DE2207421C3 - 15α, 16α -Methylen-4-östren-17β -ole bzw. -acylate, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel - Google Patents

15α, 16α -Methylen-4-östren-17β -ole bzw. -acylate, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel

Info

Publication number
DE2207421C3
DE2207421C3 DE2207421A DE2207421A DE2207421C3 DE 2207421 C3 DE2207421 C3 DE 2207421C3 DE 2207421 A DE2207421 A DE 2207421A DE 2207421 A DE2207421 A DE 2207421A DE 2207421 C3 DE2207421 C3 DE 2207421C3
Authority
DE
Germany
Prior art keywords
methylene
acid
methyl
natural
propylenedioxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2207421A
Other languages
German (de)
English (en)
Other versions
DE2207421A1 (de
DE2207421B2 (de
Inventor
Hermann Dr. Steinbeck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BE795241D priority Critical patent/BE795241A/xx
Application filed by Schering AG filed Critical Schering AG
Priority to DE2207421A priority patent/DE2207421C3/de
Priority to PL1972159970A priority patent/PL81084B1/pl
Priority to DD168198A priority patent/DD102379A5/xx
Priority to DK24273AA priority patent/DK131037B/da
Priority to FI730169A priority patent/FI52225C/fi
Priority to ES410933A priority patent/ES410933A1/es
Priority to YU243/73A priority patent/YU35035B/xx
Priority to CS73748A priority patent/CS193019B2/cs
Priority to CA163,029A priority patent/CA997753A/en
Priority to IE190/73A priority patent/IE37266B1/xx
Priority to EG49/73A priority patent/EG10914A/xx
Priority to AT112473A priority patent/AT327413B/de
Priority to GR1318A priority patent/GR63160B/el
Priority to CH186373A priority patent/CH590883A5/xx
Priority to NO528/73A priority patent/NO140304C/no
Priority to CH535776A priority patent/CH593995A5/xx
Priority to SU1891803A priority patent/SU513628A3/ru
Priority to PH14330*UA priority patent/PH9370A/en
Priority to ZA730944A priority patent/ZA73944B/xx
Priority to FR7304678A priority patent/FR2181719B1/fr
Priority to IL41506A priority patent/IL41506A/en
Priority to KR7300246A priority patent/KR780000156B1/ko
Priority to RO7373805A priority patent/RO73527A/ro
Priority to HUSE1666A priority patent/HU165253B/hu
Priority to JP48017357A priority patent/JPS5829317B2/ja
Priority to SE7301935A priority patent/SE403781B/xx
Priority to GB682173A priority patent/GB1425636A/en
Priority to NLAANVRAGE7301974,A priority patent/NL177217C/xx
Priority to AU52076/73A priority patent/AU467306B2/en
Publication of DE2207421A1 publication Critical patent/DE2207421A1/de
Priority to DK188674A priority patent/DK131635C/da
Priority to DK188774A priority patent/DK135844C/da
Priority to US05/484,068 priority patent/US3994937A/en
Priority to AT1039174A priority patent/AT339514B/de
Priority to SE7514513A priority patent/SE409329B/xx
Priority to FI770407A priority patent/FI54132C/fi
Priority to CS774125A priority patent/CS193048B2/cs
Priority to SE7713896A priority patent/SE426834B/sv
Priority to NO782754A priority patent/NO143065C/no
Publication of DE2207421B2 publication Critical patent/DE2207421B2/de
Application granted granted Critical
Publication of DE2207421C3 publication Critical patent/DE2207421C3/de
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE2207421A 1972-02-11 1972-02-11 15α, 16α -Methylen-4-östren-17β -ole bzw. -acylate, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel Expired DE2207421C3 (de)

Priority Applications (39)

