DE102006020644A1 - Antiseptikahaltige Silikonelastomere - Google Patents
Antiseptikahaltige Silikonelastomere Download PDFInfo
- Publication number
- DE102006020644A1 DE102006020644A1 DE102006020644A DE102006020644A DE102006020644A1 DE 102006020644 A1 DE102006020644 A1 DE 102006020644A1 DE 102006020644 A DE102006020644 A DE 102006020644A DE 102006020644 A DE102006020644 A DE 102006020644A DE 102006020644 A1 DE102006020644 A1 DE 102006020644A1
- Authority
- DE
- Germany
- Prior art keywords
- formula
- sio
- alkyl
- naphthyl
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229920002379 silicone rubber Polymers 0.000 claims abstract description 85
- -1 Quats Chemical compound 0.000 claims abstract description 69
- 229920000642 polymer Polymers 0.000 claims abstract description 54
- 239000000725 suspension Substances 0.000 claims abstract description 52
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 42
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical group [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims abstract description 41
- 239000004945 silicone rubber Substances 0.000 claims abstract description 41
- 125000001624 naphthyl group Chemical group 0.000 claims abstract description 36
- 229920001296 polysiloxane Polymers 0.000 claims abstract description 34
- 238000010058 rubber compounding Methods 0.000 claims abstract description 27
- 239000002245 particle Substances 0.000 claims abstract description 25
- 150000003839 salts Chemical class 0.000 claims abstract description 19
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims abstract description 19
- 230000002421 anti-septic effect Effects 0.000 claims abstract description 18
- 238000000034 method Methods 0.000 claims abstract description 16
- 239000003054 catalyst Substances 0.000 claims abstract description 15
- 238000004132 cross linking Methods 0.000 claims abstract description 15
- 238000009826 distribution Methods 0.000 claims abstract description 15
- 125000003709 fluoroalkyl group Chemical group 0.000 claims abstract description 15
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims abstract description 11
- 238000004519 manufacturing process Methods 0.000 claims abstract description 11
- SMGTYJPMKXNQFY-UHFFFAOYSA-N octenidine dihydrochloride Chemical compound Cl.Cl.C1=CC(=NCCCCCCCC)C=CN1CCCCCCCCCCN1C=CC(=NCCCCCCCC)C=C1 SMGTYJPMKXNQFY-UHFFFAOYSA-N 0.000 claims abstract description 11
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims abstract description 10
- AJKIRUJIDFJUKJ-UHFFFAOYSA-N taurolidine Chemical compound C1NS(=O)(=O)CCN1CN1CNS(=O)(=O)CC1 AJKIRUJIDFJUKJ-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229960003500 triclosan Drugs 0.000 claims abstract description 10
- 229920002413 Polyhexanide Polymers 0.000 claims abstract description 9
- 229960003260 chlorhexidine Drugs 0.000 claims abstract description 9
- 229910052751 metal Inorganic materials 0.000 claims abstract description 9
- 239000002184 metal Substances 0.000 claims abstract description 9
- 229910004283 SiO 4 Inorganic materials 0.000 claims abstract description 8
- 229960004267 taurolidine Drugs 0.000 claims abstract description 8
- 229910052684 Cerium Inorganic materials 0.000 claims abstract description 7
- 150000002736 metal compounds Chemical class 0.000 claims abstract description 7
- 229910052719 titanium Inorganic materials 0.000 claims abstract description 7
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 7
- 229910052726 zirconium Inorganic materials 0.000 claims abstract description 7
- 229910052782 aluminium Inorganic materials 0.000 claims abstract description 6
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims abstract description 6
- 229910052742 iron Inorganic materials 0.000 claims abstract description 6
- 229910052747 lanthanoid Inorganic materials 0.000 claims abstract description 6
- 150000002602 lanthanoids Chemical class 0.000 claims abstract description 6
- 229960001774 octenidine Drugs 0.000 claims abstract description 5
- 150000001875 compounds Chemical class 0.000 claims description 27
- 125000000217 alkyl group Chemical group 0.000 claims description 15
- 239000000945 filler Substances 0.000 claims description 14
- 229910052697 platinum Inorganic materials 0.000 claims description 13
- 239000001257 hydrogen Substances 0.000 claims description 11
