DE102011012060A1 - Massenspektrometrische Bestimmung der inhibitorischen Wirkung von Substanzen gegenüber beta-Lactamasen - Google Patents

Massenspektrometrische Bestimmung der inhibitorischen Wirkung von Substanzen gegenüber beta-Lactamasen Download PDF

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Publication number
DE102011012060A1
DE102011012060A1 DE201110012060 DE102011012060A DE102011012060A1 DE 102011012060 A1 DE102011012060 A1 DE 102011012060A1 DE 201110012060 DE201110012060 DE 201110012060 DE 102011012060 A DE102011012060 A DE 102011012060A DE 102011012060 A1 DE102011012060 A1 DE 102011012060A1
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Prior art keywords
beta
mass
antibiotic
mass spectrum
combination preparation
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DE201110012060
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German (de)
English (en)
Inventor
Markus Kostrzewa
Ulrich Weller
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Bruker Daltonics GmbH and Co KG
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Bruker Daltonik GmbH
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Priority to DE201110012060 priority Critical patent/DE102011012060A1/de
Priority to PCT/EP2012/052662 priority patent/WO2012113699A1/fr
Publication of DE102011012060A1 publication Critical patent/DE102011012060A1/de
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
DE201110012060 2011-02-23 2011-02-23 Massenspektrometrische Bestimmung der inhibitorischen Wirkung von Substanzen gegenüber beta-Lactamasen Pending DE102011012060A1 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE201110012060 DE102011012060A1 (de) 2011-02-23 2011-02-23 Massenspektrometrische Bestimmung der inhibitorischen Wirkung von Substanzen gegenüber beta-Lactamasen
PCT/EP2012/052662 WO2012113699A1 (fr) 2011-02-23 2012-02-16 Détermination par spectrométrie de masse de l'effet inhibiteur de substances sur les bêta-lactamases

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE201110012060 DE102011012060A1 (de) 2011-02-23 2011-02-23 Massenspektrometrische Bestimmung der inhibitorischen Wirkung von Substanzen gegenüber beta-Lactamasen

Publications (1)

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DE102011012060A1 true DE102011012060A1 (de) 2012-08-23

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DE201110012060 Pending DE102011012060A1 (de) 2011-02-23 2011-02-23 Massenspektrometrische Bestimmung der inhibitorischen Wirkung von Substanzen gegenüber beta-Lactamasen

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DE (1) DE102011012060A1 (fr)
WO (1) WO2012113699A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102014000646A1 (de) 2014-01-17 2015-07-23 Bruker Daltonik Gmbh Massenspektrometrische Resistenzbestimmung durch Metabolismus-Messung

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2806275B1 (fr) * 2013-05-23 2015-07-01 Bruker Daltonik GmbH Détermination de la résistance par spectrométrie de masse par mesure de croissance
CZ2013473A3 (cs) * 2013-06-20 2014-11-26 Univerzita Karlova v Praze, Lékařská fakulta v Plzni Způsob detekce beta-laktamáz gramnegativních bakterií hmotnostní spektrometrií
FR3024465B1 (fr) * 2014-07-30 2018-03-23 Biomerieux Caracterisation de micro-organismes par maldi-tof
KR20190054921A (ko) * 2017-11-14 2019-05-22 주식회사 노스퀘스트 항생제 변형을 유도하는 내성균에 대한 질량분석법 검사 장치 및 방법
KR20210084040A (ko) 2019-12-27 2021-07-07 주식회사 노스퀘스트 Maldi-tof를 이용한 카바페넴 분해효소-생성 장내세균 검출

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1511849B1 (fr) * 2002-05-31 2006-08-23 Kiadis B.V. Dosage d'enzyme a flux continu
DE102006021493B4 (de) 2006-05-09 2010-04-01 Bruker Daltonik Gmbh Massenspektrometrische Messung mikrobieller Resistenzen

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9012174B2 (en) * 2010-08-19 2015-04-21 Erasmus University Medical Center Rotterdam Methods and means for characterizing antibiotic resistance in microorganisms

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1511849B1 (fr) * 2002-05-31 2006-08-23 Kiadis B.V. Dosage d'enzyme a flux continu
DE102006021493B4 (de) 2006-05-09 2010-04-01 Bruker Daltonik Gmbh Massenspektrometrische Messung mikrobieller Resistenzen

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
FEMS Microbiology Reviews, 24, 2000, 193-219: "Characterization of bacteria by matrix-assisted laser desorption/ionisation and electrospray mass spectrometry"
Jarman et al., Analytical Chemistry, 72[6], 1217-1223, 2000: "An algorithm for automated bacterial identification using matrix-assisted laser desorption/ionization mass spectrometry"
Sanchez, P. A. [u. a.]: A sensitive coupled HPLC/electrospray mass spectrometry assay for SPM-1 metallo-beta-lactamase inhibitors. In: Assay Drug Dev. Tech., 2009, Vol. 7, S. 170-179 *
Sanchez, P. A. [u. a.]: A sensitive coupled HPLC/electrospray mass spectrometry assay for SPM-1 metallo-β-lactamase inhibitors. In: Assay Drug Dev. Tech., 2009, Vol. 7, S. 170-179
Saves, I. [u. a.]: Mass spectral kinetic study of acylation and deacylation during the hydrolysis of penicillins and cefotaxime by beta-lactamase TEMP-1 and the G238S mutant. In: Biochemistry, 1995, Vol. 34, S. 11660-11667 *
Saves, I. [u. a.]: Mass spectral kinetic study of acylation and deacylation during the hydrolysis of penicillins and cefotaxime by β-lactamase TEMP-1 and the G238S mutant. In: Biochemistry, 1995, Vol. 34, S. 11660-11667
Xu, Z. [u. a.]: Determination of beta-lactamase residues in milk using matrix-assisted laser desorption/ionization fourier transform mass spectrometry. In: Anal. Chem., 2010, Vol. 82, S. 2113-2118 *
Xu, Z. [u. a.]: Determination of β-lactamase residues in milk using matrix-assisted laser desorption/ionization fourier transform mass spectrometry. In: Anal. Chem., 2010, Vol. 82, S. 2113-2118
Xu, Z. [u. a.]: Monitoring enzyme reaction and screening of inhibitors of acetylcholinesterase by quantitative matrix-assisted laser desorption/ionization fourier transform mass spectrometry. In: J. Am. Soc. Mass Spectrom., 2008, Vol. 19, S. 1849-1855 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102014000646A1 (de) 2014-01-17 2015-07-23 Bruker Daltonik Gmbh Massenspektrometrische Resistenzbestimmung durch Metabolismus-Messung
WO2015107054A1 (fr) 2014-01-17 2015-07-23 Bruker Daltonik Gmbh Détermination de résistance par spectrométrie de masse par mesure du métabolisme
US11142784B2 (en) 2014-01-17 2021-10-12 Bruker Daltonik Gmbh Mass spectrometric resistance determination by measuring metabolism
DE102014000646B4 (de) 2014-01-17 2023-05-11 Bruker Daltonics GmbH & Co. KG Massenspektrometrische Resistenzbestimmung durch Metabolismus-Messung

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Owner name: BRUKER DALTONICS GMBH & CO. KG, DE

Free format text: FORMER OWNER: BRUKER DALTONIK GMBH, 28359 BREMEN, DE