DE2228750A1 - 4'-fluornucleoside, neue zwischenprodukte und verfahren zur herstellung derselben - Google Patents

4'-fluornucleoside, neue zwischenprodukte und verfahren zur herstellung derselben

Info

Publication number
DE2228750A1
DE2228750A1 DE2228750A DE2228750A DE2228750A1 DE 2228750 A1 DE2228750 A1 DE 2228750A1 DE 2228750 A DE2228750 A DE 2228750A DE 2228750 A DE2228750 A DE 2228750A DE 2228750 A1 DE2228750 A1 DE 2228750A1
Authority
DE
Germany
Prior art keywords
fluoro
formula
deoxy
corresponds
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE2228750A
Other languages
German (de)
English (en)
Inventor
Ian Jenkins
John G Moffatt
Julien P Verheyden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Palo Alto LLC
Original Assignee
Roche Palo Alto LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US00153817A external-priority patent/US3817978A/en
Application filed by Roche Palo Alto LLC filed Critical Roche Palo Alto LLC
Publication of DE2228750A1 publication Critical patent/DE2228750A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE2228750A 1971-06-16 1972-06-13 4'-fluornucleoside, neue zwischenprodukte und verfahren zur herstellung derselben Pending DE2228750A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US00153817A US3817978A (en) 1971-06-16 1971-06-16 4-fluoro nucleosides and sugar intermediates, and methods of preparing
US258327A US3928319A (en) 1971-06-16 1972-05-31 4 -Fluoro nucleosides, novel intermediates and methods of preparing same

Publications (1)

Publication Number Publication Date
DE2228750A1 true DE2228750A1 (de) 1973-01-04

Family

ID=26850886

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2228750A Pending DE2228750A1 (de) 1971-06-16 1972-06-13 4'-fluornucleoside, neue zwischenprodukte und verfahren zur herstellung derselben

Country Status (4)

Country Link
US (1) US3928319A (enExample)
DE (1) DE2228750A1 (enExample)
FR (1) FR2141971B1 (enExample)
GB (1) GB1384611A (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4071680A (en) * 1976-12-20 1978-01-31 Hoffmann-La Roche Inc. 5'-Deoxy-5-fluoropyrimidine nucleosides
US4093715A (en) * 1977-04-28 1978-06-06 Research Corporation 5-Iodo-5'-amino-2',5'-dideoxycytidine and the pharmaceutically acceptable salts thereof
US4552955A (en) * 1981-06-29 1985-11-12 Sankyo Chemical Company, Limited Process for the synthesis of 4',5'-unsaturated nucleosides
EP0111299B1 (en) * 1982-12-09 1986-04-02 Daikin Kogyo Co., Ltd. Fluorine-containing uridine derivative and preparation and use thereof
US4751221A (en) * 1985-10-18 1988-06-14 Sloan-Kettering Institute For Cancer Research 2-fluoro-arabinofuranosyl purine nucleosides
US6306647B1 (en) * 1987-06-16 2001-10-23 Ajinomoto Co., Inc. Process for producing and purifying 2′,3′-dideoxynucleosides, and process for producing 2′,3′-dideoxy-2′,3′-didehydronucleosides
NZ225906A (en) * 1987-08-26 1990-10-26 Merrell Dow Pharma Aristeromycin/adenosine derivatives and pharmaceutical compositions
US5157114A (en) * 1988-08-19 1992-10-20 Burroughs Wellcome Co. 2',3'-dideoxy-3'-fluoro-5-ethyngluridine
US5449664A (en) * 1988-11-21 1995-09-12 Syntex (U.S.A.) Inc. Antiviral agents
US5192749A (en) * 1990-05-21 1993-03-09 Syntex (U.S.A.) Inc. 4'-substituted nucleosides
US5393879A (en) * 1992-08-17 1995-02-28 The Scripps Research Institute Fructosyl C-glycoside nucleoside analogs
US5824657A (en) * 1997-03-18 1998-10-20 Cubist Pharmaceuticals, Inc. Aminoacyl sulfamides for the treatment of hyperproliferative disorders
EP1551386A4 (en) * 2002-09-27 2009-03-25 Bioenvision Inc METHOD AND COMPOSITIONS FOR TREATING LUPUS WITH CLOFARABIN
WO2004029025A2 (en) * 2002-09-27 2004-04-08 Bioenvision, Inc. Methods and compositions for the treatment of autoimmune disorders using clofarabine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3562250A (en) * 1968-07-30 1971-02-09 Akad Wissenschaften Ddr 2',5'-dideoxy-5'-fluoro nucleosides and process for preparing same
US3575959A (en) * 1969-05-13 1971-04-20 Merck & Co Inc 5'-substituted ribofuranosyl nucleosides
US3585189A (en) * 1969-06-27 1971-06-15 Syntex Corp Unsaturated nucleosides and processes for their preparation
US3622561A (en) * 1969-08-18 1971-11-23 Univ Utah Nucleoside sugar esters of sulfamic acid and method for preparation of the same
US3817978A (en) * 1971-06-16 1974-06-18 Syntex Inc 4-fluoro nucleosides and sugar intermediates, and methods of preparing

Also Published As

Publication number Publication date
FR2141971A1 (enExample) 1973-01-26
US3928319A (en) 1975-12-23
GB1384611A (en) 1975-02-19
FR2141971B1 (enExample) 1975-06-20

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