DE19824175A1 - Amino-azol-Verbindungen - Google Patents

Amino-azol-Verbindungen

Info

Publication number
DE19824175A1
DE19824175A1 DE1998124175 DE19824175A DE19824175A1 DE 19824175 A1 DE19824175 A1 DE 19824175A1 DE 1998124175 DE1998124175 DE 1998124175 DE 19824175 A DE19824175 A DE 19824175A DE 19824175 A1 DE19824175 A1 DE 19824175A1
Authority
DE
Germany
Prior art keywords
alkyl
alkoxy
phenyl
formula
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE1998124175
Other languages
German (de)
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Priority to DE1998124175 priority Critical patent/DE19824175A1/de
Priority to CO99031508A priority patent/CO5070569A1/es
Priority to AU45016/99A priority patent/AU4501699A/en
Priority to PCT/EP1999/003682 priority patent/WO1999062892A1/fr
Publication of DE19824175A1 publication Critical patent/DE19824175A1/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE1998124175 1998-05-29 1998-05-29 Amino-azol-Verbindungen Ceased DE19824175A1 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE1998124175 DE19824175A1 (de) 1998-05-29 1998-05-29 Amino-azol-Verbindungen
CO99031508A CO5070569A1 (es) 1998-05-29 1999-05-21 Compuesto de aminoazol o una sal farmaceuticamente aceptable del mismo y medicamento que los contienen
AU45016/99A AU4501699A (en) 1998-05-29 1999-05-27 Aminoazole compounds
PCT/EP1999/003682 WO1999062892A1 (fr) 1998-05-29 1999-05-27 Composes d'aminoazole

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE1998124175 DE19824175A1 (de) 1998-05-29 1998-05-29 Amino-azol-Verbindungen

Publications (1)

Publication Number Publication Date
DE19824175A1 true DE19824175A1 (de) 1999-12-02

Family

ID=7869385

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1998124175 Ceased DE19824175A1 (de) 1998-05-29 1998-05-29 Amino-azol-Verbindungen

Country Status (4)

Country Link
AU (1) AU4501699A (fr)
CO (1) CO5070569A1 (fr)
DE (1) DE19824175A1 (fr)
WO (1) WO1999062892A1 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6191160B1 (en) 1998-11-10 2001-02-20 Merck & Co., Inc. Spiro-indolines as Y5 receptor antagonists
EP1183245A1 (fr) * 1999-04-22 2002-03-06 Synaptic Pharmaceutical Corporation Antagonistes selectifs npy (y5)
US6569856B2 (en) 1999-04-22 2003-05-27 Synaptic Pharmaceutical Corporation Selective NPY (Y5) antagonists (triazines)
WO2003051356A1 (fr) * 2001-12-17 2003-06-26 Merck & Co., Inc. Traitement des ruptures du rythme circadien
US6586423B2 (en) 1999-09-10 2003-07-01 Merck & Co., Inc. Tyrosine kinase inhibitors
US6872724B2 (en) 2002-07-24 2005-03-29 Merck & Co., Inc. Polymorphs with tyrosine kinase activity
US6875767B2 (en) 2001-06-22 2005-04-05 Merck & Co., Inc. (5-cyano-2-thiazolyl)amino-4-pyridine tyrosine kinase inhibitors
US6989379B1 (en) 1999-04-22 2006-01-24 H. Lundbick A/S Selective NPY (Y5) antagonists
US7273880B2 (en) 1999-06-30 2007-09-25 H. Lunbeck A/S Selective NPY (Y5) antagonists

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6218408B1 (en) 1999-06-30 2001-04-17 Synaptic Pharmaceutical Corporation Selective NPY (Y5) antagonists (bicyclics)
US6214853B1 (en) 1999-06-30 2001-04-10 Synaptic Pharmaceutical Corporation Selective NPY (Y5) antagonists (bicyclics)
WO2001064675A1 (fr) * 2000-03-03 2001-09-07 Novartis Ag Thiazolamines condensees et leur utilisation comme antagonistes du neuropeptide y5
ES2292992T3 (es) * 2002-02-28 2008-03-16 F. Hoffmann-La Roche Ag Derivados de tiazol como antagonistas del receptor npy.
BR0313278A (pt) 2002-08-07 2005-07-05 Hoffmann La Roche Compostos, processo para a preparação de um composto, composição farmacêutica que compreende o mesmo e sua utilização, método para o tratamento e profilaxia de enfermidades e obesidade e utilização dos compostos
DE602004010529T2 (de) * 2003-08-12 2008-11-27 F. Hoffmann-La Roche Ag 2-amino-5-benzoylthiazol npy-antagonisten
ES2321299T3 (es) * 2003-08-12 2009-06-04 F. Hoffmann-La Roche Ag Derivados de tiazol como antagonistas de npy.
US9133123B2 (en) 2010-04-23 2015-09-15 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
AR081626A1 (es) 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
US8759380B2 (en) 2011-04-22 2014-06-24 Cytokinetics, Inc. Certain heterocycles, compositions thereof, and methods for their use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19544687A1 (de) * 1995-11-30 1997-06-05 Thomae Gmbh Dr K Aminosäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
WO1997020821A1 (fr) * 1995-12-01 1997-06-12 Novartis Ag Derives heteroaryles

