DD143770A5 - Verfahren zur herstellung von imidazolderivaten - Google Patents

Verfahren zur herstellung von imidazolderivaten Download PDF

Info

Publication number
DD143770A5
DD143770A5 DD79213065A DD21306579A DD143770A5 DD 143770 A5 DD143770 A5 DD 143770A5 DD 79213065 A DD79213065 A DD 79213065A DD 21306579 A DD21306579 A DD 21306579A DD 143770 A5 DD143770 A5 DD 143770A5
Authority
DD
German Democratic Republic
Prior art keywords
radical
carbon atoms
group
bis
imidazole
Prior art date
Application number
DD79213065A
Other languages
German (de)
English (en)
Inventor
Ulrich Niedballa
Irmgard Boettcher
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of DD143770A5 publication Critical patent/DD143770A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Resins (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DD79213065A 1978-05-24 1979-05-22 Verfahren zur herstellung von imidazolderivaten DD143770A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782823197 DE2823197A1 (de) 1978-05-24 1978-05-24 Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate

Publications (1)

Publication Number Publication Date
DD143770A5 true DD143770A5 (de) 1980-09-10

Family

ID=6040343

Family Applications (1)

Application Number Title Priority Date Filing Date
DD79213065A DD143770A5 (de) 1978-05-24 1979-05-22 Verfahren zur herstellung von imidazolderivaten

Country Status (24)

Country Link
US (3) US4269847A (fr)
EP (1) EP0005545B1 (fr)
JP (1) JPS54154766A (fr)
AT (1) ATE15662T1 (fr)
AU (1) AU4737979A (fr)
BG (1) BG32268A3 (fr)
CA (1) CA1177836A (fr)
DD (1) DD143770A5 (fr)
DE (2) DE2823197A1 (fr)
DK (1) DK208979A (fr)
EG (1) EG14365A (fr)
ES (1) ES480809A1 (fr)
FI (1) FI791639A (fr)
FR (1) FR2426682A1 (fr)
GB (1) GB2023600B (fr)
GR (1) GR72243B (fr)
IE (1) IE48416B1 (fr)
IL (1) IL57384A0 (fr)
NO (1) NO791707L (fr)
NZ (1) NZ190529A (fr)
PL (1) PL215774A1 (fr)
PT (1) PT69618A (fr)
RO (1) RO77293A (fr)
ZA (1) ZA792522B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0004648B1 (fr) * 1978-04-11 1982-08-25 Ciba-Geigy Ag Dérivés de mercapto-imidazole, procédé pour leur préparation, dérivés de mercapto-imidazole pour le traitement de maladies inflammatoires et leurs compositions pharmaceutiques
DE2856909A1 (de) * 1978-12-28 1980-07-17 Schering Ag Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3025484A1 (de) * 1980-07-03 1982-02-04 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue imidazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
US4503065A (en) * 1982-08-03 1985-03-05 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl 1-2-halo imidazoles
US4847270A (en) * 1985-12-12 1989-07-11 Smithkline Beckman Corporation Inhibition of the 5-lipoxygenase pathway utilizing certain 2,2'-alkyldiyl bis(thio)bis-imidazoles and derivatives
US4728656A (en) * 1985-12-12 1988-03-01 Smithkline Beckman Corporation 2,2-alkyldiylbis(thio)bis(imidazoles) useful for inhibition of the 5-lipoxygenase pathway
JPS6440467A (en) * 1987-08-04 1989-02-10 Hisamitsu Pharmaceutical Co Novel substituted diphenylimidazole derivative
US4900744A (en) * 1988-09-14 1990-02-13 E. I. Du Pont De Nemours And Company Antihypercholesterolemic 4,5-diaryl-2-substituted thioimidazoles
GB9005966D0 (en) * 1990-03-16 1990-05-09 May & Baker Ltd New compositions of matter
US5179117A (en) * 1991-12-20 1993-01-12 Du Pont Merck Pharmaceutical Company Antihypercholesterolemic 2-substituted imidazoles
US5663053A (en) * 1992-02-11 1997-09-02 Smithkline Beecham Corporation Inhibition of inflammatory lipid mediators
KR100291112B1 (ko) * 1992-02-11 2001-09-17 더 존스 홉킨스 유니버시티 코엔자임에이-독립성트랜스아실라제및혈소판활성화인자억제제
CA2295021A1 (fr) * 1997-06-30 1999-01-28 Ortho-Mcneil Pharmaceutical, Inc. Imidazoles substituees en 2 utilisables pour le traitement de maladies inflammatoires
DE10107683A1 (de) 2001-02-19 2002-08-29 Merckle Gmbh Chem Pharm Fabrik 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie
DE10114775A1 (de) * 2001-03-26 2002-10-10 Gerhard Dannhardt 2-Mercapto-4,5-diarylimidazolderivate und ihre Verwendung in der Pharmazie
DE10238045A1 (de) 2002-08-20 2004-03-04 Merckle Gmbh Chem.-Pharm. Fabrik 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie
EP1894925A1 (fr) * 2006-08-24 2008-03-05 Merckle Gmbh Derivés d'imidazole ayant une activité anti-inflammatoire

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2981739A (en) * 1958-01-27 1961-04-25 Diamond Alkali Co Certain alpha-haloaldehyde addition products of ethylenethioureas and process
NO120426B (fr) * 1965-10-21 1970-10-19 Geigy Ag J R
US3651080A (en) * 1969-11-07 1972-03-21 Ciba Geigy Corp Certain substituted 2-alkylmercaptoimidazole derivatives
US3636003A (en) * 1969-11-17 1972-01-18 Geigy Chem Corp Substituted 2-mercaptoimidazole derivatives
US3714179A (en) * 1970-09-08 1973-01-30 Searle & Co 1-alkyl-2-furfurylthioimidazoles and congeners
JPS5343958B2 (fr) * 1972-07-29 1978-11-24
DE2259627A1 (de) * 1972-12-06 1974-06-12 Hoechst Ag Imidazolyl-(2)-thio-alkansaeureester und verfahren zu ihrer herstellung
US3842097A (en) * 1973-01-22 1974-10-15 Searle & Co 2-(phenoxyalkylthio)imidazoles and congeners
US4190666A (en) * 1975-08-11 1980-02-26 E. I. Du Pont De Nemours And Company Anti-inflammatory 4,5-diarly-2-(substituted-thio)imidazoles and their corresponding sulfoxides and sulfones
SE428686B (sv) * 1975-08-11 1983-07-18 Du Pont Forfarande for framstellning av antiinflammatoriskt aktiva imidazoler
US4182769A (en) * 1977-02-09 1980-01-08 E. I. Du Pont De Nemours And Company Anti-inflammatory 1-substituted-4,5-diaryl-2-(substituted-thio) imidazoles and their corresponding sulfoxides and sulfones
US4159338A (en) * 1977-02-09 1979-06-26 E. I. Du Pont De Nemours And Company Antiinflammatory-4,5-dicyclic-2-(substituted thio)-imidazoles and their corresponding sulfoxides and sulfones
LU77703A1 (de) * 1977-07-07 1979-03-26 Ciba Geigy Ag Verfahren zur herstellung von bicyclischen thia-diaza-verbindungen
EP0004648B1 (fr) * 1978-04-11 1982-08-25 Ciba-Geigy Ag Dérivés de mercapto-imidazole, procédé pour leur préparation, dérivés de mercapto-imidazole pour le traitement de maladies inflammatoires et leurs compositions pharmaceutiques

Also Published As

Publication number Publication date
US4440776A (en) 1984-04-03
NO791707L (no) 1979-11-27
EP0005545A3 (en) 1980-01-09
FR2426682A1 (fr) 1979-12-21
JPS54154766A (en) 1979-12-06
GB2023600B (en) 1982-11-03
EP0005545A2 (fr) 1979-11-28
GB2023600A (en) 1980-01-03
ZA792522B (en) 1980-06-25
ES480809A1 (es) 1979-12-01
US4269847A (en) 1981-05-26
EG14365A (en) 1984-03-31
AU4737979A (en) 1979-11-29
DK208979A (da) 1979-11-25
US4355039A (en) 1982-10-19
PL215774A1 (fr) 1980-02-25
DE2823197A1 (de) 1979-11-29
NZ190529A (en) 1982-02-23
DE2967513D1 (en) 1985-10-24
CA1177836A (fr) 1984-11-13
IE48416B1 (en) 1985-01-09
GR72243B (fr) 1983-10-04
BG32268A3 (en) 1982-06-15
IE791000L (en) 1979-11-24
EP0005545B1 (fr) 1985-09-18
PT69618A (de) 1979-06-01
JPH0336834B2 (fr) 1991-06-03
IL57384A0 (en) 1979-09-30
RO77293A (fr) 1981-08-17
ATE15662T1 (de) 1985-10-15
FI791639A (fi) 1979-11-25

Similar Documents

Publication Publication Date Title
EP0001279B1 (fr) Dérivés de l'imidazole leur procédé de préparation et leurs compositions pharmaceutiques
DD143770A5 (de) Verfahren zur herstellung von imidazolderivaten
US4190666A (en) Anti-inflammatory 4,5-diarly-2-(substituted-thio)imidazoles and their corresponding sulfoxides and sulfones
DD200371A5 (de) Verfahren zur herstellung von 2,4-disubstituierten thiazolen
EP0183159A2 (fr) 1-Hétéroaryl-4-aryl-pyrazolin-5-ones pour application en tant que médicaments
EP0004648B1 (fr) Dérivés de mercapto-imidazole, procédé pour leur préparation, dérivés de mercapto-imidazole pour le traitement de maladies inflammatoires et leurs compositions pharmaceutiques
DE3533331A1 (de) Pyridothiazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
EP0043788B1 (fr) Derivés d'imidazole, procédé pour leur préparation et leurs compositions pharmaceutiques
EP0415065B1 (fr) Dérivés de chromane
EP0000353A2 (fr) Composés thiadiaza-bicycliques, procédé et intermédiaires pour leur préparation et médicaments contenant ces composés ou les intermédiaires
DE2602643A1 (de) 1,2-benzisothiazolinone-3, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
EP0013732B1 (fr) Dérivés d'imidazole, procédés pour leur préparation et compositions pharmaceutiques contenant ces dérivés d'imidazole
EP0056956A2 (fr) Dérivés de l'indane, leur préparation et leur utilisation
EP0261478A1 (fr) Dérivés de 4,5 dihydro-oxazoles, procédé de leur préparation et leur application
EP0101898A1 (fr) 4H-1,4-benzothiazines condensées, procédé pour leur préparation et leur application comme médicaments
DE3873278T2 (de) Aryl-substituierte thiophen-3-ole, ihre derivate und analoge als lipoxygenase-inhibitoren.
US4157340A (en) N,N'-[Bis(N-cyanoguanyl)]cystamine derivatives
CH616935A5 (en) Process for the preparation of chromone derivatives
DD157799A5 (de) Verfahren zur herstellung substituierter triarylthiazole
DD201788A5 (de) Verfahren zur herstellung neuer diaryl-imidazol-verbindungen
DD234005A5 (de) Verfahren zur herstellung neuer 1,2,4-triazacycloalkadienderivate
US4215135A (en) Antiinflammatory 2-substituted-1H-phenanthro[9,10-d]imidazoles
AT374198B (de) Verfahren zur herstellung neuer 2-substituierter mercaptoimidazolderivate, ihrer n-oxyde und ihrer salze
EP0069953A1 (fr) Dérivés de la triazino(2,1-a)isoquinoléine, leur procédé de préparation et leur application comme médicaments
AT360526B (de) Verfahren zur herstellung von neuen bicyclischen thia-diaza-verbindungen und von deren salzen und opt. ekt. isomeren