DE19628776A1 - Oral applizierbare Granulate von Hexahydropyrazinderivaten - Google Patents

Oral applizierbare Granulate von Hexahydropyrazinderivaten

Info

Publication number
DE19628776A1
DE19628776A1 DE19628776A DE19628776A DE19628776A1 DE 19628776 A1 DE19628776 A1 DE 19628776A1 DE 19628776 A DE19628776 A DE 19628776A DE 19628776 A DE19628776 A DE 19628776A DE 19628776 A1 DE19628776 A1 DE 19628776A1
Authority
DE
Germany
Prior art keywords
spp
derivatives
granules
hexahydropyrazine
hexahydropyrazine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19628776A
Other languages
German (de)
English (en)
Inventor
Jochen Dr Kalbe
Terence Dr Hopkins
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to DE19628776A priority Critical patent/DE19628776A1/de
Priority to ES97931773T priority patent/ES2183200T3/es
Priority to PCT/EP1997/003537 priority patent/WO1998003157A1/de
Priority to HU9903180A priority patent/HUP9903180A3/hu
Priority to AT97931773T priority patent/ATE227565T1/de
Priority to KR10-1999-7000198A priority patent/KR100485149B1/ko
Priority to DK97931773T priority patent/DK0912167T3/da
Priority to US09/214,858 priority patent/US6503536B2/en
Priority to NZ333745A priority patent/NZ333745A/xx
Priority to EP97931773A priority patent/EP0912167B1/de
Priority to AU35413/97A priority patent/AU711705B2/en
Priority to BRPI9710377-2A priority patent/BR9710377B1/pt
Priority to DE59708723T priority patent/DE59708723D1/de
Priority to JP50648498A priority patent/JP4202422B2/ja
Priority to PT97931773T priority patent/PT912167E/pt
Priority to CN97196483A priority patent/CN1225579A/zh
Priority to CA002260889A priority patent/CA2260889C/en
Publication of DE19628776A1 publication Critical patent/DE19628776A1/de
Priority to NO19990157A priority patent/NO325272B1/no
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
DE19628776A 1996-07-17 1996-07-17 Oral applizierbare Granulate von Hexahydropyrazinderivaten Withdrawn DE19628776A1 (de)

Priority Applications (18)

Application Number Priority Date Filing Date Title
DE19628776A DE19628776A1 (de) 1996-07-17 1996-07-17 Oral applizierbare Granulate von Hexahydropyrazinderivaten
EP97931773A EP0912167B1 (de) 1996-07-17 1997-07-04 Oral applizierbare granulate von hexahydropyrazinderivaten
AU35413/97A AU711705B2 (en) 1996-07-17 1997-07-04 Orally administrable granules of hexahydropyrazine derivatives
HU9903180A HUP9903180A3 (en) 1996-07-17 1997-07-04 Granulates of hexahydropyrazine derivatives which can be administered orally and process for producing them
AT97931773T ATE227565T1 (de) 1996-07-17 1997-07-04 Oral applizierbare granulate von hexahydropyrazinderivaten
KR10-1999-7000198A KR100485149B1 (ko) 1996-07-17 1997-07-04 경구 투여가능한 헥사하이드로피라진 유도체 과립
DK97931773T DK0912167T3 (da) 1996-07-17 1997-07-04 Oralt indgivelige granulater af hexahydropyrazinderivater
US09/214,858 US6503536B2 (en) 1996-07-17 1997-07-04 Granulates of hexahydropyrazine derivatives which can be administered orally
NZ333745A NZ333745A (en) 1996-07-17 1997-07-04 Preparation of granulates comprising hexahydropyrazine derivatives and hydrophobic carriers
ES97931773T ES2183200T3 (es) 1996-07-17 1997-07-04 Granulados aplicables por via oral de derivados de hexahidropirazina.
PCT/EP1997/003537 WO1998003157A1 (de) 1996-07-17 1997-07-04 Oral applizierbare granulate von hexahydropyrazinderivaten
BRPI9710377-2A BR9710377B1 (pt) 1996-07-17 1997-07-04 gránulos de praziquantel administráveis por via oral a gatos.
DE59708723T DE59708723D1 (de) 1996-07-17 1997-07-04 Oral applizierbare granulate von hexahydropyrazinderivaten
JP50648498A JP4202422B2 (ja) 1996-07-17 1997-07-04 ヘキサヒドロピラジン誘導体の経口投与できる顆粒剤
PT97931773T PT912167E (pt) 1996-07-17 1997-07-04 Granulos de derivados de hexa-hidropirazina administraveis por via oral
CN97196483A CN1225579A (zh) 1996-07-17 1997-07-04 可经口给药的六氢吡嗪衍生物颗粒
CA002260889A CA2260889C (en) 1996-07-17 1997-07-04 Granulates of hexahydropyrazine derivatives which can be administered orally
NO19990157A NO325272B1 (no) 1996-07-17 1999-01-14 Fremgangsmate for fremstilling av oralt administrerbare formuleringer av heksahydropyrazinderivater samt granulater inneholdende slike derivater

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19628776A DE19628776A1 (de) 1996-07-17 1996-07-17 Oral applizierbare Granulate von Hexahydropyrazinderivaten

Publications (1)

Publication Number Publication Date
DE19628776A1 true DE19628776A1 (de) 1998-01-22

Family

ID=7800044

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19628776A Withdrawn DE19628776A1 (de) 1996-07-17 1996-07-17 Oral applizierbare Granulate von Hexahydropyrazinderivaten
DE59708723T Expired - Lifetime DE59708723D1 (de) 1996-07-17 1997-07-04 Oral applizierbare granulate von hexahydropyrazinderivaten

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59708723T Expired - Lifetime DE59708723D1 (de) 1996-07-17 1997-07-04 Oral applizierbare granulate von hexahydropyrazinderivaten

Country Status (17)

Country Link
US (1) US6503536B2 (ko)
EP (1) EP0912167B1 (ko)
JP (1) JP4202422B2 (ko)
KR (1) KR100485149B1 (ko)
CN (1) CN1225579A (ko)
AT (1) ATE227565T1 (ko)
AU (1) AU711705B2 (ko)
BR (1) BR9710377B1 (ko)
CA (1) CA2260889C (ko)
DE (2) DE19628776A1 (ko)
DK (1) DK0912167T3 (ko)
ES (1) ES2183200T3 (ko)
HU (1) HUP9903180A3 (ko)
NO (1) NO325272B1 (ko)
NZ (1) NZ333745A (ko)
PT (1) PT912167E (ko)
WO (1) WO1998003157A1 (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05001727A (es) * 2002-08-13 2006-03-10 Akzo Nobel Nv Composiciones y proceso para suministrar un aditivo.
US20040180034A1 (en) * 2003-03-10 2004-09-16 Lyn Hughes Anthelmintic resinates and a method for their preparation
US7396819B2 (en) * 2003-08-08 2008-07-08 Virbac Corporation Anthelmintic formulations
DE10358525A1 (de) 2003-12-13 2005-07-07 Bayer Healthcare Ag Endoparasitizide Mittel zur topischen Applikation
US7582612B2 (en) * 2004-03-12 2009-09-01 Hartz Mountain Corporation Multi-action anthelmintic formulations
DE102005011779A1 (de) * 2005-03-11 2006-09-14 Bayer Healthcare Ag Endoparasitizide Mittel
DE102007026550A1 (de) * 2007-06-08 2008-12-11 Bayer Healthcare Ag Extrudate mit verbesserter Geschmacksmaskierung
WO2013119442A1 (en) 2012-02-06 2013-08-15 Merial Limited Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof
AU2013245011B2 (en) 2012-04-04 2017-11-23 Intervet International B.V. Solid oral pharmaceutical compositions for isoxazoline compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2362539C2 (de) 1973-12-17 1986-05-07 Merck Patent Gmbh, 6100 Darmstadt 2-Acyl-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isochinoline, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US4447414A (en) * 1982-12-21 1984-05-08 Cutter Laboratories, Inc. Carnivore anthelmintics
DE3472678D1 (de) 1983-07-18 1988-08-18 Beecham Group Plc Benzazepine and benzoxazepine derivatives
DE3623321A1 (de) 1986-07-11 1988-01-21 Bayer Ag Verfahren zur kontinuierlichen herstellung von sphaerischen granulaten
FI101344B (fi) * 1988-03-31 1998-06-15 Tanabe Seiyaku Co Menetelmä valmistaa valmiste, josta kontrolloidusti vapautuu farmaseut tisesti aktiivista ainetta
CN1099973A (zh) * 1993-09-08 1995-03-15 四川省医学科学院寄生虫病防治研究所 兽用驱虫药物复方制剂
AUPM969994A0 (en) * 1994-11-28 1994-12-22 Virbac S.A. Equine anthelmintic formulations

Also Published As

Publication number Publication date
ES2183200T3 (es) 2003-03-16
JP2000515519A (ja) 2000-11-21
AU3541397A (en) 1998-02-10
PT912167E (pt) 2003-03-31
BR9710377A (pt) 1999-08-17
EP0912167B1 (de) 2002-11-13
HUP9903180A2 (hu) 2000-04-28
CA2260889A1 (en) 1998-01-29
JP4202422B2 (ja) 2008-12-24
KR100485149B1 (ko) 2005-04-25
NO990157D0 (no) 1999-01-14
NO325272B1 (no) 2008-03-17
HUP9903180A3 (en) 2000-07-28
ATE227565T1 (de) 2002-11-15
CA2260889C (en) 2007-09-11
CN1225579A (zh) 1999-08-11
EP0912167A1 (de) 1999-05-06
NO990157L (no) 1999-01-14
DE59708723D1 (de) 2002-12-19
AU711705B2 (en) 1999-10-21
US20010055598A1 (en) 2001-12-27
US6503536B2 (en) 2003-01-07
BR9710377B1 (pt) 2011-10-18
DK0912167T3 (da) 2003-03-10
KR20000067862A (ko) 2000-11-25
NZ333745A (en) 2000-10-27
WO1998003157A1 (de) 1998-01-29

Similar Documents

Publication Publication Date Title
EP1694291B1 (de) Endoparasitizide mittel zur topischen applikation
EP0828506B1 (de) Endoparasitizide mittel
EP1296655B1 (de) Endoparasitizide mittel zur freiwilligen oralen aufnahme durch tiere
HUE032009T2 (en) Veterinary preparations for topical veterinary use
EP0279343B1 (de) Anthelminthische Wirkstoffkombinationen
EP1863535B1 (de) Endoparasitizide mittel
EP2793861B1 (de) Zubereitungen enthaltend amorphes emodepsid
DE19628776A1 (de) Oral applizierbare Granulate von Hexahydropyrazinderivaten
EP1259250B1 (de) Endoparasitizide mittel
DE4419814A1 (de) Endoparasitizide
US20040180034A1 (en) Anthelmintic resinates and a method for their preparation
BR112021012171A2 (pt) Formulações parasiticidas e uso das mesmas
EP0877598B1 (de) Anthelminthische paste
WO2009077162A1 (de) Neue verwendung von amidin-derivaten
DE3916931A1 (de) Milbemycin-derivate, verfahren zu ihrer herstellung und ihre verwendung als parasitizide

Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee