DE126287T1 - Fluorierte verbindungen mit analgetischer und entzuendungshemmender wirkung. - Google Patents

Fluorierte verbindungen mit analgetischer und entzuendungshemmender wirkung.

Info

Publication number
DE126287T1
DE126287T1 DE198484104201T DE84104201T DE126287T1 DE 126287 T1 DE126287 T1 DE 126287T1 DE 198484104201 T DE198484104201 T DE 198484104201T DE 84104201 T DE84104201 T DE 84104201T DE 126287 T1 DE126287 T1 DE 126287T1
Authority
DE
Germany
Prior art keywords
difluorophenyl
acetic acid
phenyl
compounds
pheny
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE198484104201T
Other languages
English (en)
Inventor
Graziella I-20100 Milano Bruno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medea Research SRL
Original Assignee
Medea Research SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medea Research SRL filed Critical Medea Research SRL
Publication of DE126287T1 publication Critical patent/DE126287T1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (1)

  1. Europ. Patentanmeldung 84.104201.3 MEDEA RESEARCH s.r.l. - 0126287
    Übersetzung
    Patentansprüche
    1. Verbindungen der allgemeinen Formel I 15
    worin R Hydroxy, Methoxy, Ethoxy oder Chlor ist, deren phar- < mazeutisch annehmbare Salze und Enantiomere.
    2. Alkali-, Erdalkali-, Lysin- oder Argininsalze der Verbindungen gemäß Anspruch
    3. 2-Hydroxy-2-/p-(2",4"-difluorphenyl)pheny!/-essigsäure Ia.
    4. 2-Chlor-2-/p-(2",4"-difluorphenyl)pheny!/-essigsäure Ib.
    5. 2-Methoxy-2-/ρ-(2",4"-difluorphenyl)pheny!/-essigsäure Ic.
    6. 2-Ethoxy~2-/p-(2",4"-difluorphenyl)phenyl/-essigsäure Id.
    ι ..'■.■■ ; . '. ·..'■■
    7. Pharmazeutische Zusammensetzungen mit analgetischer und entzündungshemmender Aktivität, gekennzeichnet durch einen Gehalt einer oder mehrerer Verbindungen der Ansprüche 1 bis 6 als aktiver Bestandteil.
    8. Pharmazeutische Zusammensetzungen nach Anspruch 7 in Form von Kapseln, Tabletten, Sirupen, Suppositorien, Cremes, Lotionen, Salben, Injektionsampullen.
    10
    9. Verfahren zur Herstellung von Verbindungen der Formel I, dadurch gekennzeichnet, daß
    a) 2,4-Difluorbiphenyl mit einem Monoester von Oxalsäurechlorid in Gegenwart von Lewis-Säuren umgesetzt wird;
    b) das so erhaltene Produkt durch geeignete Reduk-
    , tionsmittel, wie Hydride oder Borhydride von Alkali-
    ■■■ t - ■ ■■■■.■ ■ . · . . . · ■ . .-·■■■■■ ;. ■■ ;. ....-
    Γ■ metallen zu Alkohol reduziert und die Estergruppe
    V 20 hydrolysiert wird.
    1.0. Verfuhren zur Herstellung von. 2--Chlor-\2-/p- (2", 4 "-difluorphenyl)phenyl/essigsäure, dadurch gekennzeichnet, daß die 2-Hydroxy-2-/p-(2",4"-difluorphenyl)phenyl/essigsäure mit Thionylchlorid in wasserfreiem Toluol behandelt wird.
    11. Verfahren zur Herstellung von 2-Methoxy-2-/p-(2", 4"-difluorphenyl)phenyl/essigsäure oder von 2-Ethoxy-2-/p-(2",4"-difluorphenyl)phenyl/essigsäure, dadurch gekennzeichnet, daß die 2-Chlor-2-/p-(2",4"-difluorphenyl)phenyl/essigsäure mit Natriummethylat oder -ethylat in Methanol bzw. Ethanol umgesetzt wird.
    · ' ' ■ ' ' ' ■'■ ■ :. ■ -: ■'■/;■
DE198484104201T 1983-04-21 1984-04-13 Fluorierte verbindungen mit analgetischer und entzuendungshemmender wirkung. Pending DE126287T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT20705/83A IT1194209B (it) 1983-04-21 1983-04-21 Composti fluorurati ad attivita' analgesica e antiinfiammatoria

Publications (1)

Publication Number Publication Date
DE126287T1 true DE126287T1 (de) 1985-02-28

Family

ID=11170823

Family Applications (2)

Application Number Title Priority Date Filing Date
DE198484104201T Pending DE126287T1 (de) 1983-04-21 1984-04-13 Fluorierte verbindungen mit analgetischer und entzuendungshemmender wirkung.
DE8484104201T Expired DE3464239D1 (en) 1983-04-21 1984-04-13 Fluorinated compounds having analgesic and antiinflammatory activities

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8484104201T Expired DE3464239D1 (en) 1983-04-21 1984-04-13 Fluorinated compounds having analgesic and antiinflammatory activities

Country Status (5)

Country Link
EP (1) EP0126287B1 (de)
JP (1) JPS59205342A (de)
AT (1) ATE27805T1 (de)
DE (2) DE126287T1 (de)
IT (1) IT1194209B (de)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1091403A (en) * 1964-01-24 1967-11-15 Boots Pure Drug Co Ltd Therapeutically active phenylalkane derivatives
GB1437783A (en) * 1972-09-22 1976-06-03 Boots Co Ltd 2-substituted biphenylyl acetic acids and derivatives thereof
DE2528958A1 (de) * 1975-06-28 1977-01-13 Merck Patent Gmbh Araliphatische dihalogenverbindungen und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
IT8320705A0 (it) 1983-04-21
JPS59205342A (ja) 1984-11-20
EP0126287A1 (de) 1984-11-28
EP0126287B1 (de) 1987-06-16
IT8320705A1 (it) 1984-10-21
JPH0134978B2 (de) 1989-07-21
ATE27805T1 (de) 1987-07-15
DE3464239D1 (en) 1987-07-23
IT1194209B (it) 1988-09-14

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