DE102006058424A1 - Quantifizierung von Probeneigenschaften unter Nutzung von Kontrastverstärkung bei Sättigungstransfer - Google Patents
Quantifizierung von Probeneigenschaften unter Nutzung von Kontrastverstärkung bei Sättigungstransfer Download PDFInfo
- Publication number
- DE102006058424A1 DE102006058424A1 DE102006058424A DE102006058424A DE102006058424A1 DE 102006058424 A1 DE102006058424 A1 DE 102006058424A1 DE 102006058424 A DE102006058424 A DE 102006058424A DE 102006058424 A DE102006058424 A DE 102006058424A DE 102006058424 A1 DE102006058424 A1 DE 102006058424A1
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- Germany
- Prior art keywords
- cest
- patient
- magnetization
- resonance
- field strength
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000012546 transfer Methods 0.000 title description 7
- 238000011002 quantification Methods 0.000 title description 4
- 238000000034 method Methods 0.000 claims abstract description 22
- 238000001727 in vivo Methods 0.000 claims abstract description 9
- 238000003384 imaging method Methods 0.000 claims abstract description 7
- 230000005415 magnetization Effects 0.000 claims description 107
- 239000003795 chemical substances by application Substances 0.000 claims description 70
- 238000012545 processing Methods 0.000 claims description 19
- 238000005259 measurement Methods 0.000 claims description 18
- 230000005291 magnetic effect Effects 0.000 claims description 15
- 239000002872 contrast media Substances 0.000 claims description 12
- 238000010606 normalization Methods 0.000 claims description 10
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- 238000004590 computer program Methods 0.000 claims description 8
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- 238000003780 insertion Methods 0.000 claims description 3
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- 238000002595 magnetic resonance imaging Methods 0.000 claims 3
- 238000005481 NMR spectroscopy Methods 0.000 claims 2
- 238000000701 chemical imaging Methods 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
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- 238000001208 nuclear magnetic resonance pulse sequence Methods 0.000 description 2
- 238000012935 Averaging Methods 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/4804—Spatially selective measurement of temperature or pH
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/483—NMR imaging systems with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5605—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution by transferring coherence or polarization from a spin species to another, e.g. creating magnetization transfer contrast [MTC], polarization transfer using nuclear Overhauser enhancement [NOE]
Landscapes
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- High Energy & Nuclear Physics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Engineering & Computer Science (AREA)
- Signal Processing (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Optics & Photonics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/297,263 US7610077B2 (en) | 2005-12-08 | 2005-12-08 | Quantitation of sample properties using contrast enhancement from saturation transfer |
| US11/297,263 | 2005-12-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE102006058424A1 true DE102006058424A1 (de) | 2007-07-19 |
Family
ID=38139589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE102006058424A Withdrawn DE102006058424A1 (de) | 2005-12-08 | 2006-12-08 | Quantifizierung von Probeneigenschaften unter Nutzung von Kontrastverstärkung bei Sättigungstransfer |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US7610077B2 (enExample) |
| JP (1) | JP5193460B2 (enExample) |
| DE (1) | DE102006058424A1 (enExample) |
| NL (1) | NL1033025C2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0712326A2 (pt) * | 2006-06-09 | 2012-01-10 | Koninkl Philips Electronics Nv | método para a obtenção de informação relativa ao parámetro fìsico-quìmico através da formação de imagens mri depois da administração a um paciente de um agente de contraste, produto de programa de computador, dispositivo de armazenagem dos dados legìveis por máquina, sistema para formação de imagem mri para uso com agente de contraste, agente de contraste, e, preparação |
| US8536866B2 (en) * | 2007-09-26 | 2013-09-17 | The Johns Hopkins University | Frequency referencing for chemical exchange saturation transfer (CEST) MRI |
| US8278925B2 (en) * | 2008-03-26 | 2012-10-02 | The General Hospital Corporation | Method for relaxation-compensated fast multi-slice chemical exchange saturation transfer MRI |
| WO2009126289A2 (en) * | 2008-04-09 | 2009-10-15 | Beth Israel Deaconess Medical Center, Inc. | Positive magnetic resonance imaging contrast methods and apparatus using chemical exchange saturation transfer |
| WO2010023132A1 (en) * | 2008-08-26 | 2010-03-04 | Bracco Imaging S.P.A. | Mri-cest diagnostic technique based on non-punctual analysis |
| US8686727B2 (en) * | 2010-07-20 | 2014-04-01 | The Trustees Of The University Of Pennsylvania | CEST MRI methods for imaging of metabolites and the use of same as biomarkers |
| US9709511B2 (en) * | 2011-11-28 | 2017-07-18 | New York University | Apparatus, system, method and computer-readable medium for isolating chemical exchange saturation transfer contrast from magnetization transfer asymmetry under two-frequency RF irradiation |
| US9335393B2 (en) | 2012-09-13 | 2016-05-10 | Siemens Medical Solutions Usa, Inc. | MR parallel imaging system reducing imaging time |
| US10791989B2 (en) | 2013-04-05 | 2020-10-06 | The Trustees Of The University Of Pennsylvania | Magnetic resonance imaging of poly-L-glutamate |
| US10267881B2 (en) | 2014-12-18 | 2019-04-23 | The Johns Hopkins University | Multi-echo parametric variation saturation (MePaVARS CEST imaging and other MR imaging |
| JP7038671B2 (ja) * | 2016-06-08 | 2022-03-18 | シーダーズ－サイナイ メディカル センター | 定量的化学交換飽和移動（ｑＣＥＳＴ）を用いた非侵襲性のｐＨ依存的イメージング |
| CN111722167B (zh) * | 2019-03-19 | 2021-07-30 | 浙江大学 | 化学交换饱和转移-磁共振成像cest-mri序列生成方法、装置及可读存储介质 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1178837A2 (en) * | 1999-04-21 | 2002-02-13 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Method for enhancing contrast produced by mri |
| EP1331012A1 (en) * | 2002-01-29 | 2003-07-30 | BRACCO IMAGING S.p.A. | Responsive paramagnetic MRI contrast agents |
| US8639542B2 (en) * | 2002-06-27 | 2014-01-28 | Siebel Systems, Inc. | Method and apparatus to facilitate development of a customer-specific business process model |
| WO2006032705A2 (en) * | 2004-09-23 | 2006-03-30 | Guerbet | Contrast agents encapsulating systems for cest imaging |
| US8306603B2 (en) * | 2005-04-26 | 2012-11-06 | Koninklijke Philips Electronics N.V. | MRI involving contrast agent with time modulated contrast enhancement |
| DE602006011736D1 (de) * | 2005-04-26 | 2010-03-04 | Koninkl Philips Electronics Nv | Verfahren zur verwendung von cest-kontrastmitteln bei der magnetresonanztomographie |
-
2005
- 2005-12-08 US US11/297,263 patent/US7610077B2/en not_active Expired - Fee Related
-
2006
- 2006-12-08 JP JP2006332426A patent/JP5193460B2/ja not_active Expired - Fee Related
- 2006-12-08 DE DE102006058424A patent/DE102006058424A1/de not_active Withdrawn
- 2006-12-08 NL NL1033025A patent/NL1033025C2/nl not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007152128A (ja) | 2007-06-21 |
| NL1033025A1 (nl) | 2007-06-11 |
| NL1033025C2 (nl) | 2010-05-21 |
| US20070134159A1 (en) | 2007-06-14 |
| US7610077B2 (en) | 2009-10-27 |
| JP5193460B2 (ja) | 2013-05-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R012 | Request for examination validly filed |
Effective date: 20131031 |
|
| R119 | Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee |