DE102006027227A1 - Verfahren und Vorrichtung zum Inaktivieren von Viren und/oder Bakterien in flüssigen Medien, insbesondere in Blutplasmen und Serumkonserven - Google Patents
Verfahren und Vorrichtung zum Inaktivieren von Viren und/oder Bakterien in flüssigen Medien, insbesondere in Blutplasmen und Serumkonserven Download PDFInfo
- Publication number
- DE102006027227A1 DE102006027227A1 DE102006027227A DE102006027227A DE102006027227A1 DE 102006027227 A1 DE102006027227 A1 DE 102006027227A1 DE 102006027227 A DE102006027227 A DE 102006027227A DE 102006027227 A DE102006027227 A DE 102006027227A DE 102006027227 A1 DE102006027227 A1 DE 102006027227A1
- Authority
- DE
- Germany
- Prior art keywords
- ultrasound
- medium
- light
- containers
- irradiated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 210000002381 plasma Anatomy 0.000 title claims abstract description 34
- 241000700605 Viruses Species 0.000 title claims abstract description 30
- 238000000034 method Methods 0.000 title claims abstract description 29
- 239000007788 liquid Substances 0.000 title claims abstract description 21
- 241000894006 Bacteria Species 0.000 title claims abstract description 15
- 230000000415 inactivating effect Effects 0.000 title claims abstract description 7
- 210000002966 serum Anatomy 0.000 title claims abstract description 6
- 238000002604 ultrasonography Methods 0.000 claims abstract description 34
- 230000001681 protective effect Effects 0.000 claims abstract description 21
- 239000000463 material Substances 0.000 claims abstract description 10
- 239000007789 gas Substances 0.000 claims description 34
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 6
- 239000011261 inert gas Substances 0.000 claims description 6
- 239000001301 oxygen Substances 0.000 claims description 6
- 229910052760 oxygen Inorganic materials 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 229920006395 saturated elastomer Polymers 0.000 claims description 4
- 230000001678 irradiating effect Effects 0.000 claims description 3
- 230000035939 shock Effects 0.000 abstract description 3
- 210000004369 blood Anatomy 0.000 description 18
- 239000008280 blood Substances 0.000 description 18
- 230000002779 inactivation Effects 0.000 description 16
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 description 5
- 229960000907 methylthioninium chloride Drugs 0.000 description 5
- GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical compound [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 241000125945 Protoparvovirus Species 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 208000030507 AIDS Diseases 0.000 description 2
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 241000702619 Porcine parvovirus Species 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000010836 blood and blood product Substances 0.000 description 2
- 229940125691 blood product Drugs 0.000 description 2
- 238000001311 chemical methods and process Methods 0.000 description 2
- 239000000306 component Substances 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 239000001272 nitrous oxide Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- ZCCUUQDIBDJBTK-UHFFFAOYSA-N psoralen Chemical compound C1=C2OC(=O)C=CC2=CC2=C1OC=C2 ZCCUUQDIBDJBTK-UHFFFAOYSA-N 0.000 description 2
- 238000009210 therapy by ultrasound Methods 0.000 description 2
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- FERWCFYKULABCE-UHFFFAOYSA-N 3-(2-aminoethoxymethyl)-2,5,9-trimethylfuro[3,2-g]chromen-7-one Chemical compound O1C(=O)C=C(C)C2=C1C(C)=C1OC(C)=C(COCCN)C1=C2 FERWCFYKULABCE-UHFFFAOYSA-N 0.000 description 1
- VXGRJERITKFWPL-UHFFFAOYSA-N 4',5'-Dihydropsoralen Natural products C1=C2OC(=O)C=CC2=CC2=C1OCC2 VXGRJERITKFWPL-UHFFFAOYSA-N 0.000 description 1
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 229950004267 amotosalen Drugs 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 239000003114 blood coagulation factor Substances 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 239000004023 fresh frozen plasma Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 231100000219 mutagenic Toxicity 0.000 description 1
- 230000003505 mutagenic effect Effects 0.000 description 1
- 238000001728 nano-filtration Methods 0.000 description 1
- 229910052756 noble gas Inorganic materials 0.000 description 1
- 150000002835 noble gases Chemical class 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 238000009928 pasteurization Methods 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000012956 testing procedure Methods 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/025—Ultrasonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
- A61L2/10—Ultraviolet radiation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- External Artificial Organs (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006027227A DE102006027227A1 (de) | 2006-06-12 | 2006-06-12 | Verfahren und Vorrichtung zum Inaktivieren von Viren und/oder Bakterien in flüssigen Medien, insbesondere in Blutplasmen und Serumkonserven |
| EP07764355A EP2032174A2 (fr) | 2006-06-12 | 2007-06-11 | Procédé et dispositif d'inactivation de virus et/ou de bactéries dans des milieux liquides, en particulier dans le plasma sanguin et/ou le sérum conservé |
| PCT/DE2007/001021 WO2007143971A2 (fr) | 2006-06-12 | 2007-06-11 | Procédé et dispositif d'inactivation de virus et/ou de bactéries dans des milieux liquides, en particulier dans le plasma sanguin et/ou le sérum conservé |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006027227A DE102006027227A1 (de) | 2006-06-12 | 2006-06-12 | Verfahren und Vorrichtung zum Inaktivieren von Viren und/oder Bakterien in flüssigen Medien, insbesondere in Blutplasmen und Serumkonserven |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE102006027227A1 true DE102006027227A1 (de) | 2008-01-03 |
Family
ID=38610944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE102006027227A Withdrawn DE102006027227A1 (de) | 2006-06-12 | 2006-06-12 | Verfahren und Vorrichtung zum Inaktivieren von Viren und/oder Bakterien in flüssigen Medien, insbesondere in Blutplasmen und Serumkonserven |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP2032174A2 (fr) |
| DE (1) | DE102006027227A1 (fr) |
| WO (1) | WO2007143971A2 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL1039050C2 (en) * | 2011-09-19 | 2013-03-21 | Stichting Wetsus Ct Excellence Sustainable Water Technology | Device and method for a uv disinfection reactor. |
| WO2013067041A1 (fr) | 2011-11-01 | 2013-05-10 | Indrani Deo | Buse de distribution muni d'un dispositif d'activation à ultrasons |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1264688B (de) * | 1961-05-01 | 1968-03-28 | Bendix Corp | Verfahren zur Reinigung und Sterilisation von bakterienverseuchten Gegenstaenden |
| DE3943590C2 (de) * | 1989-02-08 | 1995-05-24 | Bran & Luebbe | Anlage zur Inaktivierung von in Flüssigkeiten befindlichen Viren |
| US5370740A (en) * | 1993-10-01 | 1994-12-06 | Hughes Aircraft Company | Chemical decomposition by sonication in liquid carbon dioxide |
| DE10104558C1 (de) * | 2001-02-01 | 2002-06-06 | Axel Stemberger | Verfahren zur Inaktivierung von Bakterien und Viren |
| AU2002306757B2 (en) | 2002-04-12 | 2009-07-02 | Throwleigh Technologies, L.L.C. | Methods and apparatus for decontaminating fluids |
| DE60311135T2 (de) * | 2002-11-04 | 2008-01-31 | Ashland Licensing And Intellectual Property Llc. | Vorrichtung und verfahren zur behandlung eines flüssigen mediums mittels ultraschall zur verhinderung des wachstums von hyperproliferativen oder infizierten zellen |
-
2006
- 2006-06-12 DE DE102006027227A patent/DE102006027227A1/de not_active Withdrawn
-
2007
- 2007-06-11 WO PCT/DE2007/001021 patent/WO2007143971A2/fr active Application Filing
- 2007-06-11 EP EP07764355A patent/EP2032174A2/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007143971A3 (fr) | 2009-03-05 |
| WO2007143971A2 (fr) | 2007-12-21 |
| EP2032174A2 (fr) | 2009-03-11 |
| WO2007143971A9 (fr) | 2012-02-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AT390734B (de) | Vorrichtung zum abtoeten bzw. inaktivieren von eiweiss- bzw. nukleinsaeurehaeltigen organismen | |
| EP1968652B1 (fr) | Procédé pour exposer des produits concentrés en thrombocytes placés dans des contenants souples à une lumière ultraviolette | |
| WO2000058824A1 (fr) | Methode et systeme relatifs a des donnees operationnelles coherentes de grappe dans une grappe de serveurs utilisant un quorum de repliques | |
| DE69735141T2 (de) | Verfahren zur sterilisation von geschlossenen behältern | |
| DE10333914B4 (de) | Mit einem Plasmabehandlungsmodul ausgerüstete Sterilisationsvorrichtung und Sterilisationsverfahren | |
| JP2008264739A (ja) | 濾過・殺菌装置 | |
| EP1962905A1 (fr) | Procédé pour inactiver des agents pathogènes dans le sang de donneurs, le plasma sanguin, ou des produits concentrés en érythrocytes dans des contenants souples, par agitation | |
| DE60208537T2 (de) | Verfahren und vorrichtung zur desinfektion eines produktes durch oberflächenbehandlung desselben | |
| WO2003022749A1 (fr) | Utilisation combinee d'ozone et d'ultraviolets pour degrader des substances endocrines | |
| DE102006027227A1 (de) | Verfahren und Vorrichtung zum Inaktivieren von Viren und/oder Bakterien in flüssigen Medien, insbesondere in Blutplasmen und Serumkonserven | |
| JP2005524683A (ja) | 流体を除染するための方法および装置 | |
| EP1651569B1 (fr) | Procede de desinfection de liquides | |
| US5512253A (en) | Irradiator apparatus | |
| US20080038364A1 (en) | Methods of processing body parts for surgery | |
| KR102320729B1 (ko) | 양액 살균 장치 및 이를 이용하는 배지재배 시스템 | |
| GB2361644A (en) | Waste treatment apparatus and methods | |
| JPH11276020A (ja) | 魚介類養殖用水処理装置及びに養殖方法 | |
| JPS58104693A (ja) | 廃水及び用水の光オゾン処理法 | |
| JPH11275988A (ja) | 植物水耕栽培の水処理装置及びに栽培方法 | |
| EP0047356B1 (fr) | Procédé de stérilisation d'articles médicaux, en particulier d'articles dentaires | |
| DE2932565A1 (de) | Verfahren und vorrichtung zum reinigen von gegenstaenden mittels ultraschall und zur sterilisationsbehandlung in einem einzigen druckbehaelter | |
| KR100342599B1 (ko) | 초음파조사에의한용수의살균처리방법 | |
| DE102007013191A1 (de) | Vorrichtung zur Aufbereitung und Entkeimung von Flüssigkeiten | |
| JPH05285472A (ja) | 液体の殺菌方法 | |
| US1982029A (en) | Process for treating food substances |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R082 | Change of representative |
Representative=s name: CZYBULKA, UWE, DIPL.-PHYS., DE |
|
| R012 | Request for examination validly filed | ||
| R081 | Change of applicant/patentee |
Owner name: SCHMIDMAIER, GERHARD, PROF. DR., DE Free format text: FORMER OWNER: DRK - BLUTSPENDEDIENST BADEN-WUERTTEMBERG-HESSEN GMBH, 60528 FRANKFURT, DE Effective date: 20130315 Owner name: STEMBERGER, AXEL, PROF. DR., DE Free format text: FORMER OWNER: DRK - BLUTSPENDEDIENST BADEN-WUERTTEMBERG-HESSEN GMBH, 60528 FRANKFURT, DE Effective date: 20130315 Owner name: RASCHKE, MICHAEL, DR., DE Free format text: FORMER OWNER: DRK - BLUTSPENDEDIENST BADEN-WUERTTEMBERG-HESSEN GMBH, 60528 FRANKFURT, DE Effective date: 20130315 |
|
| R082 | Change of representative |
Representative=s name: CZYBULKA, UWE, DIPL.-PHYS., DE Effective date: 20130315 |
|
| R012 | Request for examination validly filed |
Effective date: 20130426 |
|
| R119 | Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee |