DE2056291A1 - Vorrichtung zur Unterscheidung, zum Zahlen und Sortieren von Teilchen ent sprechend ihrer MikroStruktur - Google Patents
Vorrichtung zur Unterscheidung, zum Zahlen und Sortieren von Teilchen ent sprechend ihrer MikroStrukturInfo
- Publication number
- DE2056291A1 DE2056291A1 DE19702056291 DE2056291A DE2056291A1 DE 2056291 A1 DE2056291 A1 DE 2056291A1 DE 19702056291 DE19702056291 DE 19702056291 DE 2056291 A DE2056291 A DE 2056291A DE 2056291 A1 DE2056291 A1 DE 2056291A1
- Authority
- DE
- Germany
- Prior art keywords
- line
- output signals
- particles
- measuring device
- microstructure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002245 particle Substances 0.000 title claims description 33
- 210000004369 blood Anatomy 0.000 claims description 28
- 239000008280 blood Substances 0.000 claims description 28
- 210000001772 blood platelet Anatomy 0.000 claims description 23
- 239000012530 fluid Substances 0.000 claims description 23
- 230000003287 optical effect Effects 0.000 claims description 9
- 230000005855 radiation Effects 0.000 claims description 9
- 238000012545 processing Methods 0.000 claims description 7
- 238000004458 analytical method Methods 0.000 claims description 6
- 210000003743 erythrocyte Anatomy 0.000 claims description 5
- 239000000470 constituent Substances 0.000 claims description 3
- 238000011144 upstream manufacturing Methods 0.000 claims description 2
- 230000005670 electromagnetic radiation Effects 0.000 claims 2
- 241000937413 Axia Species 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 210000004027 cell Anatomy 0.000 description 101
- 239000000523 sample Substances 0.000 description 22
- 238000000034 method Methods 0.000 description 9
- 238000001228 spectrum Methods 0.000 description 7
- 239000003085 diluting agent Substances 0.000 description 6
- 210000003651 basophil Anatomy 0.000 description 4
- 210000000601 blood cell Anatomy 0.000 description 4
- 210000004698 lymphocyte Anatomy 0.000 description 4
- 210000001616 monocyte Anatomy 0.000 description 4
- 210000000440 neutrophil Anatomy 0.000 description 4
- 230000008859 change Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 210000003979 eosinophil Anatomy 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 210000000265 leukocyte Anatomy 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 102000001554 Hemoglobins Human genes 0.000 description 2
- 108010054147 Hemoglobins Proteins 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 239000011261 inert gas Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 238000004159 blood analysis Methods 0.000 description 1
- 241001233037 catfish Species 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 239000005340 laminated glass Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000010363 phase shift Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000010183 spectrum analysis Methods 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000012749 thinning agent Substances 0.000 description 1
- 229940098465 tincture Drugs 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
- G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1429—Signal processing
- G01N15/1433—Signal processing using image recognition
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1404—Handling flow, e.g. hydrodynamic focusing
- G01N15/1409—Handling samples, e.g. injecting samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1434—Optical arrangements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1434—Optical arrangements
- G01N2015/1454—Optical arrangements using phase shift or interference, e.g. for improving contrast
Landscapes
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Dispersion Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Signal Processing (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87772969A | 1969-11-18 | 1969-11-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2056291A1 true DE2056291A1 (de) | 1971-05-27 |
Family
ID=25370595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19702056291 Pending DE2056291A1 (de) | 1969-11-18 | 1970-11-16 | Vorrichtung zur Unterscheidung, zum Zahlen und Sortieren von Teilchen ent sprechend ihrer MikroStruktur |
Country Status (10)
| Country | Link |
|---|---|
| BE (1) | BE758948A (es) |
| CA (1) | CA932551A (es) |
| CH (1) | CH534354A (es) |
| DE (1) | DE2056291A1 (es) |
| ES (1) | ES385591A1 (es) |
| FR (1) | FR2069514A5 (es) |
| GB (1) | GB1318720A (es) |
| LU (1) | LU62070A1 (es) |
| NL (1) | NL7016704A (es) |
| SE (1) | SE372416B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2535053B1 (fr) * | 1982-10-22 | 1985-06-21 | Saint Etienne Universite | Appareil d'identification optique des proprietes multiparametriques individuelles de particules ou objets en flux continu |
| US4606636A (en) * | 1983-10-25 | 1986-08-19 | Universite De Saint-Etienne | Optical apparatus for identifying the individual multiparametric properties of particles or bodies in a continuous flow |
| US5733507A (en) * | 1995-06-07 | 1998-03-31 | Inphocyte, Inc. | Biological cell sample holder for use in infrared and/or Raman spectroscopy analysis holder |
| US5848977A (en) * | 1996-02-16 | 1998-12-15 | Inphocyte, Inc. | Sample holder for cells |
| CA2341231C (en) * | 1998-08-21 | 2003-10-21 | Union Biometrica, Inc. | Instrument for selecting and depositing multicellular organisms and other large objects |
| EP1739402B1 (en) * | 2004-04-23 | 2017-08-02 | The Furukawa Electric Co., Ltd. | Methods of separating, identifying and dispensing specimen and device therefor, and analyzing device method |
| EP3861316B1 (en) * | 2018-10-01 | 2023-08-30 | Hewlett-Packard Development Company, L.P. | Batch particle sorting |
-
0
- BE BE758948D patent/BE758948A/xx unknown
-
1970
- 1970-11-03 CA CA097251A patent/CA932551A/en not_active Expired
- 1970-11-13 NL NL7016704A patent/NL7016704A/xx unknown
- 1970-11-13 GB GB5412770A patent/GB1318720A/en not_active Expired
- 1970-11-16 ES ES385591A patent/ES385591A1/es not_active Expired
- 1970-11-16 DE DE19702056291 patent/DE2056291A1/de active Pending
- 1970-11-16 SE SE7015498A patent/SE372416B/xx unknown
- 1970-11-16 LU LU62070D patent/LU62070A1/xx unknown
- 1970-11-16 FR FR7041050A patent/FR2069514A5/fr not_active Expired
- 1970-11-16 CH CH1692570A patent/CH534354A/fr not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SE372416B (es) | 1974-12-23 |
| FR2069514A5 (es) | 1971-09-03 |
| NL7016704A (es) | 1971-05-21 |
| LU62070A1 (es) | 1971-08-12 |
| BE758948A (fr) | 1971-05-13 |
| CA932551A (en) | 1973-08-28 |
| CH534354A (fr) | 1973-02-28 |
| ES385591A1 (es) | 1973-03-16 |
| GB1318720A (en) | 1973-05-31 |
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