DE01909253T1 - Wirkstoffe, enthaltend picolinsäure, fusarsäure oder deren derivate - Google Patents
Wirkstoffe, enthaltend picolinsäure, fusarsäure oder deren derivate Download PDFInfo
- Publication number
- DE01909253T1 DE01909253T1 DE0001257262T DE01909253T DE01909253T1 DE 01909253 T1 DE01909253 T1 DE 01909253T1 DE 0001257262 T DE0001257262 T DE 0001257262T DE 01909253 T DE01909253 T DE 01909253T DE 01909253 T1 DE01909253 T1 DE 01909253T1
- Authority
- DE
- Germany
- Prior art keywords
- group
- chelating agent
- butyl
- butyl group
- metal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- DGMPVYSXXIOGJY-UHFFFAOYSA-N Fusaric acid Chemical compound CCCCC1=CC=C(C(O)=O)N=C1 DGMPVYSXXIOGJY-UHFFFAOYSA-N 0.000 title 2
- 239000013543 active substance Substances 0.000 title 1
- SIOXPEMLGUPBBT-UHFFFAOYSA-N picolinic acid Chemical compound OC(=O)C1=CC=CC=N1 SIOXPEMLGUPBBT-UHFFFAOYSA-N 0.000 title 1
- 239000002184 metal Substances 0.000 claims abstract 45
- 229910052751 metal Inorganic materials 0.000 claims abstract 45
- 239000002738 chelating agent Substances 0.000 claims abstract 41
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims abstract 27
- 239000001257 hydrogen Substances 0.000 claims abstract 24
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 24
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 21
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims abstract 14
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims abstract 14
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims abstract 14
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims abstract 14
- 150000001413 amino acids Chemical class 0.000 claims abstract 14
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims abstract 14
- 229910052794 bromium Inorganic materials 0.000 claims abstract 14
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract 14
- 229910052801 chlorine Inorganic materials 0.000 claims abstract 14
- 239000000460 chlorine Substances 0.000 claims abstract 14
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims abstract 14
- 229910052731 fluorine Inorganic materials 0.000 claims abstract 14
- 239000011737 fluorine Substances 0.000 claims abstract 14
- 229910052740 iodine Inorganic materials 0.000 claims abstract 14
- 239000011630 iodine Substances 0.000 claims abstract 14
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims abstract 14
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 claims abstract 14
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims abstract 14
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract 14
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims abstract 14
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims abstract 14
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract 14
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims abstract 14
- 150000003839 salts Chemical class 0.000 claims abstract 14
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims abstract 14
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims abstract 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract 13
- 206010042496 Sunburn Diseases 0.000 claims abstract 8
- 201000010099 disease Diseases 0.000 claims abstract 8
- 230000033115 angiogenesis Effects 0.000 claims abstract 7
- 229910021645 metal ion Inorganic materials 0.000 claims abstract 7
- 206010055114 Colon cancer metastatic Diseases 0.000 claims abstract 5
- 208000005176 Hepatitis C Diseases 0.000 claims abstract 5
- 206010057190 Respiratory tract infections Diseases 0.000 claims abstract 5
- 206010046306 Upper respiratory tract infection Diseases 0.000 claims abstract 5
- 208000035475 disorder Diseases 0.000 claims abstract 5
- 208000010710 hepatitis C virus infection Diseases 0.000 claims abstract 5
- 230000036737 immune function Effects 0.000 claims abstract 5
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract 4
- 230000001404 mediated effect Effects 0.000 claims abstract 3
- 108090000623 proteins and genes Proteins 0.000 claims abstract 3
- 102000004169 proteins and genes Human genes 0.000 claims abstract 3
- 239000003814 drug Substances 0.000 claims 20
- 229940079593 drug Drugs 0.000 claims 12
- 238000002360 preparation method Methods 0.000 claims 9
- 238000009472 formulation Methods 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- 239000000243 solution Substances 0.000 claims 6
- 229940100617 topical lotion Drugs 0.000 claims 6
- 230000009885 systemic effect Effects 0.000 claims 5
- 208000002874 Acne Vulgaris Diseases 0.000 claims 4
- 206010061218 Inflammation Diseases 0.000 claims 4
- 206010000496 acne Diseases 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 230000004054 inflammatory process Effects 0.000 claims 4
- 239000003755 preservative agent Substances 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 230000002335 preservative effect Effects 0.000 claims 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 238000011010 flushing procedure Methods 0.000 claims 2
- 208000020029 respiratory tract infectious disease Diseases 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 1
- 239000013522 chelant Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002504 physiological saline solution Substances 0.000 claims 1
- 229910052725 zinc Inorganic materials 0.000 claims 1
- 239000011701 zinc Substances 0.000 claims 1
- 0 *c1c(*)c(*)nc(C(O)=O)c1* Chemical compound *c1c(*)c(*)nc(C(O)=O)c1* 0.000 description 6
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/04—Chelating agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Ophthalmology & Optometry (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- AIDS & HIV (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18260800P | 2000-02-15 | 2000-02-15 | |
| US182608P | 2000-02-15 | ||
| PCT/US2001/004897 WO2001060349A2 (en) | 2000-02-15 | 2001-02-15 | Pharmacological agent comprising picolinic acid, fusaric acid and derivatives thereof. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE01909253T1 true DE01909253T1 (de) | 2004-04-15 |
Family
ID=22669217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE0001257262T Pending DE01909253T1 (de) | 2000-02-15 | 2001-02-15 | Wirkstoffe, enthaltend picolinsäure, fusarsäure oder deren derivate |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6403618B1 (https=) |
| EP (1) | EP1257262A2 (https=) |
| JP (1) | JP2003522786A (https=) |
| AU (1) | AU781066B2 (https=) |
| BR (1) | BR0108400A (https=) |
| DE (1) | DE01909253T1 (https=) |
| ES (1) | ES2215493T1 (https=) |
| MX (1) | MXPA02007954A (https=) |
| TR (1) | TR200301378T3 (https=) |
| WO (1) | WO2001060349A2 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060074063A1 (en) * | 1995-12-29 | 2006-04-06 | Fernandez-Pol Jose A | Pharmacological agent and method of treatment |
| US6579891B1 (en) * | 1995-12-29 | 2003-06-17 | Novactyl, Inc. | Agent and method for prevention and treatment of cancer in animals |
| EP1420786A2 (en) * | 2001-08-23 | 2004-05-26 | The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services | Methods of inhibiting formation of vascular channels and proliferation using pyridinone derivatives |
| WO2003055477A1 (en) * | 2001-12-21 | 2003-07-10 | 7Tm Pharma A/S | Method for the treatment of mc receptor related disorders with a chelate and/or a chelator |
| US8313760B2 (en) | 2002-05-24 | 2012-11-20 | Angiotech International Ag | Compositions and methods for coating medical implants |
| EP2075014B9 (en) | 2002-05-24 | 2012-02-01 | Angiotech International Ag | Compositions and methods for coating medical implants |
| CA2536192A1 (en) * | 2003-11-20 | 2005-06-09 | Angiotech International Ag | Soft tissue implants and anti-scarring agents |
| ES2702607T3 (es) * | 2004-01-07 | 2019-03-04 | E L Man Corporation | Composición cosmética y método de retardo del crecimiento del vello |
| US20050239723A1 (en) * | 2004-04-27 | 2005-10-27 | Amin Avinash N | Compositions and methods useful for treatment of acne |
| US20070178062A1 (en) * | 2005-10-07 | 2007-08-02 | Nathan Ravi | Treatment of presbyopia with picolinic acid and its analogs |
| WO2007048051A2 (en) * | 2005-10-20 | 2007-04-26 | Viamet Pharmaceuticals, Inc. | Screening for modulators of metalation pathways for metalloproteins |
| WO2011041680A2 (en) | 2009-10-02 | 2011-04-07 | The Brigham And Women's Hospital, Inc. | Compositions and methods of prophylaxis for contact dermatitis |
| GB201317619D0 (en) | 2013-10-04 | 2013-11-20 | Uni I Oslo | Compounds |
| JP6843225B2 (ja) * | 2016-07-28 | 2021-03-17 | チャンスー ヤホン メディテック カンパニー リミテッド | 癌の処置のためのドーパミンβ−ヒドロキシラーゼ（ＤＢＨ）阻害剤およびセロトニン受容体（５−ＨＴ）アンタゴニストの使用 |
| GB201613946D0 (en) | 2016-08-15 | 2016-09-28 | Univ Oslo | Compounds |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3903285A (en) | 1972-12-29 | 1975-09-02 | Microbial Chem Res Found | Method for treating parkinsonism |
| ZA767103B (en) | 1975-11-28 | 1977-10-26 | Scherico Ltd | Picolinic acid derivatives and processes for their preparation |
