DE2014133A1 - Vorrichtung zur Durchführung eines Blutgerinnungstestes und Verfahren zu ihrer Betätigung - Google Patents
Vorrichtung zur Durchführung eines Blutgerinnungstestes und Verfahren zu ihrer BetätigungInfo
- Publication number
- DE2014133A1 DE2014133A1 DE19702014133 DE2014133A DE2014133A1 DE 2014133 A1 DE2014133 A1 DE 2014133A1 DE 19702014133 DE19702014133 DE 19702014133 DE 2014133 A DE2014133 A DE 2014133A DE 2014133 A1 DE2014133 A1 DE 2014133A1
- Authority
- DE
- Germany
- Prior art keywords
- blood
- chamber
- wall
- jacket
- volume
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000012360 testing method Methods 0.000 title claims description 15
- 238000000034 method Methods 0.000 title claims description 10
- 230000023555 blood coagulation Effects 0.000 title claims description 6
- 239000008280 blood Substances 0.000 claims description 45
- 210000004369 blood Anatomy 0.000 claims description 45
- 239000000725 suspension Substances 0.000 claims description 14
- 230000015271 coagulation Effects 0.000 claims description 11
- 238000005345 coagulation Methods 0.000 claims description 11
- 239000012528 membrane Substances 0.000 claims description 9
- 239000003146 anticoagulant agent Substances 0.000 claims description 6
- 229940127219 anticoagulant drug Drugs 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 108010039209 Blood Coagulation Factors Proteins 0.000 claims description 4
- 102000015081 Blood Coagulation Factors Human genes 0.000 claims description 4
- 239000003114 blood coagulation factor Substances 0.000 claims description 4
- 229940019700 blood coagulation factors Drugs 0.000 claims description 4
- 150000002258 gallium Chemical class 0.000 claims 1
- 238000005192 partition Methods 0.000 claims 1
- 239000001509 sodium citrate Substances 0.000 description 11
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 11
- 229940038773 trisodium citrate Drugs 0.000 description 11
- 108010074860 Factor Xa Proteins 0.000 description 10
- 239000007788 liquid Substances 0.000 description 9
- 206010053567 Coagulopathies Diseases 0.000 description 8
- 230000035602 clotting Effects 0.000 description 8
- 150000002500 ions Chemical class 0.000 description 6
- 239000011575 calcium Substances 0.000 description 5
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 208000007536 Thrombosis Diseases 0.000 description 3
- 239000002131 composite material Substances 0.000 description 3
- 230000033001 locomotion Effects 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000002123 temporal effect Effects 0.000 description 3
- 230000001133 acceleration Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- ZNCPFRVNHGOPAG-UHFFFAOYSA-L sodium oxalate Chemical compound [Na+].[Na+].[O-]C(=O)C([O-])=O ZNCPFRVNHGOPAG-UHFFFAOYSA-L 0.000 description 2
- 229940039790 sodium oxalate Drugs 0.000 description 2
- PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 238000005773 Enders reaction Methods 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 102000002262 Thromboplastin Human genes 0.000 description 1
- 108010000499 Thromboplastin Proteins 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000003851 biochemical process Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 150000003388 sodium compounds Chemical class 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4905—Determining clotting time of blood
-
- G—PHYSICS
- G04—HOROLOGY
- G04F—TIME-INTERVAL MEASURING
- G04F8/00—Apparatus for measuring unknown time intervals by electromechanical means
- G04F8/006—Apparatus for measuring unknown time intervals by electromechanical means running only during the time interval to be measured, e.g. stop-watch
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- General Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Ecology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH412469A CH506791A (fr) | 1969-03-19 | 1969-03-19 | Dispositif pour l'exécution d'un test de coagulation sanguine et procédé de mise en action de ce dispositif |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2014133A1 true DE2014133A1 (de) | 1970-10-01 |
Family
ID=4270265
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19702014133 Pending DE2014133A1 (de) | 1969-03-19 | 1970-03-19 | Vorrichtung zur Durchführung eines Blutgerinnungstestes und Verfahren zu ihrer Betätigung |
| DE19702014123 Pending DE2014123A1 (enrdf_load_stackoverflow) | 1969-03-19 | 1970-03-19 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19702014123 Pending DE2014123A1 (enrdf_load_stackoverflow) | 1969-03-19 | 1970-03-19 |
Country Status (10)
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3951606A (en) * | 1974-05-17 | 1976-04-20 | Geomet, Inc. | Apparatus for prothrombin testing |
