DD258943A5 - Verfahren zur herstellung von zusammensetzungen, die zur intramammaeren infusion an einem saeugetier vorgesehen sind - Google Patents
Verfahren zur herstellung von zusammensetzungen, die zur intramammaeren infusion an einem saeugetier vorgesehen sind Download PDFInfo
- Publication number
- DD258943A5 DD258943A5 DD87300534A DD30053487A DD258943A5 DD 258943 A5 DD258943 A5 DD 258943A5 DD 87300534 A DD87300534 A DD 87300534A DD 30053487 A DD30053487 A DD 30053487A DD 258943 A5 DD258943 A5 DD 258943A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- mammal
- growth
- infusion
- mammary gland
- parenchyma
- Prior art date
Links
- 238000001802 infusion Methods 0.000 title claims abstract description 63
- 239000000203 mixture Substances 0.000 title claims description 12
- 238000004519 manufacturing process Methods 0.000 title claims description 11
- 239000000126 substance Substances 0.000 claims abstract description 38
- 241000124008 Mammalia Species 0.000 claims abstract description 31
- 230000002297 mitogenic effect Effects 0.000 claims abstract description 27
- 235000013336 milk Nutrition 0.000 claims abstract description 14
- 239000008267 milk Substances 0.000 claims abstract description 14
- 210000004080 milk Anatomy 0.000 claims abstract description 14
- 210000002919 epithelial cell Anatomy 0.000 claims abstract description 6
- 241000283690 Bos taurus Species 0.000 claims description 46
- 210000000481 breast Anatomy 0.000 claims description 41
- 241001465754 Metazoa Species 0.000 claims description 34
- 210000005075 mammary gland Anatomy 0.000 claims description 33
- 238000000034 method Methods 0.000 claims description 32
- 230000000694 effects Effects 0.000 claims description 27
- 102000009024 Epidermal Growth Factor Human genes 0.000 claims description 24
- 235000013861 fat-free Nutrition 0.000 claims description 19
- 235000013365 dairy product Nutrition 0.000 claims description 12
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 10
- 210000004907 gland Anatomy 0.000 claims description 9
- 102000004877 Insulin Human genes 0.000 claims description 7
- 108090001061 Insulin Proteins 0.000 claims description 7
- 230000001965 increasing effect Effects 0.000 claims description 7
- 241000282849 Ruminantia Species 0.000 claims description 6
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims description 6
- 101800003838 Epidermal growth factor Proteins 0.000 claims description 5
- 210000004027 cell Anatomy 0.000 claims description 5
- 229940125396 insulin Drugs 0.000 claims description 5
- 210000004738 parenchymal cell Anatomy 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 230000001568 sexual effect Effects 0.000 claims description 5
- 210000001519 tissue Anatomy 0.000 claims description 5
- 108010000521 Human Growth Hormone Proteins 0.000 claims description 4
- 102000002265 Human Growth Hormone Human genes 0.000 claims description 4
- 239000000854 Human Growth Hormone Substances 0.000 claims description 4
- 230000002708 enhancing effect Effects 0.000 claims description 4
- 230000000762 glandular Effects 0.000 claims description 4
- 229940088597 hormone Drugs 0.000 claims description 4
- 239000005556 hormone Substances 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 239000003226 mitogen Substances 0.000 claims description 4
- 229960004532 somatropin Drugs 0.000 claims description 4
- 102100021809 Chorionic somatomammotropin hormone 1 Human genes 0.000 claims description 3
- 241000699670 Mus sp. Species 0.000 claims description 3
- 108010051696 Growth Hormone Proteins 0.000 claims description 2
- 102000018997 Growth Hormone Human genes 0.000 claims description 2
- 230000003416 augmentation Effects 0.000 claims description 2
- 230000036760 body temperature Effects 0.000 claims description 2
- 229940116977 epidermal growth factor Drugs 0.000 claims description 2
- 239000003163 gonadal steroid hormone Substances 0.000 claims description 2
- 230000002611 ovarian Effects 0.000 claims description 2
- 230000003169 placental effect Effects 0.000 claims description 2
- 238000010254 subcutaneous injection Methods 0.000 claims 2
- 239000007929 subcutaneous injection Substances 0.000 claims 2
- 102000009016 Cholera Toxin Human genes 0.000 claims 1
- 108010049048 Cholera Toxin Proteins 0.000 claims 1
- 101000895818 Homo sapiens Chorionic somatomammotropin hormone 1 Proteins 0.000 claims 1
- 101000956228 Homo sapiens Chorionic somatomammotropin hormone 2 Proteins 0.000 claims 1
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
- 241000700159 Rattus Species 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 230000001919 adrenal effect Effects 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 239000000122 growth hormone Substances 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 238000002513 implantation Methods 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 210000004216 mammary stem cell Anatomy 0.000 claims 1
- 230000001817 pituitary effect Effects 0.000 claims 1
- 230000003248 secreting effect Effects 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 101000851176 Homo sapiens Pro-epidermal growth factor Proteins 0.000 description 25
- GVUGOAYIVIDWIO-UFWWTJHBSA-N nepidermin Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C(C)C)C(C)C)C1=CC=C(O)C=C1 GVUGOAYIVIDWIO-UFWWTJHBSA-N 0.000 description 25
- 239000002609 medium Substances 0.000 description 22
- 108020004414 DNA Proteins 0.000 description 21
- 101710098940 Pro-epidermal growth factor Proteins 0.000 description 19
- 235000013372 meat Nutrition 0.000 description 17
- 150000001413 amino acids Chemical group 0.000 description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- 230000035935 pregnancy Effects 0.000 description 12
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 11
- 210000002445 nipple Anatomy 0.000 description 11
- 239000003102 growth factor Substances 0.000 description 10
- 239000001963 growth medium Substances 0.000 description 10
- 102000004196 processed proteins & peptides Human genes 0.000 description 10
- 108090000765 processed proteins & peptides Proteins 0.000 description 10
- 239000002904 solvent Substances 0.000 description 10
- 102000013275 Somatomedins Human genes 0.000 description 9
- 239000000839 emulsion Substances 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- 235000001014 amino acid Nutrition 0.000 description 8
- 244000309465 heifer Species 0.000 description 8
- 229920001184 polypeptide Polymers 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 235000015278 beef Nutrition 0.000 description 7
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 7
- 239000003981 vehicle Substances 0.000 description 7
- 108020004511 Recombinant DNA Proteins 0.000 description 6
- 230000003076 paracrine Effects 0.000 description 6
- 239000008063 pharmaceutical solvent Substances 0.000 description 6
- 241001494479 Pecora Species 0.000 description 5
- 238000001514 detection method Methods 0.000 description 5
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 241000207961 Sesamum Species 0.000 description 4
- 235000003434 Sesamum indicum Nutrition 0.000 description 4
- DMBHHRLKUKUOEG-UHFFFAOYSA-N diphenylamine Chemical compound C=1C=CC=CC=1NC1=CC=CC=C1 DMBHHRLKUKUOEG-UHFFFAOYSA-N 0.000 description 4
- 239000008188 pellet Substances 0.000 description 4
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 4
- 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 description 3
- 241000219823 Medicago Species 0.000 description 3
- 235000017587 Medicago sativa ssp. sativa Nutrition 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 102000044162 human IGF1 Human genes 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- 230000009466 transformation Effects 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 101001034686 Bos taurus Insulin-like growth factor I Proteins 0.000 description 2
- 102000018386 EGF Family of Proteins Human genes 0.000 description 2
- 108010066486 EGF Family of Proteins Proteins 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 description 2
- 101000851196 Mus musculus Pro-epidermal growth factor Proteins 0.000 description 2
- 108010003044 Placental Lactogen Proteins 0.000 description 2
- 239000000381 Placental Lactogen Substances 0.000 description 2
- 108010076181 Proinsulin Proteins 0.000 description 2
- 229960000583 acetic acid Drugs 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000004899 c-terminal region Anatomy 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000012362 glacial acetic acid Substances 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 230000002608 insulinlike Effects 0.000 description 2
- 230000001983 lactogenic effect Effects 0.000 description 2
- 208000004396 mastitis Diseases 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000008159 sesame oil Substances 0.000 description 2
- 235000011803 sesame oil Nutrition 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 210000001541 thymus gland Anatomy 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 108010001897 Anterior Pituitary Hormones Proteins 0.000 description 1
- 102000000827 Anterior Pituitary Hormones Human genes 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- 241000283699 Bos indicus Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 206010011732 Cyst Diseases 0.000 description 1
- 102000006771 Gonadotropins Human genes 0.000 description 1
- 108010086677 Gonadotropins Proteins 0.000 description 1
- 102000048143 Insulin-Like Growth Factor II Human genes 0.000 description 1
- 108090001117 Insulin-Like Growth Factor II Proteins 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 108010047386 Pituitary Hormones Proteins 0.000 description 1
- 102000006877 Pituitary Hormones Human genes 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 241000549435 Pria Species 0.000 description 1
- 102100024819 Prolactin Human genes 0.000 description 1
- 108010057464 Prolactin Proteins 0.000 description 1
- 108010076504 Protein Sorting Signals Proteins 0.000 description 1
- 108010094028 Prothrombin Proteins 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 108010067390 Viral Proteins Proteins 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000003329 adenohypophysis hormone Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 230000037037 animal physiology Effects 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000007321 biological mechanism Effects 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 238000005277 cation exchange chromatography Methods 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- 239000004459 forage Substances 0.000 description 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000002622 gonadotropin Substances 0.000 description 1
- 244000144980 herd Species 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 210000004408 hybridoma Anatomy 0.000 description 1
- 239000000960 hypophysis hormone Substances 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000006651 lactation Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 210000003098 myoblast Anatomy 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 230000009701 normal cell proliferation Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 229940097325 prolactin Drugs 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 210000003079 salivary gland Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000002955 secretory cell Anatomy 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 210000001913 submandibular gland Anatomy 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1808—Epidermal growth factor [EGF] urogastrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Reproductive Health (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Cosmetics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Dairy Products (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Prostheses (AREA)
- Farming Of Fish And Shellfish (AREA)
- Feed For Specific Animals (AREA)
- Catching Or Destruction (AREA)
