DE10315377A1 - Carbonylverbindungen - Google Patents

Carbonylverbindungen Download PDF

Info

Publication number
DE10315377A1
DE10315377A1 DE10315377A DE10315377A DE10315377A1 DE 10315377 A1 DE10315377 A1 DE 10315377A1 DE 10315377 A DE10315377 A DE 10315377A DE 10315377 A DE10315377 A DE 10315377A DE 10315377 A1 DE10315377 A1 DE 10315377A1
Authority
DE
Germany
Prior art keywords
amide
phenyl
dicarboxylic acid
oxo
chlorophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE10315377A
Other languages
German (de)
English (en)
Inventor
Christos Dr. Tsaklakidis
Dieter Dr. Dorsch
Werner Dr. Mederski
Bertram Dr. Cezanne
Johannes Dr. Gleitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Priority to DE10315377A priority Critical patent/DE10315377A1/de
Priority to DE10329457A priority patent/DE10329457A1/de
Priority to MXPA05010444A priority patent/MXPA05010444A/es
Priority to CA2521069A priority patent/CA2521069C/en
Priority to RU2005133870/04A priority patent/RU2337099C2/ru
Priority to DE502004009440T priority patent/DE502004009440D1/de
Priority to AT04718299T priority patent/ATE430139T1/de
Priority to NZ543366A priority patent/NZ543366A/en
Priority to CNA2004800093547A priority patent/CN1771237A/zh
Priority to PCT/EP2004/002350 priority patent/WO2004087646A2/de
Priority to ES04718299T priority patent/ES2325077T3/es
Priority to PL377633A priority patent/PL377633A1/pl
Priority to EP04718299A priority patent/EP1720844B1/de
Priority to JP2006504581A priority patent/JP4705015B2/ja
Priority to UAA200510222A priority patent/UA85676C2/ru
Priority to AU2004226278A priority patent/AU2004226278B2/en
Priority to US10/551,557 priority patent/US7906516B2/en
Priority to KR1020057018638A priority patent/KR20050118708A/ko
Priority to BRPI0408420-9A priority patent/BRPI0408420A/pt
Priority to AT04718646T priority patent/ATE366732T1/de
Priority to PL377138A priority patent/PL377138A1/pl
Priority to KR1020057018641A priority patent/KR20050109617A/ko
Priority to CNA2004800094639A priority patent/CN1771249A/zh
Priority to EP04718646A priority patent/EP1608646B1/de
Priority to PCT/EP2004/002405 priority patent/WO2004087695A1/de
Priority to PCT/EP2004/002407 priority patent/WO2004087696A1/de
Priority to MXPA05010445A priority patent/MXPA05010445A/es
Priority to BRPI0408444-6A priority patent/BRPI0408444A/pt
Priority to CA2520893A priority patent/CA2520893C/en
Priority to EP04718641A priority patent/EP1608645B1/de
Priority to BRPI0408888-3A priority patent/BRPI0408888A/pt
Priority to US10/551,559 priority patent/US7557102B2/en
Priority to JP2006504604A priority patent/JP4624982B2/ja
Priority to MXPA05010433A priority patent/MXPA05010433A/es
Priority to ES04718646T priority patent/ES2287708T3/es
Priority to AU2004226280A priority patent/AU2004226280B2/en
Priority to US10/551,670 priority patent/US7504500B2/en
Priority to RU2005133869/04A priority patent/RU2005133869A/ru
Priority to DE502004004294T priority patent/DE502004004294D1/de
Priority to CA2520894A priority patent/CA2520894C/en
Priority to KR1020057018640A priority patent/KR20050118709A/ko
Priority to DE502004003688T priority patent/DE502004003688D1/de
Priority to ES04718641T priority patent/ES2285444T3/es
Priority to AU2004226281A priority patent/AU2004226281B2/en
Priority to PL377864A priority patent/PL377864A1/pl
Priority to AT04718641T priority patent/ATE361296T1/de
Priority to JP2006504602A priority patent/JP4634369B2/ja
Priority to CNA2004800093744A priority patent/CN1771248A/zh
Priority to MYPI20041185A priority patent/MY140031A/en
Priority to TW093108904A priority patent/TW200500339A/zh
Priority to TW093108890A priority patent/TW200512200A/zh
Priority to CL2004000719A priority patent/CL2004000719A1/es
Priority to CL200400720A priority patent/CL2004000720A1/es
Priority to ARP040101113A priority patent/AR043831A1/es
Priority to PE2004000350A priority patent/PE20050015A1/es
Priority to ARP040101115A priority patent/AR043833A1/es
Priority to ARP040101114A priority patent/AR043832A1/es
Priority to PE2004000349A priority patent/PE20050395A1/es
Publication of DE10315377A1 publication Critical patent/DE10315377A1/de
Priority to IL171214A priority patent/IL171214A/en
Priority to CO05099907A priority patent/CO5660267A2/es
Priority to EC2005006131A priority patent/ECSP056131A/es
Priority to ZA200508891A priority patent/ZA200508891B/en
Priority to ZA200508889A priority patent/ZA200508889B/xx
Priority to ZA200508888A priority patent/ZA200508888B/xx
Priority to US12/817,314 priority patent/US8129373B2/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE10315377A 2003-04-03 2003-04-03 Carbonylverbindungen Withdrawn DE10315377A1 (de)

Priority Applications (65)

Application Number Priority Date Filing Date Title
DE10315377A DE10315377A1 (de) 2003-04-03 2003-04-03 Carbonylverbindungen
DE10329457A DE10329457A1 (de) 2003-04-03 2003-07-01 Ethinylprolinderivate
MXPA05010444A MXPA05010444A (es) 2003-04-03 2004-03-08 Compuestos de carbonilo.
CA2521069A CA2521069C (en) 2003-04-03 2004-03-08 Pyrrolidino-1,2-dicarboxy-1-(phenylamide)-2-(4-(3-oxo-morpholino-4-yl)-phenylamide) derivatives and related compounds for use as inhibitors of coagulation factor xa in the treatment of thrombo-embolic diseases
RU2005133870/04A RU2337099C2 (ru) 2003-04-03 2004-03-08 Карбонильные соединения
DE502004009440T DE502004009440D1 (de) 2003-04-03 2004-03-08 Pyrrolidin-1,2-dicarbonsäure-1-(phenylamid)-2-(4-(3-oxo-morpholin-4-yl)-phenylamid) derivate und verwandte verbindungen als inhibitoren des koagulationsfaktors xa zur behandlung von thromboembolischen erkrankungen
AT04718299T ATE430139T1 (de) 2003-04-03 2004-03-08 Pyrrolidin-1,2-dicarbonsäure-1-(phenylamid)-2-( - (3-oxo-morpholin-4-yl)-phenylamid) derivate und verwandte verbindungen als inhibitoren des koagulationsfaktors xa zur behandlung von thromboembolischen erkrankungen
NZ543366A NZ543366A (en) 2003-04-03 2004-03-08 Carbonyl compounds
CNA2004800093547A CN1771237A (zh) 2003-04-03 2004-03-08 在治疗血栓栓塞性疾病中用作凝血因子 x a抑制剂的 1 － (苯基氨基甲酰基 ) － 2 － ( 4 － ( 3 －氧代－吗啉 － 4－基 ) －苯基氨基甲酰基)吡咯烷衍生物及相关化合物
PCT/EP2004/002350 WO2004087646A2 (de) 2003-04-03 2004-03-08 Pyrrolidin -1,2-dicarbonsäure-1-(phenylamid) -2- (4-(3-oxo-morpholin-4-yl)-phenylamid) derivate und verwandte verbindungen als inhibitoren des koagulationsfaktors xa zur behandlung von thromboembolischen erkrankungen
ES04718299T ES2325077T3 (es) 2003-04-03 2004-03-08 Derivados de 1-(fenilamida)-2-(4-(3-oxo-morfolin-4-il)-fenilamida) del acido pirrolidin-1,2-dicarboxilico y compuestos emparentados como inhibidores del factor de la coagulacion xa, para el tratamiento de las enfermedades tromboembolicas.
PL377633A PL377633A1 (pl) 2003-04-03 2004-03-08 Związki karbonylowe
EP04718299A EP1720844B1 (de) 2003-04-03 2004-03-08 Pyrrolidin-1,2-dicarbonsäure-1-(phenylamid)-2-(4-(3-oxo-morpholin-4-yl)-phenylamid) derivate und verwandte verbindungen als inhibitoren des koagulationsfaktors xa zur behandlung von thromboembolischen erkrankungen
JP2006504581A JP4705015B2 (ja) 2003-04-03 2004-03-08 カルボニル化合物
UAA200510222A UA85676C2 (xx) 2003-04-03 2004-03-08 Карбонільні сполуки[карбонильные соединения
AU2004226278A AU2004226278B2 (en) 2003-04-03 2004-03-08 Pyrrolidino-1,2-dicarboxy-1-(phenylamide)-2-(4-(3-oxo-morpholino-4-yl)-phenylamide) derivatives and related compounds for use as inhibitors of coagulation factor Xa in the treatment of thrombo-embolic diseases
US10/551,557 US7906516B2 (en) 2003-04-03 2004-03-08 Carbonyl compounds
