DE10309929B4 - Substituierte Benzoylureidopyridyl-piperidin- und -pyrrolidin-carbonsäurederivate, Verfahren zu deren Herstellung und deren Verwendung - Google Patents

Substituierte Benzoylureidopyridyl-piperidin- und -pyrrolidin-carbonsäurederivate, Verfahren zu deren Herstellung und deren Verwendung Download PDF

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Publication number
DE10309929B4
DE10309929B4 DE10309929A DE10309929A DE10309929B4 DE 10309929 B4 DE10309929 B4 DE 10309929B4 DE 10309929 A DE10309929 A DE 10309929A DE 10309929 A DE10309929 A DE 10309929A DE 10309929 B4 DE10309929 B4 DE 10309929B4
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DE
Germany
Prior art keywords
alkyl
agonists
compounds
formula
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE10309929A
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German (de)
English (en)
Other versions
DE10309929A1 (de
Inventor
Karl Dr. Schoenafinger
Dieter Dr. Kadereit
Elisabeth Dr. Defossa
Andreas Dr. Herling
Thomas Dr. Klabunde
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Sanofi Aventis Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE10309929A priority Critical patent/DE10309929B4/de
Application filed by Sanofi Aventis Deutschland GmbH filed Critical Sanofi Aventis Deutschland GmbH
Priority to MXPA05009122A priority patent/MXPA05009122A/es
Priority to JP2006504448A priority patent/JP2006519795A/ja
Priority to AU2004218267A priority patent/AU2004218267A1/en
Priority to CNA2004800062407A priority patent/CN1759109A/zh
Priority to KR1020057016583A priority patent/KR20050108487A/ko
Priority to PCT/EP2004/001735 priority patent/WO2004078743A1/fr
Priority to AT04713467T priority patent/ATE386735T1/de
Priority to EP04713467A priority patent/EP1603895B1/fr
Priority to DE502004006253T priority patent/DE502004006253D1/de
Priority to RU2005131011/04A priority patent/RU2005131011A/ru
Priority to CA002518322A priority patent/CA2518322A1/fr
Priority to PL377293A priority patent/PL377293A1/pl
Priority to BRPI0408148-0A priority patent/BRPI0408148A/pt
Priority to US10/795,863 priority patent/US7501440B2/en
Publication of DE10309929A1 publication Critical patent/DE10309929A1/de
Priority to ZA200506119A priority patent/ZA200506119B/en
Priority to HR20050779A priority patent/HRP20050779A2/xx
Priority to CO05089471A priority patent/CO5690587A2/es
Priority to MA28485A priority patent/MA27745A1/fr
Priority to NO20054418A priority patent/NO20054418L/no
Publication of DE10309929B4 publication Critical patent/DE10309929B4/de
Application granted granted Critical
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE10309929A 2003-03-07 2003-03-07 Substituierte Benzoylureidopyridyl-piperidin- und -pyrrolidin-carbonsäurederivate, Verfahren zu deren Herstellung und deren Verwendung Expired - Fee Related DE10309929B4 (de)

Priority Applications (20)

