DE221382T1 - Verfahren und zusammensetzungen zur behandlung von tumoren mit gehalt an einer calcium-channel-blocker-verbindung aus der klasse der dihydropyridine und an einer platin-koordinationsverbindung. - Google Patents

Verfahren und zusammensetzungen zur behandlung von tumoren mit gehalt an einer calcium-channel-blocker-verbindung aus der klasse der dihydropyridine und an einer platin-koordinationsverbindung.

Info

Publication number
DE221382T1
DE221382T1 DE198686113897T DE86113897T DE221382T1 DE 221382 T1 DE221382 T1 DE 221382T1 DE 198686113897 T DE198686113897 T DE 198686113897T DE 86113897 T DE86113897 T DE 86113897T DE 221382 T1 DE221382 T1 DE 221382T1
Authority
DE
Germany
Prior art keywords
compound
calcium channel
channel blocker
platinum coordination
coordination compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE198686113897T
Other languages
German (de)
English (en)
Inventor
Kenneth V. Grosse Pointe Woods Michigan 48236 Honn
James M. No. 203 Royal Oak Michigan 48067 Onoda
John D. Detroit Michigan 48207 Taylor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wayne State University
Original Assignee
Wayne State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wayne State University filed Critical Wayne State University
Publication of DE221382T1 publication Critical patent/DE221382T1/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
DE198686113897T 1985-10-10 1986-10-07 Verfahren und zusammensetzungen zur behandlung von tumoren mit gehalt an einer calcium-channel-blocker-verbindung aus der klasse der dihydropyridine und an einer platin-koordinationsverbindung. Pending DE221382T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/786,321 US4906646A (en) 1983-03-31 1985-10-10 Method and composition for the treatment of tumors by administering a platinum coordination compound and a calcium channel blocker compound of the dihydropyridine class

Publications (1)

Publication Number Publication Date
DE221382T1 true DE221382T1 (de) 1987-10-15

Family

ID=25138262

Family Applications (1)

Application Number Title Priority Date Filing Date
DE198686113897T Pending DE221382T1 (de) 1985-10-10 1986-10-07 Verfahren und zusammensetzungen zur behandlung von tumoren mit gehalt an einer calcium-channel-blocker-verbindung aus der klasse der dihydropyridine und an einer platin-koordinationsverbindung.

Country Status (5)

Country Link
US (1) US4906646A (cg-RX-API-DMAC7.html)
EP (1) EP0221382A1 (cg-RX-API-DMAC7.html)
JP (1) JPS6287516A (cg-RX-API-DMAC7.html)
CA (1) CA1278518C (cg-RX-API-DMAC7.html)
DE (1) DE221382T1 (cg-RX-API-DMAC7.html)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989006692A1 (en) * 1988-01-12 1989-07-27 Genentech, Inc. Method of treating tumor cells by inhibiting growth factor receptor function
US5720937A (en) * 1988-01-12 1998-02-24 Genentech, Inc. In vivo tumor detection assay
US4985558A (en) * 1988-07-28 1991-01-15 Nikken Chemicals Co., Ltd. 1,4-dihydropyridine derivative
JP2850376B2 (ja) * 1988-08-02 1999-01-27 日産化学工業株式会社 抗癌剤薬効増強剤
DE68924456T2 (de) * 1988-08-02 1996-05-30 Nissan Chemical Ind Ltd Mittel zur Verbesserung von Arzneimitteleffekten für Antitumormittel.
GB9119983D0 (en) * 1991-09-19 1991-11-06 Erba Carlo Spa Dihydropyridine derivatives useful in antitumor therapy
FR2686879B1 (fr) * 1992-02-05 1994-03-18 Adir Cie Nouveaux composes de 1,4-dihydropyridine, leur procede de preparation et les compositions pharmaceutiques les contenant.
US6749853B1 (en) * 1992-03-05 2004-06-15 Board Of Regents, The University Of Texas System Combined methods and compositions for coagulation and tumor treatment
US20040127884A1 (en) * 1994-12-12 2004-07-01 Omeros Corporation Vascular irrigation solution and method for inhibition of pain, inflammation, spasm and restenosis
US6268377B1 (en) * 1998-09-28 2001-07-31 Merck & Co., Inc. Method for treating androgen-related conditions
JP4776843B2 (ja) 1999-10-01 2011-09-21 イムノゲン インコーポレーティッド 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
US20040167165A1 (en) * 2003-01-16 2004-08-26 Geetha Shankar Methods of treating conditions associated with an Edg-7 receptor
US20100222406A1 (en) * 2007-09-11 2010-09-02 University Of Virginia Patent Foundation T Type Calcium Channel Blockers and the Treatment of Diseases
CA2576186A1 (en) * 2004-08-20 2006-03-02 University Of Virginia Patent Foundation T type calcium channel blockers and the treatment of diseases
WO2009132454A1 (en) * 2008-04-28 2009-11-05 Neuromed Pharmaceuticals Ltd. Di-t-butylphenyl piperazines as calcium channel blockers
CN102781316B (zh) 2010-03-01 2016-07-06 陶制药有限责任公司 癌症诊断和成像
US9361667B2 (en) 2010-08-27 2016-06-07 Sony Corporation Image processing apparatus and method
WO2019008516A2 (en) * 2017-07-03 2019-01-10 Menri Group Ltd. TREATMENT OF CANCER WITH DIHYDROPYRIDINES
WO2019147089A1 (ko) * 2018-01-26 2019-08-01 재단법인 대구경북첨단의료산업진흥재단 칼슘 채널 억제제 또는 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4177263A (en) * 1972-02-28 1979-12-04 Research Corporation Anti-animal tumor method
CH605550A5 (cg-RX-API-DMAC7.html) * 1972-06-08 1978-09-29 Research Corp
US4419351A (en) * 1977-06-03 1983-12-06 Research Corporation Platinum-dioxopyrimidine complexes
US4234499A (en) * 1979-03-07 1980-11-18 Engelhard Minerals & Chemicals Corporation Cis-diammireplatinum(II) organophosphate complexes
DE3379107D1 (en) * 1982-06-03 1989-03-09 Pierrel Spa Hydroxyimino and alkoxyimino derivatives of 1,4-dihydropyridine, process for the preparation thereof and pharmaceutical composition therefrom
US4690935A (en) * 1983-03-31 1987-09-01 Wayne State University Inhibition of tumor growth and metastasis with calcium channel blocker compounds

Also Published As

Publication number Publication date
JPS6287516A (ja) 1987-04-22
EP0221382A1 (en) 1987-05-13
JPH0357081B2 (cg-RX-API-DMAC7.html) 1991-08-30
US4906646A (en) 1990-03-06
CA1278518C (en) 1991-01-02

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