DE1096902T1 - Medizinische einrichtung mit poröser oberfläche zur kontrollierten wirkstofffreigage und verfahren zu ihrer herstellung - Google Patents
Medizinische einrichtung mit poröser oberfläche zur kontrollierten wirkstofffreigage und verfahren zu ihrer herstellungInfo
- Publication number
- DE1096902T1 DE1096902T1 DE1096902T DE99932279T DE1096902T1 DE 1096902 T1 DE1096902 T1 DE 1096902T1 DE 1096902 T DE1096902 T DE 1096902T DE 99932279 T DE99932279 T DE 99932279T DE 1096902 T1 DE1096902 T1 DE 1096902T1
- Authority
- DE
- Germany
- Prior art keywords
- biologically active
- active agent
- suspension
- solution
- electrode
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract 31
- 239000013543 active substance Substances 0.000 title claims abstract 28
- 238000004519 manufacturing process Methods 0.000 title claims 5
- 239000000725 suspension Substances 0.000 claims abstract 15
- 229920000642 polymer Polymers 0.000 claims abstract 6
- 239000011248 coating agent Substances 0.000 claims 8
- 238000000576 coating method Methods 0.000 claims 8
- 239000011236 particulate material Substances 0.000 claims 8
- 238000002513 implantation Methods 0.000 claims 3
- 239000002184 metal Substances 0.000 claims 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 2
- 244000309464 bull Species 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- 229920001971 elastomer Polymers 0.000 claims 2
- 239000000806 elastomer Substances 0.000 claims 2
- 239000007769 metal material Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 229920002943 EPDM rubber Polymers 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920002367 Polyisobutene Polymers 0.000 claims 1
- SMDHCQAYESWHAE-UHFFFAOYSA-N benfluralin Chemical group CCCCN(CC)C1=C([N+]([O-])=O)C=C(C(F)(F)F)C=C1[N+]([O-])=O SMDHCQAYESWHAE-UHFFFAOYSA-N 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims 1
- 229920002401 polyacrylamide Polymers 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 claims 1
- 229920006124 polyolefin elastomer Polymers 0.000 claims 1
- 229920001451 polypropylene glycol Polymers 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 229920002635 polyurethane Polymers 0.000 claims 1
- 239000004814 polyurethane Substances 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 235000000346 sugar Nutrition 0.000 claims 1
- 150000008163 sugars Chemical class 0.000 claims 1
- 229920002725 thermoplastic elastomer Polymers 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract 3
- 229940079593 drug Drugs 0.000 abstract 3
- 238000001962 electrophoresis Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000011148 porous material Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/146—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cardiology (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Materials For Medical Uses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Medicinal Preparation (AREA)
- Prostheses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/110,697 US6652581B1 (en) | 1998-07-07 | 1998-07-07 | Medical device with porous surface for controlled drug release and method of making the same |
| PCT/US1999/015237 WO2000001322A1 (en) | 1998-07-07 | 1999-07-06 | Medical device with porous surface for controlled drug release and method of making the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE1096902T1 true DE1096902T1 (de) | 2002-05-23 |
Family
ID=22334400
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE1096902T Pending DE1096902T1 (de) | 1998-07-07 | 1999-07-06 | Medizinische einrichtung mit poröser oberfläche zur kontrollierten wirkstofffreigage und verfahren zu ihrer herstellung |
| DE69938047T Expired - Lifetime DE69938047D1 (de) | 1998-07-07 | 1999-07-06 | Verfahren zur herstellung einer medizinischen einrichtung mit poröser oberfläche zur kontrollierten wirkstofffreigabe |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69938047T Expired - Lifetime DE69938047D1 (de) | 1998-07-07 | 1999-07-06 | Verfahren zur herstellung einer medizinischen einrichtung mit poröser oberfläche zur kontrollierten wirkstofffreigabe |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US6652581B1 (enExample) |
| EP (1) | EP1096902B1 (enExample) |
| JP (1) | JP2002519139A (enExample) |
| AT (1) | ATE384502T1 (enExample) |
| CA (1) | CA2336650C (enExample) |
| DE (2) | DE1096902T1 (enExample) |
| ES (1) | ES2169012T1 (enExample) |
| WO (1) | WO2000001322A1 (enExample) |
Cited By (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7931683B2 (en) | 2007-07-27 | 2011-04-26 | Boston Scientific Scimed, Inc. | Articles having ceramic coated surfaces |
| US7938855B2 (en) | 2007-11-02 | 2011-05-10 | Boston Scientific Scimed, Inc. | Deformable underlayer for stent |
| US7942926B2 (en) | 2007-07-11 | 2011-05-17 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
| US7976915B2 (en) | 2007-05-23 | 2011-07-12 | Boston Scientific Scimed, Inc. | Endoprosthesis with select ceramic morphology |
| US7981150B2 (en) | 2006-11-09 | 2011-07-19 | Boston Scientific Scimed, Inc. | Endoprosthesis with coatings |
| US8002823B2 (en) | 2007-07-11 | 2011-08-23 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
| US8029554B2 (en) | 2007-11-02 | 2011-10-04 | Boston Scientific Scimed, Inc. | Stent with embedded material |
| US8067054B2 (en) | 2007-04-05 | 2011-11-29 | Boston Scientific Scimed, Inc. | Stents with ceramic drug reservoir layer and methods of making and using the same |
| US8066763B2 (en) | 1998-04-11 | 2011-11-29 | Boston Scientific Scimed, Inc. | Drug-releasing stent with ceramic-containing layer |
| US8071156B2 (en) | 2009-03-04 | 2011-12-06 | Boston Scientific Scimed, Inc. | Endoprostheses |
| US8070797B2 (en) | 2007-03-01 | 2011-12-06 | Boston Scientific Scimed, Inc. | Medical device with a porous surface for delivery of a therapeutic agent |
| US8187620B2 (en) | 2006-03-27 | 2012-05-29 | Boston Scientific Scimed, Inc. | Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents |
| US8216632B2 (en) | 2007-11-02 | 2012-07-10 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
| US8221822B2 (en) | 2007-07-31 | 2012-07-17 | Boston Scientific Scimed, Inc. | Medical device coating by laser cladding |
| US8231980B2 (en) | 2008-12-03 | 2012-07-31 | Boston Scientific Scimed, Inc. | Medical implants including iridium oxide |
| US8287937B2 (en) | 2009-04-24 | 2012-10-16 | Boston Scientific Scimed, Inc. | Endoprosthese |
| US8353949B2 (en) | 2006-09-14 | 2013-01-15 | Boston Scientific Scimed, Inc. | Medical devices with drug-eluting coating |
| US8431149B2 (en) | 2007-03-01 | 2013-04-30 | Boston Scientific Scimed, Inc. | Coated medical devices for abluminal drug delivery |
| US8449603B2 (en) | 2008-06-18 | 2013-05-28 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
| US8574615B2 (en) | 2006-03-24 | 2013-11-05 | Boston Scientific Scimed, Inc. | Medical devices having nanoporous coatings for controlled therapeutic agent delivery |
| US8771343B2 (en) | 2006-06-29 | 2014-07-08 | Boston Scientific Scimed, Inc. | Medical devices with selective titanium oxide coatings |
| US8815275B2 (en) | 2006-06-28 | 2014-08-26 | Boston Scientific Scimed, Inc. | Coatings for medical devices comprising a therapeutic agent and a metallic material |
| US8815273B2 (en) | 2007-07-27 | 2014-08-26 | Boston Scientific Scimed, Inc. | Drug eluting medical devices having porous layers |
| US8900292B2 (en) | 2007-08-03 | 2014-12-02 | Boston Scientific Scimed, Inc. | Coating for medical device having increased surface area |
| US8920491B2 (en) | 2008-04-22 | 2014-12-30 | Boston Scientific Scimed, Inc. | Medical devices having a coating of inorganic material |
| US8932346B2 (en) | 2008-04-24 | 2015-01-13 | Boston Scientific Scimed, Inc. | Medical devices having inorganic particle layers |
| US9284409B2 (en) | 2007-07-19 | 2016-03-15 | Boston Scientific Scimed, Inc. | Endoprosthesis having a non-fouling surface |
Families Citing this family (108)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2178541C (en) | 1995-06-07 | 2009-11-24 | Neal E. Fearnot | Implantable medical device |
| US6676626B1 (en) | 1998-05-01 | 2004-01-13 | Ekos Corporation | Ultrasound assembly with increased efficacy |
| US6582392B1 (en) | 1998-05-01 | 2003-06-24 | Ekos Corporation | Ultrasound assembly for use with a catheter |
| US8177743B2 (en) | 1998-05-18 | 2012-05-15 | Boston Scientific Scimed, Inc. | Localized delivery of drug agents |
| ATE228021T1 (de) * | 1998-09-11 | 2002-12-15 | Gerhard Dr Schmidmaier | Biologisch aktive implantate |
| US6719805B1 (en) * | 1999-06-09 | 2004-04-13 | C. R. Bard, Inc. | Devices and methods for treating tissue |
| US7682647B2 (en) | 1999-09-03 | 2010-03-23 | Advanced Cardiovascular Systems, Inc. | Thermal treatment of a drug eluting implantable medical device |
| US20070032853A1 (en) | 2002-03-27 | 2007-02-08 | Hossainy Syed F | 40-O-(2-hydroxy)ethyl-rapamycin coated stent |
| US7807211B2 (en) | 1999-09-03 | 2010-10-05 | Advanced Cardiovascular Systems, Inc. | Thermal treatment of an implantable medical device |
| US8632845B2 (en) * | 2000-12-28 | 2014-01-21 | Abbott Cardiovascular Systems Inc. | Method of drying bioabsorbable coating over stents |
| US8277868B2 (en) * | 2001-01-05 | 2012-10-02 | Abbott Cardiovascular Systems Inc. | Balloon catheter for delivering therapeutic agents |
| US6544223B1 (en) * | 2001-01-05 | 2003-04-08 | Advanced Cardiovascular Systems, Inc. | Balloon catheter for delivering therapeutic agents |
| WO2002066092A2 (en) * | 2001-02-23 | 2002-08-29 | Angiogene Inc. | Drug eluting device for treating vascular diseases |
| WO2002065946A1 (en) * | 2001-02-23 | 2002-08-29 | Angiogene Inc. | Apparatus for loading a therapeutic agent onto an endovascular device |
| US7727221B2 (en) | 2001-06-27 | 2010-06-01 | Cardiac Pacemakers Inc. | Method and device for electrochemical formation of therapeutic species in vivo |
| JP2003135588A (ja) * | 2001-11-08 | 2003-05-13 | Univ Nihon | 経皮経管的ドラッグデリバリーデバイス |
| US7220239B2 (en) | 2001-12-03 | 2007-05-22 | Ekos Corporation | Catheter with multiple ultrasound radiating members |
| US7141044B2 (en) | 2001-12-11 | 2006-11-28 | Ekos Corporation | Alternate site gene therapy |
| US8226629B1 (en) | 2002-04-01 | 2012-07-24 | Ekos Corporation | Ultrasonic catheter power control |
| US7125577B2 (en) | 2002-09-27 | 2006-10-24 | Surmodics, Inc | Method and apparatus for coating of substrates |
| USRE40722E1 (en) | 2002-09-27 | 2009-06-09 | Surmodics, Inc. | Method and apparatus for coating of substrates |
| US7192484B2 (en) | 2002-09-27 | 2007-03-20 | Surmodics, Inc. | Advanced coating apparatus and method |
| US6921371B2 (en) | 2002-10-14 | 2005-07-26 | Ekos Corporation | Ultrasound radiating members for catheter |
| US9770349B2 (en) | 2002-11-13 | 2017-09-26 | University Of Virginia Patent Foundation | Nanoporous stents with enhanced cellular adhesion and reduced neointimal formation |
| US20060121080A1 (en) | 2002-11-13 | 2006-06-08 | Lye Whye K | Medical devices having nanoporous layers and methods for making the same |
| CA2503625A1 (en) | 2002-11-13 | 2004-05-27 | Setagon, Inc. | Medical devices having porous layers and methods for making same |
| US20050079199A1 (en) * | 2003-02-18 | 2005-04-14 | Medtronic, Inc. | Porous coatings for drug release from medical devices |
| CA2516175A1 (en) * | 2003-02-18 | 2004-09-02 | Medtronic, Inc. | Occlusion resistant hydrocephalic shunt |
| ES2354605T3 (es) * | 2003-02-21 | 2011-03-16 | Sorin Biomedica Cardio S.R.L. | Procedimiento de producción de stents y el stent correspondiente. |
| EP1475110A1 (de) * | 2003-05-09 | 2004-11-10 | B. Braun Melsungen Ag | Stent zur kontrollierten Abgabe von Wirkstoffen |
| US20050118344A1 (en) * | 2003-12-01 | 2005-06-02 | Pacetti Stephen D. | Temperature controlled crimping |
| US20050137520A1 (en) * | 2003-10-29 | 2005-06-23 | Rule Peter R. | Catheter with ultrasound-controllable porous membrane |
| US7803178B2 (en) | 2004-01-30 | 2010-09-28 | Trivascular, Inc. | Inflatable porous implants and methods for drug delivery |
| ATE423578T1 (de) * | 2004-05-27 | 2009-03-15 | Medtronic Inc | Medizinprodukt mit einem biologischen wirkstoff |
| DE602004027553D1 (de) * | 2004-08-03 | 2010-07-15 | Agency Science Tech & Res | Polymer mit miteinander verbundenen poren zur arzneistoffzufuhr und verfahren |
| US7507433B2 (en) * | 2004-09-03 | 2009-03-24 | Boston Scientific Scimed, Inc. | Method of coating a medical device using an electrowetting process |
| US20060051392A1 (en) * | 2004-09-03 | 2006-03-09 | Medtronic, Inc. | Porous coatings for drug release from medical devices |
| US20060051393A1 (en) * | 2004-09-08 | 2006-03-09 | Medtronic, Inc. | Method of manufacturing drug-eluting medical device |
| US7901451B2 (en) | 2004-09-24 | 2011-03-08 | Biosensors International Group, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
| US7862835B2 (en) * | 2004-10-27 | 2011-01-04 | Boston Scientific Scimed, Inc. | Method of manufacturing a medical device having a porous coating thereon |
| US7958840B2 (en) | 2004-10-27 | 2011-06-14 | Surmodics, Inc. | Method and apparatus for coating of substrates |
| US7964209B2 (en) * | 2004-12-07 | 2011-06-21 | Boston Scientific Scimed, Inc. | Orienting polymer domains for controlled drug delivery |
| US20060124466A1 (en) * | 2004-12-09 | 2006-06-15 | Scimed Life Systems, Inc. | Method and apparatus for coating a medical device by electroplating |
| US8535702B2 (en) | 2005-02-01 | 2013-09-17 | Boston Scientific Scimed, Inc. | Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility |
| WO2006138719A2 (en) | 2005-06-17 | 2006-12-28 | Georgia Tech Research Corporation | Coated microstructures and method of manufacture thereof |
| JP5063603B2 (ja) * | 2005-09-30 | 2012-10-31 | クック メディカル テクノロジーズ エルエルシー | 被覆された血管閉塞装置 |
| US20070112421A1 (en) * | 2005-11-14 | 2007-05-17 | O'brien Barry | Medical device with a grooved surface |
| US8840660B2 (en) | 2006-01-05 | 2014-09-23 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
| US20070168021A1 (en) * | 2006-01-17 | 2007-07-19 | Holmes David R Jr | Porous three dimensional nest scaffolding |
| US8089029B2 (en) | 2006-02-01 | 2012-01-03 | Boston Scientific Scimed, Inc. | Bioabsorbable metal medical device and method of manufacture |
| US20100233350A1 (en) * | 2006-03-15 | 2010-09-16 | Boston Scientific Scimed, Inc. | Drug delivery composition and methods of making same using nanofabrication |
| US8048150B2 (en) | 2006-04-12 | 2011-11-01 | Boston Scientific Scimed, Inc. | Endoprosthesis having a fiber meshwork disposed thereon |
| EP2020956A2 (en) | 2006-05-26 | 2009-02-11 | Nanyang Technological University | Implantable article, method of forming same and method for reducing thrombogenicity |
| JP2009545407A (ja) | 2006-08-02 | 2009-12-24 | ボストン サイエンティフィック サイムド,インコーポレイテッド | 三次元分解制御を備えたエンドプロテーゼ |
| US20080057102A1 (en) * | 2006-08-21 | 2008-03-06 | Wouter Roorda | Methods of manufacturing medical devices for controlled drug release |
| EP2068782B1 (en) | 2006-09-15 | 2011-07-27 | Boston Scientific Limited | Bioerodible endoprostheses |
| DE602007011114D1 (de) | 2006-09-15 | 2011-01-20 | Boston Scient Scimed Inc | Biologisch erodierbare endoprothese mit biostabilen anorganischen schichten |
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| US8815275B2 (en) | 2006-06-28 | 2014-08-26 | Boston Scientific Scimed, Inc. | Coatings for medical devices comprising a therapeutic agent and a metallic material |
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| US7931683B2 (en) | 2007-07-27 | 2011-04-26 | Boston Scientific Scimed, Inc. | Articles having ceramic coated surfaces |
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| US8920491B2 (en) | 2008-04-22 | 2014-12-30 | Boston Scientific Scimed, Inc. | Medical devices having a coating of inorganic material |
| US8932346B2 (en) | 2008-04-24 | 2015-01-13 | Boston Scientific Scimed, Inc. | Medical devices having inorganic particle layers |
| US8449603B2 (en) | 2008-06-18 | 2013-05-28 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
| US8231980B2 (en) | 2008-12-03 | 2012-07-31 | Boston Scientific Scimed, Inc. | Medical implants including iridium oxide |
| US8071156B2 (en) | 2009-03-04 | 2011-12-06 | Boston Scientific Scimed, Inc. | Endoprostheses |
| US8287937B2 (en) | 2009-04-24 | 2012-10-16 | Boston Scientific Scimed, Inc. | Endoprosthese |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000001322A1 (en) | 2000-01-13 |
| CA2336650C (en) | 2008-01-29 |
| US20040067301A1 (en) | 2004-04-08 |
| JP2002519139A (ja) | 2002-07-02 |
| ATE384502T1 (de) | 2008-02-15 |
| EP1096902B1 (en) | 2008-01-23 |
| EP1096902A1 (en) | 2001-05-09 |
| US6652581B1 (en) | 2003-11-25 |
| ES2169012T1 (es) | 2002-07-01 |
| US7758909B2 (en) | 2010-07-20 |
| CA2336650A1 (en) | 2000-01-13 |
| DE69938047D1 (de) | 2008-03-13 |
| US20070299509A1 (en) | 2007-12-27 |
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