DD201975A5 - Verfahren zur gewinnung eines neuen thrombininhibitor - Google Patents

Verfahren zur gewinnung eines neuen thrombininhibitor Download PDF

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Publication number
DD201975A5
DD201975A5 DD81233916A DD23391681A DD201975A5 DD 201975 A5 DD201975 A5 DD 201975A5 DD 81233916 A DD81233916 A DD 81233916A DD 23391681 A DD23391681 A DD 23391681A DD 201975 A5 DD201975 A5 DD 201975A5
Authority
DD
German Democratic Republic
Prior art keywords
heparin
thrombin
iii
inhibitor
dextran sulfate
Prior art date
Application number
DD81233916A
Other languages
German (de)
English (en)
Inventor
Hans Port
Juergen Schrenk
Peter Wunderwald
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of DD201975A5 publication Critical patent/DD201975A5/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
    • G01N2333/8121—Serpins
    • G01N2333/8128—Antithrombin III
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/38—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, e.g. Konjac gum, Locust bean gum, Guar gum
    • G01N2400/40—Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum
    • Y10S530/831—Cohn fractions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DD81233916A 1980-10-09 1981-10-06 Verfahren zur gewinnung eines neuen thrombininhibitor DD201975A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803038163 DE3038163A1 (de) 1980-10-09 1980-10-09 Thrombininhibitor, seine herstellung und verwendung

Publications (1)

Publication Number Publication Date
DD201975A5 true DD201975A5 (de) 1983-08-24

Family

ID=6114000

Family Applications (1)

Application Number Title Priority Date Filing Date
DD81233916A DD201975A5 (de) 1980-10-09 1981-10-06 Verfahren zur gewinnung eines neuen thrombininhibitor

Country Status (8)

Country Link
US (1) US4379142A (es)
EP (1) EP0049861B1 (es)
JP (1) JPS5932443B2 (es)
AT (1) ATE13489T1 (es)
DD (1) DD201975A5 (es)
DE (2) DE3038163A1 (es)
ES (1) ES505829A0 (es)
SU (1) SU1271379A3 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4689323A (en) * 1983-09-26 1987-08-25 Miles Laboratories, Inc. Covalently bound heparin--antithrombin-III complex
FR2553518B1 (fr) * 1983-10-13 1986-04-18 Choay Sa Nouveaux conjugues elabores par fixation d'un ligand sur un support insoluble, leur preparation et leurs applications biologiques
JPS60199819A (ja) * 1984-03-23 1985-10-09 Kowa Co トロンビン結合性物質およびその製法
DE3533516A1 (de) * 1984-09-21 1986-04-03 Boehringer Ingelheim KG, 6507 Ingelheim Blutgerinnungshemmende proteine, verfahren zur herstellung sowie deren verwendung
FR2646775A1 (fr) * 1989-05-11 1990-11-16 Centre Nat Rech Scient Utilisation du caseinoglycopeptide k, notamment de lait de vache, pour la fabrication d'une composition, notamment d'un medicament, pour la prevention et le traitement des thromboses
US5849703A (en) * 1990-08-27 1998-12-15 G. D. Searle & Co. Pre-formed anticoagulant heparin/TFPI complexes
US6291427B1 (en) 1990-08-27 2001-09-18 G.D. Searle & Co. Anticoagulant combination of LACI and sulfated polysaccharides
DE4203980A1 (de) * 1992-02-11 1993-08-12 Max Planck Gesellschaft Verfahren zur bestimmung von hirudin und synthetischen thrombininhibitoren
WO1993025220A1 (en) * 1992-06-05 1993-12-23 Reid Thomas J Iii Test for quantitative thrombin time
US5476771A (en) * 1993-02-22 1995-12-19 The United States Of America As Represented By The Secretary Of The Army Test for quantitative thrombin time
WO1998038214A1 (en) * 1997-02-28 1998-09-03 The Texas A & M University System Heparan sulfate/heparin interacting protein compositions and methods of use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE392038B (sv) * 1971-09-08 1977-03-14 Kabi Ab Forfarande for isolering av antitrombin ur blod eller blodprodukter
US4087415A (en) * 1976-06-09 1978-05-02 William L. Wilson Antithrombin III
JPS597693B2 (ja) * 1978-01-07 1984-02-20 株式会社ミドリ十字 抗トロンビン製剤及びその製法

Also Published As

Publication number Publication date
JPS5793915A (en) 1982-06-11
US4379142A (en) 1983-04-05
EP0049861A2 (de) 1982-04-21
JPS5932443B2 (ja) 1984-08-09
SU1271379A3 (ru) 1986-11-15
DE3170739D1 (en) 1985-07-04
EP0049861A3 (en) 1983-07-27
ES8205813A1 (es) 1982-08-16
DE3038163A1 (de) 1982-05-06
ES505829A0 (es) 1982-08-16
ATE13489T1 (de) 1985-06-15
EP0049861B1 (de) 1985-05-29

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