DD208619A5 - Verfahren zur herstellung neuer in 8-stellung stickstoffsubstituierter ergolinylverbindungen - Google Patents

Verfahren zur herstellung neuer in 8-stellung stickstoffsubstituierter ergolinylverbindungen Download PDF

Info

Publication number
DD208619A5
DD208619A5 DD82246012A DD24601282A DD208619A5 DD 208619 A5 DD208619 A5 DD 208619A5 DD 82246012 A DD82246012 A DD 82246012A DD 24601282 A DD24601282 A DD 24601282A DD 208619 A5 DD208619 A5 DD 208619A5
Authority
DD
German Democratic Republic
Prior art keywords
didehydro
ergolinyl
methyl
item
prepared
Prior art date
Application number
DD82246012A
Other languages
German (de)
English (en)
Inventor
Gregor Hafer
Gerhard Sauer
Helmut Wachtel
Herbert Schneider
Ulrich Eder
Hans-Peter Lorenz
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of DD208619A5 publication Critical patent/DD208619A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DD82246012A 1981-12-23 1982-12-15 Verfahren zur herstellung neuer in 8-stellung stickstoffsubstituierter ergolinylverbindungen DD208619A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813151912 DE3151912A1 (de) 1981-12-23 1981-12-23 Neue ergolin-aminoderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
DD208619A5 true DD208619A5 (de) 1984-04-04

Family

ID=6150011

Family Applications (1)

Application Number Title Priority Date Filing Date
DD82246012A DD208619A5 (de) 1981-12-23 1982-12-15 Verfahren zur herstellung neuer in 8-stellung stickstoffsubstituierter ergolinylverbindungen

Country Status (18)

Country Link
US (1) US4826852A (da)
EP (2) EP0185392A3 (da)
JP (1) JPS58150593A (da)
AT (1) ATE27458T1 (da)
AU (1) AU570621B2 (da)
CA (1) CA1319684C (da)
CS (1) CS235098B2 (da)
DD (1) DD208619A5 (da)
DE (2) DE3151912A1 (da)
DK (1) DK163240C (da)
ES (1) ES8400115A1 (da)
GR (1) GR78410B (da)
HU (1) HU191623B (da)
IE (1) IE56541B1 (da)
IL (1) IL67545A (da)
RO (2) RO87945A (da)
SU (1) SU1313348A3 (da)
YU (1) YU282382A (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8400333A (nl) * 1983-02-16 1984-09-17 Sandoz Ag Moederkoornalkaloiden, hun bereiding en hun toepassing.
NL193541C (nl) * 1984-01-12 2000-01-04 Novartis Ag 8 Alfa-acylaminoergolinen, werkwijzen voor de bereiding daarvan en preparaten die ze bevatten.
DE3413657A1 (de) * 1984-04-09 1985-10-17 Schering AG, 1000 Berlin und 4709 Bergkamen Neue ergoline
DE3413659A1 (de) * 1984-04-09 1985-10-17 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 2-substituierte ergolin-derivate
CH666035A5 (de) * 1984-12-24 1988-06-30 Sandoz Ag 8-alpha-acylaminoergolene.
DE3528584A1 (de) * 1985-08-06 1987-02-19 Schering Ag Neue 1-alkyl-ergolin-thioharnstoffderivate
DE3528576A1 (de) * 1985-08-06 1987-02-19 Schering Ag Verfahren zur herstellung von ergolin-thioharnstoffen
DE3533675A1 (de) * 1985-09-19 1987-03-26 Schering Ag Neue 12- und 13-brom-ergolinderivate
DE3533672A1 (de) * 1985-09-19 1987-03-26 Schering Ag Neue 12- und 13-substituierte ergolinderivate
DE3535929A1 (de) * 1985-10-04 1987-04-09 Schering Ag 1,2-disubstituierte ergolinderivate
HU196598B (en) * 1986-04-25 1988-12-28 Richter Gedeon Vegyeszet Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds
DK338789A (da) * 1988-07-15 1990-01-16 Schering Ag 2-substituerede ergolinylurinstofderivater og fremgangsmaade til fremstilling deraf, deres anvendelse som laegemidler samt mellemprodukter til fremstilling deraf
DE3915950A1 (de) * 1989-05-12 1990-11-15 Schering Ag 8(alpha)-acylamino-ergoline, ihre herstellung und verwendung als arzneimittel
US5229129A (en) * 1989-07-12 1993-07-20 Cygnus Therapeutic Systems Transdermal administration of lisuride
US5252335A (en) * 1989-07-12 1993-10-12 Cygnus Therapeutic Systems Transdermal administration of lisuride
GB0307377D0 (en) * 2003-03-31 2003-05-07 Merad Pharmaceuticals Ltd Ergoline derivatives
US20060140820A1 (en) 2004-12-28 2006-06-29 Udo Mattern Use of a container of an inorganic additive containing plastic material
CN101600417B (zh) * 2006-10-04 2012-05-30 M&P专利股份公司 用于神经递质的经鼻施用的控制释放递送系统
EP2083008A1 (en) * 2007-12-07 2009-07-29 Axxonis Pharma AG Ergoline derivatives as selective radical scavengers for neurons
US20130045958A1 (en) 2011-05-13 2013-02-21 Trimel Pharmaceuticals Corporation Intranasal 0.15% and 0.24% testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder
US20130040923A1 (en) 2011-05-13 2013-02-14 Trimel Pharmaceuticals Corporation Intranasal lower dosage strength testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder
US9757388B2 (en) 2011-05-13 2017-09-12 Acerus Pharmaceuticals Srl Intranasal methods of treating women for anorgasmia with 0.6% and 0.72% testosterone gels
US11744838B2 (en) 2013-03-15 2023-09-05 Acerus Biopharma Inc. Methods of treating hypogonadism with transnasal testosterone bio-adhesive gel formulations in male with allergic rhinitis, and methods for preventing an allergic rhinitis event