Application Number Priority Date Filing Date Title
BE795241D BE795241A (fr) 1972-02-11 15alpha, 16alpha-methylene-4-oestren-17beta-ols-methylenz-4-oestren-17beta-ols et leur procede de preparation
DE2207421A DE2207421C3 (de) 1972-02-11 1972-02-11 15α, 16α -Methylen-4-östren-17β -ole bzw. -acylate, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
PL1972159970A PL81084B1 (no) 1972-02-11 1972-12-29
DD168198A DD102379A5 (no) 1972-02-11 1973-01-11
DK24273AA DK131037B (da) 1972-02-11 1973-01-16 Analogifremgangsmåde til fremstilling af 15alfa,16alfa-methylen-4-østren-17beta-oler.
FI730169A FI52225C (fi) 1972-02-11 1973-01-23 Menetelmä terapeuttisesti käytettävien 15alfa,16alfa-metyleeni-4-estre eni-17beta-olien valmistamiseksi.
ES410933A ES410933A1 (es) 1972-02-11 1973-01-24 Procedimiento para la preparacion de 15a-metilen-4-estren- 17b-oles.
YU243/73A YU35035B (en) 1972-02-11 1973-01-31 Process for preparing 15 delta, 16 delta-methylene-4-estrene-17 beta-oles
CS73748A CS193019B2 (en) 1972-02-11 1973-01-31 Method of producing 15alpha-methylene-4-estrene-17beta-ols
CA163,029A CA997753A (en) 1972-02-11 1973-02-06 PROCESS FOR PRODUCING 15.alpha., 16.alpha.-METHYLENE-.DELTA.4 OESTREN-17.beta.-OLS
IE190/73A IE37266B1 (en) 1972-02-11 1973-02-06 15alpha 16alpha-methylene-delta4-oestren-17beta-ols
EG49/73A EG10914A (en) 1972-02-11 1973-02-07 A process for preparation 15 alpha 16 alpha methylen-4-ostren 17 b ole
AT112473A AT327413B (de) 1972-02-11 1973-02-08 Verfahren zur herstellung von neuen 15alpha,16alpha-methylen-4-ostren-17beta-olen
IL41506A IL41506A (en) 1972-02-11 1973-02-09 A 51, A61- Methylene 4 Kma-Astraen-B71- Olim
NO528/73A NO140304C (no) 1972-02-11 1973-02-09 Analogifremgangsmaate ved fremstilling av terapeutisk aktive nye 15alfa, 16alfa-methylen-4-oestren-17beta-oler
CH535776A CH593995A5 (no) 1972-02-11 1973-02-09
SU1891803A SU513628A3 (ru) 1972-02-11 1973-02-09 Способ получени 15 , 16 -метилен4-эстрен-17 -олов
PH14330*UA PH9370A (en) 1972-02-11 1973-02-09 15a,16a-methylene-4-oestran-17b-ols and pharmaceutical compositions thereof
ZA730944A ZA73944B (en) 1972-02-11 1973-02-09 15alpha,16alpha-methylene-delta4-oestren-17beta-ols
FR7304678A FR2181719B1 (no) 1972-02-11 1973-02-09
GR1318A GR63160B (en) 1972-02-11 1973-02-09 15a,16a-methyley-y-oistren-17b-olas
CH186373A CH590883A5 (no) 1972-02-11 1973-02-09
RO7373805A RO73527A (ro) 1972-02-11 1973-02-10 Procedeu de preparare a unor derivati de 15&,16&-metilen-4-oestren-17beta oli
KR7300246A KR780000156B1 (en) 1972-02-11 1973-02-10 Process for preparing 150 160-methylen -oestren-17-36
HUSE1666A HU165253B (no) 1972-02-11 1973-02-10
JP48017357A JPS5829317B2 (ja) 1972-02-11 1973-02-12 １５ アルフア− １６ アルフア− − メチレン −４− エストレン −１７ ベ−タ − オ−ルノセイホウ
SE7301935A SE403781B (sv) 1972-02-11 1973-02-12 Sett att framstella 15 alfa, 16 alfa-metylen-4-ostren- 17 beta-oler
GB682173A GB1425636A (en) 1972-02-11 1973-02-12 15alpha,16alpha-methylene-delta4-oestren-17beta-ols
NLAANVRAGE7301974,A NL177217C (nl) 1972-02-11 1973-02-12 Werkwijze voor de bereiding van een geneesmiddel met steroide-hormooneigenschappen, gevormd geneesmiddel en werkwijze ter bereiding van daarvoor geschikte geneeskrachtige verbindingen.
AU52076/73A AU467306B2 (en) 1972-02-11 1973-02-12 15, 16-methylene-4-oestren-17 -ols
DK188674A DK131635C (da) 1972-02-11 1974-04-04 Analogifremgangsmade til fremstilling af 15alfa, 16alfa-methylen-4-ostren-17beta-oler
DK188774A DK135844C (da) 1972-02-11 1974-04-04 15,16-methylen-4-ostren-17beta-hydroxy- eller -17beta-acyloxy-steroider til anvendelse som svangerskabsforebyggende midler
US05/484,068 US3994937A (en) 1972-02-11 1974-06-28 15α,16α-Methylene-4-estren-17β-ols
AT1039174A AT339514B (de) 1972-02-11 1974-12-30 Verfahren zur herstellung von neuen 15alfa,16alfa-methylen-4-ostren-17beta-olen
SE7514513A SE409329B (sv) 1972-02-11 1975-12-22 15 alfa, 16 alfa-metylen-4-ostren-17 beta-oler till anvendning som kontraceptionsmedel
FI770407A FI54132C (fi) 1972-02-11 1977-02-08 Foerfarande foer framstaellning av terapeutiskt anvaendbara 15alfa 16alfa-metylen-4-estren-17beta-oler
CS774125A CS193048B2 (en) 1972-02-11 1977-06-22 Process for preparing 15alpha,16alpha-methylen-4-estren-17beta-oles
SE7713896A SE426834B (sv) 1972-02-11 1977-12-07 Sett att framstella 15alfa, 16alfa-metylen-4-ostren-17beta-oler
NO782754A NO143065C (no) 1972-02-11 1978-08-14 Kjemiske forbindelser for anvendelse i antikonsepsjonsmidler

