DE10085384T1 - Ein Verfahren für die Herstellung von 6-(2,3-Dichlorphenyl)-1,2,4-triazin -3,5-diamin, im Allgemeinen bekannt als Lamotrigin - Google Patents
Ein Verfahren für die Herstellung von 6-(2,3-Dichlorphenyl)-1,2,4-triazin -3,5-diamin, im Allgemeinen bekannt als LamotriginInfo
- Publication number
- DE10085384T1 DE10085384T1 DE10085384T DE10085384T DE10085384T1 DE 10085384 T1 DE10085384 T1 DE 10085384T1 DE 10085384 T DE10085384 T DE 10085384T DE 10085384 T DE10085384 T DE 10085384T DE 10085384 T1 DE10085384 T1 DE 10085384T1
- Authority
- DE
- Germany
- Prior art keywords
- lamotrigine
- dichlorophenyl
- triazine
- diamine
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IN2000/000001 WO2001049669A1 (en) | 2000-01-03 | 2000-01-03 | A process for the preparation of 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine, commonly known as lamotrigine |
Publications (2)
Publication Number | Publication Date |
---|---|
DE10085384T1 true DE10085384T1 (de) | 2002-12-12 |
DE10085384B4 DE10085384B4 (de) | 2006-06-14 |
Family
ID=11076221
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE10085384T Expired - Fee Related DE10085384B4 (de) | 2000-01-03 | 2000-01-03 | Ein Verfahren für die Herstellung von 6-(2,3-Dichlorphenyl)-1,2,4-triazin -3,5-diamin, im Allgemeinen bekannt als Lamotrigin |
Country Status (5)
Country | Link |
---|---|
US (1) | US6639072B1 (de) |
AU (1) | AU763244B2 (de) |
DE (1) | DE10085384B4 (de) |
GB (1) | GB2372988B (de) |
WO (1) | WO2001049669A1 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL157608A0 (en) * | 2001-02-27 | 2004-03-28 | Teva Pharma | New crystal forms of lamotrigine and processes for their preparations |
DE10134980C2 (de) * | 2001-07-17 | 2003-05-28 | Helm Ag | Verfahren zur Herstellung von Lamotrigin |
ES2282628T3 (es) * | 2002-04-23 | 2007-10-16 | Teva Pharmaceutical Industries Ltd. | Composicon farmaceutica que contiene particulas de lamotrigina de morfologia definida. |
HU225667B1 (en) * | 2002-09-20 | 2007-05-29 | Richter Gedeon Nyrt | Method for producing high-purity 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine |
ES2209639B1 (es) * | 2002-10-31 | 2005-08-01 | Vita Cientifica, S.L. | Procedimiento para la obtencion de un compuesto farmaceuticamente activo y obtencion de su intermedio. |
US20120142919A1 (en) | 2006-08-02 | 2012-06-07 | Medichem, S.A. | Method for synthesizing lamotrigine |
EP2054396A1 (de) * | 2006-08-14 | 2009-05-06 | Lonza Ag | Verfahren zur herstellung von lamotrigin |
US8486927B2 (en) | 2007-11-09 | 2013-07-16 | Thar Pharmaceuticals | Crystalline forms of lamotrigine |
WO2009069073A1 (en) * | 2007-11-28 | 2009-06-04 | Alembic Limited | An improved process for the preparation of lamotrigine |
CN102070545B (zh) * | 2010-10-22 | 2012-12-05 | 蒋勇 | 制备拉莫三嗪的方法 |
CN106083753B (zh) * | 2016-06-07 | 2019-04-02 | 浙江奇彩环境科技股份有限公司 | 一种改进的拉莫三嗪合成工艺 |
CN108129409B (zh) * | 2018-01-22 | 2020-07-03 | 三金集团湖南三金制药有限责任公司 | 一种改进的合成拉莫三嗪的方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3637688A (en) | 1970-01-09 | 1972-01-25 | American Home Prod | 6-(fluoro and trifluoromethyl phenyl)-3 5-diamino - 1 2 4 - triazines and substituted - 6 - phenylalkyl-3,5-diamino-1 2 4-triazines |
CA1119592A (en) * | 1977-07-01 | 1982-03-09 | Bryan B. Molloy | Chlorinated tetrahydro-2-benzazepines, n-methyl transferase inhibitors |
AR227521A1 (es) * | 1979-06-01 | 1982-11-15 | Wellcome Found | Procedimiento para la preparacion de derivados de 3,5-diamino-6-(fenil substituido)-1,2,4-triazinas e intermediario para realizar el procedimiento |
GB8328757D0 (en) | 1983-10-27 | 1983-11-30 | Wellcome Found | Chemical compounds |
GB8613183D0 (en) | 1986-05-30 | 1986-07-02 | Wellcome Found | Triazine salt |
US4960936A (en) | 1987-12-31 | 1990-10-02 | Ciba-Geigy Corporation | Process for the preparation of halogenated aromatic primary amines |
JPH11501007A (ja) | 1994-12-30 | 1999-01-26 | ザ、ウェルカム、ファンデーション、リミテッド | ラモトリジンの製造法 |
GB9426448D0 (en) | 1994-12-30 | 1995-03-01 | Wellcome Found | Process |
GB9812413D0 (en) * | 1998-06-10 | 1998-08-05 | Glaxo Group Ltd | Compound and its use |
-
2000
- 2000-01-03 GB GB0214791A patent/GB2372988B/en not_active Expired - Fee Related
- 2000-01-03 DE DE10085384T patent/DE10085384B4/de not_active Expired - Fee Related
- 2000-01-03 US US10/149,429 patent/US6639072B1/en not_active Expired - Fee Related
- 2000-01-03 WO PCT/IN2000/000001 patent/WO2001049669A1/en active Application Filing
- 2000-01-03 AU AU44288/00A patent/AU763244B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
GB0214791D0 (en) | 2002-08-07 |
DE10085384B4 (de) | 2006-06-14 |
AU4428800A (en) | 2001-07-16 |
WO2001049669A1 (en) | 2001-07-12 |
GB2372988A (en) | 2002-09-11 |
US6639072B1 (en) | 2003-10-28 |
AU763244B2 (en) | 2003-07-17 |
GB2372988B (en) | 2004-04-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE10085384T1 (de) | Ein Verfahren für die Herstellung von 6-(2,3-Dichlorphenyl)-1,2,4-triazin -3,5-diamin, im Allgemeinen bekannt als Lamotrigin | |
DE60211535D1 (de) | Verfahren zur herstellung von 2,5-diformylfuran aus kohlenhydraten | |
EP1254880A4 (de) | Triazinderivate enthaltende, gaserzeugende reaktionsmischung | |
IS5815A (is) | Setin 1,8-naftýridín-4(1H)-ón sem fosfódíesterasa4 latar | |
ATE323683T1 (de) | Verfahren zur herstellung von 1-(carboxymethyl)- und 1(aminocarbonyl)-pyrimidin-4-on derivaten | |
ATE452125T1 (de) | Verfahren zur herstellung von lamotrigin und dessen zwischenprodukt 2,3-dichlorbenzoylchlorid | |
WO2002067675A3 (en) | Substituted 4,5-dihydro-1,2,4-triazin-6-ones, 1,2,4-triazin-6-ones, and their use as fungicides and insecticides | |
WO2002040451A3 (en) | Lactam compound | |
PL348865A1 (en) | An improved process for the preparation of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine | |
HUP0301038A3 (en) | Process for the preparation of 4,6-dimethoxy-2-(methylsulfonyl)-1,3-pyrimidine | |
DE50000141D1 (de) | Verfahren für die Herstellung von 1,2-Dichlorethan aus der Oxichlorierung | |
NO20022755L (no) | Vannfortynnbare foretrede melaminformaldehydharpikser | |
MXPA03001540A (es) | 4-fenil-1-(1-fienl-ciclohexil)-1,2,3,6-tetrahidro-piridina sustituida. | |
DE69717380D1 (de) | 1,2,4-Triazin-3,5-Dionderivate als Anticoccidiosemittel | |
HUP0401746A3 (en) | Substituted 6-(2-tolyl)-triazolopyrimidines as fungicides | |
HUP0203114A2 (hu) | Új eljárás nagy tisztaságú 3,5-diamino-6-(2,3-diklór-fenil)-triazin előállítására | |
IL159605A0 (en) | 6-(2,6-difluorophenyl)-triazolopyrimidines as fungicides | |
IL155505A0 (en) | Substituted 4,5-dihydro-1,2,4-triazin-3 ones, 1,2,4-triazin-3-ones, and their use as fungicides and insecticides | |
CA2417435A1 (en) | Method for producing lamotrigine from alpha-oxo-2,3-dichlorophenyl acetamidino-aminoguanidino hydrazone by ring closure reaction | |
DE69911462D1 (de) | Ein verbessertes verfahren zur herstellung von 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazin | |
ITPN20020001A1 (it) | Chiavistello di sicurezza autobloccante per la porta del cesto di unamacchina lavabiancheria. | |
DE69819190D1 (de) | Cokondensierte harzzusammensetzungen aus phenol/triazin derivaten sowie verfahren zu deren herstellung | |
HUP0401390A3 (en) | Process for the manufacture of homopolyamide-4,6 fibers | |
TW488230U (en) | Safety auxiliary buckle for drawer or closet door | |
PL371028A1 (en) | Piperidine-2,6-diones that are heterocyclically substituted in position 3 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8110 | Request for examination paragraph 44 | ||
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |