DE102006058424A1 - Quantifizierung von Probeneigenschaften unter Nutzung von Kontrastverstärkung bei Sättigungstransfer - Google Patents
Quantifizierung von Probeneigenschaften unter Nutzung von Kontrastverstärkung bei Sättigungstransfer Download PDFInfo
- Publication number
- DE102006058424A1 DE102006058424A1 DE102006058424A DE102006058424A DE102006058424A1 DE 102006058424 A1 DE102006058424 A1 DE 102006058424A1 DE 102006058424 A DE102006058424 A DE 102006058424A DE 102006058424 A DE102006058424 A DE 102006058424A DE 102006058424 A1 DE102006058424 A1 DE 102006058424A1
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- Germany
- Prior art keywords
- cest
- patient
- magnetization
- resonance
- field strength
- Prior art date
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- 238000012546 transfer Methods 0.000 title description 7
- 238000011002 quantification Methods 0.000 title description 4
- 238000000034 method Methods 0.000 claims abstract description 22
- 238000001727 in vivo Methods 0.000 claims abstract description 9
- 238000003384 imaging method Methods 0.000 claims abstract description 7
- 230000005415 magnetization Effects 0.000 claims description 107
- 239000003795 chemical substances by application Substances 0.000 claims description 70
- 238000012545 processing Methods 0.000 claims description 19
- 238000005259 measurement Methods 0.000 claims description 18
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/4804—Spatially selective measurement of temperature or pH
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/483—NMR imaging systems with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5605—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution by transferring coherence or polarization from a spin species to another, e.g. creating magnetization transfer contrast [MTC], polarization transfer using nuclear Overhauser enhancement [NOE]
Landscapes
- Physics & Mathematics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- High Energy & Nuclear Physics (AREA)
- Health & Medical Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Optics & Photonics (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Engineering & Computer Science (AREA)
- Signal Processing (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/297,263 | 2005-12-08 | ||
| US11/297,263 US7610077B2 (en) | 2005-12-08 | 2005-12-08 | Quantitation of sample properties using contrast enhancement from saturation transfer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE102006058424A1 true DE102006058424A1 (de) | 2007-07-19 |
Family
ID=38139589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE102006058424A Withdrawn DE102006058424A1 (de) | 2005-12-08 | 2006-12-08 | Quantifizierung von Probeneigenschaften unter Nutzung von Kontrastverstärkung bei Sättigungstransfer |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US7610077B2 (enExample) |
| JP (1) | JP5193460B2 (enExample) |
| DE (1) | DE102006058424A1 (enExample) |
| NL (1) | NL1033025C2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8463358B2 (en) * | 2006-06-09 | 2013-06-11 | Koninklijke Philips Electronics N.V. | Elimination of contrast agent concentration dependency in MRI |
| EP2205986B1 (en) * | 2007-09-26 | 2013-07-03 | The Johns Hopkins University | Frequency referencing for chemical exchange saturation transfer (cest) mri |
| US8278925B2 (en) * | 2008-03-26 | 2012-10-02 | The General Hospital Corporation | Method for relaxation-compensated fast multi-slice chemical exchange saturation transfer MRI |
| US8742755B2 (en) * | 2008-04-09 | 2014-06-03 | Beth Israel Deaconess Medical Center, Inc. | Positive magnetic resonance imaging contrast methods and apparatus using chemical exchange saturation transfer |
| CN102132169B (zh) * | 2008-08-26 | 2015-07-22 | 伯拉考成像股份公司 | 基于非即时分析的mri-cest诊断技术 |
| US8686727B2 (en) * | 2010-07-20 | 2014-04-01 | The Trustees Of The University Of Pennsylvania | CEST MRI methods for imaging of metabolites and the use of same as biomarkers |
| WO2013082137A1 (en) * | 2011-11-28 | 2013-06-06 | New York University | Apparatus, system, method and computer-readable medium for isolating chemical exchange saturation transfer contrast from magnetization transfer asymmetry under two-frequency rf irradiation |
| US9335393B2 (en) | 2012-09-13 | 2016-05-10 | Siemens Medical Solutions Usa, Inc. | MR parallel imaging system reducing imaging time |
| WO2014165719A1 (en) * | 2013-04-05 | 2014-10-09 | The Trustees Of The University Of Pennsylvania | Non-invasive imaging of tissue redox state by mri |
| US10267881B2 (en) | 2014-12-18 | 2019-04-23 | The Johns Hopkins University | Multi-echo parametric variation saturation (MePaVARS CEST imaging and other MR imaging |
| JP7038671B2 (ja) * | 2016-06-08 | 2022-03-18 | シーダーズ－サイナイ メディカル センター | 定量的化学交換飽和移動（ｑＣＥＳＴ）を用いた非侵襲性のｐＨ依存的イメージング |
| CN111722167B (zh) * | 2019-03-19 | 2021-07-30 | 浙江大学 | 化学交换饱和转移-磁共振成像cest-mri序列生成方法、装置及可读存储介质 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4656400A (en) * | 1999-04-21 | 2000-11-17 | Government of The United States of America, as represented by The Secretary Department of Health & Human Services, The National Institutes of Health, The | Method for enhancing contrast produced by mri |
| EP1331012A1 (en) | 2002-01-29 | 2003-07-30 | BRACCO IMAGING S.p.A. | Responsive paramagnetic MRI contrast agents |
| US8639542B2 (en) * | 2002-06-27 | 2014-01-28 | Siebel Systems, Inc. | Method and apparatus to facilitate development of a customer-specific business process model |
| EP1793868B1 (en) * | 2004-09-23 | 2010-12-29 | Guerbet | Liposomal contrast agents for cest imaging |
| CN101166988B (zh) * | 2005-04-26 | 2012-06-13 | 皇家飞利浦电子股份有限公司 | 改进对mri对比增强的检测的方法和设备 |
| EP1889086B1 (en) * | 2005-04-26 | 2010-01-13 | Koninklijke Philips Electronics N.V. | Method for using cest contrast agents in mri |
-
2005
- 2005-12-08 US US11/297,263 patent/US7610077B2/en not_active Expired - Fee Related
-
2006
- 2006-12-08 NL NL1033025A patent/NL1033025C2/nl not_active IP Right Cessation
- 2006-12-08 DE DE102006058424A patent/DE102006058424A1/de not_active Withdrawn
- 2006-12-08 JP JP2006332426A patent/JP5193460B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NL1033025C2 (nl) | 2010-05-21 |
| NL1033025A1 (nl) | 2007-06-11 |
| JP5193460B2 (ja) | 2013-05-08 |
| US7610077B2 (en) | 2009-10-27 |
| JP2007152128A (ja) | 2007-06-21 |
| US20070134159A1 (en) | 2007-06-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R012 | Request for examination validly filed |
Effective date: 20131031 |
|
| R119 | Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee |