AU2009253432B2 - Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors - Google Patents

Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors Download PDF

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Publication number
AU2009253432B2
AU2009253432B2 AU2009253432A AU2009253432A AU2009253432B2 AU 2009253432 B2 AU2009253432 B2 AU 2009253432B2 AU 2009253432 A AU2009253432 A AU 2009253432A AU 2009253432 A AU2009253432 A AU 2009253432A AU 2009253432 B2 AU2009253432 B2 AU 2009253432B2
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AU
Australia
Prior art keywords
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compound
nhet
formula
het
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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AU2009253432A
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English (en)
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AU2009253432A1 (en
Inventor
Andree Blaukat
Dieter Dorsch
Oliver Schadt
Frank Stieber
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Merck Patent GmbH
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Merck Patent GmbH
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Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of AU2009253432A1 publication Critical patent/AU2009253432A1/en
Application granted granted Critical
Publication of AU2009253432B2 publication Critical patent/AU2009253432B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2009253432A 2008-05-29 2009-04-24 Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors Ceased AU2009253432B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102008025750A DE102008025750A1 (de) 2008-05-29 2008-05-29 Dihydropyrazolderivate
DE102008025750.8 2008-05-29
PCT/EP2009/003030 WO2009143945A1 (de) 2008-05-29 2009-04-24 Dihydropyrazolderivate als tyrosinkinase modulatoren zur behandlung von tumoren

Publications (2)

Publication Number Publication Date
AU2009253432A1 AU2009253432A1 (en) 2009-12-03
AU2009253432B2 true AU2009253432B2 (en) 2013-08-01

Family

ID=40822993

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009253432A Ceased AU2009253432B2 (en) 2008-05-29 2009-04-24 Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors

Country Status (16)

Country Link
US (1) US8404685B2 (https=)
EP (1) EP2300434B1 (https=)
JP (1) JP5643192B2 (https=)
KR (1) KR20110010821A (https=)
CN (1) CN102046605B (https=)
AR (1) AR071951A1 (https=)
AU (1) AU2009253432B2 (https=)
BR (1) BRPI0912970A2 (https=)
CA (1) CA2726009C (https=)
DE (1) DE102008025750A1 (https=)
EA (1) EA018394B1 (https=)
ES (1) ES2507573T3 (https=)
IL (1) IL209418A (https=)
MX (1) MX2010012804A (https=)
WO (1) WO2009143945A1 (https=)
ZA (1) ZA201009085B (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2837524C (en) * 2011-07-01 2019-08-20 Merck Patent Gmbh Dihydropyrazoles
SG11201500005SA (en) * 2012-07-10 2015-01-29 Ares Trading Sa Pyrimidine pyrazolyl derivatives
WO2020113094A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006281700A1 (en) * 2005-08-16 2007-02-22 Merck Patent Gmbh 1-acyldihydropyrazol derivatives

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
BR9707495A (pt) 1996-02-13 1999-07-27 Zeneca Ltd Derivado de quinazolina processo para a preparação do mesmo composição farmacêutica e processo para a produç o de um efeito antiangiogênico e/ou de redução de permeabilidade vascular em um animal de sangue quente
US6291455B1 (en) 1996-03-05 2001-09-18 Zeneca Limited 4-anilinoquinazoline derivatives
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
NZ522074A (en) 2000-05-31 2004-06-25 Astrazeneca Ab Indole derivatives with vascular damaging activity
IL153484A0 (en) 2000-07-07 2003-07-06 Angiogene Pharm Ltd Colchinol derivatives as angiogenesis inhibitors
CN1255392C (zh) 2000-07-07 2006-05-10 安吉奥金尼药品有限公司 作为血管生成抑制剂的秋水仙醇衍生物
EP1492487B1 (en) 2002-03-08 2009-11-11 Merck & Co., Inc. Mitotic kinesin inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006281700A1 (en) * 2005-08-16 2007-02-22 Merck Patent Gmbh 1-acyldihydropyrazol derivatives

Also Published As

Publication number Publication date
ES2507573T3 (es) 2014-10-15
CN102046605A (zh) 2011-05-04
IL209418A0 (en) 2011-01-31
EP2300434A1 (de) 2011-03-30
CA2726009C (en) 2016-08-23
JP5643192B2 (ja) 2014-12-17
EA018394B1 (ru) 2013-07-30
MX2010012804A (es) 2010-12-07
DE102008025750A1 (de) 2009-12-03
AU2009253432A1 (en) 2009-12-03
KR20110010821A (ko) 2011-02-07
CN102046605B (zh) 2013-09-18
US8404685B2 (en) 2013-03-26
IL209418A (en) 2015-09-24
US20110071153A1 (en) 2011-03-24
EA201001831A1 (ru) 2011-06-30
EP2300434B1 (de) 2014-07-23
AR071951A1 (es) 2010-07-28
CA2726009A1 (en) 2009-12-03
ZA201009085B (en) 2011-10-26
WO2009143945A1 (de) 2009-12-03
BRPI0912970A2 (pt) 2015-10-13
HK1157345A1 (en) 2012-06-29
JP2011520996A (ja) 2011-07-21

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired