DE1815621C3 - Vorrichtung zur Erzielung eines feinkristallinen oder amorphen festen Zustandes beim Gefrieren wasserhaltiger Substanzen, insbesondere biologischer Objekte - Google Patents
Vorrichtung zur Erzielung eines feinkristallinen oder amorphen festen Zustandes beim Gefrieren wasserhaltiger Substanzen, insbesondere biologischer ObjekteInfo
- Publication number
- DE1815621C3 DE1815621C3 DE1815621A DE1815621A DE1815621C3 DE 1815621 C3 DE1815621 C3 DE 1815621C3 DE 1815621 A DE1815621 A DE 1815621A DE 1815621 A DE1815621 A DE 1815621A DE 1815621 C3 DE1815621 C3 DE 1815621C3
- Authority
- DE
- Germany
- Prior art keywords
- pressure
- cooling
- frozen
- freezing
- containing substances
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000126 substance Substances 0.000 title claims description 20
- 230000008014 freezing Effects 0.000 title claims description 17
- 238000007710 freezing Methods 0.000 title claims description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims description 14
- 239000007787 solid Substances 0.000 title description 2
- 238000001816 cooling Methods 0.000 claims description 23
- 239000002826 coolant Substances 0.000 claims description 9
- 238000004880 explosion Methods 0.000 claims description 7
- 239000002360 explosive Substances 0.000 claims description 6
- 230000005540 biological transmission Effects 0.000 claims description 3
- 239000012530 fluid Substances 0.000 claims 1
- 235000013611 frozen food Nutrition 0.000 description 9
- 239000013078 crystal Substances 0.000 description 7
- 239000007788 liquid Substances 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 239000004020 conductor Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000001960 triggered effect Effects 0.000 description 2
- 238000004017 vitrification Methods 0.000 description 2
- YZSCPLGKKMSBMV-UHFFFAOYSA-N 5-fluoro-4-(8-fluoro-4-propan-2-yl-2,3-dihydro-1,4-benzoxazin-6-yl)-N-[5-(1-methylpiperidin-4-yl)pyridin-2-yl]pyrimidin-2-amine Chemical compound FC=1C(=NC(=NC=1)NC1=NC=C(C=C1)C1CCN(CC1)C)C1=CC2=C(OCCN2C(C)C)C(=C1)F YZSCPLGKKMSBMV-UHFFFAOYSA-N 0.000 description 1
- 241000530268 Lycaena heteronea Species 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000001493 electron microscopy Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000002194 freeze distillation Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000035784 germination Effects 0.000 description 1
- 230000017525 heat dissipation Effects 0.000 description 1
- 239000011796 hollow space material Substances 0.000 description 1
- 230000002631 hypothermal effect Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 239000003507 refrigerant Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000012549 training Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/42—Low-temperature sample treatment, e.g. cryofixation
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
- A23B2/00—Preservation of foods or foodstuffs, in general
- A23B2/80—Freezing; Subsequent thawing; Cooling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0272—Apparatus for treatment of blood or blood constituents prior to or for conservation, e.g. freezing, drying or centrifuging
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Sampling And Sample Adjustment (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH96868A CH457900A (de) | 1968-01-18 | 1968-01-18 | Vorrichtung zur Erzielung eines feinkristallinen oder amorphen festen Zustandes beim Gefrieren wasserhaltiger Substanzen, insbesondere von biologischen Objekten |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE1815621A1 DE1815621A1 (de) | 1970-02-12 |
| DE1815621B2 DE1815621B2 (de) | 1974-03-07 |
| DE1815621C3 true DE1815621C3 (de) | 1974-10-10 |
Family
ID=4199375
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE1815621A Expired DE1815621C3 (de) | 1968-01-18 | 1968-12-19 | Vorrichtung zur Erzielung eines feinkristallinen oder amorphen festen Zustandes beim Gefrieren wasserhaltiger Substanzen, insbesondere biologischer Objekte |
Country Status (5)
| Country | Link |
|---|---|
| CH (1) | CH457900A (https=) |
| DE (1) | DE1815621C3 (https=) |
| FR (1) | FR1604076A (https=) |
| GB (1) | GB1253102A (https=) |
| NL (2) | NL6803096A (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8627288D0 (en) * | 1986-11-14 | 1986-12-17 | Marconi Co Ltd | Cold stage for microscope |
-
0
- NL NL135906D patent/NL135906C/xx active
-
1968
- 1968-01-18 CH CH96868A patent/CH457900A/de unknown
- 1968-03-05 NL NL6803096A patent/NL6803096A/xx unknown
- 1968-12-19 DE DE1815621A patent/DE1815621C3/de not_active Expired
- 1968-12-31 FR FR1604076D patent/FR1604076A/fr not_active Expired
-
1969
- 1969-01-03 GB GB42169A patent/GB1253102A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NL6803096A (https=) | 1969-07-22 |
| DE1815621A1 (de) | 1970-02-12 |
| DE1815621B2 (de) | 1974-03-07 |
| GB1253102A (https=) | 1971-11-10 |
| CH457900A (de) | 1968-06-15 |
| NL135906C (https=) | |
| FR1604076A (https=) | 1971-07-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) | ||
| E77 | Valid patent as to the heymanns-index 1977 | ||
| EHJ | Ceased/non-payment of the annual fee |