- 229910052739 hydrogen Inorganic materials 0.000 claims description 11
- 229920002554 vinyl polymer Polymers 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 8
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 7
- 238000006459 hydrosilylation reaction Methods 0.000 claims description 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
- 150000001335 aliphatic alkanes Chemical class 0.000 claims description 6
- 125000003342 alkenyl group Chemical group 0.000 claims description 6
- 150000002431 hydrogen Chemical class 0.000 claims description 6
- 125000001424 substituent group Chemical group 0.000 claims description 6
- 229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 claims description 5
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 5
- 238000006116 polymerization reaction Methods 0.000 claims description 5
- 150000003856 quaternary ammonium compounds Chemical class 0.000 claims description 5
- 229910052759 nickel Inorganic materials 0.000 claims description 4
- 229910052703 rhodium Inorganic materials 0.000 claims description 4
- 229910052707 ruthenium Inorganic materials 0.000 claims description 4
- 230000008569 process Effects 0.000 claims description 3
- IKGXIBQEEMLURG-NVPNHPEKSA-N rutin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-NVPNHPEKSA-N 0.000 claims description 3
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 description 32
- 239000002609 medium Substances 0.000 description 23
- 238000012360 testing method Methods 0.000 description 18
- 239000000203 mixture Substances 0.000 description 14
- 208000015181 infectious disease Diseases 0.000 description 12
- 239000000463 material Substances 0.000 description 11
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 description 10
- 230000005764 inhibitory process Effects 0.000 description 10
- 239000013543 active substance Substances 0.000 description 9
- 210000004027 cell Anatomy 0.000 description 9
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 9
- 238000010828 elution Methods 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 241000191967 Staphylococcus aureus Species 0.000 description 8
- 239000011324 bead Substances 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 7
- 229940079593 drug Drugs 0.000 description 7
- 239000003814 drug Substances 0.000 description 7
- 239000000284 extract Substances 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 239000003242 anti bacterial agent Substances 0.000 description 6
- 230000000844 anti-bacterial effect Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 229920001971 elastomer Polymers 0.000 description 6
- 238000000605 extraction Methods 0.000 description 6
- 238000009472 formulation Methods 0.000 description 6
- 239000011159 matrix material Substances 0.000 description 6
- 239000013642 negative control Substances 0.000 description 6
- 208000032840 Catheter-Related Infections Diseases 0.000 description 5
- 240000003517 Elaeocarpus dentatus Species 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 206010041925 Staphylococcal infections Diseases 0.000 description 5
- 229940088710 antibiotic agent Drugs 0.000 description 5
- 229940064004 antiseptic throat preparations Drugs 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 231100000433 cytotoxic Toxicity 0.000 description 5
- 230000001472 cytotoxic effect Effects 0.000 description 5
- 239000003112 inhibitor Substances 0.000 description 5
- 208000015688 methicillin-resistant staphylococcus aureus infectious disease Diseases 0.000 description 5
- 229920003023 plastic Polymers 0.000 description 5
- 239000004033 plastic Substances 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 238000011282 treatment Methods 0.000 description 5
- 229920001817 Agar Polymers 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 241000222122 Candida albicans Species 0.000 description 4
- 102000003855 L-lactate dehydrogenase Human genes 0.000 description 4
- 108700023483 L-lactate dehydrogenases Proteins 0.000 description 4
- 239000008272 agar Substances 0.000 description 4
- 230000000845 anti-microbial effect Effects 0.000 description 4
- 229940045985 antineoplastic platinum compound Drugs 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- 229940095731 candida albicans Drugs 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 239000000460 chlorine Substances 0.000 description 4
- 229910052801 chlorine Inorganic materials 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 229910052731 fluorine Inorganic materials 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 230000035755 proliferation Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 230000002485 urinary effect Effects 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 description 3
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 3
- 229910020487 SiO3/2 Inorganic materials 0.000 description 3
- 229910020485 SiO4/2 Inorganic materials 0.000 description 3
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical group [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 125000005024 alkenyl aryl group Chemical group 0.000 description 3
- 239000007795 chemical reaction product Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 238000013329 compounding Methods 0.000 description 3
- 238000009792 diffusion process Methods 0.000 description 3
- 239000000806 elastomer Substances 0.000 description 3
- 238000000227 grinding Methods 0.000 description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 3
- 230000002209 hydrophobic effect Effects 0.000 description 3
- AIPVRBGBHQDAPX-UHFFFAOYSA-N hydroxy(methyl)silane Chemical class C[SiH2]O AIPVRBGBHQDAPX-UHFFFAOYSA-N 0.000 description 3
- 238000011835 investigation Methods 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 150000003058 platinum compounds Chemical class 0.000 description 3
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 3
- 239000013641 positive control Substances 0.000 description 3
- 239000012763 reinforcing filler Substances 0.000 description 3
- 239000005060 rubber Substances 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- 150000004819 silanols Chemical class 0.000 description 3
- 229920005573 silicon-containing polymer Polymers 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 239000003381 stabilizer Substances 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 208000019206 urinary tract infection Diseases 0.000 description 3
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Chemical compound CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 description 2
- 229940123208 Biguanide Drugs 0.000 description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 2
- PFJFNQUFMTYCHB-UHFFFAOYSA-N C[SiH2]N[SiH3] Chemical class C[SiH2]N[SiH3] PFJFNQUFMTYCHB-UHFFFAOYSA-N 0.000 description 2
- 239000005046 Chlorosilane Substances 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 238000002768 Kirby-Bauer method Methods 0.000 description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
- 206010040047 Sepsis Diseases 0.000 description 2
- 241000295644 Staphylococcaceae Species 0.000 description 2
- 229920004482 WACKER® Polymers 0.000 description 2
- MCMNRKCIXSYSNV-UHFFFAOYSA-N Zirconium dioxide Chemical compound O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- 238000013006 addition curing Methods 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000010065 bacterial adhesion Effects 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 235000013877 carbamide Nutrition 0.000 description 2
- 239000006143 cell culture medium Substances 0.000 description 2
- KOPOQZFJUQMUML-UHFFFAOYSA-N chlorosilane Chemical class Cl[SiH3] KOPOQZFJUQMUML-UHFFFAOYSA-N 0.000 description 2
- 239000006781 columbia blood agar Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000001723 curing Methods 0.000 description 2
- 125000000753 cycloalkyl group Chemical group 0.000 description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 125000005395 methacrylic acid group Chemical group 0.000 description 2
- CXKWCBBOMKCUKX-UHFFFAOYSA-M methylene blue Chemical compound [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 CXKWCBBOMKCUKX-UHFFFAOYSA-M 0.000 description 2
- 229960000907 methylthioninium chloride Drugs 0.000 description 2
- 230000002906 microbiologic effect Effects 0.000 description 2
- 238000012009 microbiological test Methods 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 229920002113 octoxynol Polymers 0.000 description 2
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 229910052698 phosphorus Inorganic materials 0.000 description 2
- 239000011574 phosphorus Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000001698 pyrogenic effect Effects 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 239000005871 repellent Substances 0.000 description 2