- Mushroom Cultivation (AREA)
- Liquid Deposition Of Substances Of Which Semiconductor Devices Are Composed (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83747786A | 1986-03-07 | 1986-03-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
DD258943A5 true DD258943A5 (de) | 1988-08-10 |
Family
ID=25274560
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DD87300534A DD258943A5 (de) | 1986-03-07 | 1987-03-06 | Verfahren zur herstellung von zusammensetzungen, die zur intramammaeren infusion an einem saeugetier vorgesehen sind |
Country Status (22)
Country | Link |
---|---|
US (1) | US5059586A (fr) |
EP (1) | EP0237514B1 (fr) |
JP (1) | JPS62221635A (fr) |
KR (1) | KR900000545B1 (fr) |
CN (1) | CN87102601A (fr) |
AT (1) | ATE93730T1 (fr) |
AU (1) | AU595295B2 (fr) |
BG (1) | BG50926A3 (fr) |
CA (1) | CA1299103C (fr) |
CS (1) | CS272772B2 (fr) |
DD (1) | DD258943A5 (fr) |
DE (1) | DE3787185T2 (fr) |
DK (1) | DK116287A (fr) |
ES (1) | ES2000437T3 (fr) |
HU (1) | HU205007B (fr) |
IL (1) | IL81809A (fr) |
MX (1) | MX170911B (fr) |
NO (1) | NO870946L (fr) |
NZ (1) | NZ219530A (fr) |
PL (1) | PL154182B1 (fr) |
RU (1) | RU2033178C1 (fr) |
ZA (1) | ZA871654B (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5130299A (en) * | 1986-03-07 | 1992-07-14 | Monsanto Company | Method for enhancing growth of mammary parenchyma |
US5130300A (en) * | 1986-03-07 | 1992-07-14 | Monsanto Company | Method for enhancing growth of mammary parenchyma |
US5182302A (en) * | 1986-03-07 | 1993-01-26 | Monsanto Company | Method for enhancing growth of mammary parenchyma using a prostaglandin |
IE912345A1 (en) * | 1990-08-03 | 1992-02-12 | Pharmacia Ab | Treatment of human lactation failure |
US5336488A (en) * | 1991-08-07 | 1994-08-09 | American Cyanamid Company | Method of treating or preventing mastitis in animals with involuting mammary glands by administering recombinant cytokines |
US6828111B2 (en) | 2000-01-13 | 2004-12-07 | Wayne State University | Three-dimensional in vitro model of human preneoplastic breast disease |
CN1527879A (zh) * | 2001-05-18 | 2004-09-08 | 加拿大农业及农业食品部 | 牛表皮生长因子的核酸序列和蛋白质序列 |
JP2017046688A (ja) * | 2015-08-31 | 2017-03-09 | 株式会社みやぎヘルスイノベーション | 体重増加抑制用飲料組成物 |
CN105194642B (zh) * | 2015-10-09 | 2018-04-17 | 深圳市容大生物技术有限公司 | 一种疏通乳房微循环养护自体腺胞的组合物及制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4011312A (en) * | 1975-06-25 | 1977-03-08 | American Home Products Corporation | Prolonged release drug form for the treatment of bovine mastitis |
EP0085036A1 (fr) * | 1982-01-18 | 1983-08-03 | Monsanto Company | Méthode pour une production améliorée de lait de bovins |
US4521409A (en) * | 1983-10-03 | 1985-06-04 | Cornell Research Foundation, Inc. | Use of growth hormone to enhance ruminant mammary development |
-
1987
- 1987-02-19 CA CA000530136A patent/CA1299103C/fr not_active Expired - Lifetime
- 1987-03-04 AT AT87870029T patent/ATE93730T1/de not_active IP Right Cessation
- 1987-03-04 ES ES87870029T patent/ES2000437T3/es not_active Expired - Lifetime
- 1987-03-04 DE DE87870029T patent/DE3787185T2/de not_active Expired - Fee Related
- 1987-03-04 EP EP87870029A patent/EP0237514B1/fr not_active Expired - Lifetime
- 1987-03-06 BG BG78775A patent/BG50926A3/bg unknown
- 1987-03-06 ZA ZA871654A patent/ZA871654B/xx unknown
- 1987-03-06 AU AU69788/87A patent/AU595295B2/en not_active Ceased
- 1987-03-06 JP JP62051831A patent/JPS62221635A/ja active Pending
- 1987-03-06 RU SU874202227A patent/RU2033178C1/ru active
- 1987-03-06 NO NO870946A patent/NO870946L/no unknown
- 1987-03-06 HU HU87973A patent/HU205007B/hu not_active IP Right Cessation
- 1987-03-06 MX MX005494A patent/MX170911B/es unknown
- 1987-03-06 NZ NZ219530A patent/NZ219530A/xx unknown
- 1987-03-06 IL IL81809A patent/IL81809A/xx not_active IP Right Cessation
- 1987-03-06 CN CN198787102601A patent/CN87102601A/zh active Pending
- 1987-03-06 CS CS151887A patent/CS272772B2/cs unknown
- 1987-03-06 DK DK116287A patent/DK116287A/da not_active Application Discontinuation
- 1987-03-06 PL PL1987264490A patent/PL154182B1/pl unknown
- 1987-03-06 KR KR1019870002026A patent/KR900000545B1/ko not_active IP Right Cessation
- 1987-03-06 DD DD87300534A patent/DD258943A5/de not_active IP Right Cessation
- 1987-09-02 US US07/092,009 patent/US5059586A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE93730T1 (de) | 1993-09-15 |
AU595295B2 (en) | 1990-03-29 |
KR880010773A (ko) | 1988-10-24 |
IL81809A (en) | 1993-01-31 |
CA1299103C (fr) | 1992-04-21 |
DE3787185T2 (de) | 1994-02-03 |
CS151887A2 (en) | 1990-06-13 |
ZA871654B (en) | 1987-08-28 |
HU205007B (en) | 1992-03-30 |
MX170911B (es) | 1993-09-22 |
BG50926A3 (en) | 1992-12-30 |
ES2000437T3 (es) | 1994-01-16 |
JPS62221635A (ja) | 1987-09-29 |
DK116287D0 (da) | 1987-03-06 |
NZ219530A (en) | 1992-12-23 |
EP0237514A1 (fr) | 1987-09-16 |
IL81809A0 (en) | 1987-10-20 |
ES2000437A4 (es) | 1988-03-01 |
NO870946D0 (no) | 1987-03-06 |
PL154182B1 (en) | 1991-07-31 |
US5059586A (en) | 1991-10-22 |
DE3787185D1 (de) | 1993-10-07 |
AU6978887A (en) | 1987-09-10 |
CN87102601A (zh) | 1987-12-16 |
HUT47031A (en) | 1989-01-30 |
KR900000545B1 (ko) | 1990-01-31 |
CS272772B2 (en) | 1991-02-12 |
PL264490A1 (en) | 1988-02-18 |
NO870946L (no) | 1987-09-08 |
EP0237514B1 (fr) | 1993-09-01 |
DK116287A (da) | 1987-09-08 |
RU2033178C1 (ru) | 1995-04-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69209277T2 (de) | Kombination von igf-i und igfbp für den aufbaustoffwechsel (anabolismus) | |
DE69435033T2 (de) | Parathormonarzneizusammensetzung | |
DE3650499T2 (de) | Verwendung von "Cartilage-inducing Factor" (CIF) zur Behandlung von hemato- oder lymphopoietischen Krankheiten | |
DE3782420T2 (de) | Wachstumhormonzubereitungen mit verzoegerter wirkstoffabgabe fuer eine parenterale verabreichung und ihre verwendung. | |
DE3855970T2 (de) | Verwendung von Amylin oder CGRP zur Behandlung des Diabetes mellitus | |
DE3883254T2 (de) | Verfahren zur verlängerten Freisetzung von Somatotropin. | |
EP0357978B1 (fr) | Préparation pharmaceutique pour le traitement du diabète sucré | |
DE69915204T2 (de) | Stabilisierte Proteinzusammensetzung | |
DE2732175C2 (de) | Oxytocin-Strukturanaloga und diese Verbindungen enthaltende pharmazeutische Mittel | |
DE2512391C2 (de) | Mittel zur Behandlung der Mastitis in Milchtieren | |
DE69100376T2 (de) | Verfahren zur hemmung der follikelreifung. | |
DD258943A5 (de) | Verfahren zur herstellung von zusammensetzungen, die zur intramammaeren infusion an einem saeugetier vorgesehen sind | |
EP0867186B1 (fr) | Composition injectable parasiticide à activité de longue durée et procédé de préparation | |
DE69633396T2 (de) | Activin stimulator enthaltende pharmazeutische zusammensetzung | |
DE3872614T2 (de) | Verfahren zur behandlung der unfruchtbarkeit und mittel zur verwendung dabei. | |
CH650678A5 (de) | Pharmazeutisches mittel aus human-insulin und human-proinsulin. | |
DE69211723T2 (de) | Mit einem Zellwachstumsfaktor bewirkte Anregung von Wachstum im Knocheninneren | |
EP0083925B1 (fr) | Méthode de traitement pour provoquer l'ovulation chez les brebis ou les génisses | |
DE69305091T2 (de) | Methode zur behandlung oder verhütung von fettleibigkeit | |
DE69005108T2 (de) | Somatotropin zur steigerung der fertilität bei tieren. | |
US6193989B1 (en) | Long acting injectable parasiticidal composition and the process for its preparation | |
DE2616462A1 (de) | Polypeptidhaltige pharmazeutische zubereitungen | |
DE69105114T2 (de) | Methode zur erhöhung der fruchtbarkeit weiblicher säuger. | |
DE69531166T2 (de) | Arzneistoff zur erleichterung der durch immunsuppressiva verursachten nebenwirkungen | |
DE69933581T2 (de) | Verwendung von humanem wachstumshormon zur vermehrung der anzahl zirkulierender cd34+ zellen, zur wiederherstellung des hämopoietischen und des immunsystems nach myeloablativer oder antiblastischer therapie, bei transplantation oder re-infusion |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
ENJ | Ceased due to non-payment of renewal fee |