DE102004047840A1 - Neue substituierte Thiophencarbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel - Google Patents

Neue substituierte Thiophencarbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel Download PDF

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Publication number
DE102004047840A1
DE102004047840A1 DE102004047840A DE102004047840A DE102004047840A1 DE 102004047840 A1 DE102004047840 A1 DE 102004047840A1 DE 102004047840 A DE102004047840 A DE 102004047840A DE 102004047840 A DE102004047840 A DE 102004047840A DE 102004047840 A1 DE102004047840 A1 DE 102004047840A1
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DE
Germany
Prior art keywords
group
alkyl
methyl
atom
thiophene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE102004047840A
Other languages
German (de)
English (en)
Inventor
Henning Dr. Priepke
Kai Dr. Gerlach
Roland Dr. Pfau
Wolfgang Dr. Wienen
Annette Dr. Schuler-Metz
Herbert Dr. Nar
Sandra Dr. Handschuh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Priority to DE102004047840A priority Critical patent/DE102004047840A1/de
Priority to JP2007533923A priority patent/JP2008514665A/ja
Priority to PCT/EP2005/010307 priority patent/WO2006034822A1/de
Priority to CA002581580A priority patent/CA2581580A1/en
Priority to EP05788511A priority patent/EP1797080A1/de
Priority to US11/238,599 priority patent/US7563786B2/en
Publication of DE102004047840A1 publication Critical patent/DE102004047840A1/de
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE102004047840A 2004-09-29 2004-09-29 Neue substituierte Thiophencarbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel Withdrawn DE102004047840A1 (de)

Priority Applications (6)

Application Number Priority Date Filing Date Title
DE102004047840A DE102004047840A1 (de) 2004-09-29 2004-09-29 Neue substituierte Thiophencarbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel
JP2007533923A JP2008514665A (ja) 2004-09-29 2005-09-23 新規置換チオフェンカルボン酸アミド、それらの製造方法及び薬剤としてのそれらの使用
PCT/EP2005/010307 WO2006034822A1 (de) 2004-09-29 2005-09-23 Neue substituierte thiophencarbonsäureamide, deren herstellung und deren verwendung als arzneimittel
CA002581580A CA2581580A1 (en) 2004-09-29 2005-09-23 Novel substituted thiophencarboxylic acid amides, production thereof and use thereof as medicaments
EP05788511A EP1797080A1 (de) 2004-09-29 2005-09-23 Neue substituierte thiophencarbonsäureamide, deren herstellung und deren verwendung als arzneimittel
US11/238,599 US7563786B2 (en) 2004-09-29 2005-09-29 Substituted thiophenecarboxamides, their preparation and their use as medicaments

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004047840A DE102004047840A1 (de) 2004-09-29 2004-09-29 Neue substituierte Thiophencarbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
DE102004047840A1 true DE102004047840A1 (de) 2006-03-30

Family

ID=35385703

Family Applications (1)

Application Number Title Priority Date Filing Date
DE102004047840A Withdrawn DE102004047840A1 (de) 2004-09-29 2004-09-29 Neue substituierte Thiophencarbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel

Country Status (6)

Country Link
US (1) US7563786B2 (https=)
EP (1) EP1797080A1 (https=)
JP (1) JP2008514665A (https=)
CA (1) CA2581580A1 (https=)
DE (1) DE102004047840A1 (https=)
WO (1) WO2006034822A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3078378A1 (en) 2015-04-08 2016-10-12 Vaiomer Use of factor xa inhibitors for regulating glycemia

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005111013A1 (de) * 2004-05-13 2005-11-24 Boehringer Ingelheim International Gmbh Substituierte thiophen-2-carbonsäureamide, deren herstellung und deren verwendung als arzneimittel
PE20070171A1 (es) 2005-06-30 2007-03-08 Boehringer Ingelheim Int GLICINAMIDAS SUSTITUIDAS CON EFECTO ANTITROMBOTICO E INHIBIDOR DEL FACTOR Xa
PE20081834A1 (es) 2006-12-31 2009-01-16 Boehringer Ingelheim Int Proceso para la sintesis de derivados de acido 3-amino-tetrahidrofuran-3-carboxilico y uso de los mismos como medicamentos
US8741890B2 (en) 2007-11-15 2014-06-03 Boehringer Ingelheim International Gmbh Substituted amides, manufacturing and use thereof as medicaments
EP2559455A1 (en) 2008-07-15 2013-02-20 Novartis AG Heteroaryl derivatives as DGAT1 inhibitors
EP2480531B1 (en) 2009-09-21 2014-11-05 ChemoCentryx, Inc. Pyrrolidinone carboxamide derivatives as chemerin-r (chemr23) modulators
US8912221B2 (en) * 2010-12-27 2014-12-16 Hoffmann-La Roche Inc. Biaryl amide derivatives
CN105294669B (zh) * 2014-10-24 2019-01-22 山东凯森制药有限公司 一种第十因子抑制剂及其制备方法和应用
DK4240348T3 (da) 2020-11-06 2026-04-20 Boehringer Ingelheim Int Gmbh 2-[thiophen-2-yl)formamido]-n-(phenyl)-2-methylpropanamid-derivater og anvendelse deraf som medikament

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19962924A1 (de) * 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
GB0030305D0 (en) * 2000-12-13 2001-01-24 Lilly Co Eli Compounds
JP4266092B2 (ja) * 2001-10-09 2009-05-20 第一三共株式会社 ジアミン誘導体
EP1558606A4 (en) * 2002-10-02 2008-05-07 Bristol Myers Squibb Co DIAMINOALKYL CONTAINING LACTAM, BETA AMINO ACIDS, ALPHA AMINO ACIDS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS
DE10254336A1 (de) * 2002-11-21 2004-06-03 Merck Patent Gmbh Carbonsäureamide

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3078378A1 (en) 2015-04-08 2016-10-12 Vaiomer Use of factor xa inhibitors for regulating glycemia
WO2016162472A1 (en) 2015-04-08 2016-10-13 Vaiomer Use of factor xa inhibitors for regulating glycemia

Also Published As

Publication number Publication date
EP1797080A1 (de) 2007-06-20
JP2008514665A (ja) 2008-05-08
US7563786B2 (en) 2009-07-21
WO2006034822A1 (de) 2006-04-06
US20060069082A1 (en) 2006-03-30
CA2581580A1 (en) 2006-04-06
WO2006034822A8 (de) 2006-06-15

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Legal Events

Date Code Title Description
R119 Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee

Effective date: 20110401