- 230000002940 repellent Effects 0.000 description 2
- 238000001878 scanning electron micrograph Methods 0.000 description 2
- FZHAPNGMFPVSLP-UHFFFAOYSA-N silanamine Chemical class [SiH3]N FZHAPNGMFPVSLP-UHFFFAOYSA-N 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- UQMGAWUIVYDWBP-UHFFFAOYSA-N silyl acetate Chemical class CC(=O)O[SiH3] UQMGAWUIVYDWBP-UHFFFAOYSA-N 0.000 description 2
- 238000005496 tempering Methods 0.000 description 2
- 238000002411 thermogravimetry Methods 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 238000012549 training Methods 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea group Chemical group NC(=O)N XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 229910001928 zirconium oxide Inorganic materials 0.000 description 2
- 0 *C(*)(CCCN)CCCNC(NC(NCCCC(*)(*)CCCN)=N)=N Chemical compound *C(*)(CCCN)CCCNC(NC(NCCCC(*)(*)CCCN)=N)=N 0.000 description 1
- QYLFHLNFIHBCPR-UHFFFAOYSA-N 1-ethynylcyclohexan-1-ol Chemical compound C#CC1(O)CCCCC1 QYLFHLNFIHBCPR-UHFFFAOYSA-N 0.000 description 1
- XKFDVLUHBRJZQF-UHFFFAOYSA-N 2-(3-aminopropyl)-1-(diaminomethylidene)guanidine Chemical class NCCCNC(=N)NC(N)=N XKFDVLUHBRJZQF-UHFFFAOYSA-N 0.000 description 1
- CEBKHWWANWSNTI-UHFFFAOYSA-N 2-methylbut-3-yn-2-ol Chemical compound CC(C)(O)C#C CEBKHWWANWSNTI-UHFFFAOYSA-N 0.000 description 1
- KSLSOBUAIFEGLT-UHFFFAOYSA-N 2-phenylbut-3-yn-2-ol Chemical compound C#CC(O)(C)C1=CC=CC=C1 KSLSOBUAIFEGLT-UHFFFAOYSA-N 0.000 description 1
- 208000031729 Bacteremia Diseases 0.000 description 1
- 208000034309 Bacterial disease carrier Diseases 0.000 description 1
- 201000004538 Bacteriuria Diseases 0.000 description 1
- 239000004342 Benzoyl peroxide Substances 0.000 description 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
- 241000222455 Boletus Species 0.000 description 1
- 238000009010 Bradford assay Methods 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical class [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 description 1
- 239000004971 Cross linker Substances 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- 241000588914 Enterobacter Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241001295925 Gegenes Species 0.000 description 1
- 229920002306 Glycocalyx Polymers 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical class Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
- 239000004890 Hydrophobing Agent Substances 0.000 description 1
- 239000005909 Kieselgur Substances 0.000 description 1
- 241000588748 Klebsiella Species 0.000 description 1
- 150000000994 L-ascorbates Chemical class 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- 241000588769 Proteus <enterobacteria> Species 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 239000004433 Thermoplastic polyurethane Substances 0.000 description 1
- 150000001242 acetic acid derivatives Chemical class 0.000 description 1
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 125000004423 acyloxy group Chemical group 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 150000003851 azoles Chemical class 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 235000019400 benzoyl peroxide Nutrition 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 229920002988 biodegradable polymer Polymers 0.000 description 1
- 239000004621 biodegradable polymer Substances 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 239000004305 biphenyl Substances 0.000 description 1
- 235000010290 biphenyl Nutrition 0.000 description 1
- 125000006267 biphenyl group Chemical group 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 150000001642 boronic acid derivatives Chemical class 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 150000001860 citric acid derivatives Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000009563 continuous hemofiltration Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000007887 coronary angioplasty Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 229910052906 cristobalite Inorganic materials 0.000 description 1
- 239000012228 culture supernatant Substances 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000009513 drug distribution Methods 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 210000004517 glycocalyx Anatomy 0.000 description 1
- 238000001631 haemodialysis Methods 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000000322 hemodialysis Effects 0.000 description 1
