NL1033025C2 - Kwantificering van monstereigenschappen onder gebruikmaking van contrastverbetering uit verzadigingsoverdracht. - Google Patents
Kwantificering van monstereigenschappen onder gebruikmaking van contrastverbetering uit verzadigingsoverdracht. Download PDFInfo
- Publication number
- NL1033025C2 NL1033025C2 NL1033025A NL1033025A NL1033025C2 NL 1033025 C2 NL1033025 C2 NL 1033025C2 NL 1033025 A NL1033025 A NL 1033025A NL 1033025 A NL1033025 A NL 1033025A NL 1033025 C2 NL1033025 C2 NL 1033025C2
- Authority
- NL
- Netherlands
- Prior art keywords
- cest
- subject
- resonant
- magnetization
- strength
- Prior art date
Links
- 238000012546 transfer Methods 0.000 title description 7
- 238000011002 quantification Methods 0.000 title description 5
- 238000005070 sampling Methods 0.000 title 1
- 230000005415 magnetization Effects 0.000 claims description 107
- 239000002872 contrast media Substances 0.000 claims description 70
- 238000000034 method Methods 0.000 claims description 29
- 230000001678 irradiating effect Effects 0.000 claims description 27
- 230000005291 magnetic effect Effects 0.000 claims description 15
- 230000008859 change Effects 0.000 claims description 13
- 238000005259 measurement Methods 0.000 claims description 12
- 238000001727 in vivo Methods 0.000 claims description 7
- 239000000126 substance Substances 0.000 claims description 7
- 238000003384 imaging method Methods 0.000 claims description 6
- 238000012545 processing Methods 0.000 claims description 6
- 230000003068 static effect Effects 0.000 claims description 2
- 238000005481 NMR spectroscopy Methods 0.000 claims 2
- 238000002595 magnetic resonance imaging Methods 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000000701 chemical imaging Methods 0.000 claims 1
- 238000013507 mapping Methods 0.000 claims 1
- 230000006870 function Effects 0.000 description 18
- 230000000694 effects Effects 0.000 description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 230000008569 process Effects 0.000 description 12
- 238000004590 computer program Methods 0.000 description 11
- 238000010586 diagram Methods 0.000 description 7
- 230000005284 excitation Effects 0.000 description 6
- 238000012986 modification Methods 0.000 description 5
- 230000004048 modification Effects 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 230000001419 dependent effect Effects 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- 230000003321 amplification Effects 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- 238000001208 nuclear magnetic resonance pulse sequence Methods 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 238000012935 Averaging Methods 0.000 description 1
- 208000031872 Body Remains Diseases 0.000 description 1
- 238000013494 PH determination Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 229940039231 contrast media Drugs 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
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- 238000004519 manufacturing process Methods 0.000 description 1
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- 239000013307 optical fiber Substances 0.000 description 1
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- 238000007493 shaping process Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/4804—Spatially selective measurement of temperature or pH
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/483—NMR imaging systems with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5605—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution by transferring coherence or polarization from a spin species to another, e.g. creating magnetization transfer contrast [MTC], polarization transfer using nuclear Overhauser enhancement [NOE]
Landscapes
- Physics & Mathematics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- High Energy & Nuclear Physics (AREA)
- Health & Medical Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Optics & Photonics (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Engineering & Computer Science (AREA)
- Signal Processing (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/297,263 US7610077B2 (en) | 2005-12-08 | 2005-12-08 | Quantitation of sample properties using contrast enhancement from saturation transfer |
| US29726305 | 2005-12-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NL1033025A1 NL1033025A1 (nl) | 2007-06-11 |
| NL1033025C2 true NL1033025C2 (nl) | 2010-05-21 |
Family
ID=38139589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL1033025A NL1033025C2 (nl) | 2005-12-08 | 2006-12-08 | Kwantificering van monstereigenschappen onder gebruikmaking van contrastverbetering uit verzadigingsoverdracht. |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US7610077B2 (enExample) |
| JP (1) | JP5193460B2 (enExample) |
| DE (1) | DE102006058424A1 (enExample) |
| NL (1) | NL1033025C2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0712326A2 (pt) * | 2006-06-09 | 2012-01-10 | Koninkl Philips Electronics Nv | método para a obtenção de informação relativa ao parámetro fìsico-quìmico através da formação de imagens mri depois da administração a um paciente de um agente de contraste, produto de programa de computador, dispositivo de armazenagem dos dados legìveis por máquina, sistema para formação de imagem mri para uso com agente de contraste, agente de contraste, e, preparação |
| EP2205986B1 (en) * | 2007-09-26 | 2013-07-03 | The Johns Hopkins University | Frequency referencing for chemical exchange saturation transfer (cest) mri |
| US8278925B2 (en) * | 2008-03-26 | 2012-10-02 | The General Hospital Corporation | Method for relaxation-compensated fast multi-slice chemical exchange saturation transfer MRI |
| WO2009126289A2 (en) * | 2008-04-09 | 2009-10-15 | Beth Israel Deaconess Medical Center, Inc. | Positive magnetic resonance imaging contrast methods and apparatus using chemical exchange saturation transfer |
| WO2010023132A1 (en) * | 2008-08-26 | 2010-03-04 | Bracco Imaging S.P.A. | Mri-cest diagnostic technique based on non-punctual analysis |
| US8686727B2 (en) * | 2010-07-20 | 2014-04-01 | The Trustees Of The University Of Pennsylvania | CEST MRI methods for imaging of metabolites and the use of same as biomarkers |
| WO2013082137A1 (en) * | 2011-11-28 | 2013-06-06 | New York University | Apparatus, system, method and computer-readable medium for isolating chemical exchange saturation transfer contrast from magnetization transfer asymmetry under two-frequency rf irradiation |
| US9335393B2 (en) | 2012-09-13 | 2016-05-10 | Siemens Medical Solutions Usa, Inc. | MR parallel imaging system reducing imaging time |
| WO2014165766A1 (en) * | 2013-04-05 | 2014-10-09 | The Trustees Of The University Of Pennsylvania | Quantification of in vivo metabolite |
| US10267881B2 (en) | 2014-12-18 | 2019-04-23 | The Johns Hopkins University | Multi-echo parametric variation saturation (MePaVARS CEST imaging and other MR imaging |
| JP7038671B2 (ja) * | 2016-06-08 | 2022-03-18 | シーダーズ－サイナイ メディカル センター | 定量的化学交換飽和移動（ｑＣＥＳＴ）を用いた非侵襲性のｐＨ依存的イメージング |
| CN111722167B (zh) * | 2019-03-19 | 2021-07-30 | 浙江大学 | 化学交换饱和转移-磁共振成像cest-mri序列生成方法、装置及可读存储介质 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000066180A2 (en) * | 1999-04-21 | 2000-11-09 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The National Institutes Of Health | Method for enhancing contrast produced by mri |
| EP1331012A1 (en) * | 2002-01-29 | 2003-07-30 | BRACCO IMAGING S.p.A. | Responsive paramagnetic MRI contrast agents |
| WO2006114739A2 (en) * | 2005-04-26 | 2006-11-02 | Koninklijke Philips Electronics N.V. | Method for using cest contrast agents in mri |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8639542B2 (en) * | 2002-06-27 | 2014-01-28 | Siebel Systems, Inc. | Method and apparatus to facilitate development of a customer-specific business process model |
| US20070292354A1 (en) * | 2004-09-23 | 2007-12-20 | Guerbet | Contrast Agents Encapsulating Systems for Cest Imaging |
| US8306603B2 (en) * | 2005-04-26 | 2012-11-06 | Koninklijke Philips Electronics N.V. | MRI involving contrast agent with time modulated contrast enhancement |
-
2005
- 2005-12-08 US US11/297,263 patent/US7610077B2/en not_active Expired - Fee Related
-
2006
- 2006-12-08 NL NL1033025A patent/NL1033025C2/nl not_active IP Right Cessation
- 2006-12-08 JP JP2006332426A patent/JP5193460B2/ja not_active Expired - Fee Related
- 2006-12-08 DE DE102006058424A patent/DE102006058424A1/de not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000066180A2 (en) * | 1999-04-21 | 2000-11-09 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The National Institutes Of Health | Method for enhancing contrast produced by mri |
| EP1331012A1 (en) * | 2002-01-29 | 2003-07-30 | BRACCO IMAGING S.p.A. | Responsive paramagnetic MRI contrast agents |
| WO2006114739A2 (en) * | 2005-04-26 | 2006-11-02 | Koninklijke Philips Electronics N.V. | Method for using cest contrast agents in mri |
Non-Patent Citations (5)
| Title |
|---|
| LEPAGE M ET AL: "Proton chemical exchange saturation transfer using off-resonance rf pulses", PROCEEDINGS OF THE INTERNATIONAL SOCIETY FOR MAGNETIC RESONANCE IN MEDICINE, 10TH SCIENTIFIC MEETING AND EXHIBITION, HONOLULU, HAWAII, USA, 18-24 MAY 2002, 18 May 2002 (2002-05-18), pages 2281, XP002565447 * |
| MCMAHON MT ET AL: "Quantifying exchange rates in CEST agents using saturation time and saturation power dependencies of the magnetization transfer effect (QUEST and QUESP)", PROCEEDINGS OF THE INTERNATIONAL SOCIETY FOR MAGNETIC RESONANCE IN MEDICINE, 13TH SCIENTIFIC MEETING AND EXHIBITION, MIAMI BEACH, FLORIDA, USA, 7-13 MAY 2005, 7 May 2005 (2005-05-07), pages 172, XP002565445 * |
| MCMAHON MT ET AL: "Quantifying exchange rates in chemical exchange saturation transfer agents using the saturation time and saturation power dependencies of the magnetization transfer effect on the magnetic resonance imaging signal (QUEST and QUESP): pH calibration for poly-l-lysine and a starburst dendrimer", MAGNETIC RESONANCE IN MEDICINE, ACADEMIC PRESS, DULUTH, MN, US, vol. 55, 27 February 2006 (2006-02-27), pages 836 - 847, XP002565446 * |
| SUN P Z ET AL: "Optimization of the irradiation power in chemical exchange dependent saturation transfer experiments", JOURNAL OF MAGNETIC RESONANCE, ACADEMIC PRESS, ORLANDO, FL, US, vol. 175, no. 2, 1 August 2005 (2005-08-01), pages 193 - 200, XP004953623, ISSN: 1090-7807 * |
| VINOGRADOV ET AL: "On-resonance low B1 pulses for imaging of the effects of PARACEST agents", JOURNAL OF MAGNETIC RESONANCE, ACADEMIC PRESS, ORLANDO, FL, US, vol. 176, no. 1, 1 September 2005 (2005-09-01), pages 54 - 63, XP005051942, ISSN: 1090-7807 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US7610077B2 (en) | 2009-10-27 |
| JP5193460B2 (ja) | 2013-05-08 |
| JP2007152128A (ja) | 2007-06-21 |
| US20070134159A1 (en) | 2007-06-14 |
| NL1033025A1 (nl) | 2007-06-11 |
| DE102006058424A1 (de) | 2007-07-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AD1A | A request for search or an international type search has been filed | ||
| RD2N | Patents in respect of which a decision has been taken or a report has been made (novelty report) |
Effective date: 20100318 |
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| V1 | Lapsed because of non-payment of the annual fee |
Effective date: 20150701 |
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| V1 | Lapsed because of non-payment of the annual fee |
Effective date: 20150701 |