| CH629488A5 (en) | 1975-11-28 | 1982-04-30 | Scherico Ltd | Processes for preparing novel picolinic acid derivatives. |
| US4044140A (en) | 1975-11-28 | 1977-08-23 | Schering Corporation | Trityl picolinic acid derivatives and their use as anti-acne agents |
| US4120762A (en) | 1977-09-30 | 1978-10-17 | Alden Research Foundation | Electrochemical recording medium |
| US4293547A (en) | 1980-08-25 | 1981-10-06 | The Upjohn Company | Method of treating malaria |
| US4443459A (en) | 1981-05-26 | 1984-04-17 | Banyu Pharmaceutical Co., Ltd. | α-Tocopheryl ester of 5-substituted picolinic acid and hypotensive composition containing it |
| US4814351A (en) | 1987-06-26 | 1989-03-21 | Redken Laboratories, Inc. | Scalp treatment |
| US5536743A (en) | 1988-01-15 | 1996-07-16 | Curatek Pharmaceuticals Limited Partnership | Intravaginal treatment of vaginal infections with buffered metronidazole compositions |
| US5057320A (en) | 1988-08-01 | 1991-10-15 | Nutrition 21 | Means and method for increasing skin respiration |
| US5157046A (en) | 1988-11-29 | 1992-10-20 | Janssen Pharmaceutica N.V. | Method of treating epithelial disorders |
| US5219847A (en) | 1989-06-12 | 1993-06-15 | Shiseido Company, Ltd. | Antipruritic composition |
| FR2657259A1 (fr) | 1990-01-25 | 1991-07-26 | Adir | Utilisation de la n-myristoyl-(s)-phenylalanine pour l'obtention de medicaments destines au traitement des maladies faisant intervenir la myristoylation. |
| US5484951A (en) | 1990-10-19 | 1996-01-16 | Octamer, Incorporated | 5-iodo-6-amino-6-nitroso-1,2-benzopyrones useful as cytostatic and antiviral agents |
| US5403816A (en) | 1990-10-25 | 1995-04-04 | Kumiai Chemical Industry Co., Ltd. | Picolinic acid derivative and herbicidal composition |
| US5391537A (en) | 1990-10-25 | 1995-02-21 | Kumiai Chemical Industry Co., Ltd. | Picolinic acid derivative, and herbicidal composition |
| US5173486A (en) | 1991-08-26 | 1992-12-22 | Bristol-Myers Squibb Company | Dibenz[b,f][1,4]oxazepin-11(10H)-ones for multidrug resistance reversing agents |
| US5516941A (en) | 1991-10-22 | 1996-05-14 | Octamer, Inc. | Specific inactivators of "retroviral" (asymmetric) zinc fingers |
| IL104323A0 (en) | 1992-01-10 | 1993-05-13 | Smithkline Beecham Corp | Hemoregulatory peptides |
| US5284840A (en) | 1992-06-12 | 1994-02-08 | Merck & Co., Inc. | Alkylidene macrolides having immunosuppressive activity |
| US5962463A (en) * | 1992-10-09 | 1999-10-05 | Massachusetts Institute Of Technology | Methods of stimulating non-amyloidogenic processing of the amyloid precursor protein |
| WO1994027627A1 (en) | 1993-05-24 | 1994-12-08 | Smithkline Beecham Corporation | Hemoregulatory peptides |
| US6001555A (en) | 1994-09-23 | 1999-12-14 | The United States Of America As Represented By The Department Of Health And Human Services | Method for identifying and using compounds that inactivate HIV-1 and other retroviruses by attacking highly conserved zinc fingers in the viral nucleocapsid protein |
| FR2736263B1 (fr) | 1995-07-07 | 1997-09-26 | C3D Sarl | Composition dermocosmetique depigmentante et son utilisation |
| US5767135A (en) | 1995-12-29 | 1998-06-16 | Fernandez-Pol; Jose Alberto | Antiviral agent |
| JP3337992B2 (ja) | 1997-11-04 | 2002-10-28 | ファイザー製薬株式会社 | ５−置換ピコリン酸化合物及びその製造方法 |
-
2000
- 2000-10-02 US US09/677,506 patent/US6403618B1/en not_active Expired - Fee Related
-
2001
- 2001-02-15 WO PCT/US2001/004897 patent/WO2001060349A2/en not_active Ceased
- 2001-02-15 JP JP2001559447A patent/JP2003522786A/ja active Pending
- 2001-02-15 ES ES01909253T patent/ES2215493T1/es active Pending
- 2001-02-15 TR TR2003/01378T patent/TR200301378T3/xx unknown
- 2001-02-15 BR BR0108400-3A patent/BR0108400A/pt not_active IP Right Cessation
- 2001-02-15 DE DE0001257262T patent/DE01909253T1/de active Pending
- 2001-02-15 MX MXPA02007954A patent/MXPA02007954A/es unknown
- 2001-02-15 EP EP01909253A patent/EP1257262A2/en not_active Withdrawn
- 2001-02-15 AU AU37028/01A patent/AU781066B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001060349B1 (en) | 2001-12-27 |
| BR0108400A (pt) | 2003-03-11 |
| ES2215493T1 (es) | 2004-10-16 |
| AU3702801A (en) | 2001-08-27 |
| AU781066B2 (en) | 2005-05-05 |
| US6403618B1 (en) | 2002-06-11 |
| JP2003522786A (ja) | 2003-07-29 |
| WO2001060349A2 (en) | 2001-08-23 |
| TR200301378T3 (tr) | 2003-12-22 |
| EP1257262A2 (en) | 2002-11-20 |
| MXPA02007954A (es) | 2004-09-10 |
| WO2001060349A3 (en) | 2001-11-08 |
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