DD212252A5 - Verfahren zur herstellung von benzazepinderivaten - Google Patents

Verfahren zur herstellung von benzazepinderivaten Download PDF

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Publication number
DD212252A5
DD212252A5 DD84259822A DD25982284A DD212252A5 DD 212252 A5 DD212252 A5 DD 212252A5 DD 84259822 A DD84259822 A DD 84259822A DD 25982284 A DD25982284 A DD 25982284A DD 212252 A5 DD212252 A5 DD 212252A5
Authority
DD
German Democratic Republic
Prior art keywords
benzazepine
formula
deep
hydrogen
amino
Prior art date
Application number
DD84259822A
Other languages
German (de)
English (en)
Inventor
Jr Charles J Paget
Jr Robert R Ruffolo
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DD212252A5 publication Critical patent/DD212252A5/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16Benzazepines; Hydrogenated benzazepines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00Preparation of halogenated hydrocarbons
    • C07C17/26Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/32Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by introduction of halogenated alkyl groups into ring compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/32Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DD84259822A 1983-02-04 1984-02-02 Verfahren zur herstellung von benzazepinderivaten DD212252A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46379783A 1983-02-04 1983-02-04

Publications (1)

Publication Number Publication Date
DD212252A5 true DD212252A5 (de) 1984-08-08

Family

ID=23841406

Family Applications (1)

Application Number Title Priority Date Filing Date
DD84259822A DD212252A5 (de) 1983-02-04 1984-02-02 Verfahren zur herstellung von benzazepinderivaten

Country Status (17)

Country Link
EP (1) EP0116444A3 (da)
JP (1) JPS59152374A (da)
KR (1) KR840007721A (da)
AU (1) AU2408684A (da)
CA (1) CA1215045A (da)
DD (1) DD212252A5 (da)
DK (1) DK47184A (da)
ES (2) ES529427A0 (da)
FI (1) FI840447A (da)
GB (1) GB2134519A (da)
GR (2) GR79760B (da)
IL (1) IL70854A0 (da)
NZ (1) NZ207007A (da)
PL (2) PL250499A1 (da)
PT (1) PT78053A (da)
RO (1) RO87745A (da)
ZA (1) ZA84758B (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2932800B1 (fr) * 2008-06-20 2015-02-20 Servier Lab Nouveau procede de synthese de la 7,8-dimethoxy-1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3205222A (en) * 1963-03-19 1965-09-07 Dow Chemical Co Certain 2-amino-7-halo-3h-benz (d) azepines
US3205221A (en) * 1963-03-19 1965-09-07 Dow Chemical Co 2-amino-7-halo-3h-naphth (d) azepine compounds and their preparation
US3681340A (en) * 1968-02-12 1972-08-01 Herman Robert Rodriguez 1,3-benzodiazepines
GB1244501A (en) * 1968-03-09 1971-09-02 Aspro Nicholas Ltd Heterocyclic amines
JPS5931512B2 (ja) * 1975-03-03 1984-08-02 武田薬品工業株式会社 トリアゾロベンツアゼピン誘導体の製造法
GB1600748A (en) * 1977-05-23 1981-10-21 Sandoz Ltd Benzazepine derivatives

Also Published As

Publication number Publication date
EP0116444A3 (en) 1986-02-26
ZA84758B (en) 1985-09-25
NZ207007A (en) 1985-08-30
FI840447A0 (fi) 1984-02-03
ES544240A0 (es) 1986-07-16
AU2408684A (en) 1984-08-09
RO87745B (ro) 1985-10-01
DK47184A (da) 1984-08-05
KR840007721A (ko) 1984-12-10
PT78053A (en) 1984-03-01
ES8602681A1 (es) 1985-11-16
GB8402968D0 (en) 1984-03-07
ES8801215A1 (es) 1986-07-16
ES529427A0 (es) 1985-11-16
FI840447A (fi) 1984-08-05
GB2134519A (en) 1984-08-15
JPS59152374A (ja) 1984-08-31
IL70854A0 (en) 1984-05-31
PL250499A1 (en) 1985-04-09
PL246042A1 (en) 1985-03-26
EP0116444A2 (en) 1984-08-22
RO87745A (ro) 1985-10-31
DK47184D0 (da) 1984-02-02
GR79760B (da) 1984-10-31
CA1215045A (en) 1986-12-09
GR81693B (da) 1984-12-12

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