DE10236528A1 - Vorrichtung und Methoden zur Durchführung von elektrischen Messungen an Membrankörpern - Google Patents
Vorrichtung und Methoden zur Durchführung von elektrischen Messungen an Membrankörpern Download PDFInfo
- Publication number
- DE10236528A1 DE10236528A1 DE10236528A DE10236528A DE10236528A1 DE 10236528 A1 DE10236528 A1 DE 10236528A1 DE 10236528 A DE10236528 A DE 10236528A DE 10236528 A DE10236528 A DE 10236528A DE 10236528 A1 DE10236528 A1 DE 10236528A1
- Authority
- DE
- Germany
- Prior art keywords
- membrane
- electrical
- cells
- bodies
- membrane body
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000012528 membrane Substances 0.000 title claims abstract description 132
- 108050001175 Connexin Proteins 0.000 title claims abstract description 44
- 102000010970 Connexin Human genes 0.000 title claims abstract description 44
- 210000003976 gap junction Anatomy 0.000 title claims abstract description 34
- 239000012620 biological material Substances 0.000 title 1
- 210000004027 cell Anatomy 0.000 claims description 82
- 238000000034 method Methods 0.000 claims description 47
- 239000000126 substance Substances 0.000 claims description 17
- 230000000694 effects Effects 0.000 claims description 14
- 239000000758 substrate Substances 0.000 claims description 12
- 239000013543 active substance Substances 0.000 claims description 10
- 238000012360 testing method Methods 0.000 claims description 9
- 230000008569 process Effects 0.000 claims description 7
- 239000004480 active ingredient Substances 0.000 claims description 5
- 238000001514 detection method Methods 0.000 claims description 3
- 238000004113 cell culture Methods 0.000 claims description 2
- 239000004744 fabric Substances 0.000 claims 1
- 238000005259 measurement Methods 0.000 abstract description 28
- 102000004169 proteins and genes Human genes 0.000 abstract description 3
- 108090000623 proteins and genes Proteins 0.000 abstract description 3
- 210000004379 membrane Anatomy 0.000 description 110
- 108091006146 Channels Proteins 0.000 description 40
- 210000000170 cell membrane Anatomy 0.000 description 23
- 102000005962 receptors Human genes 0.000 description 18
- 108020003175 receptors Proteins 0.000 description 18
- 239000000823 artificial membrane Substances 0.000 description 13
- 238000013537 high throughput screening Methods 0.000 description 11
- 239000011148 porous material Substances 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 241000269370 Xenopus <genus> Species 0.000 description 4
- 210000003050 axon Anatomy 0.000 description 4
- 150000002500 ions Chemical class 0.000 description 4
- 210000000287 oocyte Anatomy 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 238000013459 approach Methods 0.000 description 3
- 239000002299 complementary DNA Substances 0.000 description 3
- 239000000975 dye Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 150000002632 lipids Chemical class 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 241001136792 Alle Species 0.000 description 2
- 241000530217 Clonostachys lucifer Species 0.000 description 2
- 239000000232 Lipid Bilayer Substances 0.000 description 2
- 108010052285 Membrane Proteins Proteins 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 210000000805 cytoplasm Anatomy 0.000 description 2
- 238000009795 derivation Methods 0.000 description 2
- 102000034287 fluorescent proteins Human genes 0.000 description 2
- 108091006047 fluorescent proteins Proteins 0.000 description 2
- 230000002538 fungal effect Effects 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- DLBFLQKQABVKGT-UHFFFAOYSA-L lucifer yellow dye Chemical compound [Li+].[Li+].[O-]S(=O)(=O)C1=CC(C(N(C(=O)NN)C2=O)=O)=C3C2=CC(S([O-])(=O)=O)=CC3=C1N DLBFLQKQABVKGT-UHFFFAOYSA-L 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 210000003449 plasmodesmata Anatomy 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- 229960001866 silicon dioxide Drugs 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241000238366 Cephalopoda Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 description 1
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 description 1
- 102100037156 Gap junction beta-2 protein Human genes 0.000 description 1
- 101710198067 Gap junction beta-2 protein Proteins 0.000 description 1
- 108050003470 Innexin Proteins 0.000 description 1
- 102000014416 Innexin Human genes 0.000 description 1
- 108090000862 Ion Channels Proteins 0.000 description 1
- 102000004310 Ion Channels Human genes 0.000 description 1
