CA2495350C - Use of lck inhibitor for treatment of immunologic diseases - Google Patents
Use of lck inhibitor for treatment of immunologic diseases Download PDFInfo
- Publication number
- CA2495350C CA2495350C CA2495350A CA2495350A CA2495350C CA 2495350 C CA2495350 C CA 2495350C CA 2495350 A CA2495350 A CA 2495350A CA 2495350 A CA2495350 A CA 2495350A CA 2495350 C CA2495350 C CA 2495350C
- Authority
- CA
- Canada
- Prior art keywords
- phenyl
- methyl
- phenylamino
- treatment
- indolinone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Neurology (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10237423.6 | 2002-08-16 | ||
| DE10237423A DE10237423A1 (de) | 2002-08-16 | 2002-08-16 | Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen |
| PCT/EP2003/008890 WO2004017948A2 (en) | 2002-08-16 | 2003-08-11 | Use of lck inhibitor for treatment of immunologic diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2495350A1 CA2495350A1 (en) | 2004-03-04 |
| CA2495350C true CA2495350C (en) | 2012-05-29 |
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| Application Number | Title | Priority Date | Filing Date |
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| CA2495350A Expired - Lifetime CA2495350C (en) | 2002-08-16 | 2003-08-11 | Use of lck inhibitor for treatment of immunologic diseases |
Country Status (11)
| Country | Link |
|---|---|
| EP (2) | EP1530466B1 (https=) |
| JP (1) | JP2006514611A (https=) |
| AU (1) | AU2003255413A1 (https=) |
| CA (1) | CA2495350C (https=) |
| CY (1) | CY1116093T1 (https=) |
| DE (1) | DE10237423A1 (https=) |
| DK (1) | DK1530466T3 (https=) |
| ES (1) | ES2530392T3 (https=) |
| PT (1) | PT1530466E (https=) |
| SI (1) | SI1530466T1 (https=) |
| WO (1) | WO2004017948A2 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060154939A1 (en) * | 2004-12-24 | 2006-07-13 | Boehringer Ingelheim International Gmbh | Medicaments for the Treatment or Prevention of Fibrotic Diseases |
| PE20060777A1 (es) * | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| WO2007057399A2 (en) * | 2005-11-15 | 2007-05-24 | Boehringer Ingelheim International Gmbh | Treatment of cancer with indole derivatives |
| WO2007057397A1 (en) * | 2005-11-15 | 2007-05-24 | Boehringer Ingelheim International Gmbh | Treatment of cancer |
| FR2909876A1 (fr) * | 2006-12-19 | 2008-06-20 | Galderma Res & Dev S N C Snc | Utilisation du nepafenac ou ses derives pour le traitement de desordres dermatologiques |
| EA022609B1 (ru) | 2007-02-12 | 2016-02-29 | А1М Фарма Аб | Применение свободного фетального гемоглобина в качестве маркера преэклампсии |
| ME02273B (me) * | 2008-06-06 | 2016-02-20 | Boehringer Ingelheim Int | Farmaceutska kombinacija |
| CA2730531A1 (en) | 2008-07-18 | 2010-01-21 | A1M Pharma Ab | Medical use of the radical scavenger and antioxidant alpha-1-microglobulin |
| US8802384B2 (en) | 2009-03-12 | 2014-08-12 | Boehringer Ingelheim International Gmbh | Method or system using biomarkers for the monitoring of a treatment |
| US20120142703A1 (en) | 2009-05-14 | 2012-06-07 | Boehringer Ingelheim International Gmbh | New combination therapy in treatment of oncological and fibrotic diseases |
| US20120107304A1 (en) | 2010-04-27 | 2012-05-03 | Boehringer Ingelheim International Gmbh | Combination therapy in treatment of oncological and fibrotic diseases |
| US20140350022A1 (en) | 2013-05-10 | 2014-11-27 | Boehringer Ingelheim International Gmbh | Efficacious treatment of NSCLC and predictive clinical marker of the responsiveness of a tumour to a treatment |
| EP3782604A1 (en) * | 2013-07-31 | 2021-02-24 | Windward Pharma, Inc. | Aerosol tyrosine kinase inhibitor compounds and uses thereof |
| EP2837626A1 (en) * | 2013-08-16 | 2015-02-18 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Indolinone derivatives as GRK5 modulators |
| KR20160117596A (ko) | 2014-02-07 | 2016-10-10 | 오스펙스 파마슈티칼스, 인코포레이티드 | 신규 제약 제제 |
| US20190160054A1 (en) | 2016-04-13 | 2019-05-30 | Boehringer Ingelheim International Gmbh | Pharmaceutical combination of nintedanib, trifluridine and tipiracil for treating colorectal cancer |
| EP3246029A1 (en) | 2016-05-19 | 2017-11-22 | Boehringer Ingelheim International Gmbh | Pharmaceutical combination of nintedanib and capecitabine for the treatment of colorectal cancer |
| WO2017203027A1 (en) | 2016-05-27 | 2017-11-30 | Boehringer Ingelheim International Gmbh | Use of ecm biomarkers for the determining the treatment onset with nintedanib and pirfenidone |