KR1020057018638A KR20050118708A (ko) 2003-04-03 2004-03-08 혈전-색전 질환의 치료에서 응고 인자 ｘａ의 저해제로서사용하기 위한피롤리디노-１,２-디카르복시-１-(페닐아미드)-２-(４-(３-옥소-모르폴리노-４-일)-페닐아미드) 유도체 및 관련화합물
BRPI0408420-9A BRPI0408420A (pt) 2003-04-03 2004-03-08 compostos de carbonila
AT04718646T ATE366732T1 (de) 2003-04-03 2004-03-09 Verfahren zur herstellung von pyrrolidin-1,2- dicarbonsäure-1 -(phenyl(-amid))-2-(phenyl(- amid)) derivaten und 1-(phenylcarbamoyl)- pyrrolidin-2-carbonsäurederivate als zwischenprodukte
PL377138A PL377138A1 (pl) 2003-04-03 2004-03-09 Sposób otrzymywania pochodnych 1-N-(fenylo)-2-N-(fenylo)pirolidyno-1,2-dikarboksyamidowych oraz pochodnych kwasu 1-(fenylokarbamoylo)-pirolidyno-2-karboksylowego jako związków pośrednich
KR1020057018641A KR20050109617A (ko) 2003-04-03 2004-03-09 혈전증 치료용 응집 인자 ｘａ 저해제로서의피라졸리딘-１,２-디카르복실디페닐아미드 유도체
CNA2004800094639A CN1771249A (zh) 2003-04-03 2004-03-09 作为凝血因子Xa抑制剂用于治疗血栓形成的1－N－苯基－2－N－苯基吡咯烷－1,2－二甲酰胺衍生物
EP04718646A EP1608646B1 (de) 2003-04-03 2004-03-09 Verfahren zur herstellung von pyrrolidin-1,2-dicarbonsäure-1 -(phenyl(-amid))-2-(phenyl(-amid)) derivaten und 1-(phenylcarbamoyl)-pyrrolidin-2-carbonsäurederivate als zwischenprodukte
PCT/EP2004/002405 WO2004087695A1 (de) 2003-04-03 2004-03-09 Verfahren zur herstellung von pyrrolidin-1,2-dicarbonsäure-1-(phenyl(-amid))-2-(phenyl(-amid)) derivaten und 1-(phenylcarbamoyl)-pyrrolidin-2-carbonsäure derivate als zwischenprodukte
PCT/EP2004/002407 WO2004087696A1 (de) 2003-04-03 2004-03-09 Pirazolidin-1,2-dicarbonsaüre-1-((phenyl)-amid)-2-((phenyl)-amid) derivate als koagulationsfaktor xa inhibitoren zur behandlung von thrombosen
MXPA05010445A MXPA05010445A (es) 2003-04-03 2004-03-09 Derivados de azaprolina.
BRPI0408444-6A BRPI0408444A (pt) 2003-04-03 2004-03-09 derivados de 1-n-(fenil)-2-n-(fenil) pirazolidina-1,2-dicarboxamida como inibidores de fator xa de coagulação para o tratamento de trombose
CA2520893A CA2520893C (en) 2003-04-03 2004-03-09 Process for the preparation of 1-n-(phenyl)-2-n-(phenyl)pyrrolidine-1,2-dicarboxamide derivatives and 1-(phenylcarbamoyl)pyrrolidine-2-carboxylic acid derivatives as intermediates
EP04718641A EP1608645B1 (de) 2003-04-03 2004-03-09 Pyrazolidin-1,2-dicarbonsäure-1-((phenyl)-amid)-2-((phenyl)-amid) derivate als koagulationsfaktor xa inhibitoren zur behandlung von thrombosen
BRPI0408888-3A BRPI0408888A (pt) 2003-04-03 2004-03-09 processo para a preparação de derivados de 1-n-(fenil)-2-n-(fenil) pirrolidina-1,2-dicarboxamida e derivados de ácido 1-(fenilcarbamoil) pirrolidina-2-carboxìlico como intermediários
US10/551,559 US7557102B2 (en) 2003-04-03 2004-03-09 Pyrazolidine-1,2-dicarboxyldiphenylamide derivatives as coagulation factor Xa inhibitors for the treatment of thromboses
JP2006504604A JP4624982B2 (ja) 2003-04-03 2004-03-09 血栓症の処置のための凝固因子Ｘａ阻害剤としての１−Ｎ−（フェニル）−２−Ｎ−（フェニル）ピラゾリジン−１，２−ジカルボキサミド誘導体
MXPA05010433A MXPA05010433A (es) 2003-04-03 2004-03-09 Derivados de pirrolidina y procedimiento para prepararlos.
ES04718646T ES2287708T3 (es) 2003-04-03 2004-03-09 Metodo para la produccion de derivados de acido pirrolidin-1,2-dicarboxilico-ii-(fenil(-amida)-2-(fenil-amida)y derivados del acido 1-(fenilcarbamoil)-pirrolidina-2-carboxilico como productos intermediarios.
AU2004226280A AU2004226280B2 (en) 2003-04-03 2004-03-09 Method for the production of pyrrolidine-1,2-dicarboxylic acid-1-(phenyl(-amide))-2-(phenyl(-amide)) derivatives and 1-(phenylcarbamoyl)-pyrrolidine-2-carboxylic acid derivatives as intermediate products
US10/551,670 US7504500B2 (en) 2003-04-03 2004-03-09 Method for the production of pyrrolidine-1,2-dicarboxylic acid-1-(phenyl(-amide))-2(phenyl(-amide)) derivatives and 1-(phenylcarbamoyl)-pyrrolidine-2-carboxylic acid derivatives as intermediate products
RU2005133869/04A RU2005133869A (ru) 2003-04-03 2004-03-09 Производные 1-n-(фенил)-2-n-(фенил)пиразолидин-1, 2-дикарбоксамида в качестве ингибиторов фактора коагуляции ха для лечения тромбозов
DE502004004294T DE502004004294D1 (de) 2003-04-03 2004-03-09 Verfahren zur herstellung von pyrrolidin-1,2-dicarbonsäure-1 -(phenyl(-amid))-2-(phenyl(-amid)) derivaten und 1-(phenylcarbamoyl)-pyrrolidin-2-carbonsäurederivate als zwischenprodukte
CA2520894A CA2520894C (en) 2003-04-03 2004-03-09 Pyrazolidine-1,2-dicarboxyldiphenylamide derivatives as coagulation factor xa inhibitors for the treatment of thromboses
KR1020057018640A KR20050118709A (ko) 2003-04-03 2004-03-09 중간체 생성물로서의피롤리딘-１,２-디카르복실산-１-(페닐(-아미드))-２-(페닐(-아미드)) 유도체 및１-(페닐카르바모일)-피롤리딘-2-카르복실산 유도체의 제조방법
DE502004003688T DE502004003688D1 (de) 2003-04-03 2004-03-09 Pyrazolidin-1,2-dicarbonsäure-1-((phenyl)-amid)-2-((phenyl)-amid) derivate als koagulationsfaktor xa inhibitoren zur behandlung von thrombosen
ES04718641T ES2285444T3 (es) 2003-04-03 2004-03-09 Derivados de la 1-(fenil)-amida)-2-(fenil)-amida) del acido pirazolidin-1,2-dicarboxilico como inhibidores del factor de coagulacion xa para el tratamiento de la trombosis.
AU2004226281A AU2004226281B2 (en) 2003-04-03 2004-03-09 Pyrazolidine-1,2-dicarboxyldiphenylamide derivatives as coagulation factor Xa inhibitors for the treatment of thromboses
PL377864A PL377864A1 (pl) 2003-04-03 2004-03-09 Pochodne 1-N-(fenylo)-2-N-(fenylo)pirazolidyno-1,2-dikarboksyamidowe jako inhibitory czynnika koagulacyjnego Xa do leczenia zakrzepic
AT04718641T ATE361296T1 (de) 2003-04-03 2004-03-09 Pyrazolidin-1,2-dicarbonsäure-1-((phenyl)-amid) 2-((phenyl)-amid) derivate als koagulationsfaktor xa inhibitoren zur behandlung von thrombosen
JP2006504602A JP4634369B2 (ja) 2003-04-03 2004-03-09 １−ｎ−（フェニル）−２−ｎ−（フェニル）ピロリジン−１，２−ジカルボキサミド誘導体の製造方法および中間体としての１−（フェニルカルバモイル）ピロリジン−２−カルボン酸誘導体
CNA2004800093744A CN1771248A (zh) 2003-04-03 2004-03-09 制备 1 － n －苯基 － 2 － n －苯基吡咯烷 － 1 , 2 －二甲酰胺衍生物以及作为中间体的 1 －苯基氨基甲酰基吡咯烷－ 2 －羧酸衍生物的方法
MYPI20041185A MY140031A (en) 2003-04-03 2004-03-31 Carbonyl compounds
TW093108904A TW200500339A (en) 2003-04-03 2004-03-31 Pyrrolidine derivatives, and process for the preparation
TW093108890A TW200512200A (en) 2003-04-03 2004-03-31 Carbonyl compounds
CL2004000719A CL2004000719A1 (es) 2003-04-03 2004-04-02 Procedimiento de preparacion de acidos pirrolidin-1,2-dicarboxilico-1-[(4-cloro-fenil)-amido]-2{[(3-oxo-morfolin-4-il)-fenil]-amida} y uno de los intermediarios que se usan en el procedimiento.
CL200400720A CL2004000720A1 (es) 2003-04-03 2004-04-02 COMPUESTOS DERIVADOS DE PIRAZOLIDINA-1,2-DICARBOXILDIFENILAMIDA, INHIBIDORES DE LOS FACTORES DE COAGULACION Xa, VIIa; PROCESO DE PREPARACION; COMPUESTOS INTERMEDIARIOS; COMPOSICION FARMACEUTICA; KIT FARMACEUTICO; Y SU USO PARA TRATAR TROMBOSIS, INFAR
ARP040101113A AR043831A1 (es) 2003-04-03 2004-04-02 Derivados de pirrodilina y procedimiento para prepararlos
PE2004000350A PE20050015A1 (es) 2003-04-03 2004-04-02 Derivados (3-oxo-morfolin-4-il)-fenilamida como inhibidores de factores de coagulacion y compuestos intermediarios en su preparacion
ARP040101115A AR043833A1 (es) 2003-04-03 2004-04-02 Derivados de 1,2 diazol. metodo de preparacion y composiciones farmaceuticas
ARP040101114A AR043832A1 (es) 2003-04-03 2004-04-02 Compuestos de carbonilo y proceso de preparacion de los mismos
PE2004000349A PE20050395A1 (es) 2003-04-03 2004-04-02 PROCEDIMIENTOS DE PREPARACION DE DERIVADOS DE ACIDO PIRROLIDIN-1,2-DICARBOXILICO-1-(FENIL(-AMIDA))-2-(FENIL(-AMIDA)) Y ACIDO-1-(FENILCARBAMOIL)-PIRROLIDIN-2-CARBOXILICO COMO INHIBIDORES DEL FACTOR Xa
IL171214A IL171214A (en) 2003-04-03 2005-09-29 Carbonyl compounds, their preparation and pharmaceutical compositions comprising them
CO05099907A CO5660267A2 (es) 2003-04-03 2005-10-03 Compuestos de carbonilo
EC2005006131A ECSP056131A (es) 2003-04-03 2005-10-28 Compuestos de carbonilo
ZA200508891A ZA200508891B (en) 2003-04-03 2005-11-02 Pyrazolidine-1,2-dicarboxyldiphenylamide derivatives as coagulation factor Xa inhibitors for the treatment of thromboses
ZA200508889A ZA200508889B (en) 2003-04-03 2005-11-02 Pyrrolidino-1,2-dicarboxy-1-(phenylamide)-2-(4-(3-oxomorpholino-4-yl)-phenylamide) derivatives and related compounds for use as inhibitors of coagulation factor Xa in the treatment of thrombo-embolic diseases
ZA200508888A ZA200508888B (en) 2003-04-03 2005-11-02 Methods for the production of pyrrolidine-1,2-dicarboxylic acid-1-(phenyl(-amide))-2-(phenyl(-amide)) derivatives and 1-(phenylcarbamoyl)-pyrrolidine-2-carboxylic acid derivatives as intermediate products
US12/817,314 US8129373B2 (en) 2003-04-03 2010-06-17 Carbonyl compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10315377A DE10315377A1 (de) 2003-04-03 2003-04-03 Carbonylverbindungen

Publications (1)

Publication Number Publication Date
DE10315377A1 true DE10315377A1 (de) 2004-10-14

Family

ID=32981039

Family Applications (1)

Application Number Title Priority Date Filing Date
DE10315377A Withdrawn DE10315377A1 (de) 2003-04-03 2003-04-03 Carbonylverbindungen

Country Status (4)

Country Link
CN (3) CN1771237A (xx)
DE (1) DE10315377A1 (xx)
UA (1) UA85676C2 (xx)
ZA (3) ZA200508891B (xx)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006032342A2 (de) * 2004-09-22 2006-03-30 Merck Patent Gmbh Arzneimittel enthaltend carbonylverbindungen sowie deren verwendung
WO2011025565A1 (en) * 2009-08-31 2011-03-03 Mochida Pharmaceutical Co., Ltd. Morpholinone compounds as factor ixa inhibitors
US8642582B2 (en) 2008-12-05 2014-02-04 Merck Sharp & Dohme Corp. Morpholinone compounds as factor IXa inhibitors
US8987242B2 (en) 2008-12-05 2015-03-24 Merck Sharp & Dohme Corp. Morpholinone compounds as factor IXA inhibitors
US9732080B2 (en) 2006-11-03 2017-08-15 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
US10071979B2 (en) 2010-04-22 2018-09-11 Vertex Pharmaceuticals Incorporated Process of producing cycloalkylcarboxamido-indole compounds
US10081621B2 (en) 2010-03-25 2018-09-25 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide
US10206877B2 (en) 2014-04-15 2019-02-19 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013291098A1 (en) * 2012-07-19 2015-02-05 Sumitomo Dainippon Pharma Co., Ltd. 1-(cycloalkyl-carbonyl)proline derivative
CA2939326A1 (en) * 2014-01-14 2015-07-23 Sumitomo Dainippon Pharma Co., Ltd. Condensed 5-oxazolidinone derivative
CN104974148B (zh) * 2014-04-14 2017-11-24 北大方正集团有限公司 一种合成4‑{4‑[(5s)‑5‑(氨基甲基)‑2‑氧代‑1,3‑恶唑烷‑3‑基]苯基}吗啉‑3‑酮的方法
CN104098497B (zh) * 2014-06-17 2016-04-13 王庚禹 一种新的酰胺类化合物
SI3355890T1 (sl) * 2015-10-01 2022-04-29 Biocryst Pharmaceuticals, Inc. Inhibitorji kalikreina človeške plazme
CN110240591A (zh) * 2018-03-08 2019-09-17 天津药物研究院有限公司 脯氨酸衍生物及其制备方法和用途
CN115974856B (zh) * 2022-12-28 2023-08-11 北京康立生医药技术开发有限公司 一种治疗成人t细胞白血病淋巴瘤药物伐美妥司他的制备方法