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2207421A DE2207421C3 (de) 1972-02-11 1972-02-11 15α, 16α -Methylen-4-östren-17β -ole bzw. -acylate, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel

Publications (3)

Publication Number Publication Date
DE2207421A1 DE2207421A1 (de) 1973-08-16
DE2207421B2 DE2207421B2 (de) 1980-07-24
DE2207421C3 true DE2207421C3 (de) 1981-05-07

Family

ID=5836211

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2207421A Expired DE2207421C3 (de) 1972-02-11 1972-02-11 15α, 16α -Methylen-4-östren-17β -ole bzw. -acylate, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel

Country Status (29)

Country Link
JP (1) JPS5829317B2 (no)
KR (1) KR780000156B1 (no)
AT (1) AT327413B (no)
AU (1) AU467306B2 (no)
BE (1) BE795241A (no)
CA (1) CA997753A (no)
CH (2) CH590883A5 (no)
CS (1) CS193019B2 (no)
DD (1) DD102379A5 (no)
DE (1) DE2207421C3 (no)
DK (1) DK131037B (no)
EG (1) EG10914A (no)
ES (1) ES410933A1 (no)
FI (1) FI52225C (no)
FR (1) FR2181719B1 (no)
GB (1) GB1425636A (no)
GR (1) GR63160B (no)
HU (1) HU165253B (no)
IE (1) IE37266B1 (no)
IL (1) IL41506A (no)
NL (1) NL177217C (no)
NO (2) NO140304C (no)
PH (1) PH9370A (no)
PL (1) PL81084B1 (no)
RO (1) RO73527A (no)
SE (3) SE403781B (no)
SU (1) SU513628A3 (no)
YU (1) YU35035B (no)
ZA (1) ZA73944B (no)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007027637A1 (de) 2007-06-12 2008-12-18 Bayer Schering Pharma Aktiengesellschaft 17ß-Cyano-19-nor-androst-4-en-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel
DE102007027636A1 (de) 2007-06-12 2008-12-18 Bayer Schering Pharma Aktiengesellschaft 17ß-Cyano-18a-homo-19-nor-androst-4-en-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT274653B (de) * 1966-11-10 1969-09-25 Alexander Schoeller & Co Kg Stapelbarer, quaderförmiger, geschlossener Transportbehälter aus Kunststoff für feinkörnige Schüttgüter und Flüssigkeiten

Also Published As

Publication number Publication date
HU165253B (no) 1974-07-27
DK131037C (no) 1975-10-20
DE2207421A1 (de) 1973-08-16
FI52225C (fi) 1977-07-11
FR2181719B1 (no) 1975-11-21
IL41506A (en) 1976-07-30
AU5207673A (en) 1974-08-15
RO73527A (ro) 1982-02-01
SE7514513L (sv) 1975-12-22
CH593995A5 (no) 1977-12-30
FI52225B (no) 1977-03-31
EG10914A (en) 1976-09-30
NO143065B (no) 1980-09-01
SE7713896L (sv) 1977-12-07
YU24373A (en) 1979-12-31
FR2181719A1 (no) 1973-12-07
JPS4886856A (no) 1973-11-15
PL81084B1 (no) 1975-08-30
NL177217B (nl) 1985-03-18
NL7301974A (no) 1973-08-14
NO140304B (no) 1979-04-30
NO140304C (no) 1979-08-08
SE403781B (sv) 1978-09-04
PH9370A (en) 1975-10-22
GB1425636A (en) 1976-02-18
ZA73944B (en) 1973-11-28
AU467306B2 (en) 1975-11-27
AT327413B (de) 1976-01-26
IE37266B1 (en) 1977-06-08
IE37266L (en) 1973-08-11
CA997753A (en) 1976-09-28
BE795241A (fr) 1973-08-09
SE409329B (sv) 1979-08-13
GR63160B (en) 1979-09-25
CH590883A5 (no) 1977-08-31
CS193019B2 (en) 1979-09-17
NO143065C (no) 1980-12-10
DK131037B (da) 1975-05-20
YU35035B (en) 1980-06-30
NL177217C (nl) 1985-08-16
NO782754L (no) 1973-08-14
JPS5829317B2 (ja) 1983-06-22
DD102379A5 (no) 1973-12-12
IL41506A0 (en) 1973-04-30
KR780000156B1 (en) 1978-05-02
DE2207421B2 (de) 1980-07-24
ES410933A1 (es) 1976-03-01
SE426834B (sv) 1983-02-14
SU513628A3 (ru) 1976-05-05
ATA112473A (de) 1975-04-15

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Legal Events

Date Code Title Description
OD Request for examination
C3 Grant after two publication steps (3rd publication)