION OF PLASMODIUM FALCIPARUM POLYPEPTIDES FROM CLONED cDNA |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5941718B2 (ja) * | 1980-01-31 | 1984-10-09 | エスエス製薬株式会社 | 新規物質m−9337およびその製造法 |
JPS6138212A (ja) * | 1984-07-30 | 1986-02-24 | Aisin Warner Ltd | 回転部材支持装置 |
US5279939A (en) * | 1986-08-18 | 1994-01-18 | Smithkline Beecham Corporation | Protein protease inhibitors from streptomyces |
AU606888B2 (en) * | 1986-08-18 | 1991-02-21 | Smithkline Beckman Corporation | Proteine protease inhibitors from streptomyces |
EP0624642B1 (en) * | 1993-05-12 | 1999-01-20 | Indian Council For Medical Research | Novel thrombolytic agent, process for preparing same and its use for the preparation of a thrombi dissolving medicament |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3740319A (en) * | 1969-06-13 | 1973-06-19 | Microbial Chem Res Found | Biologically active substance,pepstatin and production processes thereof |
-
1972
- 1972-02-08 JP JP1413272A patent/JPS5434837B2/ja not_active Expired
-
1973
- 1973-01-16 CH CH58173A patent/CH575467A5/xx not_active IP Right Cessation
- 1973-01-30 US US05/328,077 patent/US4014860A/en not_active Expired - Lifetime
- 1973-01-31 GB GB483273A patent/GB1414696A/en not_active Expired
- 1973-02-01 DE DE2304780A patent/DE2304780A1/de active Pending
- 1973-02-05 BE BE794975D patent/BE794975A/xx not_active IP Right Cessation
- 1973-02-07 CA CA163,113A patent/CA994692A/en not_active Expired
- 1973-02-07 FR FR7304357A patent/FR2181710B1/fr not_active Expired
- 1973-02-07 SE SE7301687A patent/SE390543B/xx unknown
- 1973-02-07 NO NO491/73A patent/NO136204C/no unknown
- 1973-02-08 NL NL7301822A patent/NL7301822A/xx not_active Application Discontinuation
- 1973-02-08 DK DK67973AA patent/DK130477B/da unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1984002917A1 (en) * | 1983-01-28 | 1984-08-02 | Inst Medical W & E Hall | EXPRESSION OF PLASMODIUM FALCIPARUM POLYPEPTIDES FROM CLONED cDNA |
GB2143830A (en) * | 1983-01-28 | 1985-02-20 | Inst Medical W & E Hall | Expression of plasmodium falciparum polypeptides from cloned cdna |
Also Published As
Publication number | Publication date |
---|---|
USB328077I5 (US20070031759A1-20070208-C00026.png) | 1976-04-13 |
CH575467A5 (US20070031759A1-20070208-C00026.png) | 1976-05-14 |
JPS5434837B2 (US20070031759A1-20070208-C00026.png) | 1979-10-29 |
FR2181710A1 (US20070031759A1-20070208-C00026.png) | 1973-12-07 |
SE390543B (sv) | 1976-12-27 |
DK130477B (da) | 1975-02-24 |
BE794975A (fr) | 1973-05-29 |
FR2181710B1 (US20070031759A1-20070208-C00026.png) | 1976-07-02 |
NO136204C (no) | 1977-08-03 |
DK130477C (US20070031759A1-20070208-C00026.png) | 1975-07-28 |
NO136204B (US20070031759A1-20070208-C00026.png) | 1977-04-25 |
CA994692A (en) | 1976-08-10 |
NL7301822A (US20070031759A1-20070208-C00026.png) | 1973-08-10 |
JPS4882089A (US20070031759A1-20070208-C00026.png) | 1973-11-02 |
US4014860A (en) | 1977-03-29 |
GB1414696A (en) | 1975-11-19 |
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