DD134224A5 - Verfahren zur herstellung von substituierten aminosaeuren - Google Patents

Verfahren zur herstellung von substituierten aminosaeuren

Info

Publication number
DD134224A5
DD134224A5 DD77202381A DD20238177A DD134224A5 DD 134224 A5 DD134224 A5 DD 134224A5 DD 77202381 A DD77202381 A DD 77202381A DD 20238177 A DD20238177 A DD 20238177A DD 134224 A5 DD134224 A5 DD 134224A5
Authority
DD
German Democratic Republic
Prior art keywords
aminosaures
substituted
production
substituted aminosaures
Prior art date
Application number
DD77202381A
Other languages
German (de)
English (en)
Inventor
Miguel Ondetti
Frank L Weisenborn
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of DD134224A5 publication Critical patent/DD134224A5/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
DD77202381A 1976-12-03 1977-12-02 Verfahren zur herstellung von substituierten aminosaeuren DD134224A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/747,280 US4116962A (en) 1976-12-03 1976-12-03 Pyrrolidine and piperidine-2-carboxylic acid derivatives

Publications (1)

Publication Number Publication Date
DD134224A5 true DD134224A5 (de) 1979-02-14

Family

ID=25004419

Family Applications (1)

Application Number Title Priority Date Filing Date
DD77202381A DD134224A5 (de) 1976-12-03 1977-12-02 Verfahren zur herstellung von substituierten aminosaeuren

Country Status (33)

Country Link
US (3) US4116962A (xx)
JP (1) JPS5371014A (xx)
AR (1) AR220525A1 (xx)
AT (1) AT362780B (xx)
AU (1) AU513051B2 (xx)
BE (1) BE861453A (xx)
CA (1) CA1080729A (xx)
CH (1) CH634830A5 (xx)
CS (1) CS199514B2 (xx)
DD (1) DD134224A5 (xx)
DE (1) DE2752720A1 (xx)
DK (1) DK539077A (xx)
EG (1) EG12981A (xx)
ES (1) ES464463A1 (xx)
FI (1) FI68221C (xx)
FR (1) FR2372803A1 (xx)
GB (1) GB1591229A (xx)
GR (1) GR72452B (xx)
HK (1) HK8882A (xx)
HU (1) HU176021B (xx)
IE (1) IE46264B1 (xx)
IL (1) IL53292A0 (xx)
IT (1) IT1112112B (xx)
NL (1) NL187163C (xx)
NO (1) NO774125L (xx)
NZ (1) NZ185603A (xx)
PH (2) PH13488A (xx)
PT (1) PT67353B (xx)
RO (1) RO74877A (xx)
SE (1) SE423994B (xx)
SU (1) SU731891A3 (xx)
YU (1) YU283877A (xx)
ZA (1) ZA776508B (xx)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4116962A (en) * 1976-12-03 1978-09-26 E. R. Squibb & Sons, Inc. Pyrrolidine and piperidine-2-carboxylic acid derivatives
US4198517A (en) * 1976-12-03 1980-04-15 E. R. Squibb & Sons, Inc. Histidine derivatives
US4113715A (en) * 1977-01-17 1978-09-12 E. R. Squibb & Sons, Inc. Amino acid derivatives
US4284780A (en) * 1977-01-17 1981-08-18 E. R. Squibb & Sons, Inc. Amino acid derivatives
US4284779A (en) * 1977-01-17 1981-08-18 E. R. Squibb & Sons, Inc. Amino acid derivatives
US4241076A (en) * 1978-02-21 1980-12-23 E. R. Squibb & Sons, Inc. Halogenated substituted mercaptoacylamino acids
JPS559058A (en) * 1978-07-06 1980-01-22 Dainippon Pharmaceut Co Ltd 1-(3-mercapto-2-methylpropanoyl)prolyl amino acid derivative
US4179568A (en) * 1978-07-31 1979-12-18 E. R. Squibb & Sons, Inc. (N-lower alkyl-3,5-dioxo-3-pyrrolidinyl)thioalkanoylpyrrolidine-and piperidine-carboxylic acid compounds
CA1144930A (en) * 1978-08-11 1983-04-19 Miguel A. Ondetti Mercaptoacyl derivatives of substituted prolines
NZ190995A (en) * 1978-09-05 1982-03-09 American Cyanamid Co Substituted omega propionyl or butyryl l-prolines and pharmaceutical compositions
NL7809120A (nl) * 1978-09-07 1980-03-11 Oce Andeno B V Grubbenvorsterw Werkwijze voor de bereiding van proline-derivaten.
US4698355A (en) * 1979-08-14 1987-10-06 University Of Miami Anti-hypertensive agents
US4695577A (en) * 1979-08-14 1987-09-22 University Of Miami Anti-hypertensive agents
US4690937A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
US4690938A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
GR73585B (xx) * 1978-09-11 1984-03-26 Univ Miami
US4698356A (en) * 1979-08-14 1987-10-06 University Of Miami Anti-hypertensive agents
US4690939A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
US4690940A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
ZA794723B (en) * 1978-09-11 1980-08-27 Univ Miami Anti-hypertensive agents
US4311697A (en) * 1978-12-22 1982-01-19 E. R. Squibb & Sons, Inc. Derivatives of mercaptoacyl prolines and pipecolic acids
US4217359A (en) * 1979-01-15 1980-08-12 E. R. Squibb & Sons, Inc. Carbamate derivatives of mercaptoacyl hydroxy prolines
US4297282A (en) * 1979-03-02 1981-10-27 Sumitomo Chemical Company, Limited Resolution of mercaptopropionic acids
US4329473A (en) * 1979-06-01 1982-05-11 Almquist Ronald G Oxoalkanoic acid derivatives as inhibitors of angiotensin converting enzyme
US4549992A (en) * 1979-07-13 1985-10-29 Usv Pharmaceutical Corp. Antihypertensive amides
US4256761A (en) * 1979-07-13 1981-03-17 Usv Pharmaceutical Corporation Antihypertensive amides
US4595675A (en) * 1979-09-19 1986-06-17 Hoechst Aktiengesellschaft Bicyclic α-iminocarboxylic acid compounds having hypotensive activity
US4291040A (en) * 1979-10-22 1981-09-22 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 4-disubstituted prolines and 4-substituted dehydroprolines
