DE102007061763A1 - Substituierte azabicyclische Verbindungen und ihre Verwendung - Google Patents

Substituierte azabicyclische Verbindungen und ihre Verwendung Download PDF

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Publication number
DE102007061763A1
DE102007061763A1 DE102007061763A DE102007061763A DE102007061763A1 DE 102007061763 A1 DE102007061763 A1 DE 102007061763A1 DE 102007061763 A DE102007061763 A DE 102007061763A DE 102007061763 A DE102007061763 A DE 102007061763A DE 102007061763 A1 DE102007061763 A1 DE 102007061763A1
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Germany
Prior art keywords
alkoxy
group
hydroxy
alkyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
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DE102007061763A
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German (de)
English (en)
Inventor
Alexandros Dr. Vakalopoulos
Peter Dr. Nell
Frank SÜSSMEIER
Barbara Dr. Albrecht-Küpper
Katja Dr. Zimmermann
Jörg Dr. Keldenich
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Bayer AG
Original Assignee
Bayer Healthcare AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare AG filed Critical Bayer Healthcare AG
Priority to DE102007061763A priority Critical patent/DE102007061763A1/de
Priority to EP08864918A priority patent/EP2235011B1/de
Priority to CA2709776A priority patent/CA2709776A1/en
Priority to US12/809,674 priority patent/US8609686B2/en
Priority to PCT/EP2008/010409 priority patent/WO2009080197A1/de
Priority to JP2010538405A priority patent/JP5479360B2/ja
Priority to ES08864918T priority patent/ES2379308T3/es
Priority to AT08864918T priority patent/ATE542819T1/de
Publication of DE102007061763A1 publication Critical patent/DE102007061763A1/de
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE102007061763A 2007-12-20 2007-12-20 Substituierte azabicyclische Verbindungen und ihre Verwendung Withdrawn DE102007061763A1 (de)

Priority Applications (8)

Application Number Priority Date Filing Date Title
DE102007061763A DE102007061763A1 (de) 2007-12-20 2007-12-20 Substituierte azabicyclische Verbindungen und ihre Verwendung
EP08864918A EP2235011B1 (de) 2007-12-20 2008-12-09 Substituierte pyrrolo[2, 3-b]- und pyrazolo[3, 4-b]pyridine als adenosin rezeptor liganden
CA2709776A CA2709776A1 (en) 2007-12-20 2008-12-09 Substituted pyrrolo[2, 3-b] and pyrazolo[3, 4-b] pyridines for use as adenosine receptor ligands
US12/809,674 US8609686B2 (en) 2007-12-20 2008-12-09 Substituted azabicyclic compounds and the use thereof
PCT/EP2008/010409 WO2009080197A1 (de) 2007-12-20 2008-12-09 Substituierte pyrrolo[2, 3-b]- und pyrazolo[3, 4-b] pyridine als adenosin rezeptor liganden
JP2010538405A JP5479360B2 (ja) 2007-12-20 2008-12-09 置換アザ二環式化合物およびそれらの使用
ES08864918T ES2379308T3 (es) 2007-12-20 2008-12-09 Pirrolo[2,3-B]- y pirazolo[3,4-B]piridinas sustituidas como ligandos del receptor de adenosina
AT08864918T ATE542819T1 (de) 2007-12-20 2008-12-09 Substituierte pyrroloä2, 3-bü- und pyrazoloä3, 4- büpyridine als adenosin rezeptor liganden

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102007061763A DE102007061763A1 (de) 2007-12-20 2007-12-20 Substituierte azabicyclische Verbindungen und ihre Verwendung

Publications (1)

Publication Number Publication Date
DE102007061763A1 true DE102007061763A1 (de) 2009-06-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
DE102007061763A Withdrawn DE102007061763A1 (de) 2007-12-20 2007-12-20 Substituierte azabicyclische Verbindungen und ihre Verwendung

Country Status (8)

Country Link
US (1) US8609686B2 (ja)
EP (1) EP2235011B1 (ja)
JP (1) JP5479360B2 (ja)
AT (1) ATE542819T1 (ja)
CA (1) CA2709776A1 (ja)
DE (1) DE102007061763A1 (ja)
ES (1) ES2379308T3 (ja)
WO (1) WO2009080197A1 (ja)

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DE102007035367A1 (de) * 2007-07-27 2009-01-29 Bayer Healthcare Ag Substituierte Aryloxazole und ihre Verwendung
DE102007061764A1 (de) * 2007-12-20 2009-06-25 Bayer Healthcare Ag Anellierte Cyanopyridine und ihre Verwendung
DE102009006602A1 (de) * 2009-01-29 2010-08-05 Bayer Schering Pharma Aktiengesellschaft Alkylamino-substituierte Dicyanopyridine und deren Aminosäureester-Prodrugs
DE102010030688A1 (de) * 2010-06-30 2012-01-05 Bayer Schering Pharma Aktiengesellschaft Substituierte Dicyanopyridine und ihre Verwendung
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP3569596A4 (en) 2017-01-13 2020-08-26 Jiangsu Hengrui Medicine Co. Ltd. 1,2,4-TRIAZINE-3-AMINE DERIVATIVE, PROCESS OF PREPARATION AND USE IN MEDICINE
WO2018153898A1 (de) 2017-02-22 2018-08-30 Bayer Pharma Aktiengesellschaft Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit mineralocorticoid-rezeptor-antagonisten
WO2018153900A1 (de) 2017-02-22 2018-08-30 Bayer Aktiengesellschaft Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit sglt-2-hemmern
WO2018153895A1 (de) 2017-02-22 2018-08-30 Bayer Pharma Aktiengesellschaft Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit einem inhibitor der neutralen endopeptidase und/oder einem angiotensin ii rezeptor-antagonisten
WO2018153899A1 (de) 2017-02-22 2018-08-30 Bayer Pharma Aktiengesellschaft Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit stimulatoren und/oder aktivatoren der löslichen guanylatcyclase (sgc)
WO2018153897A1 (de) 2017-02-22 2018-08-30 Bayer Pharma Aktiengesellschaft Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit hcn-kanal-hemmern
CN108467386B (zh) * 2017-02-23 2020-11-17 江苏恒瑞医药股份有限公司 稠杂芳基取代的1,2,4-三嗪-3-胺类衍生物、其制备方法及其在医药上的应用
WO2018166493A1 (zh) 2017-03-16 2018-09-20 江苏恒瑞医药股份有限公司 杂芳基并[4，3-c]嘧啶-5-胺类衍生物、其制备方法及其在医药上的应用
WO2019154294A1 (zh) 2018-02-06 2019-08-15 江苏恒瑞医药股份有限公司 吡唑并[1,5-a][1,3,5]三嗪-2-胺类衍生物、其制备方法及其在医药上的应用

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