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006032342A2 (de) * 2004-09-22 2006-03-30 Merck Patent Gmbh Arzneimittel enthaltend carbonylverbindungen sowie deren verwendung
WO2006032342A3 (de) * 2004-09-22 2007-01-11 Merck Patent Gmbh Arzneimittel enthaltend carbonylverbindungen sowie deren verwendung
US9732080B2 (en) 2006-11-03 2017-08-15 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
US8642582B2 (en) 2008-12-05 2014-02-04 Merck Sharp & Dohme Corp. Morpholinone compounds as factor IXa inhibitors
US8987242B2 (en) 2008-12-05 2015-03-24 Merck Sharp & Dohme Corp. Morpholinone compounds as factor IXA inhibitors
WO2011025565A1 (en) * 2009-08-31 2011-03-03 Mochida Pharmaceutical Co., Ltd. Morpholinone compounds as factor ixa inhibitors
US10081621B2 (en) 2010-03-25 2018-09-25 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide
US10071979B2 (en) 2010-04-22 2018-09-11 Vertex Pharmaceuticals Incorporated Process of producing cycloalkylcarboxamido-indole compounds
US10206877B2 (en) 2014-04-15 2019-02-19 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases

Also Published As

Publication number Publication date
UA85676C2 (xx) 2009-02-25
ZA200508888B (en) 2007-02-28
CN1771248A (zh) 2006-05-10
ZA200508889B (en) 2007-02-28
ZA200508891B (en) 2007-03-28
CN1771237A (zh) 2006-05-10
CN1771249A (zh) 2006-05-10

Similar Documents

Publication Publication Date Title
EP1720844B1 (de) Pyrrolidin-1,2-dicarbonsäure-1-(phenylamid)-2-(4-(3-oxo-morpholin-4-yl)-phenylamid) derivate und verwandte verbindungen als inhibitoren des koagulationsfaktors xa zur behandlung von thromboembolischen erkrankungen
EP1558247B1 (de) Benzimidazolderivate
EP1633346B1 (de) Pyrrolidin-1,2-dicarbonsäure-1-¬(4-ethinyl-phenyl)-amid|-2-¬(phenyl)-amid| derivate als inhibitoren der koagulationsfaktoren xa und viia zur behandlung von thrombosen
DE102004045796A1 (de) Arzneimittel enthaltend Carbonylverbindungen sowie deren Verwendung
WO2004087696A1 (de) Pirazolidin-1,2-dicarbonsaüre-1-((phenyl)-amid)-2-((phenyl)-amid) derivate als koagulationsfaktor xa inhibitoren zur behandlung von thrombosen
DE10329457A1 (de) Ethinylprolinderivate
DE10112768A1 (de) Phenylderivate 3
DE10315377A1 (de) Carbonylverbindungen
DE10229070A1 (de) Phenylderivate 5
EP1562939B1 (de) Carbonsäureamide
EP1441726B1 (de) Derivate des phenoxy-n-'4-(isothiazolidin-1,1-dioxid-2yl)pheny]-valerian-säureamids und andere verbindungen als inhibitoren des koagulationsfaktors xa zur behandlung von thromboembolischen erkrankungen und tumoren
EP1414456B1 (de) Phenylderivate als faktor xa inhibitoren
DE10214832A1 (de) Phenylderivate 4
DE10302500A1 (de) Carbonsäureamidderivate
WO2003093235A1 (de) Carbonsäureamide als inhibitoren des koagulationsfaktors xa
DE10247226A1 (de) Heterocyclische Amide
DE10329295A1 (de) Carbonylverbindungen
DE10236868A1 (de) Carbonsäureamide
DE10218974A1 (de) Carnonsäureamide
DE10336570A1 (de) Azaprolinderivate
WO2003002568A1 (de) Kohlenhydratderivate
DE10327428A1 (de) Ethinylprolinderivate

Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee