DE10059415A1 - Verwendung von schwachen Opioiden und gemischten Opioidagonisten/-antagonisten zur Therapie der Harninkontinenz - Google Patents

Verwendung von schwachen Opioiden und gemischten Opioidagonisten/-antagonisten zur Therapie der Harninkontinenz

Info

Publication number
DE10059415A1
DE10059415A1 DE10059415A DE10059415A DE10059415A1 DE 10059415 A1 DE10059415 A1 DE 10059415A1 DE 10059415 A DE10059415 A DE 10059415A DE 10059415 A DE10059415 A DE 10059415A DE 10059415 A1 DE10059415 A1 DE 10059415A1
Authority
DE
Germany
Prior art keywords
diastereomers
enantiomers
use according
codeine
tilidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE10059415A
Other languages
German (de)
English (en)
Inventor
Thomas Christoph
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
Original Assignee
Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Priority to DE10059415A priority Critical patent/DE10059415A1/de
Priority to PT01998335T priority patent/PT1337254E/pt
Priority to PL363677A priority patent/PL204246B1/pl
Priority to EP01998335A priority patent/EP1337254B1/de
Priority to MXPA03004713A priority patent/MXPA03004713A/es
Priority to HU0303285A priority patent/HUP0303285A3/hu
Priority to SI200130315T priority patent/SI1337254T1/xx
Priority to DE50105150T priority patent/DE50105150D1/de
Priority to AU2073602A priority patent/AU2073602A/xx
Priority to ES01998335T priority patent/ES2234933T3/es
Priority to CA002430281A priority patent/CA2430281C/en
Priority to AU2002220736A priority patent/AU2002220736B2/en
Priority to JP2002545684A priority patent/JP2004527465A/ja
Priority to PCT/EP2001/013911 priority patent/WO2002043713A2/de
Priority to AT01998335T priority patent/ATE287265T1/de
Priority to NZ526604A priority patent/NZ526604A/en
Publication of DE10059415A1 publication Critical patent/DE10059415A1/de
Priority to US10/448,322 priority patent/US7008939B2/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE10059415A 2000-11-30 2000-11-30 Verwendung von schwachen Opioiden und gemischten Opioidagonisten/-antagonisten zur Therapie der Harninkontinenz Withdrawn DE10059415A1 (de)

Priority Applications (17)

Application Number Priority Date Filing Date Title
DE10059415A DE10059415A1 (de) 2000-11-30 2000-11-30 Verwendung von schwachen Opioiden und gemischten Opioidagonisten/-antagonisten zur Therapie der Harninkontinenz
ES01998335T ES2234933T3 (es) 2000-11-30 2001-11-28 Utilizacion de opiaceos debiles y mixtos agonistas/antagonistas para el tratamiento de la incontinencia urinaria.
CA002430281A CA2430281C (en) 2000-11-30 2001-11-28 Use of weak opioids and mixed opioid agonists/antagonists for treatment of urinary incontinence
EP01998335A EP1337254B1 (de) 2000-11-30 2001-11-28 Verwendung von schwachen opioiden und gemischten opioidagonisten / -antagonisten zur therapie der harninkontinenz
MXPA03004713A MXPA03004713A (es) 2000-11-30 2001-11-28 Uso de opiaceos debiles y agonistas/antagonistas de opiaceos mezclados para el tratamiento de la incontinencia urinaria.
HU0303285A HUP0303285A3 (en) 2000-11-30 2001-11-28 Use of weak opioids and mixed opioid agonists/antagonists for preparing of pharmaceutical composition for treating urinary incontinence
SI200130315T SI1337254T1 (en) 2000-11-30 2001-11-28 Use of weak opioids and mixed opioid agonists/antagonists for treating urinary incontinence
DE50105150T DE50105150D1 (de) 2000-11-30 2001-11-28 Verwendung von schwachen opioiden und gemischten opioidagonisten / -antagonisten zur therapie der harninkontinenz
AU2073602A AU2073602A (en) 2000-11-30 2001-11-28 Use of weak opioids and mixed opioid agonists/antagonists for treating urinary incontinence
PT01998335T PT1337254E (pt) 2000-11-30 2001-11-28 Utilizacao de opioides fracos e de agonistas / antagonistas opioides mistos para tratamento da incontinencia urinaria
PL363677A PL204246B1 (pl) 2000-11-30 2001-11-28 Zastosowanie słabych opioidów i mieszanych opioidowych substancji agonistycznych/antagonistycznych do terapii nietrzymania moczu
AU2002220736A AU2002220736B2 (en) 2000-11-30 2001-11-28 Use of weak opioids and mixed opioid agonists/antagonists for treating urinary incontinence
JP2002545684A JP2004527465A (ja) 2000-11-30 2001-11-28 弱いオピオイド及び混合されたオピオイドアンタゴニスト／−アゴニストを尿失禁の治療に使用する方法
PCT/EP2001/013911 WO2002043713A2 (de) 2000-11-30 2001-11-28 Verwendung von schwachen opioiden und gemischten opioidagonisten / -antagonisten zur therapie der harninkontinenz
AT01998335T ATE287265T1 (de) 2000-11-30 2001-11-28 Verwendung von schwachen opioiden und gemischten opioidagonisten / -antagonisten zur therapie der harninkontinenz
NZ526604A NZ526604A (en) 2000-11-30 2001-11-28 Use of weak opioids and mixed opioid agonists/antagonists for treating urinary incontinence
US10/448,322 US7008939B2 (en) 2000-11-30 2003-05-30 Use of weak opioids and mixed opioid agonists/antagonists for treatment of urinary incontinence

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10059415A DE10059415A1 (de) 2000-11-30 2000-11-30 Verwendung von schwachen Opioiden und gemischten Opioidagonisten/-antagonisten zur Therapie der Harninkontinenz

Publications (1)

Publication Number Publication Date
DE10059415A1 true DE10059415A1 (de) 2002-06-06

Family

ID=7665212

Family Applications (2)

Application Number Title Priority Date Filing Date
DE10059415A Withdrawn DE10059415A1 (de) 2000-11-30 2000-11-30 Verwendung von schwachen Opioiden und gemischten Opioidagonisten/-antagonisten zur Therapie der Harninkontinenz
DE50105150T Expired - Lifetime DE50105150D1 (de) 2000-11-30 2001-11-28 Verwendung von schwachen opioiden und gemischten opioidagonisten / -antagonisten zur therapie der harninkontinenz

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE50105150T Expired - Lifetime DE50105150D1 (de) 2000-11-30 2001-11-28 Verwendung von schwachen opioiden und gemischten opioidagonisten / -antagonisten zur therapie der harninkontinenz

Country Status (14)

Country Link
US (1) US7008939B2 (https=)
EP (1) EP1337254B1 (https=)
JP (1) JP2004527465A (https=)
AT (1) ATE287265T1 (https=)
AU (2) AU2002220736B2 (https=)
CA (1) CA2430281C (https=)
DE (2) DE10059415A1 (https=)
ES (1) ES2234933T3 (https=)
HU (1) HUP0303285A3 (https=)
MX (1) MXPA03004713A (https=)
NZ (1) NZ526604A (https=)
PL (1) PL204246B1 (https=)
PT (1) PT1337254E (https=)
WO (1) WO2002043713A2 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8476280B2 (en) 2002-05-09 2013-07-02 Versi Group, Llc Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists
US7964315B2 (en) * 2003-09-12 2011-06-21 Bdf Ip Holdings Ltd. Shutdown methods and designs for fuel cell stacks
JP4902883B2 (ja) * 2005-03-11 2012-03-21 ビーディーエフ アイピー ホールディングス リミテッド 燃料電池スタックのシャットダウン方法および設計
TW200800223A (en) * 2005-12-21 2008-01-01 Shire Pharmaceuticals Inc Transdermal delivery of meptazinol
US8748448B2 (en) 2007-10-18 2014-06-10 Aiko Biotechnology Combination analgesic employing opioid agonist and neutral antagonist
EP2214672B1 (en) * 2007-10-18 2012-10-17 Aiko Biotechnology Combination analgesic employing opioid and neutral antagonist
CN102836122A (zh) * 2011-06-24 2012-12-26 扬子江药业集团四川海蓉药业有限公司 含有盐酸美普他酚的组合物注射液及其制备方法
CN109646397A (zh) * 2015-02-13 2019-04-19 成都苑东生物制药股份有限公司 一种盐酸美普他酚注射液药物组合物及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998046216A1 (fr) * 1997-04-11 1998-10-22 Nippon Shinyaku Co., Ltd. Traitements des mictions frequentes et de l'incontinence urinaire
US5840696A (en) * 1997-09-11 1998-11-24 Lippton; Howard Diuretic and antinatriuretic responses produced by the endogenous opioid-like peptide, nociceptin (orphanin FQ)
US5859043A (en) * 1996-06-11 1999-01-12 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Method for maintaining kidney function during surgery or severe trauma under general anesthesia
WO1999022737A1 (en) * 1997-11-03 1999-05-14 Arch Development Corporation Use of methylnaltrexone and related compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5354863A (en) * 1992-01-21 1994-10-11 G. D. Searle & Co. Opioid agonist compounds
GB9202238D0 (en) * 1992-02-03 1992-03-18 Wellcome Found Compounds
USRE36547E (en) * 1992-09-21 2000-02-01 Albert Einstein College Of Medicine Of Yeshiva University Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by exogenous and endogenous opioid agonists
US6159501A (en) * 1996-03-08 2000-12-12 Nycomed Danmark A/S Modified release multiple-units dosage composition for release of opioid compounds
ATE210983T1 (de) * 1997-11-03 2002-01-15 Stada Arzneimittel Ag Stabilisiertes kombinationsarzneimittel enthaltend naloxone und ein opiatanalgetikum
DE19947747A1 (de) * 1999-10-05 2001-04-12 Gruenenthal Gmbh Verwendung von (+)-Tramadol, O-Demethyltramadol bzw. (+)-O-Demethyltramadol zur Therapie der Harninkontinenz
US8410129B2 (en) * 2002-02-15 2013-04-02 Howard Brooks-Korn Treatment for paresis/paralysis

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859043A (en) * 1996-06-11 1999-01-12 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Method for maintaining kidney function during surgery or severe trauma under general anesthesia
WO1998046216A1 (fr) * 1997-04-11 1998-10-22 Nippon Shinyaku Co., Ltd. Traitements des mictions frequentes et de l'incontinence urinaire
US5840696A (en) * 1997-09-11 1998-11-24 Lippton; Howard Diuretic and antinatriuretic responses produced by the endogenous opioid-like peptide, nociceptin (orphanin FQ)
WO1999022737A1 (en) * 1997-11-03 1999-05-14 Arch Development Corporation Use of methylnaltrexone and related compounds

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DRAY,A., et.al.: Meptazinol: Unusual In Vivo Opioid Receptor Activity At Supraspinal And Spinal Sites. In: Neuropharmacology, Vol.25, No.4, 1986, S.343-349 *
JP 07053534 A.,In: Patent Abstracts of Japan *

Also Published As

Publication number Publication date
CA2430281C (en) 2009-08-25
HUP0303285A3 (en) 2005-05-30
PL204246B1 (pl) 2009-12-31
DE50105150D1 (de) 2005-02-24
AU2002220736B2 (en) 2006-04-06
JP2004527465A (ja) 2004-09-09
AU2073602A (en) 2002-06-11
WO2002043713A2 (de) 2002-06-06
US7008939B2 (en) 2006-03-07
WO2002043713A3 (de) 2002-10-31
ATE287265T1 (de) 2005-02-15
ES2234933T3 (es) 2005-07-01
HUP0303285A2 (hu) 2004-01-28
CA2430281A1 (en) 2002-06-06
EP1337254A2 (de) 2003-08-27
PT1337254E (pt) 2005-05-31
NZ526604A (en) 2005-04-29
EP1337254B1 (de) 2005-01-19
PL363677A1 (en) 2004-11-29
MXPA03004713A (es) 2003-08-19
US20040029905A1 (en) 2004-02-12

Similar Documents

Publication Publication Date Title
EP1572181A2 (de) Pharmazeutische zusammensetzung aus einem beta-3-adrenozeptor-agonisten und einem serotonin- und/oder norepinephrin-reuptake-inhibitor und deren verwendung zur behandlung von blasenfunktionsstoerungen
EP1217998B1 (de) Verwendung von (+)-tramadol, o-demethyltramadol, o-desmethyl-n-mono-desmethyl-tramadol zur therapie der harninkontinenz
DE10146275A1 (de) Kombination ausgewählter Opioide mit Muscarin-Antagonisten zur Therapie der Harninkontinenz
EP1438034B1 (de) Verwendung von 1-phenyl-3-dimethylamino-propan-verbindungen zur therapie der harninkontinenz
EP1337254B1 (de) Verwendung von schwachen opioiden und gemischten opioidagonisten / -antagonisten zur therapie der harninkontinenz
DE102007018150A1 (de) VR1-Rezeptor-Liganden und µ-Opioid-Rezeptor-Liganden zur Behandlung von Schmerz
DE10224107A1 (de) Kombination ausgewählter Opioide mit anderen Wirkstoffen zur Therapie der Harninkontinenz
EP1368023B1 (de) Verwendung von buprenorphin zur therapie der harninkontinenz
EP1353660B1 (de) Verwendung von substituierten 6-dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur therapie der harninkontinenz
DE10059411A1 (de) Verwendung von 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur Therapie der Harninkontinenz
DE19947747A1 (de) Verwendung von (+)-Tramadol, O-Demethyltramadol bzw. (+)-O-Demethyltramadol zur Therapie der Harninkontinenz
WO2005046664A1 (de) Pharmazeutische zusammensetzung aus einem beta-3-adrenozeptor-agonisten und einem alpha agonisten
DE20115429U1 (de) Opioide in der Harninkontinenz
DE10107828A1 (de) Verwendung von Buprenorphin zur Therapie der Harninkontinenz
EP0870499A1 (de) Orale Anwendung von (+)-0-Demethyltramadol als Schmerzmittel
DE10162704A1 (de) Verwendung von Buprenorphin zur Therapie der Harninkontinenz
DE10225315A1 (de) Wirkstoffsalze und Ester von 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl- pentan-3-ol und 3-(3-Dimethylamino-1-ethyl-1-hydroxy-2-methyl- propyl)-phenol
EP1507519B1 (de) 1-dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol enthaltendes arzneimittel mit verzögerter wirkstofffreisetzung
DE10224624A1 (de) Metabolite und Prodrugs von 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol

Legal Events

Date Code Title Description
OM8 Search report available as to paragraph 43 lit. 1 sentence 1 patent law
8139 Disposal/non-payment of the annual fee