FI773639A - Substituerade acylderivat av aminosyror - Google Patents

Substituerade acylderivat av aminosyror

Info

Publication number
FI773639A
FI773639A FI773639A FI773639A FI773639A FI 773639 A FI773639 A FI 773639A FI 773639 A FI773639 A FI 773639A FI 773639 A FI773639 A FI 773639A FI 773639 A FI773639 A FI 773639A
Authority
FI
Finland
Prior art keywords
acylderivat
aminosyror
substitute
substitute acylderivat
Prior art date
Application number
FI773639A
Other languages
English (en)
Other versions
FI68221C (fi
FI68221B (fi
Inventor
Miguel A Ondetti
Frank L Weisenborn
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of FI773639A publication Critical patent/FI773639A/fi
Application granted granted Critical
Publication of FI68221B publication Critical patent/FI68221B/fi
Publication of FI68221C publication Critical patent/FI68221C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
FI773639A 1976-12-03 1977-12-01 Foerfarande foer framstaellning av terapeutiskt anvaendbara deivat av prolin och pipekolinsyra FI68221C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/747,280 US4116962A (en) 1976-12-03 1976-12-03 Pyrrolidine and piperidine-2-carboxylic acid derivatives
US74728076 1976-12-03

Publications (3)

Publication Number Publication Date
FI773639A true FI773639A (fi) 1978-06-04
FI68221B FI68221B (fi) 1985-04-30
FI68221C FI68221C (fi) 1985-08-12

Family

ID=25004419

Family Applications (1)

Application Number Title Priority Date Filing Date
FI773639A FI68221C (fi) 1976-12-03 1977-12-01 Foerfarande foer framstaellning av terapeutiskt anvaendbara deivat av prolin och pipekolinsyra

Country Status (33)

