DD202804A5 - Verfahren zur herstellung eines mittels zur vorbeugung und behandlung von leber- und nierenerkrankungen - Google Patents
Verfahren zur herstellung eines mittels zur vorbeugung und behandlung von leber- und nierenerkrankungen Download PDFInfo
- Publication number
- DD202804A5 DD202804A5 DD82242397A DD24239782A DD202804A5 DD 202804 A5 DD202804 A5 DD 202804A5 DD 82242397 A DD82242397 A DD 82242397A DD 24239782 A DD24239782 A DD 24239782A DD 202804 A5 DD202804 A5 DD 202804A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- liver
- item
- treatment
- enzyme
- pronase
- Prior art date
Links
- 210000004185 liver Anatomy 0.000 title claims abstract description 22
- 208000019423 liver disease Diseases 0.000 title claims abstract description 11
- 208000017169 kidney disease Diseases 0.000 title claims abstract description 8
- 230000002265 prevention Effects 0.000 title claims abstract description 8
- 238000004519 manufacturing process Methods 0.000 title description 2
- 102000004190 Enzymes Human genes 0.000 claims abstract description 17
- 108090000790 Enzymes Proteins 0.000 claims abstract description 17
- 108091005804 Peptidases Proteins 0.000 claims abstract description 13
- 102000035195 Peptidases Human genes 0.000 claims abstract description 13
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 11
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 5
- 239000005017 polysaccharide Substances 0.000 claims abstract description 5
- 150000004676 glycans Chemical class 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims description 21
- 108010059712 Pronase Proteins 0.000 claims description 17
- 239000004480 active ingredient Substances 0.000 claims description 9
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- 238000009472 formulation Methods 0.000 claims description 4
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- 229920002683 Glycosaminoglycan Polymers 0.000 claims description 3
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
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- 230000003907 kidney function Effects 0.000 description 2
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 201000008383 nephritis Diseases 0.000 description 2
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- 241000187392 Streptomyces griseus Species 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 description 1
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 description 1
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 description 1
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- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
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- 210000003292 kidney cell Anatomy 0.000 description 1
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- 201000007270 liver cancer Diseases 0.000 description 1
- 210000005229 liver cell Anatomy 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 210000005228 liver tissue Anatomy 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 208000009928 nephrosis Diseases 0.000 description 1
- 231100001027 nephrosis Toxicity 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229940055695 pancreatin Drugs 0.000 description 1
- 229940055729 papain Drugs 0.000 description 1
- 235000019834 papain Nutrition 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
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- 201000001474 proteinuria Diseases 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 238000002562 urinalysis Methods 0.000 description 1
- 229960005356 urokinase Drugs 0.000 description 1
- 201000001862 viral hepatitis Diseases 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21081—Streptogrisin B (3.4.21.81)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56125002A JPS5826822A (ja) | 1981-08-10 | 1981-08-10 | 慢性腎炎治療剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD202804A5 true DD202804A5 (de) | 1983-10-05 |
Family
ID=14899442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD82242397A DD202804A5 (de) | 1981-08-10 | 1982-08-10 | Verfahren zur herstellung eines mittels zur vorbeugung und behandlung von leber- und nierenerkrankungen |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4485095A (Direct) |
| EP (1) | EP0072947B2 (Direct) |
| JP (1) | JPS5826822A (Direct) |
| AT (1) | ATE20185T1 (Direct) |
| AU (1) | AU558711B2 (Direct) |
| DD (1) | DD202804A5 (Direct) |
| DE (1) | DE3271549D1 (Direct) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3941324A1 (de) * | 1989-05-08 | 1990-11-15 | Shigemi Fujisaki | Aktivator fuer verletzte neurozyten zur verhuetung und behandlung von krankheiten |
| DE19726253A1 (de) * | 1997-06-20 | 1998-12-24 | Mucos Pharma Gmbh & Co | Verwendung von mindestens einem proteolytischen Enzym zur Behandlung von Glomerulonephritis |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4844897A (en) * | 1985-09-13 | 1989-07-04 | Hiroshi Maeda | Anti-tumor protease preparations |
| JPS62215533A (ja) * | 1986-03-17 | 1987-09-22 | Shigemi Fujisaki | 膠原病又は関節リウマチの予防治療剤 |
| JPS61293928A (ja) * | 1986-06-18 | 1986-12-24 | Kaken Pharmaceut Co Ltd | 腎ネフロ−ゼ治療剤 |
| EP0309602B1 (de) * | 1987-09-30 | 1993-03-24 | MUCOS EMULSIONSGESELLSCHAFT m.b.H. | Verwendung katabolischer Enzyme zur Herstellung eines Medikaments zum Bekämpfen der erworbenen Immunschwäche (AIDS) und deren Vorstadien (LAS, ARC) |
| US5116615A (en) * | 1989-01-27 | 1992-05-26 | Immunolytics, Inc. | Method for treating benign prostatic hypertrophy |
| DK0456724T3 (da) | 1989-01-27 | 1995-10-02 | Immunolytics Inc | Præparat og fremgangsmåde til behandling af benign prostatisk hypertrofi |
| NL9201842A (nl) * | 1992-10-23 | 1994-05-16 | Teng Hian Khoe | Toepassing van een papaine bevattend voedingssupplement voor therapeutische behandeling van AIDS aandoeningen. |
| US5639934A (en) * | 1993-04-01 | 1997-06-17 | Nakamichi Yamasaki | Process for the desulfurization of sulfur-containing compositions by hydrothermal reaction |
| JP2673417B2 (ja) * | 1994-08-03 | 1997-11-05 | 茂巳 藤崎 | Ｂ型肝炎又はｃ型肝炎のウイルス性疾患の予防治療剤 |
| US5814328A (en) | 1997-01-13 | 1998-09-29 | Gunasekaran; Subramanian | Preparation of collagen using papain and a reducing agent |
| US20020102253A1 (en) | 1997-02-25 | 2002-08-01 | Mynott Tracey Lehanne | Component of bromelain |
| GB9713667D0 (en) * | 1997-06-27 | 1997-09-03 | Cortecs Ltd | Enhancement of intestinal permeability |
| JP2002087990A (ja) * | 2000-09-18 | 2002-03-27 | Shigemi Fujisaki | エイズ、ｂ型肝炎、ｃ型肝炎、インフルエンザなどのウイルス性疾患予防治療剤 |
| EP1471935A2 (de) * | 2002-02-06 | 2004-11-03 | N-Zyme BioTec GmbH | Protease-screening und neue verwendung von proteasen |
| AUPS242702A0 (en) * | 2002-05-21 | 2002-06-13 | Colltech Australia Limited | Improved method for the extraction and purification of collagen |
| US8388951B2 (en) | 2003-07-14 | 2013-03-05 | Cls Therapeutics Limited | Method for treating systemic DNA mutation disease |
| US8431123B2 (en) | 2003-07-14 | 2013-04-30 | Cls Therapeutics Limited | Method for treating systemic bacterial, fungal and protozoan infection |
| WO2006130034A1 (fr) * | 2005-04-25 | 2006-12-07 | Dmitry Dmitrievich Genkin | Procede pour prolonger la duree de vie d'animaux ou de l'humain |
| US8710012B2 (en) * | 2003-07-14 | 2014-04-29 | Cls Therapeutics Limited | Method for treating oncological diseases |
| ES2421538T3 (es) * | 2003-10-29 | 2013-09-03 | Cystic Fibrosis Foundation Therapeutics Inc | Proteasas no pancreáticas para controlar la concentración de colecistocinina (CCK) en plasma y para tratar el dolor |
| JP5372769B2 (ja) * | 2006-11-28 | 2013-12-18 | シーエルエス セラピューティック リミティド | 組織の細胞外間隙においてデオキシリボ核酸の量が増量することに関連するヒトの病気の治療方法及び該方法を実施するための医薬製剤 |
| UA28103U (uk) * | 2007-07-12 | 2007-11-26 | Ольга Олександрівна Біляєва | Комплексний сорбційно-протеолітичний препарат сертасил для лікування гнійних ран, трофічних виразок, опіків |
| WO2010079209A2 (en) * | 2009-01-08 | 2010-07-15 | Golub Alexandr A | Compositions for treating wounds and skin conditions |
| ITTO20121050A1 (it) * | 2012-12-06 | 2014-06-07 | Giuseppe Carpignoli | Sostanze vegetali ad effetto curativo |
| US10086053B2 (en) | 2012-12-06 | 2018-10-02 | Giuseppe CARPIGNOLI | Therapeutic vegetable substances |
| US10617743B2 (en) | 2014-06-19 | 2020-04-14 | Cls Therapeutics Limited | Method to improve safety and efficacy of anti-cancer therapy |
| CN108289932A (zh) | 2015-05-22 | 2018-07-17 | D·D·格恩金 | 胞外dna作为神经变性的治疗靶点 |
| WO2019143272A1 (en) | 2018-01-16 | 2019-07-25 | Cls Therapeutics Limited | Treatment of diseases by liver expression of an enzyme which has a deoxyribonuclease (dnase) activity |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2073659A (en) * | 1933-12-13 | 1937-03-16 | Ernest K Stratton | Medicinal compounds |
| US3004893A (en) * | 1959-10-21 | 1961-10-17 | Richardson Merrell Inc | Enteric coated trypsin and chymotrypsin anti-inflammatory compositions |
| FR2603M (fr) * | 1962-01-22 | 1964-06-22 | Roussel Uclaf | Nouveau médicament notamment pour le traitement des dégénérescences hépatiques d'origine chimique, bactérienne, toxique ou sénile. |
| US3324002A (en) * | 1962-09-17 | 1967-06-06 | Armour Pharma | Anti-inflammatory preparations containing proteolytic enzymes and adrenal glucocorticoids |
| FR3536M (Direct) * | 1964-06-16 | 1965-09-13 | Mauvernay Roland Yves | |
| BE684147A (Direct) * | 1965-07-22 | 1966-12-16 | ||
| LU59502A1 (Direct) * | 1969-09-24 | 1970-02-26 | ||
| US3819830A (en) * | 1971-07-01 | 1974-06-25 | Dainippon Pharmaceutical Co | Method for treating diseases by coenzyme a and adenosine triphosphate and composition therefor |
| FR2448903A1 (fr) * | 1979-02-19 | 1980-09-12 | Martin Henri | Medicament nouveau a base d'agents antimicrobiens, d'enzymes, d'anti-inflammatoires, d'anesthesique local, d'agents keratolytiques, d'agents mucolytiques et d'au moins un emulsionnant |
-
1981
- 1981-08-10 JP JP56125002A patent/JPS5826822A/ja active Granted
-
1982
- 1982-07-09 AU AU85792/82A patent/AU558711B2/en not_active Ceased
- 1982-08-05 EP EP82107092A patent/EP0072947B2/en not_active Expired - Lifetime
- 1982-08-05 AT AT82107092T patent/ATE20185T1/de active
- 1982-08-05 DE DE8282107092T patent/DE3271549D1/de not_active Expired
- 1982-08-06 US US06/405,770 patent/US4485095A/en not_active Expired - Fee Related
- 1982-08-10 DD DD82242397A patent/DD202804A5/de not_active IP Right Cessation
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3941324A1 (de) * | 1989-05-08 | 1990-11-15 | Shigemi Fujisaki | Aktivator fuer verletzte neurozyten zur verhuetung und behandlung von krankheiten |
| DE3941324C2 (Direct) * | 1989-05-08 | 1992-06-25 | Fujisaki, Shigemi, Nishinomiya, Hyogo, Jp | |
| DE3943649C2 (Direct) * | 1989-05-08 | 1992-10-29 | Fujisaki, Shigemi, Nishinomiya, Hyogo, Jp | |
| DE19726253A1 (de) * | 1997-06-20 | 1998-12-24 | Mucos Pharma Gmbh & Co | Verwendung von mindestens einem proteolytischen Enzym zur Behandlung von Glomerulonephritis |
| DE19726253C2 (de) * | 1997-06-20 | 2000-03-16 | Mucos Pharma Gmbh & Co | Verwendung von mindestens einem proteolytischen Enzym und Rutosid zur Behandlung von Glomerulonephritis |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0072947A2 (en) | 1983-03-02 |
| JPS5826822A (ja) | 1983-02-17 |
| JPH0133085B2 (Direct) | 1989-07-11 |
| EP0072947B2 (en) | 1994-01-12 |
| AU558711B2 (en) | 1987-02-05 |
| EP0072947A3 (en) | 1983-07-27 |
| DE3271549D1 (en) | 1986-07-10 |
| AU8579282A (en) | 1983-02-17 |
| US4485095A (en) | 1984-11-27 |
| ATE20185T1 (de) | 1986-06-15 |
| EP0072947B1 (en) | 1986-06-04 |
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| ENJ | Ceased due to non-payment of renewal fee |