DE10232572A1 - Neue 2,5-disubstituierte Pyrimidinderivate - Google Patents

Neue 2,5-disubstituierte Pyrimidinderivate Download PDF

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Publication number
DE10232572A1
DE10232572A1 DE10232572A DE10232572A DE10232572A1 DE 10232572 A1 DE10232572 A1 DE 10232572A1 DE 10232572 A DE10232572 A DE 10232572A DE 10232572 A DE10232572 A DE 10232572A DE 10232572 A1 DE10232572 A1 DE 10232572A1
Authority
DE
Germany
Prior art keywords
alkyl
substituted
formula
compounds
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE10232572A
Other languages
German (de)
English (en)
Inventor
Achim Dr. Feurer
Joachim Dr. Luithle
Stephan-Nicholas Dr. Wirtz
Gerhard Dr. König
Johannes-Peter Dr. Stasch
Frank Dr. Wunder
Dieter Dr. Lang
Elke Dr. Stahl
Rudy Dr. Mountain View Schreiber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to DE10232572A priority Critical patent/DE10232572A1/de
Priority to EP03764943A priority patent/EP1525202B1/de
Priority to PCT/EP2003/007238 priority patent/WO2004009589A1/de
Priority to AU2003257437A priority patent/AU2003257437A1/en
Priority to US10/521,538 priority patent/US7091198B1/en
Priority to CA2492723A priority patent/CA2492723C/en
Priority to DE50302202T priority patent/DE50302202D1/de
Priority to ES03764943T priority patent/ES2256779T3/es
Priority to JP2004522411A priority patent/JP2006502119A/ja
Publication of DE10232572A1 publication Critical patent/DE10232572A1/de
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE10232572A 2002-07-18 2002-07-18 Neue 2,5-disubstituierte Pyrimidinderivate Withdrawn DE10232572A1 (de)

Priority Applications (9)

Application Number Priority Date Filing Date Title
DE10232572A DE10232572A1 (de) 2002-07-18 2002-07-18 Neue 2,5-disubstituierte Pyrimidinderivate
EP03764943A EP1525202B1 (de) 2002-07-18 2003-07-07 Neue 2,5-disubstituierte pyrimidinderivate
PCT/EP2003/007238 WO2004009589A1 (de) 2002-07-18 2003-07-07 Neue 2,5-disubstituierte pyrimidinderivate
AU2003257437A AU2003257437A1 (en) 2002-07-18 2003-07-07 Novel 2,5-disubstituted pyrimidine derivatives
US10/521,538 US7091198B1 (en) 2002-07-18 2003-07-07 2,5-disubstituted pyrimidine derivatives
CA2492723A CA2492723C (en) 2002-07-18 2003-07-07 Novel 2,5-disubstituted pyrimidine derivatives
DE50302202T DE50302202D1 (de) 2002-07-18 2003-07-07 Neue 2,5-disubstituierte pyrimidinderivate
ES03764943T ES2256779T3 (es) 2002-07-18 2003-07-07 Nuevos derivados de pirimidina 2,5-disubstituidos.
JP2004522411A JP2006502119A (ja) 2002-07-18 2003-07-07 新規２，５−二置換ピリミジン誘導体

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10232572A DE10232572A1 (de) 2002-07-18 2002-07-18 Neue 2,5-disubstituierte Pyrimidinderivate

Publications (1)

Publication Number Publication Date
DE10232572A1 true DE10232572A1 (de) 2004-02-05

Family

ID=30010152

Family Applications (2)

Application Number Title Priority Date Filing Date
DE10232572A Withdrawn DE10232572A1 (de) 2002-07-18 2002-07-18 Neue 2,5-disubstituierte Pyrimidinderivate
DE50302202T Expired - Lifetime DE50302202D1 (de) 2002-07-18 2003-07-07 Neue 2,5-disubstituierte pyrimidinderivate

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE50302202T Expired - Lifetime DE50302202D1 (de) 2002-07-18 2003-07-07 Neue 2,5-disubstituierte pyrimidinderivate

Country Status (8)

Country Link
US (1) US7091198B1 (enExample)
EP (1) EP1525202B1 (enExample)
JP (1) JP2006502119A (enExample)
AU (1) AU2003257437A1 (enExample)
CA (1) CA2492723C (enExample)
DE (2) DE10232572A1 (enExample)
ES (1) ES2256779T3 (enExample)
WO (1) WO2004009589A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005047286A1 (ja) * 2003-11-13 2005-05-26 Ono Pharmaceutical Co., Ltd. スピロ複素環化合物

Families Citing this family (30)

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JP4605952B2 (ja) * 2001-08-29 2011-01-05 株式会社日立製作所 蓄電装置及びその制御方法
EP1620428A1 (en) * 2003-04-23 2006-02-01 Pharmacia & Upjohn Company LLC Substituted pyrimidinones and pyrimidinthiones as crf antagonists
US7399765B2 (en) 2003-09-19 2008-07-15 Abbott Laboratories Substituted diazabicycloalkane derivatives
US20050065178A1 (en) * 2003-09-19 2005-03-24 Anwer Basha Substituted diazabicycloakane derivatives
KR20080100473A (ko) * 2006-03-02 2008-11-18 아이스모스 테크날러지 코포레이션 비감광성 영역에 대한 감광성 영역의 증가된 비율을 갖는 포토다이오드
DE102007026392A1 (de) * 2007-06-06 2008-12-11 Bayer Healthcare Ag Lösungen für die Perfusion und Konservierung von Organen und Geweben
TW201004963A (en) * 2008-07-03 2010-02-01 Targacept Inc Derivatives of oxabispidine as neuronal nicotinic acetylcholine receptor ligands
TW201028410A (en) 2008-12-22 2010-08-01 Astrazeneca Ab Chemical compounds 610
DE102010021637A1 (de) 2010-05-26 2011-12-01 Bayer Schering Pharma Aktiengesellschaft Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
DE102010040234A1 (de) * 2010-09-03 2012-03-08 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Herstellung von 5-Flour-1H-pyrazolo[3,4-b]pyridin-3-carbonitril
DE102010043380A1 (de) 2010-11-04 2012-05-10 Bayer Schering Pharma Aktiengesellschaft Benzyl-substituierte Carbamate und ihre Verwendung
DE102010043379A1 (de) 2010-11-04 2012-05-10 Bayer Schering Pharma Aktiengesellschaft Substituierte 6-Fluor-1H-Pyrazolo[4,3-b]pyridine und ihre Verwendung
EP2453000A1 (en) * 2010-11-08 2012-05-16 Infineum International Limited Lubricating Oil Composition comprising a hydrogenated imide derived from a Diels-Alder adduct of maleic anhydride and a furan
PE20190180A1 (es) 2011-11-25 2019-02-01 Adverio Pharma Gmbh Procedimiento de preparacion de 5-fluoro-1h-pirazolopiridinas sustituidas
WO2014128109A1 (en) 2013-02-21 2014-08-28 Bayer Pharma Aktiengesellschaft Forms of methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridino-3-yl]pyrimidino-5-yl}methyl carbamate
EP3094327A1 (en) 2014-01-13 2016-11-23 Ironwood Pharmaceuticals, Inc. USE OF sGC STIMULATORS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS
HK1243645A1 (zh) 2015-05-06 2018-07-20 Bayer Pharma Aktiengesellschaft 单独和与pde5抑制剂组合的sgc刺激剂、sgc活化剂用於治疗伴随系统性硬化症(ssc)的指溃疡(du)的用途
LT3325013T (lt) 2015-07-23 2020-11-10 Bayer Pharma Aktiengesellschaft Tirpios guanilatciklazės (sgc) stimuliatoriai/aktyvatoriai derinyje su nep inhibitoriumi ir (arba) angiotenzino aii antagonistu ir jų naudojimas
CN105367567B (zh) * 2015-11-18 2017-11-28 浙江京新药业股份有限公司 一种化合物及其在制备利奥西呱中的应用