Country Link
US (3) US4116962A (fi)
JP (1) JPS5371014A (fi)
AR (1) AR220525A1 (fi)
AT (1) AT362780B (fi)
AU (1) AU513051B2 (fi)
BE (1) BE861453A (fi)
CA (1) CA1080729A (fi)
CH (1) CH634830A5 (fi)
CS (1) CS199514B2 (fi)
DD (1) DD134224A5 (fi)
DE (1) DE2752720A1 (fi)
DK (1) DK539077A (fi)
EG (1) EG12981A (fi)
ES (1) ES464463A1 (fi)
FI (1) FI68221C (fi)
FR (1) FR2372803A1 (fi)
GB (1) GB1591229A (fi)
GR (1) GR72452B (fi)
HK (1) HK8882A (fi)
HU (1) HU176021B (fi)
IE (1) IE46264B1 (fi)
IL (1) IL53292A0 (fi)
IT (1) IT1112112B (fi)
NL (1) NL187163C (fi)
NO (1) NO774125L (fi)
NZ (1) NZ185603A (fi)
PH (2) PH13488A (fi)
PT (1) PT67353B (fi)
RO (1) RO74877A (fi)
SE (1) SE423994B (fi)
SU (1) SU731891A3 (fi)
YU (1) YU283877A (fi)
ZA (1) ZA776508B (fi)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4116962A (en) * 1976-12-03 1978-09-26 E. R. Squibb & Sons, Inc. Pyrrolidine and piperidine-2-carboxylic acid derivatives
US4198517A (en) * 1976-12-03 1980-04-15 E. R. Squibb & Sons, Inc. Histidine derivatives
US4113715A (en) * 1977-01-17 1978-09-12 E. R. Squibb & Sons, Inc. Amino acid derivatives
US4284779A (en) * 1977-01-17 1981-08-18 E. R. Squibb & Sons, Inc. Amino acid derivatives
US4284780A (en) * 1977-01-17 1981-08-18 E. R. Squibb & Sons, Inc. Amino acid derivatives
US4241076A (en) * 1978-02-21 1980-12-23 E. R. Squibb & Sons, Inc. Halogenated substituted mercaptoacylamino acids
JPS559058A (en) * 1978-07-06 1980-01-22 Dainippon Pharmaceut Co Ltd 1-(3-mercapto-2-methylpropanoyl)prolyl amino acid derivative
US4179568A (en) * 1978-07-31 1979-12-18 E. R. Squibb & Sons, Inc. (N-lower alkyl-3,5-dioxo-3-pyrrolidinyl)thioalkanoylpyrrolidine-and piperidine-carboxylic acid compounds
CA1144930A (en) * 1978-08-11 1983-04-19 Miguel A. Ondetti Mercaptoacyl derivatives of substituted prolines
NZ190995A (en) * 1978-09-05 1982-03-09 American Cyanamid Co Substituted omega propionyl or butyryl l-prolines and pharmaceutical compositions
NL7809120A (nl) * 1978-09-07 1980-03-11 Oce Andeno B V Grubbenvorsterw Werkwijze voor de bereiding van proline-derivaten.
US4695577A (en) * 1979-08-14 1987-09-22 University Of Miami Anti-hypertensive agents
US4690938A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
US4690939A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
US4698356A (en) * 1979-08-14 1987-10-06 University Of Miami Anti-hypertensive agents
US4690940A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
ZA794723B (en) * 1978-09-11 1980-08-27 Univ Miami Anti-hypertensive agents
GR73585B (fi) * 1978-09-11 1984-03-26 Univ Miami
US4698355A (en) * 1979-08-14 1987-10-06 University Of Miami Anti-hypertensive agents
US4690937A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
US4311697A (en) * 1978-12-22 1982-01-19 E. R. Squibb & Sons, Inc. Derivatives of mercaptoacyl prolines and pipecolic acids
US4217359A (en) * 1979-01-15 1980-08-12 E. R. Squibb & Sons, Inc. Carbamate derivatives of mercaptoacyl hydroxy prolines
US4297282A (en) * 1979-03-02 1981-10-27 Sumitomo Chemical Company, Limited Resolution of mercaptopropionic acids
US4329473A (en) * 1979-06-01 1982-05-11 Almquist Ronald G Oxoalkanoic acid derivatives as inhibitors of angiotensin converting enzyme
US4549992A (en) * 1979-07-13 1985-10-29 Usv Pharmaceutical Corp. Antihypertensive amides
US4256761A (en) * 1979-07-13 1981-03-17 Usv Pharmaceutical Corporation Antihypertensive amides
US4595675A (en) * 1979-09-19 1986-06-17 Hoechst Aktiengesellschaft Bicyclic α-iminocarboxylic acid compounds having hypotensive activity
US4356182A (en) * 1979-10-22 1982-10-26 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 4-disubstituted prolines
US4291040A (en) * 1979-10-22 1981-09-22 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 4-disubstituted prolines and 4-substituted dehydroprolines
US4330548A (en) * 1980-01-14 1982-05-18 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of keto substituted pipecolic acid
US4296113A (en) * 1980-01-14 1981-10-20 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of keto substituted proline and pipecolic acid
IT1144077B (it) * 1980-01-29 1986-10-29 Sigma Tau Ind Farmaceuti Carnitinammidi di amminoacidi otticamente attivi e procedimento per la loro preparazione
US4321392A (en) * 1980-02-06 1982-03-23 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 4-oxazolidine-carboxylic acids
US4692458A (en) * 1980-03-05 1987-09-08 University Of Miami Anti-hypertensive agents
US4690936A (en) * 1980-03-05 1987-09-01 University Of Miami Anti-hypertensive agents
US4734420A (en) * 1980-03-05 1988-03-29 University Of Miami Anti-hypertensive agents
US4350704A (en) * 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
US4342691A (en) * 1980-04-28 1982-08-03 American Cyanamid Company ω-Heteroaroyl(propionyl or butyryl)-L-prolines
US4342689A (en) * 1980-04-28 1982-08-03 American Cyanamid Company ω-Heteroaroyl(propionyl or butyryl)-L-prolines
US4342690A (en) * 1980-04-28 1982-08-03 American Cyanamid Company ω-Heteroaroyl(propionyl or butyryl)-L-prolines
US4299769A (en) * 1980-04-28 1981-11-10 American Cyanamid Company ω-Heteroaroyl(propionyl or butyryl)-L-prolines
US4316905A (en) * 1980-07-01 1982-02-23 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of various 4-substituted prolines
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4499287A (en) * 1981-02-02 1985-02-12 E. R. Squibb & Sons, Inc. Certain-4-hydroxy-proline derivatives
US4456761A (en) * 1981-02-02 1984-06-26 E. R. Squibb & Sons, Inc. 4-Substituted dehydroprolines
US4532342A (en) * 1981-02-20 1985-07-30 Warner-Lambert Company N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4521607A (en) * 1981-02-27 1985-06-04 Takeda Chemical Industries, Ltd. Chromanyl glycines
US4503043A (en) * 1981-12-07 1985-03-05 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-isoindole-1-carboxylic acids
US4442038A (en) * 1982-09-17 1984-04-10 Norwich Eaton Pharmaceuticals, Inc. Converting enzyme inhibitors
DE3243369A1 (de) 1982-11-24 1984-05-24 Basf Ag, 6700 Ludwigshafen Bis-(benzoylthio)-carbonsaeuren, ihre herstellung und verwendung zur herstellung von wirkstoffen
US5096925A (en) * 1984-06-08 1992-03-17 Ciba-Geigy Corporation N-substituted butyramide derivatives
DE3565677D1 (de) * 1984-06-08 1988-11-24 Ciba Geigy Ag N-substituted butyramide derivatives
EP0225292A3 (en) * 1985-12-06 1988-11-30 Ciba-Geigy Ag Certain n-substituted butyramide derivatives
US5166212A (en) * 1985-12-06 1992-11-24 Ciba-Geigy Corporation Certain n-substituted butyramide derivatives
EP0384636A1 (en) * 1989-02-21 1990-08-29 FISONS plc Pharmaceutically active compounds
CA2141739A1 (en) * 1993-05-03 1994-11-10 Alfons M. Verbruggen Method for preparing a metal-radionuclide-labelled protein
US20070087061A1 (en) * 2005-10-14 2007-04-19 Medafor, Incorporated Method and composition for creating and/or activating a platelet-rich gel by contact with a porous particulate material, for use in wound care, tissue adhesion, or as a matrix for delivery of therapeutic components
US20070086958A1 (en) * 2005-10-14 2007-04-19 Medafor, Incorporated Formation of medically useful gels comprising microporous particles and methods of use
WO2016111310A1 (ja) * 2015-01-06 2016-07-14 国立研究開発法人理化学研究所 新規アンジオテンシン変換酵素阻害剤

