DE102008025750A1 - Dihydropyrazolderivate - Google Patents
Dihydropyrazolderivate Download PDFInfo
- Publication number
- DE102008025750A1 DE102008025750A1 DE102008025750A DE102008025750A DE102008025750A1 DE 102008025750 A1 DE102008025750 A1 DE 102008025750A1 DE 102008025750 A DE102008025750 A DE 102008025750A DE 102008025750 A DE102008025750 A DE 102008025750A DE 102008025750 A1 DE102008025750 A1 DE 102008025750A1
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- Germany
- Prior art keywords
- het
- formula
- diyl
- stereoisomers
- pharmaceutically acceptable
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102008025750A DE102008025750A1 (de) | 2008-05-29 | 2008-05-29 | Dihydropyrazolderivate |
| CA2726009A CA2726009C (en) | 2008-05-29 | 2009-04-24 | Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumours |
| PCT/EP2009/003030 WO2009143945A1 (de) | 2008-05-29 | 2009-04-24 | Dihydropyrazolderivate als tyrosinkinase modulatoren zur behandlung von tumoren |
| JP2011510855A JP5643192B2 (ja) | 2008-05-29 | 2009-04-24 | 腫瘍を処置するためのチロシンキナーゼモジュレーターとしてのジヒドロピラゾール誘導体 |
| US12/993,892 US8404685B2 (en) | 2008-05-29 | 2009-04-24 | Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors |
| BRPI0912970A BRPI0912970A2 (pt) | 2008-05-29 | 2009-04-24 | derivados de di-hidropirazol como moduladores de tirosina quinase para o tratamento de tumores |
| CN2009801192665A CN102046605B (zh) | 2008-05-29 | 2009-04-24 | 作为酪氨酸激酶调节剂用于治疗肿瘤的二氢吡唑衍生物 |
| KR1020107029265A KR20110010821A (ko) | 2008-05-29 | 2009-04-24 | 종양 치료를 위한 티로신 키나아제 조정제로서의 디히드로피라졸 유도체 |
| ES09753600.7T ES2507573T3 (es) | 2008-05-29 | 2009-04-24 | Derivados de dihidropirazol como moduladores de tirosina quinasa para el tratamiento de tumores |
| MX2010012804A MX2010012804A (es) | 2008-05-29 | 2009-04-24 | Derivados de dihidropirazol como moduladores de tirosina cinasa para el tratamiento de tumores. |
| HK11111868.3A HK1157345B (en) | 2008-05-29 | 2009-04-24 | Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors |
| EP09753600.7A EP2300434B1 (de) | 2008-05-29 | 2009-04-24 | Dihydropyrazolderivate als tyrosinkinase modulatoren zur behandlung von tumoren |
| EA201001831A EA018394B1 (ru) | 2008-05-29 | 2009-04-24 | Производные дигидропиразола в качестве модуляторов тирозинкиназы для лечения опухолей |
| AU2009253432A AU2009253432B2 (en) | 2008-05-29 | 2009-04-24 | Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors |
| ARP090101932A AR071951A1 (es) | 2008-05-29 | 2009-05-29 | Derivados de dihidropirazol |
| IL209418A IL209418A (en) | 2008-05-29 | 2010-11-18 | History of benzyl-5,4-dihydropyrazole-1-carboxamide and drugs containing it for the treatment of malignant tumors |
| ZA2010/09085A ZA201009085B (en) | 2008-05-29 | 2010-12-17 | Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102008025750A DE102008025750A1 (de) | 2008-05-29 | 2008-05-29 | Dihydropyrazolderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE102008025750A1 true DE102008025750A1 (de) | 2009-12-03 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE102008025750A Withdrawn DE102008025750A1 (de) | 2008-05-29 | 2008-05-29 | Dihydropyrazolderivate |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8404685B2 (https=) |
| EP (1) | EP2300434B1 (https=) |
| JP (1) | JP5643192B2 (https=) |
| KR (1) | KR20110010821A (https=) |
| CN (1) | CN102046605B (https=) |
| AR (1) | AR071951A1 (https=) |
| AU (1) | AU2009253432B2 (https=) |
| BR (1) | BRPI0912970A2 (https=) |
| CA (1) | CA2726009C (https=) |
| DE (1) | DE102008025750A1 (https=) |
| EA (1) | EA018394B1 (https=) |
| ES (1) | ES2507573T3 (https=) |
| IL (1) | IL209418A (https=) |
| MX (1) | MX2010012804A (https=) |
| WO (1) | WO2009143945A1 (https=) |
| ZA (1) | ZA201009085B (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013006308A2 (en) | 2011-07-01 | 2013-01-10 | Merck Patent Gmbh | Dihydropyrazoles |
| JP6189434B2 (ja) * | 2012-07-10 | 2017-08-30 | アレス トレーディング ソシエテ アノニム | ピリミジンピラゾリル誘導体 |
| CA3121202A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997022596A1 (en) | 1995-12-18 | 1997-06-26 | Zeneca Limited | Quinazoline derivatives |
| WO1997030035A1 (en) | 1996-02-13 | 1997-08-21 | Zeneca Limited | Quinazoline derivatives as vegf inhibitors |
| WO1997032856A1 (en) | 1996-03-05 | 1997-09-12 | Zeneca Limited | 4-anilinoquinazoline derivatives |
| WO1998013354A1 (en) | 1996-09-25 | 1998-04-02 | Zeneca Limited | Quinazoline derivatives and pharmaceutical compositions containing them |
| WO1999002166A1 (en) | 1997-07-08 | 1999-01-21 | Angiogene Pharmaceuticals Ltd. | Use of colchinol derivatives as vascular damaging agents |
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2008
- 2008-05-29 DE DE102008025750A patent/DE102008025750A1/de not_active Withdrawn
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- 2009-04-24 WO PCT/EP2009/003030 patent/WO2009143945A1/de not_active Ceased
- 2009-04-24 AU AU2009253432A patent/AU2009253432B2/en not_active Ceased
- 2009-04-24 CN CN2009801192665A patent/CN102046605B/zh not_active Expired - Fee Related
- 2009-04-24 EA EA201001831A patent/EA018394B1/ru not_active IP Right Cessation
- 2009-04-24 ES ES09753600.7T patent/ES2507573T3/es active Active
- 2009-04-24 BR BRPI0912970A patent/BRPI0912970A2/pt not_active IP Right Cessation
- 2009-04-24 EP EP09753600.7A patent/EP2300434B1/de not_active Not-in-force
- 2009-04-24 CA CA2726009A patent/CA2726009C/en active Active
- 2009-04-24 MX MX2010012804A patent/MX2010012804A/es active IP Right Grant
- 2009-04-24 JP JP2011510855A patent/JP5643192B2/ja not_active Expired - Fee Related
- 2009-04-24 KR KR1020107029265A patent/KR20110010821A/ko not_active Ceased
- 2009-04-24 US US12/993,892 patent/US8404685B2/en not_active Expired - Fee Related
- 2009-05-29 AR ARP090101932A patent/AR071951A1/es unknown
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2010
- 2010-11-18 IL IL209418A patent/IL209418A/en active IP Right Grant
- 2010-12-17 ZA ZA2010/09085A patent/ZA201009085B/en unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| US20110071153A1 (en) | 2011-03-24 |
| WO2009143945A1 (de) | 2009-12-03 |
| MX2010012804A (es) | 2010-12-07 |
| ES2507573T3 (es) | 2014-10-15 |
| IL209418A (en) | 2015-09-24 |
| AU2009253432A1 (en) | 2009-12-03 |
| CN102046605B (zh) | 2013-09-18 |
| EA201001831A1 (ru) | 2011-06-30 |
| ZA201009085B (en) | 2011-10-26 |
| US8404685B2 (en) | 2013-03-26 |
| EA018394B1 (ru) | 2013-07-30 |
| JP2011520996A (ja) | 2011-07-21 |
| CN102046605A (zh) | 2011-05-04 |
| HK1157345A1 (en) | 2012-06-29 |
| AU2009253432B2 (en) | 2013-08-01 |
| KR20110010821A (ko) | 2011-02-07 |
| IL209418A0 (en) | 2011-01-31 |
| EP2300434B1 (de) | 2014-07-23 |
| BRPI0912970A2 (pt) | 2015-10-13 |
| CA2726009A1 (en) | 2009-12-03 |
| JP5643192B2 (ja) | 2014-12-17 |
| CA2726009C (en) | 2016-08-23 |
| AR071951A1 (es) | 2010-07-28 |
| EP2300434A1 (de) | 2011-03-30 |
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