DE112019000463B4 - Mikrofluid-chips zum reinigen und fraktionieren von partikeln - Google Patents

Mikrofluid-chips zum reinigen und fraktionieren von partikeln Download PDF

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DE112019000463B4
DE112019000463B4 DE112019000463.8T DE112019000463T DE112019000463B4 DE 112019000463 B4 DE112019000463 B4 DE 112019000463B4 DE 112019000463 T DE112019000463 T DE 112019000463T DE 112019000463 B4 DE112019000463 B4 DE 112019000463B4
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DE112019000463T5 (de
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Joshua Smith
Stacey Gifford
Sung-cheol Kim
Benjamin Wunsch
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International Business Machines Corp
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International Business Machines Corp
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40Concentrating samples
    • G01N1/4077Concentrating samples by other techniques involving separation of suspended solids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0647Handling flowable solids, e.g. microscopic beads, cells, particles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0647Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652Sorting or classification of particles or molecules
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0816Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/18Means for temperature control
    • B01L2300/1894Cooling means; Cryo cooling
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/34Purifying; Cleaning

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Sampling And Sample Adjustment (AREA)
DE112019000463.8T 2018-01-19 2019-01-14 Mikrofluid-chips zum reinigen und fraktionieren von partikeln Active DE112019000463B4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15/875,905 US10946380B2 (en) 2018-01-19 2018-01-19 Microfluidic chips for particle purification and fractionation
US15/875,905 2018-01-19
PCT/IB2019/050272 WO2019142087A1 (en) 2018-01-19 2019-01-14 Microfluidic chips for particle purification and fractionation

Publications (2)

Publication Number Publication Date
DE112019000463T5 DE112019000463T5 (de) 2020-10-01
DE112019000463B4 true DE112019000463B4 (de) 2024-04-25

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DE112019000463.8T Active DE112019000463B4 (de) 2018-01-19 2019-01-14 Mikrofluid-chips zum reinigen und fraktionieren von partikeln

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US (2) US10946380B2 (https=)
JP (1) JP2021510516A (https=)
CN (1) CN111615552B (https=)
DE (1) DE112019000463B4 (https=)
GB (1) GB2583625A (https=)
WO (1) WO2019142087A1 (https=)

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US10946380B2 (en) 2018-01-19 2021-03-16 International Business Machines Corporation Microfluidic chips for particle purification and fractionation
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US20200316230A1 (en) * 2019-04-08 2020-10-08 Vanderbilt University Devices and methods for radiopharmaceutical synthesis
US11266989B2 (en) * 2019-08-07 2022-03-08 International Business Machines Corporation Immunodetection and separation on nanoDLD
US11517873B2 (en) 2019-10-29 2022-12-06 International Business Machines Corporation Controlled chemical synthesis using polymer substrates and nanofluidic separation systems
US11565262B2 (en) * 2020-03-10 2023-01-31 International Business Machines Corporation Continous band-pass filter size separation using a negative angle DLD array
CN111821601A (zh) * 2020-05-27 2020-10-27 深圳艾素科技有限公司 一种电子过滤装置及其操作方法
CN111778138B (zh) * 2020-07-06 2022-01-11 中南大学 一种分选血浆中外泌体的微流控器件及其使用方法
CN113652333B (zh) * 2021-08-03 2023-03-21 中国科学院上海微系统与信息技术研究所 一种优化流体分布的微柱式多相位移通道
CN114574357B (zh) * 2022-02-14 2025-11-11 大连交通大学 一种基于确定性侧向位移和介电泳技术联用的微藻与细菌分选装置
TWI889038B (zh) * 2023-04-14 2025-07-01 前瞻優勢生醫股份有限公司 微流體微粒分選器
CN117504956B (zh) * 2023-10-16 2024-12-17 北京大学 一种微纳流控芯片及生化标志物分子的分离方法
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Also Published As

Publication number Publication date
WO2019142087A1 (en) 2019-07-25
US11872560B2 (en) 2024-01-16
JP2021510516A (ja) 2021-04-30
GB2583625A (en) 2020-11-04
GB202010486D0 (en) 2020-08-19
CN111615552B (zh) 2023-07-11
CN111615552A (zh) 2020-09-01
US20190224677A1 (en) 2019-07-25
US10946380B2 (en) 2021-03-16
DE112019000463T5 (de) 2020-10-01
US20210114028A1 (en) 2021-04-22

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