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2714119A (en) * 1953-08-07 1955-07-26 Sterling Drug Inc Process for preparing amides of alphamercapto lower fatty acids
US3510504A (en) * 1965-01-21 1970-05-05 Lilly Co Eli Adamantyloxycarbonyl derivatives of alpha-amino acids
US3624143A (en) * 1968-05-10 1971-11-30 Merck & Co Inc Compounds of the class {62 -aralkylthio-substituted-{60 -amino acids
BE792042A (fr) * 1971-11-30 1973-05-29 Ciba Geigy Procede de preparation de nouvelles alcenylene-amines substituees en 3
US3971828A (en) * 1972-10-03 1976-07-27 Santen Pharmaceutical Co. Ltd. N-(mercaptoacyl)aminoacids
US4046889A (en) * 1976-02-13 1977-09-06 E. R. Squibb & Sons, Inc. Azetidine-2-carboxylic acid derivatives
US4053651A (en) * 1976-05-10 1977-10-11 E. R. Squibb & Sons, Inc. Compounds and method for alleviating angiotensin related hypertension
US4116962A (en) * 1976-12-03 1978-09-26 E. R. Squibb & Sons, Inc. Pyrrolidine and piperidine-2-carboxylic acid derivatives

Also Published As

Publication number Publication date
JPS5371014A (en) 1978-06-24
AU3048577A (en) 1979-05-17
US4154936A (en) 1979-05-15
PH14255A (en) 1981-04-13
IL53292A0 (en) 1978-01-31
ZA776508B (en) 1978-08-30
DE2752720A1 (de) 1978-06-08
NO774125L (no) 1978-06-06
FR2372803A1 (fr) 1978-06-30
ATA857477A (de) 1980-11-15
FI68221C (fi) 1985-08-12
CH634830A5 (de) 1983-02-28
JPS6121225B2 (fi) 1986-05-26
PT67353B (fr) 1979-05-15
US4116962A (en) 1978-09-26
PH13488A (en) 1980-05-21
NL187163B (nl) 1991-01-16
EG12981A (en) 1980-10-31
SE7713721L (sv) 1978-06-04
PT67353A (fr) 1978-01-01
BE861453A (fr) 1978-06-02
GR72452B (fi) 1983-11-09
NL187163C (nl) 1991-06-17
HU176021B (en) 1980-11-28
SU731891A3 (ru) 1980-04-30
HK8882A (en) 1982-03-05
FI68221B (fi) 1985-04-30
SE423994B (sv) 1982-06-21
IE46264B1 (en) 1983-04-20
DD134224A5 (de) 1979-02-14
US4140864A (en) 1979-02-20
AR220525A1 (es) 1980-11-14
YU283877A (en) 1983-01-21
DK539077A (da) 1978-06-04
FR2372803B1 (fi) 1981-07-03
IE46264L (en) 1978-06-03
CA1080729A (en) 1980-07-01
NZ185603A (en) 1982-03-09
GB1591229A (en) 1981-06-17
ES464463A1 (es) 1978-09-01
AU513051B2 (en) 1980-11-13
RO74877A (ro) 1980-10-30
IT1112112B (it) 1986-01-13
AT362780B (de) 1981-06-10
CS199514B2 (en) 1980-07-31
NL7712612A (nl) 1978-06-06

Similar Documents

Publication Publication Date Title
FI773639A (fi) Substituerade acylderivat av aminosyror
FI763349A (fi) Foerfarande foer framstaellning av pizzaost
FI56135C (fi) Anordning foer avbarkning av virke
FI53522C (fi) Foerfarande foer tillverkning av hoegspaenningsplastkabel
FI55217B (fi) Foerfarande foer tillvaratagande av xantangummi
FI65827B (fi) Anordning foer behandling av vaetskehaltiga aemnesblandningar saerskilt fibersuspensioner
FI56699B (fi) Maskinelement av segjaern foer kraftoeverfoering medelst friktion
FI55605C (fi) Saett foer installering av gardinbraede
FI53757C (fi) Foerfarande foer maetning av ytvikterna
FI65772B (fi) Foerfarande foer framstaellning av antimikrobiellt verksamma av huden foerdragbara 2-klor-6-metyl-4-aralkylfenoler
FI762835A (fi) Noetningsbestaendigt maskinelement av segjaern foer behandling av mineraler
FI55528C (fi) Saett foer tillverkning av en mineralfiberbana
FI54596C (fi) Anordning foer framstaellning av jordfoerbaettringsmedel
FI54182C (fi) Anordning foer pumpgjutning av betong
FI56863B (fi) Saett foer tillverkning av en mineralfiberbana
FI56056C (fi) Anlaeggning foer tillvaratagande av vaerme av en vaermekraftmaskin saosom dieselmotor
FI53949C (fi) Av traktor dragen arbetsmaskin
FI56579B (fi) Foerband foer hopfaestning av parallella profilkroppar bredvid varandra
FI53399C (fi) Kokare foer behandling av organiska aemnen saosom livsmedel
FI53288C (fi) Anordning foer sortering av virke speciellt stockar
FI65606B (fi) Foerfarande foer framstaellning av klordioxid
FI53532C (fi) Staellning foer uppredning av fisknaet
FI53595C (fi) Foerfaringssaett foer reliefmoenstring av laeder
FI53437C (fi) Anordning foer foerflyttning av virkesknippen fraon en dammbassaeng
FI763523A (fi) Larvkaetting av skogmaskin

Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: E.R. SQUIBB & SONS, INC.