US4356182A (en) * 1979-10-22 1982-10-26 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 4-disubstituted prolines
US4296113A (en) * 1980-01-14 1981-10-20 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of keto substituted proline and pipecolic acid
US4330548A (en) * 1980-01-14 1982-05-18 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of keto substituted pipecolic acid
IT1144077B (it) * 1980-01-29 1986-10-29 Sigma Tau Ind Farmaceuti Carnitinammidi di amminoacidi otticamente attivi e procedimento per la loro preparazione
US4321392A (en) * 1980-02-06 1982-03-23 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 4-oxazolidine-carboxylic acids
US4690936A (en) * 1980-03-05 1987-09-01 University Of Miami Anti-hypertensive agents
US4734420A (en) * 1980-03-05 1988-03-29 University Of Miami Anti-hypertensive agents
US4692458A (en) * 1980-03-05 1987-09-08 University Of Miami Anti-hypertensive agents
US4350704A (en) * 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
US4342691A (en) * 1980-04-28 1982-08-03 American Cyanamid Company ω-Heteroaroyl(propionyl or butyryl)-L-prolines
US4342689A (en) * 1980-04-28 1982-08-03 American Cyanamid Company ω-Heteroaroyl(propionyl or butyryl)-L-prolines
US4342690A (en) * 1980-04-28 1982-08-03 American Cyanamid Company ω-Heteroaroyl(propionyl or butyryl)-L-prolines
US4299769A (en) * 1980-04-28 1981-11-10 American Cyanamid Company ω-Heteroaroyl(propionyl or butyryl)-L-prolines
US4316905A (en) * 1980-07-01 1982-02-23 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of various 4-substituted prolines
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4456761A (en) * 1981-02-02 1984-06-26 E. R. Squibb & Sons, Inc. 4-Substituted dehydroprolines
US4499287A (en) * 1981-02-02 1985-02-12 E. R. Squibb & Sons, Inc. Certain-4-hydroxy-proline derivatives
US4532342A (en) * 1981-02-20 1985-07-30 Warner-Lambert Company N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4521607A (en) * 1981-02-27 1985-06-04 Takeda Chemical Industries, Ltd. Chromanyl glycines
US4503043A (en) * 1981-12-07 1985-03-05 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-isoindole-1-carboxylic acids
US4442038A (en) * 1982-09-17 1984-04-10 Norwich Eaton Pharmaceuticals, Inc. Converting enzyme inhibitors
DE3243369A1 (de) * 1982-11-24 1984-05-24 Basf Ag, 6700 Ludwigshafen Bis-(benzoylthio)-carbonsaeuren, ihre herstellung und verwendung zur herstellung von wirkstoffen
US5096925A (en) * 1984-06-08 1992-03-17 Ciba-Geigy Corporation N-substituted butyramide derivatives
JPS61502468A (ja) * 1984-06-08 1986-10-30 チバ・ガイギ−・アクチェンゲゼルシャフト Ｎ−置換ブチルアミド誘導体
US5166212A (en) * 1985-12-06 1992-11-24 Ciba-Geigy Corporation Certain n-substituted butyramide derivatives
EP0225292A3 (en) * 1985-12-06 1988-11-30 Ciba-Geigy Ag Certain n-substituted butyramide derivatives
EP0384636A1 (en) * 1989-02-21 1990-08-29 FISONS plc Pharmaceutically active compounds
CA2141739A1 (en) * 1993-05-03 1994-11-10 Alfons M. Verbruggen Method for preparing a metal-radionuclide-labelled protein
US20070086958A1 (en) * 2005-10-14 2007-04-19 Medafor, Incorporated Formation of medically useful gels comprising microporous particles and methods of use
US20070087061A1 (en) * 2005-10-14 2007-04-19 Medafor, Incorporated Method and composition for creating and/or activating a platelet-rich gel by contact with a porous particulate material, for use in wound care, tissue adhesion, or as a matrix for delivery of therapeutic components
WO2016111310A1 (ja) * 2015-01-06 2016-07-14 国立研究開発法人理化学研究所 新規アンジオテンシン変換酵素阻害剤

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2714119A (en) * 1953-08-07 1955-07-26 Sterling Drug Inc Process for preparing amides of alphamercapto lower fatty acids
US3510504A (en) * 1965-01-21 1970-05-05 Lilly Co Eli Adamantyloxycarbonyl derivatives of alpha-amino acids
US3624143A (en) * 1968-05-10 1971-11-30 Merck & Co Inc Compounds of the class {62 -aralkylthio-substituted-{60 -amino acids
BE792042A (fr) * 1971-11-30 1973-05-29 Ciba Geigy Procede de preparation de nouvelles alcenylene-amines substituees en 3
US3971828A (en) * 1972-10-03 1976-07-27 Santen Pharmaceutical Co. Ltd. N-(mercaptoacyl)aminoacids
US4046889A (en) * 1976-02-13 1977-09-06 E. R. Squibb & Sons, Inc. Azetidine-2-carboxylic acid derivatives
US4053651A (en) * 1976-05-10 1977-10-11 E. R. Squibb & Sons, Inc. Compounds and method for alleviating angiotensin related hypertension
US4116962A (en) * 1976-12-03 1978-09-26 E. R. Squibb & Sons, Inc. Pyrrolidine and piperidine-2-carboxylic acid derivatives

Also Published As

Publication number Publication date
DK539077A (da) 1978-06-04
CA1080729A (en) 1980-07-01
ES464463A1 (es) 1978-09-01
PT67353A (fr) 1978-01-01
JPS5371014A (en) 1978-06-24
FR2372803B1 (xx) 1981-07-03
PH13488A (en) 1980-05-21
FR2372803A1 (fr) 1978-06-30
DE2752720A1 (de) 1978-06-08
FI773639A (fi) 1978-06-04
HU176021B (en) 1980-11-28
NL7712612A (nl) 1978-06-06
HK8882A (en) 1982-03-05
PH14255A (en) 1981-04-13
ATA857477A (de) 1980-11-15
CH634830A5 (de) 1983-02-28
ZA776508B (en) 1978-08-30
IE46264B1 (en) 1983-04-20
RO74877A (ro) 1980-10-30
AU513051B2 (en) 1980-11-13
BE861453A (fr) 1978-06-02
YU283877A (en) 1983-01-21
FI68221C (fi) 1985-08-12
IE46264L (en) 1978-06-03
IL53292A0 (en) 1978-01-31
GB1591229A (en) 1981-06-17
SU731891A3 (ru) 1980-04-30
AT362780B (de) 1981-06-10
AU3048577A (en) 1979-05-17
US4140864A (en) 1979-02-20
EG12981A (en) 1980-10-31
FI68221B (fi) 1985-04-30
NL187163B (nl) 1991-01-16
SE423994B (sv) 1982-06-21
US4154936A (en) 1979-05-15
JPS6121225B2 (xx) 1986-05-26
IT1112112B (it) 1986-01-13
GR72452B (xx) 1983-11-09
NZ185603A (en) 1982-03-09
PT67353B (fr) 1979-05-15
CS199514B2 (en) 1980-07-31
US4116962A (en) 1978-09-26
NL187163C (nl) 1991-06-17
AR220525A1 (es) 1980-11-14
SE7713721L (sv) 1978-06-04
NO774125L (no) 1978-06-06

Similar Documents

Publication Publication Date Title
DD134224A5 (de) Verfahren zur herstellung von substituierten aminosaeuren
AT356384B (de) Verfahren zur herstellung von oligourethanen
PT71603A (de) Verfahren zur herstellung von substituierten 3-amino-sydnoniminen
AT373567B (de) Verfahren zur herstellung von hochreinem elektroschmelzkorund
ATA853577A (de) Verfahren zur herstellung von polykondensaten
AT352138B (de) Verfahren zur herstellung von 2-chlorsulfinyl- azetidin-4-onen
AT347437B (de) Verfahren zur herstellung von benzoylcyanid
AT347439B (de) Verfahren zur herstellung von benzoylcyanid
AT352753B (de) Verfahren zur herstellung von methyldichlor- phosphan
DD133055A5 (de) Verfahren zur herstellung von dimeren indol-dihydroindolcarboxamiden
AT356676B (de) Verfahren zur herstellung von distickstoff- monoxid
AT356129B (de) Verfahren zur herstellung von substituierten 1-carbamoyl-2-cyanaziridinen
AT349454B (de) Verfahren zur herstellung von alfa-cyano- benzylestern
DD134227A5 (de) Verfahren zur herstellung von dimeren indoldihydroindoldionen
AT347438B (de) Verfahren zur herstellung von benzoylcyanid
ATA980876A (de) Verfahren zur herstellung von 2-oxo-pyrrolidin- n-alkylamiden
AT351676B (de) Verfahren zur herstellung von 7-alkoxy-3- chlormethyl-3-cephemen
AT357280B (de) Verfahren zur herstellung von 17alpha- -alkinyl-androst-4-enderivaten
AT347929B (de) Verfahren zur herstellung von triphenylalken- derivaten
AT364919B (de) Verfahren zur herstellung von bogentragwerken
DD128663A1 (de) Verfahren zur kontinuierlichen herstellung von perestern
AT348506B (de) Verfahren zur herstellung von bis- polybromphenoxy-alkanen
AT358189B (de) Verfahren zur herstellung von neuen aspidosper- midinen
AT360757B (de) Verfahren zur kontinuierlichen herstellung von aethylenpolymerisaten
AT347918B (de) Verfahren zur herstellung von hexachlor- cyclobuten