- 150000004688 heptahydrates Chemical class 0.000 description 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 150000003840 hydrochlorides Chemical class 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 150000002688 maleic acid derivatives Chemical class 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 125000005641 methacryl group Chemical group 0.000 description 1
- HPHQLYLFWORZEH-UHFFFAOYSA-N methyl(silylimino)silane Chemical compound C[SiH]=N[SiH3] HPHQLYLFWORZEH-UHFFFAOYSA-N 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000013008 moisture curing Methods 0.000 description 1
- 239000006082 mold release agent Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000003136 n-heptyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 1
- QGWFCGFCQNJOCQ-UHFFFAOYSA-N n-octyl-1-[10-[4-(octylamino)pyridin-1-ium-1-yl]decyl]pyridin-1-ium-4-amine;dichloride;dihydrochloride Chemical compound Cl.Cl.Cl.Cl.C1=CC(=NCCCCCCCC)C=CN1CCCCCCCCCCN1C=CC(=NCCCCCCCC)C=C1 QGWFCGFCQNJOCQ-UHFFFAOYSA-N 0.000 description 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 230000006855 networking Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 150000003961 organosilicon compounds Chemical class 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 1
- 150000003003 phosphines Chemical class 0.000 description 1
- AQSJGOWTSHOLKH-UHFFFAOYSA-N phosphite(3-) Chemical class [O-]P([O-])[O-] AQSJGOWTSHOLKH-UHFFFAOYSA-N 0.000 description 1
- 238000005375 photometry Methods 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000002683 reaction inhibitor Substances 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 229920002631 room-temperature vulcanizate silicone Polymers 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 239000012885 slow-release drug carrier Substances 0.000 description 1
- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000011885 synergistic combination Substances 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- RSNQKPMXXVDJFG-UHFFFAOYSA-N tetrasiloxane Chemical class [SiH3]O[SiH2]O[SiH2]O[SiH3] RSNQKPMXXVDJFG-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000001757 thermogravimetry curve Methods 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 229920002803 thermoplastic polyurethane Polymers 0.000 description 1
- 229920001187 thermosetting polymer Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 230000009424 thromboembolic effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 125000000725 trifluoropropyl group Chemical group [H]C([H])(*)C([H])([H])C(F)(F)F 0.000 description 1
- 150000003672 ureas Chemical class 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 238000004073 vulcanization Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
- C08L83/04—Polysiloxanes
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
- A01N25/10—Macromolecular compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/88—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with three ring hetero atoms
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/04—Polysiloxanes
- C08G77/12—Polysiloxanes containing silicon bound to hydrogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/04—Polysiloxanes
- C08G77/20—Polysiloxanes containing silicon bound to unsaturated aliphatic groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/70—Siloxanes defined by use of the MDTQ nomenclature
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K13/00—Use of mixtures of ingredients not covered by one single of the preceding main groups, each of these compounds being essential
- C08K13/08—Ingredients of unknown constitution and ingredients covered by the main groups C08K3/00 - C08K9/00
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Pest Control & Pesticides (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Toxicology (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Priority Applications (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006020644A DE102006020644A1 (de) | 2006-04-28 | 2006-04-28 | Antiseptikahaltige Silikonelastomere |
| RU2008146860/04A RU2008146860A (ru) | 2006-04-28 | 2007-04-17 | Силиконовые эластомеры, содержащие антисептик |
| JP2009506949A JP5110609B2 (ja) | 2006-04-28 | 2007-04-17 | 防腐剤含有シリコーンエラストマー |
| SG201102974-1A SG171625A1 (en) | 2006-04-28 | 2007-04-17 | Antiseptic-containing silicone elastomers |
| AU2007245897A AU2007245897B2 (en) | 2006-04-28 | 2007-04-17 | Antiseptic-containing silicone elastomers |
| EP07724282.4A EP2016126B1 (de) | 2006-04-28 | 2007-04-17 | Antiseptikahaltige silikonelastomere |
| CN2007800155000A CN101432353B (zh) | 2006-04-28 | 2007-04-17 | 含防腐剂的硅氧烷弹性体 |
| BRPI0711074-0A BRPI0711074A2 (pt) | 2006-04-28 | 2007-04-17 | elastÈmeros de silicone contendo antisséptico |
| KR1020087029012A KR20090012250A (ko) | 2006-04-28 | 2007-04-17 | 방부제를 함유하는 실리콘 탄성중합체 |
| CA2646202A CA2646202C (en) | 2006-04-28 | 2007-04-17 | Antiseptic-containing silicone elastomers |
| PCT/EP2007/003344 WO2007124855A2 (de) | 2006-04-28 | 2007-04-17 | Antiseptikahaltige silikonelastomere |
| MX2008013714A MX2008013714A (es) | 2006-04-28 | 2007-04-17 | Elastomeros de silicona que contienen antisepticos. |
| ARP070101741A AR060580A1 (es) | 2006-04-28 | 2007-04-23 | Elastomeros de silicona que contienen antisepticos |
| TW096114877A TW200806747A (en) | 2006-04-28 | 2007-04-27 | Antiseptic-containing silicone elastomers |
| US11/741,275 US7977403B2 (en) | 2006-04-28 | 2007-04-27 | Antiseptic containing silicone elastomers |
| IL194756A IL194756A0 (en) | 2006-04-28 | 2008-10-22 | Antiseptic-containing silicone elastomers |
| NO20084798A NO20084798L (no) | 2006-04-28 | 2008-11-13 | Antiseptik-inneholdende silikonelastomerer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006020644A DE102006020644A1 (de) | 2006-04-28 | 2006-04-28 | Antiseptikahaltige Silikonelastomere |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE102006020644A1 true DE102006020644A1 (de) | 2007-10-31 |
Family
ID=38542438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE102006020644A Withdrawn DE102006020644A1 (de) | 2006-04-28 | 2006-04-28 | Antiseptikahaltige Silikonelastomere |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7977403B2 (enExample) |
| EP (1) | EP2016126B1 (enExample) |
| JP (1) | JP5110609B2 (enExample) |
| KR (1) | KR20090012250A (enExample) |
| CN (1) | CN101432353B (enExample) |
| AR (1) | AR060580A1 (enExample) |
| AU (1) | AU2007245897B2 (enExample) |
| BR (1) | BRPI0711074A2 (enExample) |
| CA (1) | CA2646202C (enExample) |
| DE (1) | DE102006020644A1 (enExample) |
| IL (1) | IL194756A0 (enExample) |
| MX (1) | MX2008013714A (enExample) |
| NO (1) | NO20084798L (enExample) |
| RU (1) | RU2008146860A (enExample) |
| SG (1) | SG171625A1 (enExample) |
| TW (1) | TW200806747A (enExample) |
| WO (1) | WO2007124855A2 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014191367A1 (fr) * | 2013-05-28 | 2014-12-04 | Universite Du Maine | Composition antimicrobienne à base de silicone |
| CN115895276A (zh) * | 2022-12-10 | 2023-04-04 | 宁波韩太硅胶制品有限公司 | 一种食品级抗菌防霉合成高温硫化硅橡胶及其制备方法 |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8961491B2 (en) | 2006-04-21 | 2015-02-24 | Bayer Medical Care Inc | Catheters and related equipment |
| US8071706B2 (en) * | 2008-02-13 | 2011-12-06 | Ndsu Research Foundation | Siloxane polymer containing tethered levofloxacin |
| FR2932648B1 (fr) * | 2008-06-24 | 2010-07-30 | Saint Gobain Performance Plast | Produit en elastomere de silicone presentant une activite biocide. |
| US9200112B2 (en) | 2009-08-10 | 2015-12-01 | Ethicon, Inc. | Semi-crystalline, fast absorbing polymer formulation |
| US8673388B2 (en) * | 2009-09-09 | 2014-03-18 | Cook Medical Technologies Llc | Methods of manufacturing drug-loaded substrates |
| US9044524B2 (en) | 2009-10-30 | 2015-06-02 | Ethicon, Inc. | Absorbable polyethylene diglycolate copolymers to reduce microbial adhesion to medical devices and implants |
| US8940799B2 (en) * | 2010-03-25 | 2015-01-27 | Medtronic Xomed, Inc. | Adjusting drug loading in polymeric materials |
| US20110287074A1 (en) * | 2010-05-24 | 2011-11-24 | University Of Florida Research Foundation, Inc. | Antimicrobial Compositions, Methods of Manufacture Thereof and Articles Comprising the Same |
| JP6003518B2 (ja) * | 2012-02-23 | 2016-10-05 | 住友ベークライト株式会社 | バルーンカテーテル |
| US9687432B2 (en) | 2012-12-21 | 2017-06-27 | Lonza Inc. | Antimicrobial bispyridine amine compositions and uses |
| CA2928330C (en) | 2015-04-28 | 2021-08-17 | Frank Dicosmo | Antimicrobial silicone adhesive dressings comprising phmb and edta |
| WO2020228917A1 (en) | 2019-05-14 | 2020-11-19 | Coloplast A/S | Elastomeric silicone compositions comprising glycerol, cyclodextrin and octenidine |
| US11820890B2 (en) | 2021-04-01 | 2023-11-21 | Stratasys Inc | Pulverulent thermoplastic polymer blends |
| US11738120B1 (en) | 2022-04-14 | 2023-08-29 | Cormedix Inc. | Synthesis of taurolidine, purity profiles and polymorphs |
| US20250325045A1 (en) * | 2024-04-23 | 2025-10-23 | Sally Nason | Catheter-Accessible Trousers with Integrated Fastener |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE494972A (enExample) * | 1949-04-07 | |||
| GB702268A (en) | 1949-08-22 | 1954-01-13 | Francis Leslie Rose | Polymeric diguanides |
| US3002951A (en) * | 1959-04-27 | 1961-10-03 | Dow Corning | Method of polymerizing cyclic diorganosiloxanes |
| GB1152243A (en) * | 1965-11-26 | 1969-05-14 | Ici Ltd | Process for the Manufacture of Polymeric Diguanides |
| US3715334A (en) * | 1970-11-27 | 1973-02-06 | Gen Electric | Platinum-vinylsiloxanes |
| BE791632A (fr) * | 1971-11-20 | 1973-05-21 | Schering Ag | Supports a base de caoutchouc siliconique pour agents medicamenteux |
| US4107313A (en) * | 1976-02-25 | 1978-08-15 | Sterling Drug Inc. | α,α-Bis-[4-(R-amino)-1-pyridinium]xylenes and antibacterial and antifungal uses |
| US4230666A (en) * | 1978-07-11 | 1980-10-28 | Phillips Petroleum Company | Hydrocarbon purification apparatus |
| US4320686A (en) * | 1978-07-20 | 1982-03-23 | Lewis Jeffrey J | Wind instrument with continuously variable pitch control |
| DE3265929D1 (en) | 1981-01-26 | 1985-10-10 | Blasius Ind | High-voltage insulated connector |
| JPS6080457A (ja) * | 1983-10-07 | 1985-05-08 | ユニチカ株式会社 | 抗菌剤徐放性導尿カテ−テル |
| US4714563A (en) * | 1986-07-18 | 1987-12-22 | The Procter & Gamble Company | Antimicrobial toilet bars |
| US4925686A (en) * | 1987-12-02 | 1990-05-15 | Leader Candies, Inc. | Liquid shelf-stable freezable fruit juice containing composition and method of making the same |
| US5019096A (en) * | 1988-02-11 | 1991-05-28 | Trustees Of Columbia University In The City Of New York | Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same |
| NO178843C (no) * | 1988-07-11 | 1996-06-19 | Sspl Sa Safe Sex Prod Licens | Fremgangsmåte for fremstilling av et farmasöytisk preparat for å forhindre seksuelt overförbare sykdommer |
| US5165952A (en) * | 1989-01-18 | 1992-11-24 | Becton, Dickinson And Company | Anti-infective and antithrombogenic medical articles and method for their preparation |
| JP2819417B2 (ja) * | 1989-04-17 | 1998-10-30 | 東レ・ダウコーニング・シリコーン株式会社 | 抗菌性シリコーンゴム粒状物の製造方法 |
| FR2671091B1 (fr) * | 1990-12-27 | 1993-04-16 | Rhone Poulenc Chimie | Systeme organosilicique comprenant un biguanide polymere, utilisable notamment pour lutter contre la proliferation bacterienne dans les eponges. |
| US5338312A (en) * | 1992-10-02 | 1994-08-16 | Becton, Dickinson And Company | Article having multi-layered lubricant and method therefor |
| JPH0762242A (ja) * | 1993-08-27 | 1995-03-07 | Shin Etsu Chem Co Ltd | 抗菌・抗かび性シリコーンゴム組成物 |
| EP0688564B1 (en) * | 1994-06-20 | 1999-08-04 | Dow Corning Corporation | Method of controlling release of an active substance or drug from a silicone rubber matrix |
| DE4428458A1 (de) | 1994-08-11 | 1996-02-15 | Bayer Ag | Cycloaliphatische thermoplastische Polyurethanelastomere |
| US6558686B1 (en) * | 1995-11-08 | 2003-05-06 | Baylor College Of Medicine | Method of coating medical devices with a combination of antiseptics and antiseptic coating therefor |
| DE19638570A1 (de) * | 1996-09-20 | 1998-03-26 | Bayer Ag | Wirkstoffhaltige thermoplastische Polyurethane |
| FR2760971B1 (fr) * | 1997-03-20 | 1999-12-10 | Dow Corning Sa | Procede de production d'une composition a liberation controlee |
| BR9809483A (pt) * | 1997-05-27 | 2000-06-20 | Akzo Nobel Nv | Composição de reticulação, processo para faze-la, e, uso da mesma. |
| WO1999032168A1 (en) * | 1997-12-22 | 1999-07-01 | Becton Dickinson And Company | A material for use in medical devices with a self-replenishing antimicrobial and/or lubricious surface |
| DE19812160C1 (de) * | 1998-03-20 | 1999-07-08 | Bayer Ag | Formkörper aus wirkstoffhaltigen thermoplastischen Polyurethanen |
| DE19852192C2 (de) * | 1998-11-12 | 2003-04-24 | Bayer Ag | Wirkstoffhaltige aromatische Copolyester |
| KR100668568B1 (ko) * | 1998-11-12 | 2007-01-17 | 바이엘 악티엔게젤샤프트 | 활성 물질을 포함하는 폴리에테르 블록 아미드 |
| JP2005041823A (ja) * | 2003-07-23 | 2005-02-17 | Nippon Chem Ind Co Ltd | 抗菌剤 |
| US7381751B2 (en) * | 2003-08-26 | 2008-06-03 | Shantha Sarangapani | Antimicrobial composition for medical articles |
| EP1640031A3 (en) * | 2004-09-28 | 2006-06-07 | Nipro Corporation | Syringe coated with lubricant containing silicone oil and silica powder |
| DE102004054040A1 (de) * | 2004-11-05 | 2006-05-11 | Bayer Innovation Gmbh | Wirkstoffhaltige Silikonelastomere |
-
2006
- 2006-04-28 DE DE102006020644A patent/DE102006020644A1/de not_active Withdrawn
-
2007
- 2007-04-17 AU AU2007245897A patent/AU2007245897B2/en not_active Ceased
- 2007-04-17 RU RU2008146860/04A patent/RU2008146860A/ru unknown
- 2007-04-17 EP EP07724282.4A patent/EP2016126B1/de not_active Not-in-force
- 2007-04-17 CA CA2646202A patent/CA2646202C/en not_active Expired - Fee Related
- 2007-04-17 MX MX2008013714A patent/MX2008013714A/es unknown
- 2007-04-17 WO PCT/EP2007/003344 patent/WO2007124855A2/de not_active Ceased
- 2007-04-17 CN CN2007800155000A patent/CN101432353B/zh not_active Expired - Fee Related
- 2007-04-17 BR BRPI0711074-0A patent/BRPI0711074A2/pt not_active IP Right Cessation
- 2007-04-17 JP JP2009506949A patent/JP5110609B2/ja not_active Expired - Fee Related
- 2007-04-17 KR KR1020087029012A patent/KR20090012250A/ko not_active Ceased
- 2007-04-17 SG SG201102974-1A patent/SG171625A1/en unknown
- 2007-04-23 AR ARP070101741A patent/AR060580A1/es not_active Application Discontinuation
- 2007-04-27 TW TW096114877A patent/TW200806747A/zh unknown
- 2007-04-27 US US11/741,275 patent/US7977403B2/en not_active Expired - Fee Related
-
2008
- 2008-10-22 IL IL194756A patent/IL194756A0/en unknown
- 2008-11-13 NO NO20084798A patent/NO20084798L/no not_active Application Discontinuation
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014191367A1 (fr) * | 2013-05-28 | 2014-12-04 | Universite Du Maine | Composition antimicrobienne à base de silicone |
| FR3006149A1 (fr) * | 2013-05-28 | 2014-12-05 | Univ Maine | Composition antimicrobienne a base de silicone |
| CN115895276A (zh) * | 2022-12-10 | 2023-04-04 | 宁波韩太硅胶制品有限公司 | 一种食品级抗菌防霉合成高温硫化硅橡胶及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007124855A2 (de) | 2007-11-08 |
| CN101432353B (zh) | 2012-12-05 |
| EP2016126A2 (de) | 2009-01-21 |
| WO2007124855A8 (de) | 2008-11-20 |
| US20070255004A1 (en) | 2007-11-01 |
| AU2007245897B2 (en) | 2012-12-20 |
| SG171625A1 (en) | 2011-06-29 |
| CA2646202A1 (en) | 2007-11-08 |
| NO20084798L (no) | 2008-10-17 |
| JP2009535434A (ja) | 2009-10-01 |
| IL194756A0 (en) | 2009-08-03 |
| MX2008013714A (es) | 2008-11-06 |
| CN101432353A (zh) | 2009-05-13 |
| AR060580A1 (es) | 2008-06-25 |
| KR20090012250A (ko) | 2009-02-02 |
| BRPI0711074A2 (pt) | 2011-08-23 |
| AU2007245897A1 (en) | 2007-11-08 |
| JP5110609B2 (ja) | 2012-12-26 |
| TW200806747A (en) | 2008-02-01 |
| WO2007124855A3 (de) | 2008-03-06 |
| RU2008146860A (ru) | 2010-06-20 |
| CA2646202C (en) | 2015-06-30 |
| US7977403B2 (en) | 2011-07-12 |
| EP2016126B1 (de) | 2017-08-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2016126B1 (de) | Antiseptikahaltige silikonelastomere | |
| DE60023137T2 (de) | Antimikrobielle silikongummizusammensetzung und verfahren zu deren herstellung | |
| EP1536848B1 (de) | Verfahren zur herstellung eines antimikrobiellen kunststoffproduktes | |
| US7772296B2 (en) | Antimicrobial polyurethane resins and products made therefrom | |
| DE102004054040A1 (de) | Wirkstoffhaltige Silikonelastomere | |
| EP1128723B1 (de) | Wirkstoffhaltige aromatische copolyester | |
| EP2498834B1 (de) | Verwendung von polyoxyalkylendiamin-basierten polyguanidinderivaten für medizinische artikel | |
| EP1940938B1 (de) | Antimikrobielle kunststoffzusammensetzung mit niedriger elutionsrate und langer wirksamkeit | |
| EP2120552A1 (de) | Teilneutralisierte wirkstoffe enthaltende polymerformmassen | |
| DE102011102635B4 (de) | Verfahren zur Herstellung eines antimikrobiellen Kunststoffproduktes unter Verwendung eines Reduktons | |
| WO2002092336A1 (de) | Mikrobizide folienstacksysteme | |
| US20190388466A1 (en) | Silicone materials having antimicrobial efficiency | |
| WO2012163806A1 (de) | Verfahren zur herstellung eines antimikrobiellen kunststoffproduktes | |
| Fong | Antibacterial polyurethane nanocomposites for urinary devices |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R005 | Application deemed withdrawn due to failure to request examination |
Effective date: 20130430 |