DE2021968A1 - Verfahren zur Blutuntersuchung unter Verwendung radioaktiver Indikator-Substanzen und Ionenaustauscherharz-Membranen - Google Patents
Verfahren zur Blutuntersuchung unter Verwendung radioaktiver Indikator-Substanzen und Ionenaustauscherharz-MembranenInfo
- Publication number
- DE2021968A1 DE2021968A1 DE19702021968 DE2021968A DE2021968A1 DE 2021968 A1 DE2021968 A1 DE 2021968A1 DE 19702021968 DE19702021968 DE 19702021968 DE 2021968 A DE2021968 A DE 2021968A DE 2021968 A1 DE2021968 A1 DE 2021968A1
- Authority
- DE
- Germany
- Prior art keywords
- thyroxine
- radioactive
- serum
- membrane
- blood serum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000012528 membrane Substances 0.000 title claims description 41
- 230000002285 radioactive effect Effects 0.000 title claims description 38
- 238000000034 method Methods 0.000 title claims description 36
- 239000000126 substance Substances 0.000 title claims description 35
- 239000003456 ion exchange resin Substances 0.000 title claims description 20
- 229920003303 ion-exchange polymer Polymers 0.000 title claims description 20
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 title claims description 18
- 238000012360 testing method Methods 0.000 title claims description 14
- 210000004369 blood Anatomy 0.000 title claims description 11
- 239000008280 blood Substances 0.000 title claims description 11
- 210000002966 serum Anatomy 0.000 claims description 63
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 claims description 62
- XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 claims description 58
- 229940034208 thyroxine Drugs 0.000 claims description 58
- 239000000243 solution Substances 0.000 claims description 33
- 239000011347 resin Substances 0.000 claims description 31
- 229920005989 resin Polymers 0.000 claims description 31
- 102000004506 Blood Proteins Human genes 0.000 claims description 22
- 108010017384 Blood Proteins Proteins 0.000 claims description 22
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 19
- 239000007788 liquid Substances 0.000 claims description 18
- 239000003153 chemical reaction reagent Substances 0.000 claims description 14
- 102000006395 Globulins Human genes 0.000 claims description 11
- 108010044091 Globulins Proteins 0.000 claims description 11
- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical class IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 claims description 11
- 239000005495 thyroid hormone Substances 0.000 claims description 6
- 229940036555 thyroid hormone Drugs 0.000 claims description 6
- 238000000338 in vitro Methods 0.000 claims description 5
- 108010000259 Thyroxine-Binding Globulin Proteins 0.000 claims description 4
- 102000002248 Thyroxine-Binding Globulin Human genes 0.000 claims description 4
- 239000012675 alcoholic extract Substances 0.000 claims description 4
- 238000004159 blood analysis Methods 0.000 claims description 4
- 239000000284 extract Substances 0.000 claims description 4
- 150000002500 ions Chemical class 0.000 claims description 3
- 239000011159 matrix material Substances 0.000 claims description 3
- 125000001453 quaternary ammonium group Chemical group 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 102000009027 Albumins Human genes 0.000 claims description 2
- 108010088751 Albumins Proteins 0.000 claims description 2
- 239000002657 fibrous material Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 239000008366 buffered solution Substances 0.000 claims 3
- 125000003010 ionic group Chemical group 0.000 claims 2
- 102000007584 Prealbumin Human genes 0.000 claims 1
- 108010071690 Prealbumin Proteins 0.000 claims 1
- 239000000523 sample Substances 0.000 description 29
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 12
- FTOAOBMCPZCFFF-UHFFFAOYSA-N 5,5-diethylbarbituric acid Chemical compound CCC1(CC)C(=O)NC(=O)NC1=O FTOAOBMCPZCFFF-UHFFFAOYSA-N 0.000 description 9
- 102100028709 Thyroxine-binding globulin Human genes 0.000 description 9
- 239000007853 buffer solution Substances 0.000 description 7
- 238000011534 incubation Methods 0.000 description 7
- 102000009488 Thyroxine-Binding Proteins Human genes 0.000 description 6
- 108010048889 Thyroxine-Binding Proteins Proteins 0.000 description 6
- 229910052742 iron Inorganic materials 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 150000001450 anions Chemical class 0.000 description 4
- 229960002319 barbital Drugs 0.000 description 4
- 125000002091 cationic group Chemical group 0.000 description 4
- 229920001577 copolymer Polymers 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 239000011630 iodine Substances 0.000 description 4
- 229910052740 iodine Inorganic materials 0.000 description 4
- 239000003014 ion exchange membrane Substances 0.000 description 4
- 230000001476 alcoholic effect Effects 0.000 description 3
- 150000001768 cations Chemical class 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- 210000001685 thyroid gland Anatomy 0.000 description 3
- 229920002466 Dynel Polymers 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 2
- RCITVHFNWJIDNA-UHFFFAOYSA-K [NH4+].[NH4+].[NH4+].[Fe+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O Chemical compound [NH4+].[NH4+].[NH4+].[Fe+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O RCITVHFNWJIDNA-UHFFFAOYSA-K 0.000 description 2
- 125000000129 anionic group Chemical group 0.000 description 2
- 239000007982 barbital buffer Substances 0.000 description 2
- 229960000796 barbital sodium Drugs 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 239000013068 control sample Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 230000003014 reinforcing effect Effects 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- RGHFKWPGWBFQLN-UHFFFAOYSA-M sodium;5,5-diethylpyrimidin-3-ide-2,4,6-trione Chemical compound [Na+].CCC1(CC)C([O-])=NC(=O)NC1=O RGHFKWPGWBFQLN-UHFFFAOYSA-M 0.000 description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 2
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 1
- 241000237518 Arion Species 0.000 description 1
- 241000736355 Euthyroides Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-M iodide Chemical compound [I-] XMBWDFGMSWQBCA-UHFFFAOYSA-M 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- FYFFGSSZFBZTAH-UHFFFAOYSA-N methylaminomethanetriol Chemical compound CNC(O)(O)O FYFFGSSZFBZTAH-UHFFFAOYSA-N 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 239000000941 radioactive substance Substances 0.000 description 1
- 239000000700 radioactive tracer Substances 0.000 description 1
- 239000013074 reference sample Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000036186 satiety Effects 0.000 description 1
- 235000019627 satiety Nutrition 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21H—OBTAINING ENERGY FROM RADIOACTIVE SOURCES; APPLICATIONS OF RADIATION FROM RADIOACTIVE SOURCES, NOT OTHERWISE PROVIDED FOR; UTILISING COSMIC RADIATION
- G21H5/00—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for
- G21H5/02—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for as tracers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/825—Pretreatment for removal of interfering factors from sample
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/826—Additives, e.g. buffers, diluents, preservatives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82109769A | 1969-05-01 | 1969-05-01 | |
| US86578569A | 1969-10-13 | 1969-10-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2021968A1 true DE2021968A1 (de) | 1970-11-05 |
Family
ID=27124511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19702021968 Pending DE2021968A1 (de) | 1969-05-01 | 1970-04-27 | Verfahren zur Blutuntersuchung unter Verwendung radioaktiver Indikator-Substanzen und Ionenaustauscherharz-Membranen |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US3714344A (OSRAM) |
| JP (2) | JPS5617620B1 (OSRAM) |
| BE (1) | BE749772A (OSRAM) |
| CH (1) | CH526781A (OSRAM) |
| DE (1) | DE2021968A1 (OSRAM) |
| FR (1) | FR2047211A5 (OSRAM) |
| GB (1) | GB1314263A (OSRAM) |
| IL (1) | IL34387A (OSRAM) |
| IT (1) | IT943545B (OSRAM) |
| NL (2) | NL7006455A (OSRAM) |
| SE (1) | SE378679B (OSRAM) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE32098E (en) * | 1972-06-23 | 1986-03-25 | Research And Education Institute, Inc. | Radioimmunoassay for measurement of thyroxine (T4) and triiodothyronine (T3) in blood serum |
| US3911096A (en) * | 1972-06-23 | 1975-10-07 | Professional Staff Ass Of The | Radioimmunoassay for measurement of thyroxine (T{HD 4{B ) and triiodothyonine (T{HD 3{B ) in blood serum |
| US3966897A (en) * | 1973-04-02 | 1976-06-29 | Marine Colloids, Inc. | Medium for use in bioassay and method of using same |
| GB1412274A (en) * | 1973-05-29 | 1975-11-05 | Bio Rad Laboratories | Radioactive determination of serum thyroxine |
| US3929981A (en) * | 1974-02-27 | 1975-12-30 | Squibb & Sons Inc | Method for determining thyroid function |
| CA1050425A (en) * | 1975-06-26 | 1979-03-13 | Mallinckrodt | Radioimmunoassay methods for the determination of l-triiodothyronine and thyroxine |
| US4289748A (en) * | 1979-05-31 | 1981-09-15 | United States Of America | Ultrasensitive enzymatic radioimmunoassay method |
| US4282002A (en) * | 1979-09-06 | 1981-08-04 | Akzona Incorporated | Sensitized sheep stroma immunoassay for rheumatoid factor |
| US6242261B1 (en) | 1992-02-10 | 2001-06-05 | University Of Saskatchewan | Assessment of ion availability in heterogeneous media using ion-exchange membranes |
| WO1993020442A1 (en) * | 1992-03-30 | 1993-10-14 | Abbott Laboratories | Reagents and methods for the detection and quantification of thyroxine in fluid samples |
| US5352803A (en) * | 1992-03-30 | 1994-10-04 | Abbott Laboratories | 5(6)-methyl substituted fluorescein derivatives |
| FR2878333B1 (fr) * | 2004-11-25 | 2007-04-27 | Cie Gen De S Eaux Soc En Comma | Mallette pour le prelevement d'eau et la capture de substances generatrices d'odeurs et/ou de gouts presents dans l'eau |
| US11768689B2 (en) | 2013-08-08 | 2023-09-26 | Movidius Limited | Apparatus, systems, and methods for low power computational imaging |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3414383A (en) * | 1965-08-09 | 1968-12-03 | Canadian Patents Dev | Determination of thyroxine |
-
1969
- 1969-10-13 US US00865785A patent/US3714344A/en not_active Expired - Lifetime
-
1970
- 1970-04-22 GB GB1939170A patent/GB1314263A/en not_active Expired
- 1970-04-24 IL IL34387A patent/IL34387A/en unknown
- 1970-04-27 DE DE19702021968 patent/DE2021968A1/de active Pending
- 1970-04-28 SE SE7005892A patent/SE378679B/xx unknown
- 1970-04-28 IT IT50306/70A patent/IT943545B/it active
- 1970-04-30 BE BE749772D patent/BE749772A/xx unknown
- 1970-04-30 FR FR7016059A patent/FR2047211A5/fr not_active Expired
- 1970-05-01 CH CH660670A patent/CH526781A/de not_active IP Right Cessation
- 1970-05-01 NL NL7006455A patent/NL7006455A/xx unknown
- 1970-05-01 JP JP3743570A patent/JPS5617620B1/ja active Pending
-
1974
- 1974-12-31 NL NL7417037A patent/NL7417037A/xx unknown
-
1976
- 1976-01-30 JP JP917876A patent/JPS5542704B1/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL34387A0 (en) | 1970-06-17 |
| US3714344A (en) | 1973-01-30 |
| JPS5617620B1 (OSRAM) | 1981-04-23 |
| CH526781A (de) | 1972-08-15 |
| SE378679B (OSRAM) | 1975-09-08 |
| BE749772A (fr) | 1970-10-30 |
| NL7006455A (OSRAM) | 1970-11-03 |
| GB1314263A (en) | 1973-04-18 |
| IT943545B (it) | 1973-04-10 |
| IL34387A (en) | 1973-04-30 |
| FR2047211A5 (OSRAM) | 1971-03-12 |
| JPS5542704B1 (OSRAM) | 1980-11-01 |
| NL7417037A (nl) | 1975-04-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OHW | Rejection |