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2533698A (en) * 1950-12-12 Urethanes containing the lysergic
US2864822A (en) * 1956-10-22 1958-12-16 Lilly Co Eli 9-amino-7-methyl-belta10-ergolene and derivatives thereof
DE1212097B (de) * 1962-09-05 1966-03-10 Sdruzeni Podnikuu Pro Zdravotn Verfahren zur Herstellung von N-[D-1, 6-Dimethylisoergolenyl-(8)]-N', N'-dialkylharnstoffen
FR1339406A (fr) * 1962-11-23 1963-10-04 Farmaceutici Italia Procédé de préparation de nouveaux dérivés de 6-méthylergoline pi et de 1, 6-diméthylergoline pi
BR6915443D0 (pt) * 1969-07-18 1973-03-13 Farmaceutici Italia Processo para a preparacao de derivados de ergolina
CH573937A5 (da) * 1971-08-05 1976-03-31 Spofa Vereinigte Pharma Werke
GB1573621A (en) * 1976-01-02 1980-08-28 Sandoz Ltd Acylated 6-methyl-8a-amino-ergoline i compounds
US4348392A (en) * 1974-07-19 1982-09-07 Sandoz Ltd. 8α-Substituted ergoline-I derivatives
US3922347A (en) * 1974-12-19 1975-11-25 Lilly Co Eli Method of inhibiting prolactin secretion with 8-acylaminoergolenes
CH615929A5 (en) * 1975-06-02 1980-02-29 Sandoz Ag Process for the preparation of novel ergoline compounds
DE2656344A1 (de) * 1975-12-23 1977-07-07 Sandoz Ag Ergolinderivate, ihre verwendung und herstellung
CH622518A5 (en) * 1976-12-14 1981-04-15 Sandoz Ag Process for the preparation of novel ergoline compounds
EP0021206B1 (de) * 1979-06-13 1983-06-22 Schering Aktiengesellschaft Neue (Ergolin-yl)-N', N'-diäthylharnstoff-Derivate, ihre Herstellung und sie enthaltende Arzneimittel
WO1982000463A1 (en) * 1980-07-25 1982-02-18 Ag Sandoz Ergoline derivatives,method for their preparation,pharmaceutical compositions containing them and their therapeutic application
DE3135305C2 (de) * 1981-09-03 1983-07-21 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von 8-Ergolinyl-harnstoffen
GB2112382B (en) * 1981-11-06 1985-03-06 Erba Farmitalia Ergoline derivatives
DE3533675A1 (de) * 1985-09-19 1987-03-26 Schering Ag Neue 12- und 13-brom-ergolinderivate

