DD284044A5 - Verfahren zur herstellung von desulfatohirudinmutanten - Google Patents
Verfahren zur herstellung von desulfatohirudinmutanten Download PDFInfo
- Publication number
- DD284044A5 DD284044A5 DD89330939A DD33093989A DD284044A5 DD 284044 A5 DD284044 A5 DD 284044A5 DD 89330939 A DD89330939 A DD 89330939A DD 33093989 A DD33093989 A DD 33093989A DD 284044 A5 DD284044 A5 DD 284044A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- giu
- dna
- asn
- leu
- desulphatohirudin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888817161A GB8817161D0 (en) | 1988-07-19 | 1988-07-19 | Modified proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD284044A5 true DD284044A5 (de) | 1990-10-31 |
Family
ID=10640715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD89330939A DD284044A5 (de) | 1988-07-19 | 1989-07-18 | Verfahren zur herstellung von desulfatohirudinmutanten |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0352227A3 (fi) |
| JP (1) | JPH02119792A (fi) |
| KR (1) | KR900001849A (fi) |
| AU (1) | AU3804689A (fi) |
| DD (1) | DD284044A5 (fi) |
| DK (1) | DK354989A (fi) |
| FI (1) | FI893450A (fi) |
| GB (1) | GB8817161D0 (fi) |
| HU (1) | HUT51670A (fi) |
| IL (1) | IL91002A0 (fi) |
| NO (1) | NO892948L (fi) |
| PT (1) | PT91189A (fi) |
| ZA (1) | ZA895461B (fi) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU614121B2 (en) * | 1988-05-04 | 1991-08-22 | Novartis Ag | Improvements in the production of polypeptides |
| US6060451A (en) * | 1990-06-15 | 2000-05-09 | The National Research Council Of Canada | Thrombin inhibitors based on the amino acid sequence of hirudin |
| US5837808A (en) * | 1991-08-20 | 1998-11-17 | Baxter International Inc. | Analogs of hirudin |
| GB9401447D0 (en) | 1994-01-26 | 1994-03-23 | Ciba Geigy Ag | Pharmaceutical compositions |
| US7795205B2 (en) | 2004-04-12 | 2010-09-14 | Canyon Pharmaceuticals, Inc. | Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor |
| CN115677850B (zh) * | 2021-07-24 | 2024-03-08 | 王大勇 | 具备较强抗凝血活性的医蛭基因突变水蛭素及其制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0168342B1 (de) * | 1984-06-14 | 1991-07-03 | Ciba-Geigy Ag | Verfahren zur Herstellung von Thrombin-Inhibitoren |
| FR2607517B2 (fr) * | 1986-12-01 | 1989-12-22 | Transgene Sa | Vecteurs d'expression de variants de l'hirudine dans les levures, procede et produit obtenu |
-
1988
- 1988-07-19 GB GB888817161A patent/GB8817161D0/en active Pending
-
1989
- 1989-07-11 EP EP89810521A patent/EP0352227A3/en not_active Withdrawn
- 1989-07-12 AU AU38046/89A patent/AU3804689A/en not_active Abandoned
- 1989-07-17 PT PT91189A patent/PT91189A/pt not_active Application Discontinuation
- 1989-07-17 IL IL91002A patent/IL91002A0/xx unknown
- 1989-07-17 FI FI893450A patent/FI893450A/fi not_active Application Discontinuation
- 1989-07-18 KR KR1019890010122A patent/KR900001849A/ko not_active Application Discontinuation
- 1989-07-18 NO NO89892948A patent/NO892948L/no unknown
- 1989-07-18 HU HU893611A patent/HUT51670A/hu unknown
- 1989-07-18 DK DK354989A patent/DK354989A/da not_active Application Discontinuation
- 1989-07-18 JP JP1183827A patent/JPH02119792A/ja active Pending
- 1989-07-18 DD DD89330939A patent/DD284044A5/de not_active IP Right Cessation
- 1989-07-18 ZA ZA895461A patent/ZA895461B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB8817161D0 (en) | 1988-08-24 |
| HUT51670A (en) | 1990-05-28 |
| FI893450A (fi) | 1990-01-20 |
| NO892948L (no) | 1990-01-22 |
| FI893450A0 (fi) | 1989-07-17 |
| AU3804689A (en) | 1990-01-25 |
| DK354989A (da) | 1990-01-20 |
| KR900001849A (ko) | 1990-02-27 |
| IL91002A0 (en) | 1990-02-09 |
| ZA895461B (en) | 1990-02-28 |
| DK354989D0 (da) | 1989-07-18 |
| EP0352227A3 (en) | 1990-07-11 |
| PT91189A (pt) | 1990-02-08 |
| EP0352227A2 (en) | 1990-01-24 |
| JPH02119792A (ja) | 1990-05-07 |
| NO892948D0 (no) | 1989-07-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ENJ | Ceased due to non-payment of renewal fee |