- 108010036176 Melitten Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000238413 Octopus Species 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 102000004257 Potassium Channel Human genes 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000036982 action potential Effects 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 230000000692 anti-sense effect Effects 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000009460 calcium influx Effects 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 210000004671 cell-free system Anatomy 0.000 description 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 210000000695 crystalline len Anatomy 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000007876 drug discovery Methods 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 210000004242 electrical synapse Anatomy 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 239000008151 electrolyte solution Substances 0.000 description 1
- 238000003372 electrophysiological method Methods 0.000 description 1
- 230000007831 electrophysiology Effects 0.000 description 1
- 238000002001 electrophysiology Methods 0.000 description 1
- 210000003890 endocrine cell Anatomy 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 230000028023 exocytosis Effects 0.000 description 1
- 238000001506 fluorescence spectroscopy Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000005090 green fluorescent protein Substances 0.000 description 1
- 239000003228 hemolysin Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229910001410 inorganic ion Inorganic materials 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- VDXZNPDIRNWWCW-JFTDCZMZSA-N melittin Chemical compound NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)CC1=CNC2=CC=CC=C12 VDXZNPDIRNWWCW-JFTDCZMZSA-N 0.000 description 1
- 102000006240 membrane receptors Human genes 0.000 description 1
- 108020004084 membrane receptors Proteins 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 210000000663 muscle cell Anatomy 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 108020001213 potassium channel Proteins 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 210000001938 protoplast Anatomy 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 150000003839 salts Chemical group 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003153 stable transfection Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 210000003568 synaptosome Anatomy 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
- G01N33/48728—Investigating individual cells, e.g. by patch clamp, voltage clamp
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10236528A DE10236528A1 (de) | 2002-08-09 | 2002-08-09 | Vorrichtung und Methoden zur Durchführung von elektrischen Messungen an Membrankörpern |
| JP2004531823A JP4498139B2 (ja) | 2002-08-09 | 2003-07-28 | 膜体上で電気的測定を実行するための装置および方法 |
| US10/523,784 US20050227139A1 (en) | 2002-08-09 | 2003-07-28 | Device and methods for carring out electrical measurements on membrane bodies |
| EP03790822A EP1529215A1 (de) | 2002-08-09 | 2003-07-28 | Vorrichtung und methoden zur durchführung von elektrischen messungen an membrankörpern |
| CA002494927A CA2494927A1 (en) | 2002-08-09 | 2003-07-28 | Device and methods for carrying out electrical measurements on membrane bodies |
| PCT/EP2003/008299 WO2004021002A1 (de) | 2002-08-09 | 2003-07-28 | Vorrichtung und methoden zur durchführung von elektrischen messungen an membrankörpern |
| AU2003253343A AU2003253343B2 (en) | 2002-08-09 | 2003-07-28 | Device and methods for carrying out electrical measurements on membrane bodies |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10236528A DE10236528A1 (de) | 2002-08-09 | 2002-08-09 | Vorrichtung und Methoden zur Durchführung von elektrischen Messungen an Membrankörpern |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE10236528A1 true DE10236528A1 (de) | 2004-02-19 |
Family
ID=30469635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE10236528A Withdrawn DE10236528A1 (de) | 2002-08-09 | 2002-08-09 | Vorrichtung und Methoden zur Durchführung von elektrischen Messungen an Membrankörpern |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20050227139A1 (https=) |
| EP (1) | EP1529215A1 (https=) |
| JP (1) | JP4498139B2 (https=) |
| AU (1) | AU2003253343B2 (https=) |
| CA (1) | CA2494927A1 (https=) |
| DE (1) | DE10236528A1 (https=) |
| WO (1) | WO2004021002A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7244349B2 (en) | 1997-12-17 | 2007-07-17 | Molecular Devices Corporation | Multiaperture sample positioning and analysis system |
| US20020144905A1 (en) | 1997-12-17 | 2002-10-10 | Christian Schmidt | Sample positioning and analysis system |
| US7266457B1 (en) * | 1999-05-21 | 2007-09-04 | Hesperos, Llc | High throughput functional genomics |
| US7270730B2 (en) | 2000-08-04 | 2007-09-18 | Essen Instruments, Inc. | High-throughput electrophysiological measurement system |
| US7067046B2 (en) | 2000-08-04 | 2006-06-27 | Essen Instruments, Inc. | System for rapid chemical activation in high-throughput electrophysiological measurements |
| EP1588616A3 (en) * | 2004-04-19 | 2011-09-07 | Becton Dickinson and Company | Method of transporting transgenic Xenopus laevis oocytes |