Also Published As

Publication number Publication date
IE56541B1 (en) 1991-08-28
CS955382A2 (en) 1984-02-13
SU1313348A3 (ru) 1987-05-23
ES518482A0 (es) 1983-11-01
DK163240C (da) 1992-06-29
AU570621B2 (en) 1988-03-24
JPS58150593A (ja) 1983-09-07
EP0185392A3 (en) 1987-05-13
RO85270A (ro) 1984-09-29
JPH0352463B2 (da) 1991-08-12
EP0082808A1 (en) 1983-06-29
CA1319684C (en) 1993-06-29
ES8400115A1 (es) 1983-11-01
DE3151912A1 (de) 1983-06-30
YU282382A (en) 1986-12-31
IE823051L (en) 1983-06-23
IL67545A (en) 1986-09-30
RO85270B (ro) 1984-10-30
CS235098B2 (en) 1985-04-16
GR78410B (da) 1984-09-27
IL67545A0 (en) 1983-05-15
ATE27458T1 (de) 1987-06-15
RO87945A (ro) 1986-09-30
HU191623B (en) 1987-03-30
EP0082808B1 (en) 1987-05-27
US4826852A (en) 1989-05-02
DK566982A (da) 1983-06-24
EP0185392A2 (en) 1986-06-25
DE3276433D1 (en) 1987-07-02
DK163240B (da) 1992-02-10
AU9146882A (en) 1983-06-30

Similar Documents

Publication Publication Date Title
DD208619A5 (de) Verfahren zur herstellung neuer in 8-stellung stickstoffsubstituierter ergolinylverbindungen
DD141928A5 (de) Verfahren zur herstellung neuer ergolinderivate
DE3445377A1 (de) Carbocylische und heterocyclische carbonsaeureester und -amide von ueberbrueckten und nicht ueberbrueckten cyclischen stickstoffhaltigen aminen oder alkoholen
EP0153277A2 (de) Neue Pleuromutilinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung
EP0021206A1 (de) Neue (Ergolin-yl)-N', N'-diäthylharnstoff-Derivate, ihre Herstellung und sie enthaltende Arzneimittel
DD202027A5 (de) Verfahren zur herstellung von neuen (2-halogen-ergolinyl)-n'.n'-diethyl-harnstoffderivaten
DE3309493A1 (de) Neue ergolin-derivate, verfahren zu ihrer herstellung sowie verwendung als arzneimittel
DE1620449A1 (de) Substituierte Benzimidazole
DE3500251A1 (de) Neue 8(alpha)-acylaminoergoline
DE3413657A1 (de) Neue ergoline
DE2648248A1 (de) Substituierte tetrahydrobenzothiophene, verfahren zu ihrer herstellung und deren verwendung
DD203544A5 (de) Verfahren zur herstellung von ergolinderivaten
WO1994012498A1 (de) NEUES VERFAHREN ZUR HERSTELLUNG VON β-CARBOLINEN
CH622518A5 (en) Process for the preparation of novel ergoline compounds
CH666035A5 (de) 8-alpha-acylaminoergolene.
DE3413659A1 (de) Neue 2-substituierte ergolin-derivate
DD144671A5 (de) Verfahren zur herstellung von 2-azaergolinen und 2-aza-8(oder 9)ergolenen
DD294259A5 (de) 8alpha-acylamino-ergoline, ihre herstellung und verwendung als arzneimittel
DE69012407T2 (de) Imidazobenzodiazepine und ihre Salze, Verfahren zur Herstellung, Verwendung als Arzneimittel und diese Substanzen enthaltende Zusammensetzungen.
DE3623503A1 (de) 1-aryl-ergolinyl-harnstoffderivate, verfahren zu deren herstellung sowie die verwendung dieser verbindungen als arzneimittel
EP0250357A1 (de) 1- und/oder 2-substituierte Ergolinderivate
DE3535930A1 (de) Neue 2-substituierte ergolinderivate
DE69104797T2 (de) 2-Substituierte-1-Hydroxyindole.
AT385987B (de) Verfahren zur herstellung neuer ergolinderivate und ihrer salze
DE3505017A1 (de) Diazepinoindole, verfahren zu deren herstellung und diese enthaltende arzneimittel