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4326465A1 (de) * 1993-01-20 1995-02-09 Thomae Gmbh Dr K Aminosäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
TW399051B (en) * 1996-01-31 2000-07-21 Ssp Co Ltd A novel benzoazine thiazolidinedione derivative and pharmaceutical composition for reducing blood glucose
PL334833A1 (en) * 1997-01-28 2000-03-27 Merck & Co Inc Thiazolobenzenosulphonamides as beta3 agonists for treating diabetes and obesity
SG72827A1 (en) * 1997-06-23 2000-05-23 Hoffmann La Roche Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19544687A1 (de) * 1995-11-30 1997-06-05 Thomae Gmbh Dr K Aminosäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
WO1997020821A1 (fr) * 1995-12-01 1997-06-12 Novartis Ag Derives heteroaryles

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Chemical Abstracts: Vol.129, 1998, Ref. 616n *
MÜLLER,Manfred, et.al.: Synthesis and Neuropeptide Y Y¶1¶ Receptor Antagonistic Activity of N,N-Disubstituted omega-Guanidino- and omega-Aminoalkanoic Acid Amides. In: Arch. Pharm. Pharm. Med. Chem. 330, 1997, S.333-342 *
Vol.111, 1989, Ref. 17598j *
Vol.128, 1998, Ref. 44251y *

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495559B2 (en) 1998-11-10 2002-12-17 Merck & Co., Inc. NPY Y5 receptor antagonists
US6313298B1 (en) 1998-11-10 2001-11-06 Merck & Co., Inc. Spiro-indolines as Y5 receptor antagonists
US6191160B1 (en) 1998-11-10 2001-02-20 Merck & Co., Inc. Spiro-indolines as Y5 receptor antagonists
US6638942B1 (en) 1998-11-10 2003-10-28 Merck & Co., Inc. Spiro-indolines as Y5 receptor antagonists
US6989379B1 (en) 1999-04-22 2006-01-24 H. Lundbick A/S Selective NPY (Y5) antagonists
US6569856B2 (en) 1999-04-22 2003-05-27 Synaptic Pharmaceutical Corporation Selective NPY (Y5) antagonists (triazines)
EP1183245A4 (fr) * 1999-04-22 2002-10-02 Synaptic Pharma Corp Antagonistes selectifs npy (y5)
EP1183245A1 (fr) * 1999-04-22 2002-03-06 Synaptic Pharmaceutical Corporation Antagonistes selectifs npy (y5)
US7189720B2 (en) 1999-04-22 2007-03-13 H. Lundbeck A/S Selective NPY (Y5) antagonists
EP1816127A1 (fr) * 1999-04-22 2007-08-08 H. Lundbeck A/S Dérivés triazines utiles comme des antagonistes sélectifs du npy(y5)
US7273880B2 (en) 1999-06-30 2007-09-25 H. Lunbeck A/S Selective NPY (Y5) antagonists
US6586423B2 (en) 1999-09-10 2003-07-01 Merck & Co., Inc. Tyrosine kinase inhibitors
US6586424B2 (en) 1999-09-10 2003-07-01 Merck & Co., Inc. Tyrosine kinase inhibitors
US6875767B2 (en) 2001-06-22 2005-04-05 Merck & Co., Inc. (5-cyano-2-thiazolyl)amino-4-pyridine tyrosine kinase inhibitors
WO2003051356A1 (fr) * 2001-12-17 2003-06-26 Merck & Co., Inc. Traitement des ruptures du rythme circadien
AU2002351381B2 (en) * 2001-12-17 2007-06-07 Merck & Co., Inc. Method for treating circadian rhythm disruptions
US6872724B2 (en) 2002-07-24 2005-03-29 Merck & Co., Inc. Polymorphs with tyrosine kinase activity

Also Published As

Publication number Publication date
CO5070569A1 (es) 2001-08-28
AU4501699A (en) 1999-12-20
WO1999062892A1 (fr) 1999-12-09

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Legal Events

Date Code Title Description
OM8 Search report available as to paragraph 43 lit. 1 sentence 1 patent law
8131 Rejection