JP2003522786A5 - - Google Patents
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- Publication number
- JP2003522786A5 JP2003522786A5 JP2001559447A JP2001559447A JP2003522786A5 JP 2003522786 A5 JP2003522786 A5 JP 2003522786A5 JP 2001559447 A JP2001559447 A JP 2001559447A JP 2001559447 A JP2001559447 A JP 2001559447A JP 2003522786 A5 JP2003522786 A5 JP 2003522786A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- butyl
- butyl group
- metal
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 80
- 239000002738 chelating agent Substances 0.000 claims 63
- 239000002184 metal Substances 0.000 claims 54
- 229910052751 metal Inorganic materials 0.000 claims 54
- 239000001257 hydrogen Substances 0.000 claims 30
- 229910052739 hydrogen Inorganic materials 0.000 claims 30
- 150000003839 salts Chemical class 0.000 claims 21
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 20
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 20
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 20
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 20
- 150000001413 amino acids Chemical class 0.000 claims 20
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 20
- 229910052794 bromium Inorganic materials 0.000 claims 20
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 20
- 229910052801 chlorine Inorganic materials 0.000 claims 20
- 239000000460 chlorine Substances 0.000 claims 20
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 20
- 229910052731 fluorine Inorganic materials 0.000 claims 20
- 239000011737 fluorine Substances 0.000 claims 20
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 20
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 20
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 claims 20
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 20
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 20
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 20
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 20
- 108090000765 processed proteins & peptides Proteins 0.000 claims 20
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 20
- 238000009472 formulation Methods 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 15
- 229910021645 metal ion Inorganic materials 0.000 claims 13
- 239000003814 drug Substances 0.000 claims 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 150000002431 hydrogen Chemical class 0.000 claims 10
- 239000000126 substance Substances 0.000 claims 10
- 239000003795 chemical substances by application Substances 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 8
- 239000003380 propellant Substances 0.000 claims 8
- 206010042496 Sunburn Diseases 0.000 claims 7
- 230000033115 angiogenesis Effects 0.000 claims 7
- 229940100656 nasal solution Drugs 0.000 claims 6
- 239000003755 preservative agent Substances 0.000 claims 6
- 229940100617 topical lotion Drugs 0.000 claims 6
- 230000002335 preservative effect Effects 0.000 claims 5
- 238000007910 systemic administration Methods 0.000 claims 5
- 208000002874 Acne Vulgaris Diseases 0.000 claims 4
- 206010055114 Colon cancer metastatic Diseases 0.000 claims 4
- 206010061218 Inflammation Diseases 0.000 claims 4
- 206010057190 Respiratory tract infections Diseases 0.000 claims 4
- 206010046306 Upper respiratory tract infection Diseases 0.000 claims 4
- 206010000496 acne Diseases 0.000 claims 4
- 208000010710 hepatitis C virus infection Diseases 0.000 claims 4
- 230000036737 immune function Effects 0.000 claims 4
- 230000004054 inflammatory process Effects 0.000 claims 4
- 208000020029 respiratory tract infectious disease Diseases 0.000 claims 4
- 239000012459 cleaning agent Substances 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000002504 physiological saline solution Substances 0.000 claims 3
- SIOXPEMLGUPBBT-UHFFFAOYSA-N picolinic acid Chemical compound OC(=O)C1=CC=CC=N1 SIOXPEMLGUPBBT-UHFFFAOYSA-N 0.000 claims 3
