DE10247233A1 - Neue Verbindungen, die Topoisomerase IV inhibieren - Google Patents

Neue Verbindungen, die Topoisomerase IV inhibieren Download PDF

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Publication number
DE10247233A1
DE10247233A1 DE2002147233 DE10247233A DE10247233A1 DE 10247233 A1 DE10247233 A1 DE 10247233A1 DE 2002147233 DE2002147233 DE 2002147233 DE 10247233 A DE10247233 A DE 10247233A DE 10247233 A1 DE10247233 A1 DE 10247233A1
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DE
Germany
Prior art keywords
group
alkyl
heteroalkyl
cycloalkyl
alkynyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE2002147233
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German (de)
English (en)
Inventor
Jean-Philippe Surivet
Cornelia Zumbrunn
Christian Hubschwerlen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Morphochem AG fuer Kombinatorische Chemie
Original Assignee
Morphochem AG fuer Kombinatorische Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphochem AG fuer Kombinatorische Chemie filed Critical Morphochem AG fuer Kombinatorische Chemie
Priority to DE2002147233 priority Critical patent/DE10247233A1/de
Priority to JP2005501280A priority patent/JP4602903B2/ja
Priority to AT03808720T priority patent/ATE463494T1/de
Priority to CNB2003801012434A priority patent/CN100569769C/zh
Priority to EP03808720A priority patent/EP1551829B1/de
Priority to PL03375525A priority patent/PL375525A1/xx
Priority to BR0315221-9A priority patent/BR0315221A/pt
Priority to US10/529,986 priority patent/US7223776B2/en
Priority to AU2003301414A priority patent/AU2003301414B8/en
Priority to EP10003710A priority patent/EP2239260A1/de
Priority to DE50312598T priority patent/DE50312598D1/de
Priority to KR1020057006098A priority patent/KR20050072432A/ko
Priority to PCT/EP2003/011203 priority patent/WO2004035569A2/de
Priority to CA002500320A priority patent/CA2500320A1/en
Priority to CN200910209212A priority patent/CN101817815A/zh
Publication of DE10247233A1 publication Critical patent/DE10247233A1/de
Priority to ZA200502862A priority patent/ZA200502862B/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE2002147233 2002-10-10 2002-10-10 Neue Verbindungen, die Topoisomerase IV inhibieren Ceased DE10247233A1 (de)

Priority Applications (16)

Application Number Priority Date Filing Date Title
DE2002147233 DE10247233A1 (de) 2002-10-10 2002-10-10 Neue Verbindungen, die Topoisomerase IV inhibieren
US10/529,986 US7223776B2 (en) 2002-10-10 2003-10-09 Compounds with anti-bacterial activity
DE50312598T DE50312598D1 (de) 2002-10-10 2003-10-09 Neue verbindungen mit antibakterieller aktivität
CNB2003801012434A CN100569769C (zh) 2002-10-10 2003-10-09 具有杀菌活性的化合物
EP03808720A EP1551829B1 (de) 2002-10-10 2003-10-09 Neue verbindungen mit antibakterieller aktivität
PL03375525A PL375525A1 (en) 2002-10-10 2003-10-09 Novel compounds with antibacterial activity
BR0315221-9A BR0315221A (pt) 2002-10-10 2003-10-09 Compostos com atividade antibacteriana
JP2005501280A JP4602903B2 (ja) 2002-10-10 2003-10-09 抗菌活性を有する新規化合物
AU2003301414A AU2003301414B8 (en) 2002-10-10 2003-10-09 Novel compounds with antibacterial activity
EP10003710A EP2239260A1 (de) 2002-10-10 2003-10-09 Neue Verbindungen mit antibakterieller Aktivität
AT03808720T ATE463494T1 (de) 2002-10-10 2003-10-09 Neue verbindungen mit antibakterieller aktivität
KR1020057006098A KR20050072432A (ko) 2002-10-10 2003-10-09 항균 활성을 갖는 신규한 화합물
PCT/EP2003/011203 WO2004035569A2 (de) 2002-10-10 2003-10-09 Neue verbindungen mit antibakterieller aktivität
CA002500320A CA2500320A1 (en) 2002-10-10 2003-10-09 Novel compounds with antibacterial activity
CN200910209212A CN101817815A (zh) 2002-10-10 2003-10-09 具有杀菌活性的化合物
ZA200502862A ZA200502862B (en) 2002-10-10 2005-04-08 Novel compounds with antibacterial activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2002147233 DE10247233A1 (de) 2002-10-10 2002-10-10 Neue Verbindungen, die Topoisomerase IV inhibieren

Publications (1)

Publication Number Publication Date
DE10247233A1 true DE10247233A1 (de) 2004-06-17

Family

ID=32318487

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2002147233 Ceased DE10247233A1 (de) 2002-10-10 2002-10-10 Neue Verbindungen, die Topoisomerase IV inhibieren

Country Status (3)

Country Link
CN (1) CN100569769C (zh)
DE (1) DE10247233A1 (zh)
ZA (1) ZA200502862B (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006021448A1 (en) * 2004-08-25 2006-03-02 Morphochem Aktiengesellschaft für kombinatorische Chemie Novel compounds having an anti-bacterial activity
WO2006038172A1 (en) * 2004-10-05 2006-04-13 Actelion Pharmaceuticals Ltd New piperidine antibiotics

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2008001002A1 (es) * 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
JP5662346B2 (ja) * 2009-01-21 2015-01-28 バジリア ファルマスーチカ アーゲーＢａｓｉｌｅａ Ｐｈａｒｍａｃｅｕｔｉｃａ ＡＧ 新規二環式抗生物質
RS57047B1 (sr) * 2010-11-15 2018-05-31 Neuroderm Ltd Neprekidno davanje l dope, inhibitora dopa dekarboksilaze, inhibitora katehol-o-metil transferaze i kompozicije za iste
CN109111397B (zh) * 2018-08-28 2021-12-10 广东工业大学 一种喹啉芳香乙烯类衍生物及其制备方法和应用
CN109111396B (zh) * 2018-08-28 2021-09-03 广东工业大学 一种喹啉芳香乙烯衍生物及其制备方法和应用

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006021448A1 (en) * 2004-08-25 2006-03-02 Morphochem Aktiengesellschaft für kombinatorische Chemie Novel compounds having an anti-bacterial activity
WO2006038172A1 (en) * 2004-10-05 2006-04-13 Actelion Pharmaceuticals Ltd New piperidine antibiotics
CN101039935B (zh) * 2004-10-05 2011-04-20 埃科特莱茵药品有限公司 哌啶抗生素

Also Published As

Publication number Publication date
ZA200502862B (en) 2006-06-28
CN1703412A (zh) 2005-11-30
CN100569769C (zh) 2009-12-16

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Effective date: 20120306