DE10237423A1 - Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen - Google Patents
Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen Download PDFInfo
- Publication number
- DE10237423A1 DE10237423A1 DE10237423A DE10237423A DE10237423A1 DE 10237423 A1 DE10237423 A1 DE 10237423A1 DE 10237423 A DE10237423 A DE 10237423A DE 10237423 A DE10237423 A DE 10237423A DE 10237423 A1 DE10237423 A1 DE 10237423A1
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- Prior art keywords
- indolinone
- phenylamino
- phenylmethylene
- methylene
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Landscapes
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Priority Applications (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10237423A DE10237423A1 (de) | 2002-08-16 | 2002-08-16 | Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen |
| CA2495350A CA2495350C (en) | 2002-08-16 | 2003-08-11 | Use of lck inhibitor for treatment of immunologic diseases |
| EP10184940A EP2281561A3 (en) | 2002-08-16 | 2003-08-11 | Use of LCK inhibitors for treatment of immunologic diseases |
| PT37922929T PT1530466E (pt) | 2002-08-16 | 2003-08-11 | Utilização de nintedanib para o tratamento de fibrose pulmonar |
| ES03792292T ES2530392T3 (es) | 2002-08-16 | 2003-08-11 | Uso del nintedanib para el tratamiento de la fibrosis pulmonar |
| SI200332413T SI1530466T1 (sl) | 2002-08-16 | 2003-08-11 | Uporaba nintedaniba za zdravljenje pljučne fibroze |
| DK03792292T DK1530466T3 (da) | 2002-08-16 | 2003-08-11 | Anvendelse af nintedanib til behandling af lungefibrose |
| AU2003255413A AU2003255413A1 (en) | 2002-08-16 | 2003-08-11 | Use of lck inhibitor for treatment of immunologic diseases |
| PCT/EP2003/008890 WO2004017948A2 (en) | 2002-08-16 | 2003-08-11 | Use of lck inhibitor for treatment of immunologic diseases |
| EP03792292.9A EP1530466B1 (en) | 2002-08-16 | 2003-08-11 | Use of Nintedanib for the treatment of lung fibrosis |
| JP2004530121A JP2006514611A (ja) | 2002-08-16 | 2003-08-11 | 免疫疾患の治療のためのＬｃｋインヒビターの使用 |
| US10/640,926 US20040204458A1 (en) | 2002-08-16 | 2003-08-14 | Use of Lck inhibitors for treatment of immunologic diseases |
| US12/334,323 US7989474B2 (en) | 2002-08-16 | 2008-12-12 | Use of Lck inhibitors for treatment of immunologic diseases |
| US12/541,961 US20090306104A1 (en) | 2002-08-16 | 2009-08-16 | Use of Lck inhibitors for treatment of immunologic diseases |
| CY20151100238T CY1116093T1 (el) | 2002-08-16 | 2015-03-09 | Χρηση νιντεντανιμπης για την αγωγη της πνευμονικης ινωσεως |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10237423A DE10237423A1 (de) | 2002-08-16 | 2002-08-16 | Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE10237423A1 true DE10237423A1 (de) | 2004-02-19 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE10237423A Withdrawn DE10237423A1 (de) | 2002-08-16 | 2002-08-16 | Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen |
Country Status (11)
| Country | Link |
|---|---|
| EP (2) | EP1530466B1 (https=) |
| JP (1) | JP2006514611A (https=) |
| AU (1) | AU2003255413A1 (https=) |
| CA (1) | CA2495350C (https=) |
| CY (1) | CY1116093T1 (https=) |
| DE (1) | DE10237423A1 (https=) |
| DK (1) | DK1530466T3 (https=) |
| ES (1) | ES2530392T3 (https=) |
| PT (1) | PT1530466E (https=) |
| SI (1) | SI1530466T1 (https=) |
| WO (1) | WO2004017948A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2837626A1 (en) * | 2013-08-16 | 2015-02-18 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Indolinone derivatives as GRK5 modulators |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060154939A1 (en) * | 2004-12-24 | 2006-07-13 | Boehringer Ingelheim International Gmbh | Medicaments for the Treatment or Prevention of Fibrotic Diseases |
| PE20060777A1 (es) * | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| WO2007057399A2 (en) * | 2005-11-15 | 2007-05-24 | Boehringer Ingelheim International Gmbh | Treatment of cancer with indole derivatives |
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| EA022609B1 (ru) | 2007-02-12 | 2016-02-29 | А1М Фарма Аб | Применение свободного фетального гемоглобина в качестве маркера преэклампсии |
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| US20140350022A1 (en) | 2013-05-10 | 2014-11-27 | Boehringer Ingelheim International Gmbh | Efficacious treatment of NSCLC and predictive clinical marker of the responsiveness of a tumour to a treatment |
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| US20190160054A1 (en) | 2016-04-13 | 2019-05-30 | Boehringer Ingelheim International Gmbh | Pharmaceutical combination of nintedanib, trifluridine and tipiracil for treating colorectal cancer |
| EP3246029A1 (en) | 2016-05-19 | 2017-11-22 | Boehringer Ingelheim International Gmbh | Pharmaceutical combination of nintedanib and capecitabine for the treatment of colorectal cancer |
| WO2017203027A1 (en) | 2016-05-27 | 2017-11-30 | Boehringer Ingelheim International Gmbh | Use of ecm biomarkers for the determining the treatment onset with nintedanib and pirfenidone |
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| EP3784213B1 (en) | 2018-04-23 | 2023-09-06 | InspirMed Corp. | Inhalable liposomal sustained release composition for use in treating pulmonary diseases |
| CN111285872B (zh) * | 2018-12-06 | 2022-05-17 | 北京志健金瑞生物医药科技有限公司 | 吲哚-2-酮衍生物及其制备方法与用途 |
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| JPH0892248A (ja) * | 1994-09-26 | 1996-04-09 | Yamanouchi Pharmaceut Co Ltd | インドリノン誘導体 |
| GB9608435D0 (en) * | 1996-04-24 | 1996-06-26 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9619284D0 (en) * | 1996-09-16 | 1996-10-30 | Celltech Therapeutics Ltd | Chemical compounds |
| WO1998024432A2 (en) * | 1996-12-05 | 1998-06-11 | Sugen, Inc. | Use of indolinone compounds as modulators of protein kinases |
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| HRP20010216A2 (en) | 1998-09-25 | 2002-04-30 | Boehringer Ingelheim Pharma | New substituted indolinones, their preparation and their use as medicaments |
| DE19924401A1 (de) * | 1999-05-27 | 2000-11-30 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
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| MXPA02005350A (es) * | 1999-11-30 | 2002-12-11 | Pfizer Prod Inc | Compuestos de 2,4-diamino pirimidina utiles como supresores de inmunidad. |
| AR035851A1 (es) * | 2000-03-28 | 2004-07-21 | Wyeth Corp | 3-cianoquinolinas, 3-ciano-1,6-naftiridinas y 3-ciano-1,7-naftiridinas como inhibidoras de proteina quinasas |
| DE10054019A1 (de) * | 2000-11-01 | 2002-05-23 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
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2002
- 2002-08-16 DE DE10237423A patent/DE10237423A1/de not_active Withdrawn
-
2003
- 2003-08-11 CA CA2495350A patent/CA2495350C/en not_active Expired - Lifetime
- 2003-08-11 DK DK03792292T patent/DK1530466T3/da active
- 2003-08-11 JP JP2004530121A patent/JP2006514611A/ja active Pending
- 2003-08-11 SI SI200332413T patent/SI1530466T1/sl unknown
- 2003-08-11 AU AU2003255413A patent/AU2003255413A1/en not_active Abandoned
- 2003-08-11 EP EP03792292.9A patent/EP1530466B1/en not_active Expired - Lifetime
- 2003-08-11 EP EP10184940A patent/EP2281561A3/en not_active Withdrawn
- 2003-08-11 PT PT37922929T patent/PT1530466E/pt unknown
- 2003-08-11 WO PCT/EP2003/008890 patent/WO2004017948A2/en not_active Ceased
- 2003-08-11 ES ES03792292T patent/ES2530392T3/es not_active Expired - Lifetime
-
2015
- 2015-03-09 CY CY20151100238T patent/CY1116093T1/el unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2837626A1 (en) * | 2013-08-16 | 2015-02-18 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Indolinone derivatives as GRK5 modulators |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004017948A8 (en) | 2005-03-24 |
| PT1530466E (pt) | 2015-02-24 |
| EP1530466B1 (en) | 2014-12-10 |
| SI1530466T1 (sl) | 2015-03-31 |
| EP2281561A3 (en) | 2012-05-09 |
| EP1530466A2 (en) | 2005-05-18 |
| CA2495350A1 (en) | 2004-03-04 |
| ES2530392T3 (es) | 2015-03-02 |
| CY1116093T1 (el) | 2017-02-08 |
| CA2495350C (en) | 2012-05-29 |
| DK1530466T3 (da) | 2015-03-16 |
| AU2003255413A8 (en) | 2004-03-11 |
| JP2006514611A (ja) | 2006-05-11 |
| EP2281561A2 (en) | 2011-02-09 |
| WO2004017948A3 (en) | 2004-04-22 |
| AU2003255413A1 (en) | 2004-03-11 |
| WO2004017948A2 (en) | 2004-03-04 |
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