| US3918908A (en) * | 1974-05-17 | 1975-11-11 | Geomet | Method for prothrombin testing |
| US4000972A (en) * | 1976-01-16 | 1977-01-04 | Hemotec, Inc. | Measuring system for the pharmacological manipulation of the coagulation mechanism in blood and for the elapsed coagulation time |
| DE2962562D1 (en) | 1978-08-31 | 1982-06-03 | Nat Res Dev | Apparatus and method for harvesting material from micro-culture plates |
| US4262521A (en) * | 1979-08-27 | 1981-04-21 | Sperry Corporation | Epoxy resin gel tester |
| LU84191A1 (fr) * | 1981-06-12 | 1982-12-13 | Ferrero Spa | Recipient pour boisson perforable par une paille |
| US4663127A (en) * | 1982-10-15 | 1987-05-05 | Hemotec, Inc. | Gas flow cartridge having resilient flexible membrane with slit separating reaction and reagent chambers |
| US4533519A (en) * | 1983-07-20 | 1985-08-06 | Hemotec, Inc. | Gas flow coagulation test cartridge having movable member establishing communication between reagent and reaction chambers |
| US4797369A (en) * | 1985-04-05 | 1989-01-10 | International Technidyne Corp. | Method and apparatus for detecting a blood clot |
| US4947679A (en) * | 1989-04-21 | 1990-08-14 | The Dow Chemical Company | Apparatus for determining resin gel time |
| US5174961A (en) * | 1991-01-18 | 1992-12-29 | Hemotec, Inc. | High sensitivity coagulation detection apparatus |
| US5314826A (en) * | 1991-08-23 | 1994-05-24 | Medtronic Hemotec, Inc. | Platelet activation and function evaluation technique |
| US5302348A (en) * | 1992-12-10 | 1994-04-12 | Itc Corporation | Blood coagulation time test apparatus and method |
| US5925319A (en) * | 1996-04-30 | 1999-07-20 | Medtronic, Inc. | Test cartridge for evaluating blood platelet functionality |
| US6746872B2 (en) * | 2002-01-16 | 2004-06-08 | Lifescan, Inc. | Control compositions and methods of use for coagulation tests |
| EP1747451B1 (en) * | 2004-05-17 | 2011-11-02 | Medtronic, Inc. | Point of care heparin determination system |
| US10823743B1 (en) | 2013-10-28 | 2020-11-03 | Ifirst Medical Technologies, Inc. | Methods of measuring coagulation of a biological sample |
| EP3217168A1 (en) * | 2016-03-08 | 2017-09-13 | Roche Diagnostics GmbH | Test element analysis system for the analytical examination of a sample |
| RU2645081C1 (ru) * | 2016-12-28 | 2018-02-15 | Анна Николаевна Плаксина | Анализатор коагуляции - тромбоэластограф |
| CN117920371A (zh) | 2017-07-27 | 2024-04-26 | 生物梅里埃有限公司 | 分离容器、包括分离容器的组件以及使用分离容器和组件的方法 |
| US11282596B2 (en) | 2017-11-22 | 2022-03-22 | 3M Innovative Properties Company | Automated code feedback system |
| CN110583628B (zh) * | 2019-10-11 | 2021-08-24 | 山东山大附属生殖医院有限公司 | 便于查找的生物细胞冷冻装置 |
| US12277814B2 (en) | 2020-01-29 | 2025-04-15 | Ifirst Medical Technologies, Inc. | Medical analyzer and diagnostic sample profiler |
| CN115253987B (zh) * | 2022-09-26 | 2022-12-09 | 山东新港化工有限公司 | 一种驱油用表面活性剂中和辅助装置及使用方法 |
-
1969
- 1969-03-19 CH CH1125570A patent/CH533307A/fr not_active IP Right Cessation
- 1969-03-19 CH CH412469A patent/CH506791A/fr not_active IP Right Cessation
-
1970
- 1970-03-17 FR FR7009534A patent/FR2039644A5/fr not_active Expired
- 1970-03-17 FR FR7009533A patent/FR2039643A5/fr not_active Expired
- 1970-03-17 US US20340A patent/US3692487A/en not_active Expired - Lifetime
- 1970-03-17 US US20341A patent/US3704099A/en not_active Expired - Lifetime
- 1970-03-18 ES ES377637A patent/ES377637A1/es not_active Expired
- 1970-03-19 GB GB1325170A patent/GB1310245A/en not_active Expired
- 1970-03-19 DE DE19702014133 patent/DE2014133A1/de active Pending
- 1970-03-19 AU AU12835/70A patent/AU1283570A/en not_active Expired
- 1970-03-19 IL IL34113A patent/IL34113A0/xx unknown
- 1970-03-19 NL NL7003917A patent/NL7003917A/xx unknown
- 1970-03-19 ZA ZA701872A patent/ZA701872B/xx unknown
- 1970-03-19 NL NL7003916A patent/NL7003916A/xx unknown
- 1970-03-19 IL IL34114A patent/IL34114A0/xx unknown
- 1970-03-19 DE DE19702014123 patent/DE2014123A1/de active Pending
- 1970-03-19 GB GB1325270A patent/GB1310246A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2039643A5 (enrdf_load_stackoverflow) | 1971-01-15 |
| CH506791A (fr) | 1971-04-30 |
| IL34113A0 (en) | 1970-05-21 |
| GB1310245A (en) | 1973-03-14 |
| US3692487A (en) | 1972-09-19 |
| US3704099A (en) | 1972-11-28 |
| CH533307A (fr) | 1973-01-31 |
| AU1283570A (en) | 1971-09-23 |
| NL7003916A (enrdf_load_stackoverflow) | 1970-09-22 |
| IL34114A0 (en) | 1970-05-21 |
| FR2039644A5 (enrdf_load_stackoverflow) | 1971-01-15 |
| DE2014123A1 (enrdf_load_stackoverflow) | 1970-10-08 |
| ES377637A1 (es) | 1972-07-16 |
| ZA701872B (en) | 1971-05-27 |
| GB1310246A (en) | 1973-03-14 |
| NL7003917A (enrdf_load_stackoverflow) | 1970-09-22 |
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