- 239000000243 solution Substances 0.000 claims 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 239000003599 detergent Substances 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 239000007921 spray Substances 0.000 claims 2
- 241001529453 unidentified herpesvirus Species 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 229910052725 zinc Inorganic materials 0.000 claims 2
- 239000011701 zinc Substances 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical class [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 229940081066 picolinic acid Drugs 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18260800P | 2000-02-15 | 2000-02-15 | |
| US60/182,608 | 2000-02-15 | ||
| PCT/US2001/004897 WO2001060349A2 (en) | 2000-02-15 | 2001-02-15 | Pharmacological agent comprising picolinic acid, fusaric acid and derivatives thereof. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003522786A JP2003522786A (ja) | 2003-07-29 |
| JP2003522786A5 true JP2003522786A5 (https=) | 2005-08-25 |
Family
ID=22669217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001559447A Pending JP2003522786A (ja) | 2000-02-15 | 2001-02-15 | 薬理学的薬剤、及び治療の方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6403618B1 (https=) |
| EP (1) | EP1257262A2 (https=) |
| JP (1) | JP2003522786A (https=) |
| AU (1) | AU781066B2 (https=) |
| BR (1) | BR0108400A (https=) |
| DE (1) | DE01909253T1 (https=) |
| ES (1) | ES2215493T1 (https=) |
| MX (1) | MXPA02007954A (https=) |
| TR (1) | TR200301378T3 (https=) |
| WO (1) | WO2001060349A2 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060074063A1 (en) * | 1995-12-29 | 2006-04-06 | Fernandez-Pol Jose A | Pharmacological agent and method of treatment |
| US6579891B1 (en) * | 1995-12-29 | 2003-06-17 | Novactyl, Inc. | Agent and method for prevention and treatment of cancer in animals |
| EP1420786A2 (en) * | 2001-08-23 | 2004-05-26 | The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services | Methods of inhibiting formation of vascular channels and proliferation using pyridinone derivatives |
| WO2003055477A1 (en) * | 2001-12-21 | 2003-07-10 | 7Tm Pharma A/S | Method for the treatment of mc receptor related disorders with a chelate and/or a chelator |
| US8313760B2 (en) | 2002-05-24 | 2012-11-20 | Angiotech International Ag | Compositions and methods for coating medical implants |
| EP2075014B9 (en) | 2002-05-24 | 2012-02-01 | Angiotech International Ag | Compositions and methods for coating medical implants |
| CA2536192A1 (en) * | 2003-11-20 | 2005-06-09 | Angiotech International Ag | Soft tissue implants and anti-scarring agents |
| ES2702607T3 (es) * | 2004-01-07 | 2019-03-04 | E L Man Corporation | Composición cosmética y método de retardo del crecimiento del vello |
| US20050239723A1 (en) * | 2004-04-27 | 2005-10-27 | Amin Avinash N | Compositions and methods useful for treatment of acne |
| US20070178062A1 (en) * | 2005-10-07 | 2007-08-02 | Nathan Ravi | Treatment of presbyopia with picolinic acid and its analogs |
| WO2007048051A2 (en) * | 2005-10-20 | 2007-04-26 | Viamet Pharmaceuticals, Inc. | Screening for modulators of metalation pathways for metalloproteins |
| WO2011041680A2 (en) | 2009-10-02 | 2011-04-07 | The Brigham And Women's Hospital, Inc. | Compositions and methods of prophylaxis for contact dermatitis |
| GB201317619D0 (en) | 2013-10-04 | 2013-11-20 | Uni I Oslo | Compounds |
| JP6843225B2 (ja) * | 2016-07-28 | 2021-03-17 | チャンスー ヤホン メディテック カンパニー リミテッド | 癌の処置のためのドーパミンβ−ヒドロキシラーゼ（ＤＢＨ）阻害剤およびセロトニン受容体（５−ＨＴ）アンタゴニストの使用 |
| GB201613946D0 (en) | 2016-08-15 | 2016-09-28 | Univ Oslo | Compounds |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3903285A (en) | 1972-12-29 | 1975-09-02 | Microbial Chem Res Found | Method for treating parkinsonism |
| ZA767103B (en) | 1975-11-28 | 1977-10-26 | Scherico Ltd | Picolinic acid derivatives and processes for their preparation |
| CH629488A5 (en) | 1975-11-28 | 1982-04-30 | Scherico Ltd | Processes for preparing novel picolinic acid derivatives. |
| US4044140A (en) | 1975-11-28 | 1977-08-23 | Schering Corporation | Trityl picolinic acid derivatives and their use as anti-acne agents |
| US4120762A (en) | 1977-09-30 | 1978-10-17 | Alden Research Foundation | Electrochemical recording medium |
| US4293547A (en) | 1980-08-25 | 1981-10-06 | The Upjohn Company | Method of treating malaria |
| US4443459A (en) | 1981-05-26 | 1984-04-17 | Banyu Pharmaceutical Co., Ltd. | α-Tocopheryl ester of 5-substituted picolinic acid and hypotensive composition containing it |
| US4814351A (en) | 1987-06-26 | 1989-03-21 | Redken Laboratories, Inc. | Scalp treatment |
| US5536743A (en) | 1988-01-15 | 1996-07-16 | Curatek Pharmaceuticals Limited Partnership | Intravaginal treatment of vaginal infections with buffered metronidazole compositions |
| US5057320A (en) | 1988-08-01 | 1991-10-15 | Nutrition 21 | Means and method for increasing skin respiration |
| US5157046A (en) | 1988-11-29 | 1992-10-20 | Janssen Pharmaceutica N.V. | Method of treating epithelial disorders |
| US5219847A (en) | 1989-06-12 | 1993-06-15 | Shiseido Company, Ltd. | Antipruritic composition |
| FR2657259A1 (fr) | 1990-01-25 | 1991-07-26 | Adir | Utilisation de la n-myristoyl-(s)-phenylalanine pour l'obtention de medicaments destines au traitement des maladies faisant intervenir la myristoylation. |
| US5484951A (en) | 1990-10-19 | 1996-01-16 | Octamer, Incorporated | 5-iodo-6-amino-6-nitroso-1,2-benzopyrones useful as cytostatic and antiviral agents |
| US5403816A (en) | 1990-10-25 | 1995-04-04 | Kumiai Chemical Industry Co., Ltd. | Picolinic acid derivative and herbicidal composition |
| US5391537A (en) | 1990-10-25 | 1995-02-21 | Kumiai Chemical Industry Co., Ltd. | Picolinic acid derivative, and herbicidal composition |
| US5173486A (en) | 1991-08-26 | 1992-12-22 | Bristol-Myers Squibb Company | Dibenz[b,f][1,4]oxazepin-11(10H)-ones for multidrug resistance reversing agents |
| US5516941A (en) | 1991-10-22 | 1996-05-14 | Octamer, Inc. | Specific inactivators of "retroviral" (asymmetric) zinc fingers |
| IL104323A0 (en) | 1992-01-10 | 1993-05-13 | Smithkline Beecham Corp | Hemoregulatory peptides |
| US5284840A (en) | 1992-06-12 | 1994-02-08 | Merck & Co., Inc. | Alkylidene macrolides having immunosuppressive activity |
| US5962463A (en) * | 1992-10-09 | 1999-10-05 | Massachusetts Institute Of Technology | Methods of stimulating non-amyloidogenic processing of the amyloid precursor protein |
| WO1994027627A1 (en) | 1993-05-24 | 1994-12-08 | Smithkline Beecham Corporation | Hemoregulatory peptides |
| US6001555A (en) | 1994-09-23 | 1999-12-14 | The United States Of America As Represented By The Department Of Health And Human Services | Method for identifying and using compounds that inactivate HIV-1 and other retroviruses by attacking highly conserved zinc fingers in the viral nucleocapsid protein |
| FR2736263B1 (fr) | 1995-07-07 | 1997-09-26 | C3D Sarl | Composition dermocosmetique depigmentante et son utilisation |
| US5767135A (en) | 1995-12-29 | 1998-06-16 | Fernandez-Pol; Jose Alberto | Antiviral agent |
| JP3337992B2 (ja) | 1997-11-04 | 2002-10-28 | ファイザー製薬株式会社 | ５−置換ピコリン酸化合物及びその製造方法 |
-
2000
- 2000-10-02 US US09/677,506 patent/US6403618B1/en not_active Expired - Fee Related
-
2001
- 2001-02-15 WO PCT/US2001/004897 patent/WO2001060349A2/en not_active Ceased
- 2001-02-15 JP JP2001559447A patent/JP2003522786A/ja active Pending
- 2001-02-15 ES ES01909253T patent/ES2215493T1/es active Pending
- 2001-02-15 TR TR2003/01378T patent/TR200301378T3/xx unknown
- 2001-02-15 BR BR0108400-3A patent/BR0108400A/pt not_active IP Right Cessation
- 2001-02-15 DE DE0001257262T patent/DE01909253T1/de active Pending
- 2001-02-15 MX MXPA02007954A patent/MXPA02007954A/es unknown
- 2001-02-15 EP EP01909253A patent/EP1257262A2/en not_active Withdrawn
- 2001-02-15 AU AU37028/01A patent/AU781066B2/en not_active Ceased
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