| JP4897681B2 (ja) * | 2004-07-23 | 2012-03-14 | エレクトロニック・バイオサイエンシーズ・エルエルシー | イオン・チャネルを通過する時間的に変化する電流を検出するための方法及び装置 |
| JP2007225300A (ja) * | 2006-02-21 | 2007-09-06 | Mie Univ | 物質認識機能と情報変換機能を併せ持つセンサー |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5874668A (en) * | 1995-10-24 | 1999-02-23 | Arch Development Corporation | Atomic force microscope for biological specimens |
| GB9812783D0 (en) * | 1998-06-12 | 1998-08-12 | Cenes Ltd | High throuoghput screen |
| JP2002522028A (ja) * | 1998-07-23 | 2002-07-23 | シンビオシス ゲーエムベーハー | 細胞外電気生理学的記録用アッセンブリと装置及びその使用 |
| DE10102117A1 (de) * | 2001-01-18 | 2002-08-08 | Diehl Ako Stiftung Gmbh & Co | Verfahren zum schnellen Starten eines Asynchronmotors |
| GB0119438D0 (en) * | 2001-02-16 | 2001-10-03 | Aventis Pharm Prod Inc | Gap junction permeability assay |
| WO2003032964A2 (en) * | 2001-10-17 | 2003-04-24 | University Of Wales College Of Medecine | Gap junctions and endothelial-derived hyperpolarizing factor (edhf) |
| HRP20040784A2 (en) * | 2002-01-29 | 2005-04-30 | Wyeth | Compositions and methods for modulating connexin hemichannels |
-
2002
- 2002-08-09 DE DE10236528A patent/DE10236528A1/de not_active Withdrawn
-
2003
- 2003-07-28 JP JP2004531823A patent/JP4498139B2/ja not_active Expired - Fee Related
- 2003-07-28 CA CA002494927A patent/CA2494927A1/en not_active Abandoned
- 2003-07-28 EP EP03790822A patent/EP1529215A1/de not_active Withdrawn
- 2003-07-28 WO PCT/EP2003/008299 patent/WO2004021002A1/de not_active Ceased
- 2003-07-28 US US10/523,784 patent/US20050227139A1/en not_active Abandoned
- 2003-07-28 AU AU2003253343A patent/AU2003253343B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003253343A1 (en) | 2004-03-19 |
| CA2494927A1 (en) | 2004-03-11 |
| JP2005535906A (ja) | 2005-11-24 |
| EP1529215A1 (de) | 2005-05-11 |
| WO2004021002A1 (de) | 2004-03-11 |
| AU2003253343B2 (en) | 2009-04-30 |
| JP4498139B2 (ja) | 2010-07-07 |
| US20050227139A1 (en) | 2005-10-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1040349B2 (de) | Positionierung und elektrophysiologische charakterisierung einzelner zellen und rekonstituierter membransysteme auf mikrostrukturierten trägern | |
| DE602004013042T2 (de) | Testchip sowie verwendungen des testchips zur bestimmung molekularer strukturen und funktionen | |
| DE10112505C1 (de) | Sensoranordnung und Vorrichtung zur amperometrischen und/oder potentiometrischen, pharmakologischen Wirkort- und/oder Wirkstofftestung sowie Verfahren zur amperometrischen und/oder potentiometrischen, pharmakologischen Wirkort- und/oder Wirkstofftestung | |
| WO2011039242A1 (de) | Anordnung und verfahren unter verwendung von mikrosensoren zum messen von zell-vitalitäten | |
| DE10236528A1 (de) | Vorrichtung und Methoden zur Durchführung von elektrischen Messungen an Membrankörpern | |
| EP1660886B1 (de) | Vorrichtungen zum nachweis biochemischer aktivität enthaltend gap junctions | |
| EP1400805B1 (de) | Messvorrichtung und -verfahren für ein Screening bei auf Elektroden immobilisierten Zellen | |
| DE10320898A1 (de) | Biokompatible Sensorelektrodenanordnung und Verfahren zu deren Herstellung | |
| EP2607475B1 (de) | Monitoringzelle und Verfahren zur Analyse eines Zell- und Gewebewachstums | |
| EP1807696B1 (de) | Vorrichtung und verfahren zur messung von zelleigenschaften | |
| US12590282B2 (en) | Cell culture apparatus | |
| DE60110598T2 (de) | Quantitatives fluoreszenz-bestimmungsverfahren für transportproteinenaktivität | |
| DE20104431U1 (de) | Sensorelektrodeneinrichtung, Sensoranordnung und Vorrichtung zur amperometrischen und/oder potentiometrischen, insbesondere pharmakologischen Wirkort- und/oder Wirkstofftestung | |
| EP2092319A1 (de) | Vorrichtung und verfahren zur messung biologischer und elektronischer eigenschaften einer probe | |
| DE102006011925B3 (de) | Typ-PAT1-Protein-Assay | |
| DE102007006585B3 (de) | Verfahren zum Identifizieren eines Wirkstoffkomplexes, welcher eine enzymatische Eigenschaft eines synaptosomalen/synaptischen Wirkortkomplexes im Bereich einer synaptosomalen/synaptischen Membran modifiziert | |
| DE102004048391B4 (de) | Typ-PepT1-Protein-Assay | |
| DE102011080772B3 (de) | Vorrichtung, System und Verfahren zum Detektieren einer Sinneswahrnehmung | |
| DE10202482B4 (de) | Molekularer Sensorkomplex, Messsondenanordnung und Verfahren zur pharmakologischen Wirkstoff- und/oder Wirkorttestung | |
| DE102006032953A1 (de) | Biosensorrohling und Verfahren zum Herstellen einer Biosensoranordnung | |
| EP2336767A1 (de) | Mittel zum Nachweis biochemischer Aktivität von Membrankörpern | |
| DE102006031913A1 (de) | GAT1-Assay |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8127 | New person/name/address of the applicant |
Owner name: BAYER TECHNOLOGY SERVICES GMBH, 51373 LEVERKUSEN, |
|
| 8139 | Disposal/non-payment of the annual fee |