CN105367569B (zh) * 2015-11-18 2017-10-27 浙江京新药业股份有限公司 一种化合物及其作为利奥西呱中间体的应用
EA201891416A1 (ru) 2015-12-14 2018-12-28 Айронвуд Фармасьютикалз, Инк. ПРИМЕНЕНИЕ СТИМУЛЯТОРОВ sGC ДЛЯ ЛЕЧЕНИЯ ДИСФУНКЦИИ ЖЕЛУДОЧНО-КИШЕЧНОГО СФИНКТЕРА
WO2018069148A1 (de) 2016-10-11 2018-04-19 Bayer Pharma Aktiengesellschaft Kombination enthaltend sgc aktivatoren und mineralocorticoid-rezeptor-antagonisten
WO2018069126A1 (de) 2016-10-11 2018-04-19 Bayer Pharma Aktiengesellschaft Kombination enthaltend sgc stimulatoren und mineralocorticoid-rezeptor-antagonisten
US11180493B2 (en) 2016-11-08 2021-11-23 Cyclerion Therapeutics, Inc. SGC stimulators
WO2018111795A2 (en) 2016-12-13 2018-06-21 Ironwood Pharmaceuticals, Inc. Use of sgc stimulators for the treatment of esophageal motility disorders
MA52616A (fr) 2018-05-15 2021-03-24 Bayer Ag Benzamides à substitution 1,3-thiazol-2-yl pour le traitement de maladies associées à la sensibilisation de fibres nerveuses
JP7542518B2 (ja) 2018-07-11 2024-08-30 ティセント セラピューティクス インコーポレーテッド ミトコンドリア（ｍｉｔｏｃｈｏｎｒｉａｌ）障害の処置のためのｓＧＣ刺激剤の使用
WO2020164008A1 (en) 2019-02-13 2020-08-20 Bayer Aktiengesellschaft Process for the preparation of porous microparticles
CN112457308B (zh) * 2019-09-09 2024-01-02 上海长森药业有限公司 新型三环芳香杂环化合物，及其制备方法、药物组合物和应用
CN118772140A (zh) * 2023-04-07 2024-10-15 四川大学 一类化合物及其在治疗hDHODH介导的疾病中的用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19649460A1 (de) 1996-11-26 1998-05-28 Bayer Ag Neue substituierte Pyrazolderivate
DE19834045A1 (de) * 1998-07-29 2000-02-03 Bayer Ag (4-Amino-5-ethylpyrimidin-2-yl)-1-(2-fluorbenzyl)-1H-pyrazolo[3,4-b]pyridin
DE19834047A1 (de) 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate
DE19846514A1 (de) * 1998-10-09 2000-04-20 Bayer Ag Neue Heterocyclyl-methyl-substituierte Pyrazole
DE10054278A1 (de) * 2000-11-02 2002-05-08 Bayer Ag Verwendung von Stimulatoren der löslichen Guanylatcyclase zur Behandlung von Osteoporose
CA2429308C (en) * 2000-11-22 2010-09-21 Bayer Aktiengesellschaft Novel lactam-substituted pyrazolopyridine derivatives
AR031176A1 (es) * 2000-11-22 2003-09-10 Bayer Ag Nuevos derivados de pirazolpiridina sustituidos con piridina
DE10057754A1 (de) * 2000-11-22 2002-05-23 Bayer Ag Neue Sulfonamid-substituierte Pyrazolopyridinderivate

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005047286A1 (ja) * 2003-11-13 2005-05-26 Ono Pharmaceutical Co., Ltd. スピロ複素環化合物

Also Published As

Publication number Publication date
ES2256779T3 (es) 2006-07-16
CA2492723C (en) 2012-09-04
DE50302202D1 (de) 2006-04-06
EP1525202A1 (de) 2005-04-27
WO2004009589A1 (de) 2004-01-29
EP1525202B1 (de) 2006-01-11
US20060167016A1 (en) 2006-07-27
AU2003257437A1 (en) 2004-02-09
CA2492723A1 (en) 2004-01-29
US7091198B1 (en) 2006-08-15
JP2006502119A (ja) 2006-01-19

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Legal Events

Date Code Title Description
8127 New person/name/address of the applicant

Owner name: BAYER HEALTHCARE AG, 51373 LEVERKUSEN, DE

8139 Disposal/non-payment of the annual fee