DE102005049527B4 - Verfahren zur Herstellung von L-Serin, Gensequenz, Vektoren sowie Mikroorganismus - Google Patents

Verfahren zur Herstellung von L-Serin, Gensequenz, Vektoren sowie Mikroorganismus Download PDF

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Publication number
DE102005049527B4
DE102005049527B4 DE102005049527A DE102005049527A DE102005049527B4 DE 102005049527 B4 DE102005049527 B4 DE 102005049527B4 DE 102005049527 A DE102005049527 A DE 102005049527A DE 102005049527 A DE102005049527 A DE 102005049527A DE 102005049527 B4 DE102005049527 B4 DE 102005049527B4
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Prior art keywords
folic acid
seq
gene
genes
amino
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Expired - Lifetime
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DE102005049527A
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German (de)
English (en)
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DE102005049527A1 (de
Inventor
Dr. Eggeling Lothar
Dr. Peters-Wendisch Petra
Michael Stolz
Prof. Dr. Sahm Hermann
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Forschungszentrum Juelich GmbH
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Forschungszentrum Juelich GmbH
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Priority to DE102005049527A priority Critical patent/DE102005049527B4/de
Application filed by Forschungszentrum Juelich GmbH filed Critical Forschungszentrum Juelich GmbH
Priority to US12/083,662 priority patent/US20090181435A1/en
Priority to JP2008535878A priority patent/JP2009511076A/ja
Priority to KR1020087008076A priority patent/KR20080049094A/ko
Priority to BRPI0617498-1A priority patent/BRPI0617498A2/pt
Priority to PCT/DE2006/001756 priority patent/WO2007045210A1/de
Priority to EP06805376A priority patent/EP1937823A1/de
Publication of DE102005049527A1 publication Critical patent/DE102005049527A1/de
Priority to ZA200804137A priority patent/ZA200804137B/xx
Application granted granted Critical
Publication of DE102005049527B4 publication Critical patent/DE102005049527B4/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/13—Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/15—Corynebacterium

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE102005049527A 2005-10-17 2005-10-17 Verfahren zur Herstellung von L-Serin, Gensequenz, Vektoren sowie Mikroorganismus Expired - Lifetime DE102005049527B4 (de)

Priority Applications (8)

Application Number Priority Date Filing Date Title
DE102005049527A DE102005049527B4 (de) 2005-10-17 2005-10-17 Verfahren zur Herstellung von L-Serin, Gensequenz, Vektoren sowie Mikroorganismus
JP2008535878A JP2009511076A (ja) 2005-10-17 2006-10-09 Ｌ−セリンの製造方法、遺伝子配列、ベクターおよび微生物
KR1020087008076A KR20080049094A (ko) 2005-10-17 2006-10-09 Ｌ－세린, 유전자 서열, 벡터, 및 미생물의 생산 방법
BRPI0617498-1A BRPI0617498A2 (pt) 2005-10-17 2006-10-09 processo para a produÇço de l-serina, seqÜÊncia de gene, vetores e microorganismos
US12/083,662 US20090181435A1 (en) 2005-10-17 2006-10-09 Method for Determining L-Serine, Gene Sequene, Vectors and Micro-Organisms
PCT/DE2006/001756 WO2007045210A1 (de) 2005-10-17 2006-10-09 Verfahren zur herstellung von l-serin, gensequenz, vektoren sowie mikroorganismus
EP06805376A EP1937823A1 (de) 2005-10-17 2006-10-09 Verfahren zur herstellung von l-serin, gensequenz, vektoren sowie mikroorganismus
ZA200804137A ZA200804137B (en) 2005-10-17 2008-05-14 Process for the production of L-serine, gene sequence, vectors and micro-organism

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102005049527A DE102005049527B4 (de) 2005-10-17 2005-10-17 Verfahren zur Herstellung von L-Serin, Gensequenz, Vektoren sowie Mikroorganismus

Publications (2)

Publication Number Publication Date
DE102005049527A1 DE102005049527A1 (de) 2007-04-19
DE102005049527B4 true DE102005049527B4 (de) 2013-05-08

Family

ID=37775257

Family Applications (1)

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DE102005049527A Expired - Lifetime DE102005049527B4 (de) 2005-10-17 2005-10-17 Verfahren zur Herstellung von L-Serin, Gensequenz, Vektoren sowie Mikroorganismus

Country Status (8)

Country Link
US (1) US20090181435A1 (enExample)
EP (1) EP1937823A1 (enExample)
JP (1) JP2009511076A (enExample)
KR (1) KR20080049094A (enExample)
BR (1) BRPI0617498A2 (enExample)
DE (1) DE102005049527B4 (enExample)
WO (1) WO2007045210A1 (enExample)
ZA (1) ZA200804137B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY186949A (en) * 2015-01-27 2021-08-26 Cysbio Aps Genetically modified microorganisms having improved tolerance towards l-serine
KR102674702B1 (ko) * 2016-11-11 2024-06-14 베링거잉겔하임베트메디카게엠베하 세균의 폴레이트 수송의 약화에 의한 세균 병독성의 약독화
KR102869970B1 (ko) * 2023-06-23 2025-10-14 씨제이제일제당 (주) 변이된 rbs 염기 서열을 포함하는 폴리뉴클리오티드, 상기 폴리뉴클레오티드를 포함하는 미생물, 및 이를 이용한 글리신 생산 방법

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5212273B1 (enExample) * 1970-05-06 1977-04-06
CA1097240A (en) 1976-11-30 1981-03-10 Kiyoshi Nakayama Process for production of l-serine
JPS5372893A (en) * 1976-12-08 1978-06-28 Kyowa Hakko Kogyo Co Ltd Preparation of l-serine by fermentation
DE3580463D1 (de) * 1984-12-27 1990-12-13 Ajinomoto Kk Verfahren zur herstellung von l-serine.
JP3036912B2 (ja) * 1991-09-02 2000-04-24 協和醗酵工業株式会社 遺伝子発現調節ｄｎａ
TW313589B (enExample) * 1991-12-12 1997-08-21 Wacker Chemie Gmbh
JPH08107788A (ja) * 1994-10-11 1996-04-30 Mitsubishi Chem Corp セリンヒドロキシメチルトランスフェラーゼをコードする遺伝子を含むｄｎａ断片
JP3997631B2 (ja) * 1998-01-12 2007-10-24 味の素株式会社 発酵法によるｌ−セリンの製造法
JP4066543B2 (ja) * 1998-01-12 2008-03-26 味の素株式会社 発酵法によるｌ−セリンの製造法
JP2001112479A (ja) * 1999-08-12 2001-04-24 Ajinomoto Co Inc コリネ型細菌で自律複製可能な新規プラスミド
DE19959329A1 (de) * 1999-12-09 2001-06-13 Degussa Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien
DE10154292A1 (de) * 2001-11-05 2003-05-15 Basf Ag Gene die für Stoffwechselweg-Proteine codieren
DE10311399A1 (de) * 2003-03-13 2004-09-23 Forschungszentrum Jülich GmbH Nukleotidsequenzen coryneformer Bakterien codierend für am L-Serinstoffwechsel beteiligte Proteine sowie Verfahren zur mikrobiellen Herstellung von L-Serin

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Internet-Recherche am 05.05.2006 [www.biocarta.com/pathfiles/GlycinePathway.asp], Biosynthesis of Glycine and Serine 2002 *
Internet-Recherche am 05.05.2006 [www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?41325213: OLD12:2941821], Corynebacterium glutamicum ATCC 13032, GI: 41325213 *
Sequenzvergleich von Sequenz 1 mit GI: 41325213 *
Sequenzvergleich von Sequenz 3 mit GI: 41325213 *
Sequenzvergleich von Sequenz 5 mit GI: 41325213 *
SYBESMA, W.F.H.: Metabolic Engineering of Folate Production in Lactic Acid Bacteria. Thesis 2003, Universität Wageningen *

Also Published As

Publication number Publication date
JP2009511076A (ja) 2009-03-19
ZA200804137B (en) 2009-10-28
US20090181435A1 (en) 2009-07-16
KR20080049094A (ko) 2008-06-03
WO2007045210A1 (de) 2007-04-26
BRPI0617498A2 (pt) 2011-07-26
DE102005049527A1 (de) 2007-04-19
EP1937823A1 (de) 2008-07-02

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