| WO2017207643A1 (en) | 2016-06-01 | 2017-12-07 | Boehringer Ingelheim International Gmbh | Use of ecm biomarkers for the determining the treatment onset with nintedanib and pirfenidone |
| CN110573161A (zh) | 2017-03-28 | 2019-12-13 | 勃林格殷格翰国际有限公司 | 用于治疗肌营养不良的方法的尼达尼布 |
| EP3784213B1 (en) | 2018-04-23 | 2023-09-06 | InspirMed Corp. | Inhalable liposomal sustained release composition for use in treating pulmonary diseases |
| CN111285872B (zh) * | 2018-12-06 | 2022-05-17 | 北京志健金瑞生物医药科技有限公司 | 吲哚-2-酮衍生物及其制备方法与用途 |
| US20230135671A1 (en) | 2020-04-01 | 2023-05-04 | Boehringer Ingelheim International Gmbh | Use of biomarkers in the treatment of fibrotic conditions |
| NO346587B1 (en) * | 2021-06-02 | 2022-10-17 | Axichem Ab | Capsaicin derivatives in the treatment of idiopathic pulmonary fibrosis |
| CN119630398A (zh) | 2022-08-16 | 2025-03-14 | 勃林格殷格翰国际有限公司 | 眼内用尼达尼布的药物制剂 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0892248A (ja) * | 1994-09-26 | 1996-04-09 | Yamanouchi Pharmaceut Co Ltd | インドリノン誘導体 |
| GB9608435D0 (en) * | 1996-04-24 | 1996-06-26 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9619284D0 (en) * | 1996-09-16 | 1996-10-30 | Celltech Therapeutics Ltd | Chemical compounds |
| WO1998024432A2 (en) * | 1996-12-05 | 1998-06-11 | Sugen, Inc. | Use of indolinone compounds as modulators of protein kinases |
| SI0991628T1 (en) * | 1997-05-28 | 2005-06-30 | Aventis Pharmaceuticals Inc | QUINOLINE AND QUINOXALINE COMPOUNDS WHICH INHIBIT PLATELET-DERIVED GROWTH FACTOR AND/OR P56lck TYROSINE KINASES |
| DE19816624A1 (de) | 1998-04-15 | 1999-10-21 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| HRP20010216A2 (en) | 1998-09-25 | 2002-04-30 | Boehringer Ingelheim Pharma | New substituted indolinones, their preparation and their use as medicaments |
| DE19924401A1 (de) * | 1999-05-27 | 2000-11-30 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| CA2384378C (en) * | 1999-10-06 | 2011-05-24 | Boehringer Ingelheim Pharmaceuticals, Inc. | Heterocyclic compounds useful as inhibitors of tyrosine kinases |
| UA75054C2 (uk) | 1999-10-13 | 2006-03-15 | Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг | Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу |
| DE19949209A1 (de) | 1999-10-13 | 2001-04-19 | Boehringer Ingelheim Pharma | In 5-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| KR100881105B1 (ko) | 1999-11-05 | 2009-02-02 | 아스트라제네카 아베 | Ｖｅｇｆ 억제제로서의 퀴나졸린 유도체 |
| MXPA02005350A (es) * | 1999-11-30 | 2002-12-11 | Pfizer Prod Inc | Compuestos de 2,4-diamino pirimidina utiles como supresores de inmunidad. |
| AR035851A1 (es) * | 2000-03-28 | 2004-07-21 | Wyeth Corp | 3-cianoquinolinas, 3-ciano-1,6-naftiridinas y 3-ciano-1,7-naftiridinas como inhibidoras de proteina quinasas |
| DE10054019A1 (de) * | 2000-11-01 | 2002-05-23 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
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2002
- 2002-08-16 DE DE10237423A patent/DE10237423A1/de not_active Withdrawn
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2003
- 2003-08-11 CA CA2495350A patent/CA2495350C/en not_active Expired - Lifetime
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- 2003-08-11 JP JP2004530121A patent/JP2006514611A/ja active Pending
- 2003-08-11 SI SI200332413T patent/SI1530466T1/sl unknown
- 2003-08-11 AU AU2003255413A patent/AU2003255413A1/en not_active Abandoned
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- 2003-08-11 PT PT37922929T patent/PT1530466E/pt unknown
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- 2003-08-11 ES ES03792292T patent/ES2530392T3/es not_active Expired - Lifetime
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2004017948A8 (en) | 2005-03-24 |
| PT1530466E (pt) | 2015-02-24 |
| EP1530466B1 (en) | 2014-12-10 |
| SI1530466T1 (sl) | 2015-03-31 |
| EP2281561A3 (en) | 2012-05-09 |
| EP1530466A2 (en) | 2005-05-18 |
| CA2495350A1 (en) | 2004-03-04 |
| DE10237423A1 (de) | 2004-02-19 |
| ES2530392T3 (es) | 2015-03-02 |
| CY1116093T1 (el) | 2017-02-08 |
| DK1530466T3 (da) | 2015-03-16 |
| AU2003255413A8 (en) | 2004-03-11 |
| JP2006514611A (ja) | 2006-05-11 |
| EP2281561A2 (en) | 2011-02-09 |
| WO2004017948A3 (en) | 2004-04-22 |
| AU2003255413A1 (en) | 2004-03-11 |
| WO2004017948A2 (en) | 2004-03-04 |
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