Application Number Priority Date Filing Date Title
DE10309929A DE10309929B4 (de) 2003-03-07 2003-03-07 Substituierte Benzoylureidopyridyl-piperidin- und -pyrrolidin-carbonsäurederivate, Verfahren zu deren Herstellung und deren Verwendung
EP04713467A EP1603895B1 (fr) 2003-03-07 2004-02-21 Derives substitues de l'acide benzoylureidopyridyl-piperidine-carboxylique et de l'acide benzoylureidopyridyl-pyrrolidine-carboxylique, leur procede de production et leur utilisation
AU2004218267A AU2004218267A1 (en) 2003-03-07 2004-02-21 Substituted benzoylureidopyridyl-piperidine and -pyrrolidine carboxylic acid derivatives, method for the production thereof and the use thereof
CNA2004800062407A CN1759109A (zh) 2003-03-07 2004-02-21 取代的苯甲酰基脲基吡啶基－哌啶－和－吡咯烷甲酸衍生物,它们的制备方法和用途
KR1020057016583A KR20050108487A (ko) 2003-03-07 2004-02-21 치환된 벤조일우레이도피리딜-피페리딘 및 -피롤리딘카복실산 유도체, 이의 제조방법 및 이의 용도
PCT/EP2004/001735 WO2004078743A1 (fr) 2003-03-07 2004-02-21 Derives substitues de l'acide benzoylureidopyridyl-piperidine-carboxylique et de l'acide benzoylureidopyridyl-pyrrolidine-carboxylique, leur procede de production et leur utilisation
AT04713467T ATE386735T1 (de) 2003-03-07 2004-02-21 Substituierte benzoylureidopyridyl-piperidin- und pyrrolidin-carbons urederivate, verfahren zu deren herstellung und deren v erwendung
JP2006504448A JP2006519795A (ja) 2003-03-07 2004-02-21 置換されたベンゾイルウレイドピリジル−ピペリジン−及び−ピロリジン−カルボン酸誘導体、その製造方法、並びに、その使用
DE502004006253T DE502004006253D1 (de) 2003-03-07 2004-02-21 Substituierte benzoylureidopyridyl-piperidin- und -pyrrolidin-carbons urederivate, verfahren zu deren herstellung und deren v erwendung
RU2005131011/04A RU2005131011A (ru) 2003-03-07 2004-02-21 Замещенные производные бензоилуреидопиридилпиперидин-и-пирролидинкарбоновой кислоты, способ их получения и их применение
MXPA05009122A MXPA05009122A (es) 2003-03-07 2004-02-21 Derivados de acido benzoilureidopiridil-piperidin-y pirrolidin-carboxilico sustituido, metodo para su produccion y su uso.
CA002518322A CA2518322A1 (fr) 2003-03-07 2004-02-21 Derives substitues de l'acide benzoylureidopyridyl-piperidine-carboxylique et de l'acide benzoylureidopyridyl-pyrrolidine-carboxylique, leur procede de production et leur utilisation
PL377293A PL377293A1 (pl) 2003-03-07 2004-02-21 Podstawione pochodne kwasu benzoiloureidopirydynylo-piperydyno- i pirolidynokarboksylowego, sposób ich wytwarzania oraz ich zastosowanie
BRPI0408148-0A BRPI0408148A (pt) 2003-03-07 2004-02-21 derivados de ácido benzoilureidopiridil-piperidina e -pirrolidina-carboxìlico, processos para a preparação e uso dos mesmos
US10/795,863 US7501440B2 (en) 2003-03-07 2004-03-08 Substituted benzoylureidopyridylpiperidine-and-pyrrolidinecarboxylic acid derivatives, processes for preparing them and their use
ZA200506119A ZA200506119B (en) 2003-03-07 2005-08-01 Substituted benzoylureidopyridyl-piperidine and pyrrolidine carboxylic acid derivatives, method for the production thereof and the use thereof
HR20050779A HRP20050779A2 (en) 2003-03-07 2005-09-06 Supstituted benzoylureidopyridyl-piperidine and pyrrolidine carboxylic acid derivatives, method for the production thereof and the use thereof
CO05089471A CO5690587A2 (es) 2003-03-07 2005-09-06 Derivados de acido bensoilureidopiridil-piperidin-y pirrolidin carboxilico sustituido, metodo para su produccion y su uso
MA28485A MA27745A1 (fr) 2003-03-07 2005-09-07 Derives d'acide benzoylureidopyridyl-piperidine et pyrrolidinecarboxylique substitues, methode de production de ceux-ci et utilisation de ceux-ci.
NO20054418A NO20054418L (no) 2003-03-07 2005-09-23 Substituert benzoylureidopyridylpiperidin- og -pyrrolidinkarboksylsyrederivater, deres fremstilling og anvendelse

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10309929A DE10309929B4 (de) 2003-03-07 2003-03-07 Substituierte Benzoylureidopyridyl-piperidin- und -pyrrolidin-carbonsäurederivate, Verfahren zu deren Herstellung und deren Verwendung

Publications (2)

Publication Number Publication Date
DE10309929A1 DE10309929A1 (de) 2004-12-02
DE10309929B4 true DE10309929B4 (de) 2006-02-23

Family

ID=32945839

Family Applications (2)

Application Number Title Priority Date Filing Date
DE10309929A Expired - Fee Related DE10309929B4 (de) 2003-03-07 2003-03-07 Substituierte Benzoylureidopyridyl-piperidin- und -pyrrolidin-carbonsäurederivate, Verfahren zu deren Herstellung und deren Verwendung
DE502004006253T Expired - Lifetime DE502004006253D1 (de) 2003-03-07 2004-02-21 Substituierte benzoylureidopyridyl-piperidin- und -pyrrolidin-carbons urederivate, verfahren zu deren herstellung und deren v erwendung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE502004006253T Expired - Lifetime DE502004006253D1 (de) 2003-03-07 2004-02-21 Substituierte benzoylureidopyridyl-piperidin- und -pyrrolidin-carbons urederivate, verfahren zu deren herstellung und deren v erwendung

Country Status (18)

Country Link
EP (1) EP1603895B1 (fr)
JP (1) JP2006519795A (fr)
KR (1) KR20050108487A (fr)
CN (1) CN1759109A (fr)
AT (1) ATE386735T1 (fr)
AU (1) AU2004218267A1 (fr)
BR (1) BRPI0408148A (fr)
CA (1) CA2518322A1 (fr)
CO (1) CO5690587A2 (fr)
DE (2) DE10309929B4 (fr)
HR (1) HRP20050779A2 (fr)
MA (1) MA27745A1 (fr)
MX (1) MXPA05009122A (fr)
NO (1) NO20054418L (fr)
PL (1) PL377293A1 (fr)
RU (1) RU2005131011A (fr)
WO (1) WO2004078743A1 (fr)
ZA (1) ZA200506119B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7226942B2 (en) 2004-11-15 2007-06-05 Bristol-Myers Squibb Company 2-amino-4-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
US7365061B2 (en) 2004-11-15 2008-04-29 Bristol-Myers Squibb Company 2-Amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
WO2006053274A2 (fr) 2004-11-15 2006-05-18 Bristol-Myers Squibb Company Derives de tetraline 2-amino-1-fonctionnalises et inhibiteurs correspondants de glycogene phosphorylase
WO2006055435A1 (fr) 2004-11-15 2006-05-26 Bristol-Myers Squibb Company Derives de 2-aminonaphtalene et inhibiteurs de la glycogene phosphorylase associes
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
EP2486005B1 (fr) * 2009-10-06 2014-06-18 Bristol-Myers Squibb Company Modulateurs du gpr40 à base de pyrrolidine

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0047496A1 (fr) * 1980-09-10 1982-03-17 Hoechst Aktiengesellschaft Sulfonylurées, procédés pour les préparer, compositions pharmaceutiques à base de ces composés et leur utilisation
DE10116768A1 (de) * 2001-04-04 2002-10-10 Aventis Pharma Gmbh Acylphenylharnstoffderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE10125567A1 (de) * 2001-05-25 2002-12-05 Aventis Pharma Gmbh Carbonamid substituierte Phenylharnstoffderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU91002A (sh) * 2000-06-09 2006-05-25 Aventis Pharma Deutschland Derivati acilfenil-karbamida, postupak za njihovu proizvodnju i njihova primena kao leka
PE20021091A1 (es) * 2001-05-25 2003-02-04 Aventis Pharma Gmbh Derivados de fenilurea sustituidos con carbonamida y procedimiento para su preparacion
DE10215907A1 (de) * 2002-04-11 2003-11-06 Aventis Pharma Gmbh Acyl-4-carboxyphenyl-harnstoffderivate, Verfahren zu deren Herstellung und deren Verwendung
JP4374428B2 (ja) * 2002-07-11 2009-12-02 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 尿素置換されたおよびウレタン置換されたアシル尿素、それらの製造方法および医薬としてのそれらの使用方法
PL373329A1 (en) * 2002-07-12 2005-08-22 Sanofi-Aventis Deutschland Gmbh Heterocyclically substituted benzoylureas, method for their production and their use as medicaments

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0047496A1 (fr) * 1980-09-10 1982-03-17 Hoechst Aktiengesellschaft Sulfonylurées, procédés pour les préparer, compositions pharmaceutiques à base de ces composés et leur utilisation
DE10116768A1 (de) * 2001-04-04 2002-10-10 Aventis Pharma Gmbh Acylphenylharnstoffderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE10125567A1 (de) * 2001-05-25 2002-12-05 Aventis Pharma Gmbh Carbonamid substituierte Phenylharnstoffderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Also Published As

Publication number Publication date
HRP20050779A2 (en) 2006-10-31
KR20050108487A (ko) 2005-11-16
EP1603895B1 (fr) 2008-02-20
RU2005131011A (ru) 2006-05-10
DE502004006253D1 (de) 2008-04-03
EP1603895A1 (fr) 2005-12-14
MXPA05009122A (es) 2005-10-20
CO5690587A2 (es) 2006-10-31
ZA200506119B (en) 2006-11-29
MA27745A1 (fr) 2006-02-01
BRPI0408148A (pt) 2006-03-01
NO20054418L (no) 2005-09-23
CN1759109A (zh) 2006-04-12
JP2006519795A (ja) 2006-08-31
DE10309929A1 (de) 2004-12-02
AU2004218267A1 (en) 2004-09-16
PL377293A1 (pl) 2006-01-23
WO2004078743A1 (fr) 2004-09-16
ATE386735T1 (de) 2008-03-15
CA2518322A1 (fr) 2004-09-16

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Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
8127 New person/name/address of the applicant

Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH, 65929 FRANKFURT,

8364 No opposition during term of opposition
R119 Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee

Effective date: 20131001